Article
Obstetrics & Gynecology
Jianjun Hu, Emanuela Molinari, Sarah K. Darmon, Lin Zhang, Pasquale Patrizio, David H. Barad, Norbert Gleicher
Summary: The study found that the granulation patterns of donor oocytes are predictive of IVF success rates, with higher quality granulation patterns associated with higher pregnancy and live birth rates in fresh donor oocytes. Similar trends were observed in thawed donor oocytes, but with relatively worse outcomes.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Jianjun Hu, Emanuela Molinari, Sarah Darmon, Lin Zhang, Pasquale Patrizio, David H. Barad, Norbert Gleicher
Summary: The study showed that four distinct cytoplasmic granulation patterns in human metaphase II oocytes were predictive of fertilization, pregnancy, and live birth outcomes in in vitro fertilization cycles, largely independent of age and other variables. These findings suggest that ooplasm granulation patterns should be considered in embryo selection for poor-prognosis patients undergoing IVF.
FERTILITY AND STERILITY
(2021)
Article
Environmental Sciences
Hai-Xia Jin, Yu-Han Guo, Wen-Yan Song, Gang Li, Yan Liu, Sen-Lin Shi
Summary: With the rapid urbanization and industrialization in China, air pollution has become a significant environmental issue. A retrospective data analysis of 6564 patients from the Center for Reproductive Medicine at the First Affiliated Hospital of Zhengzhou University between 2015 and 2020 revealed that air pollutants have a significant impact on the outcome of in vitro fertilization and embryo transfer (IVF-ET), particularly in patients younger than 35 years old, those undergoing single embryo transfer, and cleavage stage embryo transfer.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Giulia Scaravelli, Carlotta Zaca, Paolo Emanuele Levi Setti, Claudia Livi, Filippo Maria Ubaldi, Maria Teresa Villani, Ermanno Greco, Maria Elisabetta Coccia, Alberto Revelli, Giuseppe Ricci, Francesco Fusi, Vincenzo Vigiliano, Roberto De Luca, Simone Bolli, Andrea Borini
Summary: The study revealed a positive association between fertilization rate and CLBR, suggesting the predictive clinical relevance of this parameter and its adoption as a key performance indicator.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Yueming Xu, Jie Zhang, Aimin Li, Ni Yang, Na Cui, Guimin Hao, Bu-Lang Gao
Summary: Elevated progesterone levels during the late follicular phase significantly impact early pregnancy outcomes and live births among IVF/ICSI patients after fresh embryo transfers. With increasing progesterone levels, clinical pregnancy rate, intrauterine pregnancy rate, and live birth rate all decrease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Ruiying Wang, Guojun Zhou, Lukanxuan Wu, Xin Huang, Yujing Li, Bin Luo, Huili Zhu, Wei Huang
Summary: The study reveals that the cervical microbiota is more diverse than the vaginal microbiota, but there is a correlation between the two sites due to anatomical continuity. The microbial composition of the vagina and cervical canal may influence the outcome of IVF-ET, although more samples are needed to verify this conclusion.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Obstetrics & Gynecology
Paolo Emanuele Levi-Setti, Andrea Busnelli, Roberto De Luca, Giulia Scaravelli
Summary: The study indicates that strategies favoring frozen-thawed embryo transfer (FET) are associated with increased cumulative live birth rate (CLBR), decreased weighted mean cost per live birth, and reduced multiple pregnancy rate (MPR).
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Rachel M. Whynott, Karen M. Summers, G. David Ball, Bradley J. Van Voorhis, Amy Sparks
Summary: This study aimed to determine whether transfer of fresh embryos derived from fresh or cryopreserved donor oocytes yields a higher live birth rate. The results showed that the live birth rate was higher in fresh embryo transfer cycles using fresh oocytes compared to cryopreserved oocytes. Negative predictors of live birth included recipient Black non-Hispanic or Asian race and increasing BMI.
FERTILITY AND STERILITY
(2022)
Article
Acoustics
D. Chen, Q. Xu, X. Mao, J. Zhang, L. Wu
Summary: This study aimed to investigate the effect of women's reproductive history on live-birth rate and perinatal outcome after first frozen-thawed embryo transfer (FET) without preimplantation genetic testing for aneuploidy. The results showed that women with a previous termination of pregnancy (TOP), pregnancy loss, ectopic pregnancy (EP), or live birth did not have compromised live-birth rate or perinatal outcomes following FET, except for an increased risk of EP in those with prior TOP or EP.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Bahar Shakerian, Engin Turkgeldi, Sule Yildiz, Ipek Keles, Baris Ata
Summary: This study found that endometrial thickness (EMT) does not have predictive value for live birth when a lower threshold of EMT is not employed for embryo transfer (ET). There was no linear association between EMT and live birth or miscarriage rates, and the predictive value of EMT for live birth after fresh, frozen-thawed, and all ETs was low.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Yixuan Wu, Mingzhu Cao, Yanshan Lin, Zijin Xu, Zhu Liang, Qing Huang, Sichen Li, Lei Li, Yaming Meng, Chunyan An, Haiying Liu, Jianqiao Liu
Summary: The study found that inactivated COVID-19 vaccines have minimal impact on IVF outcomes, including ovarian stimulation, embryo development, and pregnancy rates.
HUMAN REPRODUCTION
(2022)
Article
Genetics & Heredity
Sarah M. Capelouto, Audrey J. Gaskins, Zsolt Peter Nagy, Daniel B. Shapiro, Jessica B. Spencer, Heather S. Hipp
Summary: This study found that in oocyte donor IVF, the stage of embryo transfer can impact reproductive success, with cleavage stage transfers associated with lower live birth rates compared to blastocyst transfers. Particularly in cases with limited number of quality embryos available, extended culture and blastocyst transfer can improve success rates.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Health Care Sciences & Services
Ioana Zaha, Petronela Naghi, Liana Stefan, Cosmina Bunescu, Mihaela Radu, Mariana Eugenia Muresan, Mircea Sandor, Liliana Sachelarie, Anca Huniadi
Summary: The microfluidic sperm selection method was found to improve the outcomes of in vitro fertilization (IVF) procedures. This method, which selects spermatozoa with the lowest DNA fragmentation rate, resulted in higher blastocyst rates and clinical pregnancy rates. It has the potential to be widely used in intracytoplasmic sperm injection (ICSI) and improve the workflow of standard IVF, reducing intervention by laboratory personnel and providing more consistent incubation conditions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Acoustics
P. Cai, Y. Ouyang, G. Lin, Y. Peng, J. Qin, X. Li, F. Gong
Summary: This study investigated the pregnancy and obstetric outcomes of patients with congenital uterus didelphys who achieved clinical pregnancy after IVF/ICSI. The presence of uterus didelphys was associated with increased risks of preterm birth, Cesarean section, and low birth weight in singleton pregnancies, and even worse perinatal outcomes in twin pregnancies compared to women with normal uterine morphology.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Giovanni Coticchio, Kenji Ezoe, Cristina Lagalla, Kiyoe Shimazaki, Kazuki Ohata, Maya Ninomiya, Natsuki Wakabayashi, Tadashi Okimura, Kazuo Uchiyama, Keiichi Kato, Andrea Borini
Summary: The study showed that the exclusion and extrusion of cells during blastocyst formation have a significant impact on the embryo development and clinical outcomes, especially with negative effects on pregnancy and live birth rates.
HUMAN REPRODUCTION
(2021)
Article
Urology & Nephrology
Adriana Nicholson Vest, Lauren M. Kipling, Dattatraya Patil, Heather S. Hipp, Jennifer F. Kawwass, Akanksha Mehta
Summary: This study aimed to investigate the association between paternal race and reproductive outcomes following in vitro fertilization (IVF). The results showed that although paternal race was associated with IVF cycle characteristics, it did not independently contribute to outcomes after controlling for potential confounders.
Editorial Material
Obstetrics & Gynecology
Nazokat Usmanova, Heather S. Hipp
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Shae M. Boguslawski, Naima T. Joseph, Kaitlyn K. Stanhope, Angeline J. Ti, Franklyn H. Geary, Sheree L. Boulet
Summary: The aim of this study was to compare rates of prenatal care utilization before and after implementing a telehealth-supplemented prenatal care model during the COVID-19 pandemic. Results showed that pregnant persons receiving prenatal care during the pandemic entered care earlier and had higher utilization of certain antenatal screening services compared to those receiving prenatal care prior to the pandemic. However, there was no difference in the number of prenatal care visits between the two groups, and the proportion of patients with emergency department visits and rates of labor induction were higher in the pandemic-exposed cohort.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Tatyana A. Johnson, Denise J. Jamieson, Franklyn H. Geary, Kaitlyn K. Stanhope, Sheree L. Boulet
Summary: This study aimed to assess the impact of the COVID-19 pandemic on rates of obstetric procedures and severe maternal morbidity (SMM) at an urban safety net institution. The results showed that the rates of obstetric interventions and SMM remained constant during the pandemic period, indicating that the rapid implementation of measures to reduce viral transmission did not significantly affect routine clinical management or rates of serious maternal complications.
