Article
Developmental Biology
Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong, Susan P. Walker, Teresa M. MacDonald, Ping Cannon, Tuong-Vi Nguyen, Suresh Anand Sadananthan, Mya-Thway Tint, Yi Ying Ong, Loy See Ling, Peter D. Gluckman, Yap-Seng Chong, Keith M. Godfrey, Shiao-Yng Chan, Kok Hian Tan, Yung Seng Lee, Navin Michael, Johan G. Eriksson, Mary E. Wlodek
Summary: Low maternal circulating SPINT1 concentrations are associated with poor fetal growth, as validated by a study in Singapore where pregnant women with lower SPINT1 levels were more likely to deliver small-for-gestational age infants.
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Aurelie Pham, Delphine Mitanchez, Anne Forhan, Laurence Perin, Yves Le Bouc, Frederic Brioude, Marie-Laure Sobrier, Barbara Heude, Irene Netchine
Summary: Research suggests that lower levels of DLK1 in maternal blood during the second trimester of pregnancy may indicate a higher risk of SGA. However, DLK1 alone is not a reliable predictor of SGA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Acoustics
S. Ruiz-Martinez, J. L. Delgado, C. Paules, A. Cavallaro, C. De Paco, J. Villar, A. Papageorghiou, D. Oros
Summary: This study identified nine clinical phenotypes of small-for-gestational-age (SGA) fetuses that are associated with different patterns of adverse perinatal outcomes. The findings suggest that considering clinical characteristics in addition to ultrasound findings could improve risk stratification and decision-making for managing SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Acoustics
E. Meler, R. J. Martinez-Portilla, J. Caradeux, E. Mazarico, C. Gil-Armas, D. Boada, J. Martinez, P. Carrillo, M. Camacho, F. Figueras
Summary: This study investigates the performance of severe smallness in predicting adverse perinatal outcomes among fetuses with suspected late-onset small-for-gestational age (SGA). Although suspected severe SGA is associated with a higher risk of perinatal complications, it performs poorly as a standalone parameter in predicting adverse perinatal outcome.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
D. L. Lip-Sosa, M. Perez-Cruz, P. Ahumada-Droguett, T. Ribas-Prats, M. Puertollano, M. A. Garcia-Gomez, E. Mazarico, E. Eixarch, C. Escera, M. D. Gomez-Roig
Summary: This study aimed to investigate the measurements of midbrain morphology on neurosonography in late-onset small fetuses classified as small-for-gestational-age (SGA) or growth-restricted (FGR). The results showed that small fetuses had significantly shorter corpus callosum-fastigium length and tectal length compared to controls, and these differences were more pronounced in fetuses with more severe smallness. These findings suggest the potential value of midbrain measurements as biomarkers for brain development in a high-risk population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nikolaos Vrachnis, Savvas Argyridis, Dionysios Vrachnis, Nikolaos Antonakopoulos, Georgios Valsamakis, Christos Iavazzo, Dimitrios Zygouris, Nikolaos Salakos, Alexandros Rodolakis, Nikolaos Vlahos, George Mastorakos, Peter Drakakis, Zoi Iliodromiti
Summary: The study found that both FGF21 and insulin concentrations increased in cases of abnormal fetal growth. Higher levels of these hormones were observed in fetuses with restricted growth (SGA) or macrosomia (LGA).
Article
Pediatrics
Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel Ganzevoort
Summary: This study reflects on the unexpected finding of pulmonary hypertension in infants born within the Dutch STRIDER trial and discusses its definition and possible pathophysiological mechanisms. It was found that infants of mothers allocated to antenatal sildenafil had a higher rate of pulmonary hypertension compared to those in the placebo group.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Youn Hee Jee, Sanjay Jumani, Veronica Mericq
Summary: Accelerated early growth and early timing of puberty are risk factors for metabolic syndrome, especially in children born small for gestational age (SGA) or with premature adrenarche (PA). These children, especially those with SGA and accelerated catch-up growth, are at a higher risk for long-term metabolic consequences like type 2 diabetes and cardiovascular diseases. Studies also show that children born SGA or with a history of PA may have earlier pubertal timing, which is associated with various metabolic risks. This review aims to summarize recent studies exploring the relationship between early infantile growth, timing of puberty, and metabolic risks to enhance our understanding of the underlying pathophysiology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Obstetrics & Gynecology
Emily Butler, Oliver Hugh, Jason Gardosi
Summary: Many stillbirths are associated with fetal growth restriction, but this can be avoided. The GAP program has been successful in improving antenatal detection of SGA babies and reducing national stillbirth rates. However, expanding the program in low and middle income settings remains a challenge.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
E. Inzaghi, A. Deodati, S. Loddo, M. Mucciolo, F. Verdecchia, E. Sallicandro, G. Catino, M. Cappa, A. Novelli, S. Cianfarani
Summary: In SGA children with persistent short stature and complex clinical phenotypes, CNVs are common, with a relatively high frequency of variation in the 17p13.3 region. Short-term rhGH therapy has similar efficacy in terms of height gain and growth velocity whether CNVs are present or not.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Pediatrics
Wayne Cutfield, Ahila Ayyavoo
Summary: 'Small for Gestational Age' (SGA) refers to children born with low birth weight and/or short birth length, most of whom experience catch-up growth within 6 months of age. Treatment with recombinant human growth hormone (rhGH) can help SGA children achieve normal adult height, although they may still face long-term consequences such as insulin resistance, abdominal fat accumulation, and metabolic disorders.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Elvira Di Pasquo, Tullio Ghi, Andrea Dall'Asta, Laura Angeli, Sara Ciavarella, Giulia Armano, Veronica Sesenna, Antonio Di Peri, Tiziana Frusca
Summary: This study compared maternal hemodynamic parameters between normotensive women with small-for-gestational-age (SGA) and FGR fetuses. It found that women with FGR had lower cardiac output and higher systemic vascular resistance compared to SGA and controls. Additionally, a negative correlation was observed between maternal cardiac output and the length of neonatal hospitalization.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Genetics & Heredity
Hwal Rim Jeong, Jae-A Han, Heeji Kim, Hye Jin Lee, Young Suk Shim, Min Jae Kang, Jong Seo Yoon, Seongho Ryu, Il Tae Hwang
Summary: This study investigated the exosomal miRNA signature associated with catch-up growth in small-for-gestational-age (SGA) children. The results showed that SGA children without catch-up growth have a distinct exosomal miRNA expression profile compared with SGA children with catch-up growth and appropriate-for-gestational-age (AGA) children. The study also identified certain miRNAs that may be associated with growth failure in SGA children.
