Staphylococcus aureus heme and siderophore-iron acquisition pathways

SbnI is a free serine kinase that generatesO-phospho-l-serine for staphyloferrin B biosynthesis inStaphylococcus aureus

(2018) Meghan M. Verstraete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–function analyses reveal key features inStaphylococcus aureusIsdB-associated unfolding of the heme-binding pocket of human hemoglobin

(2017) Catherine F. M. Bowden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis

(2016) Marek J. Kobylarz et al.   BIOCHEMISTRY

TheStaphylococcus aureusProtein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen

(2016) Kirstine Lindhardt Sæderup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin

(2016) Megan Sjodt et al.   JOURNAL OF MOLECULAR BIOLOGY

A Ferric–Peroxo Intermediate in the Oxidation of Heme by IsdI

(2015) Shin-ichi J. Takayama et al.   BIOCHEMISTRY

Bacillithiol: a key protective thiol inStaphylococcusaureus

(2015) Varahenage R Perera et al.   Expert Review of Anti-Infective Therapy

Involvement of major facilitator superfamily proteins SfaA and SbnD in staphyloferrin secretion inStaphylococcus aureus

(2015) Mélissa Hannauer et al.   FEBS LETTERS

Four-Component Staphylococcus aureus Vaccine 4C-Staph Enhances Fcγ Receptor Expression in Neutrophils and Monocytes and Mitigates S. aureus Infection in Neutropenic Mice

(2015) Antonina Torre et al.   INFECTION AND IMMUNITY

A Heme-responsive Regulator Controls Synthesis of Staphyloferrin B inStaphylococcus aureus

(2015) Holly A. Laakso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus

(2015) Julie L. H. Madsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Involvement of reductases IruO and NtrA in iron acquisition byStaphylococcus aureus

(2015) Mélissa Hannauer et al.   MOLECULAR MICROBIOLOGY

Rapid Heme Transfer Reactions between NEAr Transporter Domains of Staphylococcus aureus: A Theoretical Study Using QM/MM and MD Simulations

(2015) Yoshitaka Moriwaki et al.   PLoS One

Hemoglobin Binding and Catalytic Heme Extraction by IsdB Near Iron Transporter Domains

(2014) Catherine F. M. Bowden et al.   BIOCHEMISTRY

Crystal and Solution Structure Analysis of FhuD2 from Staphylococcus aureus in Multiple Unliganded Conformations and Bound to Ferrioxamine-B

(2014) Krzysztof J. Podkowa et al.   BIOCHEMISTRY

Synthesis of L-2,3-Diaminopropionic Acid, a Siderophore and Antibiotic Precursor

(2014) Marek J. Kobylarz et al.   CHEMISTRY & BIOLOGY

SbnG, a Citrate Synthase inStaphylococcus aureus

(2014) Marek J. Kobylarz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture byStaphylococcus aureus

(2014) Claire F. Dickson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis

(2014) Ashootosh Tripathi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TCA cycle activity inStaphylococcus aureusis essential for iron-regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase

(2014) Jessica R. Sheldon et al.   MOLECULAR MICROBIOLOGY

Nasal Carriage of Staphylococcus aureus in Botucatu, Brazil: A Population-Based Survey

(2014) Fabiana Venegas Pires et al.   PLoS One

Heme Degradation by Staphylococcus aureus IsdG and IsdI Liberates Formaldehyde Rather Than Carbon Monoxide

(2013) Toshitaka Matsui et al.   BIOCHEMISTRY

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

IruO Is a Reductase for Heme Degradation by IsdI and IsdG Proteins inStaphylococcus aureus

(2013) Slade A. Loutet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IsdB-dependent Hemoglobin Binding Is Required for Acquisition of Heme by Staphylococcus aureus

(2013) Gleb Pishchany et al.   JOURNAL OF INFECTIOUS DISEASES

Staphyloferrin A as siderophore-component in fluoroquinolone-based Trojan horse antibiotics

(2013) Stephen J. Milner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Trends in Invasive Methicillin-Resistant Staphylococcus aureus Infections

(2013) M. Iwamoto et al.   PEDIATRICS

Structural and functional characterization of theStaphylococcus aureusvirulence factor and vaccine candidate FhuD2

(2012) Paolo Mariotti et al.   BIOCHEMICAL JOURNAL

Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus

(2012) Johnson Cheung et al.   CHEMISTRY & BIOLOGY

Staphylococcus aureusUses a Novel Multidomain Receptor to Break Apart Human Hemoglobin and Steal Its Heme