WOMENS HEALTH ISSUES
(2023)
Editorial Material
Obstetrics & Gynecology
Allison Bosch, Heather S. Hipp
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Jerrine R. Morris, Jennifer F. Kawwass, Heather S. Hipp
Summary: This study aimed to determine the prevalence of physical intimate partner violence (IPV) among postpartum women who reported preconception fertility treatment compared to those who conceived without assisted reproduction. The results showed that about 2% of the respondents reported physical IPV. Women reporting preconception fertility treatment were less likely to experience physical IPV than those who conceived without fertility treatment. However, the odds of physical IPV were similar among postpartum women regardless of fertility treatment exposure after adjusting for other factors. Factors such as low household income and increased preconception stressors were predictive of reported physical IPV. There was no difference in the type of fertility treatment and reported physical IPV, but among women exposed to fertility treatment, self-identification as Black or Hispanic and reporting higher stressors were associated with physical IPV. The use of fertility treatment did not increase the risk of physical IPV in this postpartum population, but further research is needed to understand the association between infertility, fertility treatment exposure, and physical IPV.
FERTILITY AND STERILITY
(2023)
Article
Genetics & Heredity
Bonnie Poteet, Nadia Ali, Cecelia Bellcross, Stephanie L. Sherman, Whitney Espinel, Heather Hipp, Emily G. Allen
Summary: This study aimed to identify barriers and facilitators to receiving a FXPOI diagnosis and follow-up care. Interviews revealed that FXPOI patients often face issues such as lack of clinician awareness, absence of clear clinical treatment guidelines, and difficulty finding centralized sources of care.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Editorial Material
Obstetrics & Gynecology
Jamie M. Merkison, Jennifer F. Kawwass
FERTILITY AND STERILITY
(2023)
Article
Genetics & Heredity
Jacqueline C. Lee, Natalia S. Calzada-Jorge, Heather S. Hipp, Jennifer F. Kawwass
Summary: Most U.S. ART clinics offer NC-FET, but it is not frequently used for endometrial preparation in FET cycles, and there are often restrictions on its use.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Medicine, General & Internal
Kaitlyn K. Stanhope, Anna Goebel, Monica Simmonds, Patience Timi, Sristi Das, Asha Immanuelle, Denise J. Jamieson, Sheree L. Boulet
Summary: This study systematically reviewed the clinical utility of screening for social determinants of health in clinical obstetric and gynecologic care. The findings suggest limited evidence on the benefits of screening in this setting, highlighting the need for innovative research to expand and improve screening practices.
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Sheree L. L. Boulet, Kaitlyn K. K. Stanhope, Carol DeSantis, Anna Goebel, Julia Dolak, Onyie Eze, Asmita Gathoo, Caroline Braun, Madeline Sutton, Denise J. J. Jamieson
Summary: The objective of this study was to estimate the uptake of influenza, Tdap, and COVID-19 vaccines during pregnancy and examine vaccine attitudes and beliefs in predominantly racial and ethnic minority individuals delivering at a publicly funded hospital. The study found low rates of vaccination in this population, possibly due to low perceived susceptibility to vaccine-preventable diseases. Obstetricians and midwives were trusted sources of vaccine information, highlighting the importance of effective communication strategies to address maternal vaccine hesitancy, particularly in communities of color affected by medical mistrust.
WOMENS HEALTH REPORTS
(2023)
Letter
Medicine, General & Internal
Lisa M. Shandley, Carol E. Desantis, Jacqueline C. Lee, Jennifer F. Kawwass, Heather S. Hipp
Summary: This study used national surveillance data to compare trends and outcomes in assisted reproductive technology cycles using a gestational carrier versus those not using a gestational carrier.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Andrew P. King, Nadia Ali, Cecelia Bellcross, Fabienne Ehivet, Heather S. Hipp, Jessica Vaughn, Emily G. Allen
Summary: This study aims to understand the healthcare experiences of African American women with a fragile X premutation (PM) and explores the disparities they face in receiving healthcare as well as their psychosocial experiences. The findings highlight concerns about not being taken seriously by providers, mistrust of medical institutions, and high incidences of anxiety and depression among participants.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Anna K. Knight, Heather S. Hipp, Sina Abhari, Sabrina Gerkowicz, Quinton S. Katler, Laurie J. McKenzie, Weirong Shang, Alicia K. Smith, Jessica B. Spencer
REPRODUCTIVE SCIENCES
(2022)