Article
Obstetrics & Gynecology
Caroline Marrs, Sean Blackwell, Ashley Hester, Gayle Olson, George R. Saade, Jonathan Faro, Claudia Pedroza, Baha Sibai
AMERICAN JOURNAL OF PERINATOLOGY
(2019)
Letter
Pediatrics
Abbot Laptook, Jon E. Tyson, Claudia Pedroza, Seetha Shankaran, Edward F. Bell, Ronald Goldberg, Namasivayam Ambalavanan, Breda Munoz, Abhik Das
Article
Health Care Sciences & Services
Deepa V. Cherla, Cristina P. Viso, Julie L. Holihan, Karla Bernardi, Maya L. Moses, Krislynn M. Mueck, Oscar A. Olavarria, Juan R. Flores-Gonzalez, Courtney J. Balentine, Tien C. Ko, Sasha D. Adams, Claudia Pedroza, Lillian S. Kao, Mike K. Liang
JOURNAL OF GENERAL INTERNAL MEDICINE
(2019)
Article
Pediatrics
Elenir B. C. Avritscher, Ricardo A. Mosquera, Jon E. Tyson, Claudia Pedroza, Cheryl L. Samuels, Tomika S. Harris, Ana Gomez-Rubio, Fernando A. Navarro, Shade B. Moody, Rebecca M. Beyda
JOURNAL OF PEDIATRICS
(2019)
Article
Surgery
John A. Harvin, Charles E. Green, Claudia Pedroza, Jon E. Tyson, Laura J. Moore, Charles E. Wade, John B. Holcomb, Lillian S. Kao
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Article
Pediatrics
Louis A. Carrillo, Akshita Kumar, Matthew T. Harting, Claudia Pedroza, Charles S. Cox
PEDIATRIC SURGERY INTERNATIONAL
(2019)
Article
Rheumatology
Samantha Stanley, Chi Chiu Mok, Kamala Vanarsa, Deena Habazi, Jennifer Li, Claudia Pedroza, Ramesh Saxena, Chandra Mohan
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Rheumatology
Maryam Buni, Joyce Joseph, Claudia Pedroza, Sam Theodore, Deepthi Nair, Terry A. McNearney, Hilda T. Draeger, John D. Reveille, Shervin Assassi, Maureen D. Mayes
JOURNAL OF RHEUMATOLOGY
(2019)
Article
Emergency Medicine
Henry E. Wang, Andrew Humbert, Graham Nichol, Jestin N. Carlson, Mohamud R. Daya, Ryan P. Radecki, Matthew Hansen, Clifton W. Callaway, Claudia Pedroza
ANNALS OF EMERGENCY MEDICINE
(2019)
Article
Surgery
Krislynn M. Mueck, Shuyan Wei, Claudia Pedroza, Karla Bernardi, Margaret L. Jackson, Mike K. Liang, Tien C. Ko, Jon E. Tyson, Lillian S. Kao
Article
Surgery
Gabrielle E. Hatton, Reginald E. Du, Claudia Pedroza, Shuyan Wei, John A. Harvin, Kevin W. Finkel, Charles E. Wade, Lillian S. Kao
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Correction
Rheumatology
Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Thi Thanh Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena, Chandra Mohan
ARTHRITIS RESEARCH & THERAPY
(2019)
Article
Rheumatology
Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena, Chandra Mohan
ARTHRITIS RESEARCH & THERAPY
(2019)
Article
Medicine, General & Internal
Raymond Parlar-Chun, Meaghan Lafferty-Prather, Veronica Gonzalez, Claudia Pedroza, Anand Gourishankar
Article
Rheumatology
Ling Qin, Yong Du, Huihua Ding, Anam Haque, John Hicks, Claudia Pedroza, Chandra Mohan
ARTHRITIS RESEARCH & THERAPY
(2019)