(2012) Thomas Spirig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling

(2012) Georgia Ukpabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Ultra-weak Protein-Protein Interactions between Heme Transporters ofStaphylococcus aureus

(2012) Ryota Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiprotein Heme Shuttle Pathway in Staphylococcus aureus: Iron-Regulated Surface Determinant Cog-Wheel Kinetics

(2012) Michael T. Tiedemann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unique Heme-Iron Coordination by the Hemoglobin Receptor IsdB ofStaphylococcus aureus

(2011) Catherine F. M. Gaudin et al.   BIOCHEMISTRY

Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus

(2011) Federico C Beasley et al.   BMC MICROBIOLOGY

Staphylococcus aureus Transporters Hts, Sir, and Sst Capture Iron Liberated from Human Transferrin by Staphyloferrin A, Staphyloferrin B, and Catecholamine Stress Hormones, Respectively, and Contribute to Virulence

(2011) Federico C. Beasley et al.   INFECTION AND IMMUNITY

Iron-Coordinating Tyrosine Is a Key Determinant of NEAT Domain Heme Transfer

(2011) Jason C. Grigg et al.   JOURNAL OF MOLECULAR BIOLOGY

Transient Weak Protein–Protein Complexes Transfer Heme Across the Cell Wall of Staphylococcus aureus

(2011) Valerie A. Villareal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI

(2011) Shin-ichi J. Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A structural classification of substrate-binding proteins

(2010) Ronnie P.-A. Berntsson et al.   FEBS LETTERS

The Ferrichrome Uptake Pathway in Pseudomonas aeruginosa Involves an Iron Release Mechanism with Acylation of the Siderophore and Recycling of the Modified Desferrichrome

(2010) M. Hannauer et al.   JOURNAL OF BACTERIOLOGY

Specificity of Staphyloferrin B Recognition by the SirA Receptor fromStaphylococcus aureus

(2010) Jason C. Grigg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheStaphylococcus aureusSiderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket

(2010) Jason C. Grigg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IsdG-family of haem oxygenases degrades haem to a novel chromophore

(2010) Michelle L. Reniere et al.   MOLECULAR MICROBIOLOGY

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Identification and Characterization of theStaphylococcus aureusGene Cluster Coding for Staphyloferrin A†

(2009) Jennifer L. Cotton et al.   BIOCHEMISTRY

Sideromycins: tools and antibiotics

(2009) Volkmar Braun et al.   BIOMETALS

Management of common bacterial infections of the skin

(2009) Philippe Bernard   CURRENT OPINION IN INFECTIOUS DISEASES

Staphylococcal Vaccines and Immunotherapies

(2009) Adam C. Schaffer et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

A Novel Nitroreductase of Staphylococcus aureus with S-Nitrosoglutathione Reductase Activity

(2009) A. F. N. Tavares et al.   JOURNAL OF BACTERIOLOGY

Elucidation of the Mechanism by Which Catecholamine Stress Hormones Liberate Iron from the Innate Immune Defense Proteins Transferrin and Lactoferrin

(2009) S. M. Sandrini et al.   JOURNAL OF BACTERIOLOGY

Siderophore-mediated iron acquisition in the staphylococci

(2009) Federico C. Beasley et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Characterization of staphyloferrin A biosynthetic and transport mutants inStaphylococcus aureus

(2009) Federico C. Beasley et al.   MOLECULAR MICROBIOLOGY

Molecular characterization of staphyloferrin B biosynthesis inStaphylococcus aureus

(2009) Johnson Cheung et al.   MOLECULAR MICROBIOLOGY

Ruffling of Metalloporphyrins Bound to IsdG and IsdI, Two Heme-degrading Enzymes inStaphylococcus aureus

(2008) Woo Cheol Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functionally Distinct NEAT (NEAr Transporter) Domains within theStaphylococcus aureusIsdH/HarA Protein Extract Heme from Methemoglobin

(2008) Rosemarie M. Pilpa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathway for Heme Uptake from Human Methemoglobin by the Iron-regulated Surface Determinants System ofStaphylococcus aureus

(2008) Hui Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Multimeric Heme Complexation through a Specific Protein-Heme Interaction

(2008) Masato Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of the Iron-regulated Surface Determinant (Isd) Heme Transfer Pathway inStaphylococcus aureus

(2008) Naomi Muryoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Hemin Transfer from IsdA to IsdC in the Iron-regulated Surface Determinant (Isd) Heme Acquisition System ofStaphylococcus aureus

(2008) Mengyao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

(2008) A. L. Davidson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS