Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics

Siderophore–antibiotic conjugates: exploiting iron uptake to deliver drugs into bacteria

(2018) I.J. Schalk   CLINICAL MICROBIOLOGY AND INFECTION

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic

(2018) Rui Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Trojan-Horse Strategy Including a Bacterial Suicide Action for the Efficient Use of a Specific Gram-Positive Antibiotic on Gram-Negative Bacteria

(2018) Isabelle J. Schalk   JOURNAL OF MEDICINAL CHEMISTRY

Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin–Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity

(2018) Wilma Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Siderophore Conjugates of Daptomycin are Potent Inhibitors of Carbapenem Resistant Strains of Acinetobacter baumannii

(2018) Manuka Ghosh et al.   ACS Infectious Diseases

Impedance-Based Detection of Bacteria

(2018) Ariel L. Furst et al.   CHEMICAL REVIEWS

Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial

(2018) Simon Portsmouth et al.   LANCET INFECTIOUS DISEASES

Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68

(2017) Ruslan Cusnir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted β-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii

(2017) Serena Carosso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo

(2017) Manuka Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates

(2016) Karina Calvopiña et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases

(2016) Tsukasa Ito-Horiyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The action mechanism of daptomycin

(2016) Scott D. Taylor et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Endless resistance. Endless antibiotics?

(2016) Jed F. Fisher et al.   MedChemComm

Potentiation of Antibacterial Activity of the MB-1 Siderophore-Monobactam Conjugate Using an Efflux Pump Inhibitor

(2015) Andrew P. Tomaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroAntimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains

(2015) Naoki Kohira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore–antibiotic conjugates

(2015) Tengfei Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vitroantimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

(2015) Akinobu Ito et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Syntheses and Antibacterial Activity of N-Acylated Ciprofloxacin Derivatives Based on the Trimethyl Lock

(2015) Cheng Ji et al.   ACS Medicinal Chemistry Letters

Siderophore Receptor-Mediated Uptake of Lactivicin Analogues in Gram-Negative Bacteria

(2014) Jeremy Starr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli

(2014) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa

(2014) Gaëtan L. A. Mislin et al.   Metallomics

ND4BB: addressing the antimicrobial resistance crisis

(2014) John H. Rex   NATURE REVIEWS MICROBIOLOGY

Fate of ferrisiderophores after import across bacterial outer membranes: different iron release strategies are observed in the cytoplasm or periplasm depending on the siderophore pathways

(2013) Isabelle J. Schalk et al.   AMINO ACIDS

Biscatecholate–Monohydroxamate Mixed Ligand Siderophore–Carbacephalosporin Conjugates are Selective Sideromycin Antibiotics that Target Acinetobacter baumannii

(2013) Timothy A. Wencewicz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinically Relevant Gram-Negative Resistance Mechanisms Have No Effect on the Efficacy of MC-1, a Novel Siderophore-Conjugated Monocarbam

(2012) Craig J. McPherson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers

(2012) Cheng Ji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Daptomycin-Mediated Reorganization of Membrane Architecture Causes Mislocalization of Essential Cell Division Proteins

(2012) J. Pogliano et al.   JOURNAL OF BACTERIOLOGY

Iron Transport-Mediated Drug Delivery: Practical Syntheses and In Vitro Antibacterial Studies of Tris-Catecholate Siderophore–Aminopenicillin Conjugates Reveals Selectively Potent Antipseudomonal Activity

(2012) Cheng Ji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin–Cargo Conjugate Uptake

(2012) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Study of a Mycobactin−Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria

(2011) Marvin J. Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols

(2011) Mark E. Flanagan et al.   ACS Medicinal Chemistry Letters

In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli

(2010) M. G. P. Page et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents

(2009) Marvin J. Miller et al.   BIOMETALS

Siderophores as drug delivery agents: application of the “Trojan Horse” strategy

(2009) Ute Möllmann et al.   BIOMETALS

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

(2009) Timothy A. Wencewicz et al.   BIOMETALS

Sideromycins: tools and antibiotics

(2009) Volkmar Braun et al.   BIOMETALS

Enzymatic Hydrolysis of Trilactone Siderophores: Where Chiral Recognition Occurs in Enterobactin and Bacillibactin Iron Transport(1)

(2009) Rebecca J. Abergel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY