Article
Cell Biology
Yan Pu, Jing Han, Mengmeng Zhang, Mengxue Liu, Gulnazar Abdusamat, Huibin Liu
Summary: Clear cell renal cell carcinoma (ccRCC) is a highly aggressive urologic cancer with high fatality rate and poor prognosis due to tumor metastasis at initial presentation. This study found that Spindle and kinetochore-associated protein 1 (SKA1) expression is significantly upregulated in ccRCC tissues and associated with aggressive clinicopathologic characteristics. Functional study revealed that SKA1 knockdown in ccRCC cells reduced cancer cell motility in both in vivo and in vitro research, potentially through its specific interaction with scaffold attachment factor B and subsequent transcriptional repression of dual specificity phosphatase 6 (DUSP6).
Article
Cell Biology
Jiangqi Xu, Xiaohong Huang, Shixiang Liu, Dongdong Chen, Yufang Xie, Zhenwu Zhao
Summary: The present study investigated the protective mechanism of ZFAS1 in cerebral ischemia-reperfusion injury. The up-regulation of ZFAS1 was found to improve cell damage, inhibit apoptosis, and reduce inflammation. MiR-421-3p was identified as a target miRNA of ZFAS1 and its up-regulation attenuated the protective effect of ZFAS1 overexpression. MEF2C, the downstream target gene of miR-421-3p, reversed the enhanced cell damage caused by miR-421-3p mimic when overexpressed. In vivo experiments confirmed the protective effects of ZFAS1 overexpression in reducing brain tissue infarction, apoptosis, and gene regulation.
Article
Oncology
Zhifeng Wang, Zihao Chen, Tengyun Guo, Menglin Hou, Junpeng Wang, Yanping Guo, Tao Du, Xiaoli Zhang, Ning Wang, Degang Ding, Xiqing Li
Summary: The study identified key lncRNAs associated with immune subtypes in ccRCC, and constructed corresponding lncRNA-mRNA networks. These lncRNAs may serve as predictive markers for ccRCC and offer insights into novel biomarkers for the disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Yunze Dong, Ding Liu, Hongmin Zhou, Yuchen Gao, Yimingniyizi Nueraihemaiti, Yunfei Xu
Summary: A risk model based on ccRCC patient data can effectively predict the prognosis of ccRCC patients and provide a new direction for clinical treatment. Ferroptosis-related lncRNAs have independent prognostic characteristics in ccRCC patients and are associated with oxygen metabolic processes and immune pathways.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Wuping Yang, Jingcheng Zhou, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Lin Cai, Yanqing Gong, Kan Gong
Summary: This study identified 10 VHL-related lncRNAs in ccRCC tissues and revealed their down-regulation. High expression of these lncRNAs was associated with longer overall and disease free survival, with FGD5-AS1 showing potential as a novel biomarker for ccRCC. Additionally, DNA hypermethylation was implicated in the decreased expression of FGD5-AS1.
Article
Medicine, Research & Experimental
Duo Shen, Hong-Yu Zhao, Ai-Dong Gu, Yin-Wei Wu, Yu-Hang Weng, Shu-Jie Li, Jin-Yun Song, Xue-Feng Gu, Jie Qiu, Wei Zhao
Summary: A variety of miRNAs are involved in the development of hepatocellular carcinoma (HCC), with miR-10a-5p playing a role in inhibiting the migration, invasion, and epithelial-mesenchymal transition of HCC cells. SKA1 has been identified as a downstream target of miR-10a-5p, and its overexpression can reverse the inhibitory effects of miR-10a-5p in HCC progression. Low expression of miR-10a-5p is associated with the malignant development of HCC.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Shi-Yao Wei, Bei Feng, Min Bi, Hai-Ying Guo, Shang-Wei Ning, Rui Cui
Summary: In this study, we developed a prognostic signature based on ferroptosis-related lncRNAs (FRLs) for clear cell renal cell carcinoma (ccRCC) patients. The signature showed accurate predictive performance and was associated with immune infiltration as well as differential expression of immune checkpoint and m6A-related genes.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Aurore Dumond, Etienne Brachet, Jerome Durivault, Valerie Vial, Anna K. Puszko, Yves Lepelletier, Christopher Montemagno, Marina Pagnuzzi-Boncompagni, Olivier Hermine, Christiane Garbay, Nathalie Lagarde, Matthieu Montes, Luc Demange, Renaud Grepin, Gilles Pages
Summary: Inhibition of NRPs is a promising treatment for mccRCC patients in therapeutic impasses, and NRPa-308 presents as a relevant hit for this purpose, showing efficient inhibition of cell metabolism and migration/invasion.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huantao Zong, Anning Li, Yongjin Huang, Xuanyan Che, Yong Zhang, Guikai Ma, Zhongbao Zhou
Summary: This study investigated the role of ferroptosis-associated long noncoding RNAs (FALs) in clear cell renal cell carcinoma (ccRCC). The researchers discovered a signature composed of eight lncRNAs that accurately predicted survival outcomes in ccRCC patients. This signature also represented the immunological environment, immunotherapy response, and drug sensitivity of ccRCC, making it a potential biomarker and therapeutic target.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Genetics & Heredity
Xian Chang, Ya Cao, Wan-Lei Fu, Xue-Feng Tang, Ya-Li Wang, Yang-Fan Lv, Qiao-Nan Guo
Summary: The study showed that higher XCR1 expression in ccRCC is associated with longer overall survival, and XCR1 knockdown significantly promotes proliferation and migration while reducing apoptosis of renal cell carcinoma cells. XCR1 may serve as a prognostic biomarker for ccRCC in the future.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Genetics & Heredity
Xian Chang, Ya Cao, Wan-Lei Fu, Xue-Feng Tang, Ya-Li Wang, Yang-Fan Lv, Qiao-Nan Guo
Summary: In this study, higher XCR1 expression in ccRCC compared to normal tissues was associated with longer overall survival in patients with ccRCC. XCR1 knockdown significantly increased RCC cell proliferation and migration, and decreased apoptosis. XCR1 may serve as a potential prognostic biomarker in ccRCC.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Biochemical Research Methods
Gui Ma, Bin Zhang, Shengjun Fu, Jianzhong Lu, Lili Zhang, Panfeng Shang, Zhongjin Yue
Summary: FRL1 is overexpressed in ccRCC and is associated with unfavorable clinicopathological features and poor prognosis. FRL1 contributes to invasion and aggressive phenotype of ccRCC by promoting EMT through the MAPK/MMP2 axis.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Oncology
Huiying Yang, Xiaoling Xiong, Hua Li
Summary: This study identified long non-coding RNAs associated with genomic instability in clear cell renal cell carcinoma and developed a risk signature for prognosis prediction and medication guidance. The risk signature effectively predicted patient outcomes and response to treatment, shedding light on the roles of genomic instability derived lncRNAs in ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jian Chang, Geqiong Xiao, Wenwen Zhu, Mengyu Ding, Hui Liao, Qiong Wang
Summary: This study found that miR-10a-5p plays a crucial role in the progression of clear cell renal cell carcinoma (ccRCC) by inhibiting the expression of SERPINE1. It can restrain the proliferative, migratory, and invasive abilities of ccRCC cells and promote cell apoptosis. These findings provide a new approach for the treatment of ccRCC.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jueyi Zhou, Peng Li, Jihong Feng, Qi Wu, Shengjie You
Summary: MiRNAs are important epigenetic modulators regulating protein expression. This study investigated the role of miR-24-1-5p in clear cell renal cell carcinoma (ccRCC). The study found that miR-24-1-5p was under-expressed in ccRCC and its target gene SHOX2 was significantly expressed in cancer tissues. Functional experiments demonstrated that overexpression of miR-24-1-5p inhibited SHOX2 level and malignant phenotypes of ccRCC cells. These results highlight the critical role of the miR-24-1-5p/SHOX2 axis in ccRCC development, providing potential insights into the mechanism and therapeutic strategies for ccRCC.
BIOCHEMICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Ning Wei, Jun Li, Cheng Fang, Jin Chang, Vasiliki Xirou, Nick K. Syrigos, Benjamin J. Marks, Edward Chu, John C. Schmitz
Article
Oncology
Zhongyi Mu, Dan Dong, Ning Wei, Mingli Sun, Wei Wang, Yue Shao, Jian Gao, Ping Yin, Chenghai Zhao
Article
Biochemistry & Molecular Biology
Fengli Li, Jing Wang, Ning Wu, Hua Zhang, Zheng Li, Ning Wei
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Oncology
Xiaomei Liu, Yuxi Wang, Rong Zhang, Ting Jin, Liangliang Qu, Qianwen Jin, Jiasu Zheng, Jiaqi Sun, Ziqing Wu, Linxi Wang, Tianxu Liu, Yinxu Zhang, Xiao Meng, Ying Wang, Ning Wei
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nannan Tian, Huanxian Wu, Huiwu Zhang, Danni Yang, Lin Lv, Zichao Yang, Tingting Zhang, Dongling Quan, Lei Zhou, Ying Xie, Yimei Xu, Ning Wei, Jiajie Zhang, Mian Chen, John C. Schmitz, Yuanxin Tian, Wu Shaoyu
BIOORGANIC & MEDICINAL CHEMISTRY
(2020)
Article
Polymer Science
Zhongyi Mu, Liangliang Pei, Dongbing Cao, Jing Guo, Ning Wei, Liqun Yang, Bin Hu
POLYMER DEGRADATION AND STABILITY
(2020)
Article
Oncology
Zhongyi Mu, Dan Dong, Mingli Sun, Liwen Li, Ning Wei, Bin Hu
FRONTIERS IN ONCOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Gang Zhang, Daoxing Chen, Sufang Wang, Hualong Chen, Ning Wei, Guirong Chen
Article
Hematology
Zhixiang Zhu, Lili Wang, Ran Guo, Daoran Pang, Wenxuan Wang, Yan Wu, Ning Wei, Jun Li, Pengfei Tu
Summary: The natural compound XJ-8 isolated from Sanguis draxonis was found to significantly inhibit platelet activation and thrombosis by targeting MAP3K3. This suggests that XJ-8 has the potential to be developed into a novel therapeutic agent for the treatment of thrombotic diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Chemistry, Medicinal
Jun Li, Dayong Zheng, Ning Wei, Yunfeng Sun, Li Liu, Yuan Yuan, Qinghua Jiang
Summary: A new quassinoid, dehydrobruceantinol B, was isolated from Brucea javanica seeds, along with two known compounds, bruceantinol and bruceine A. The structure of the new compound was determined using advanced spectrometric methods. The inhibitory effects of these compounds on nitric oxide production in activated macrophages were investigated.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Review
Pharmacology & Pharmacy
Xuepei Cai, Haokun Li, Manyi Wang, Edward Chu, Ning Wei, Jiayu Lin, Yun Hu, Jingtao Dai, Aijie Chen, Hua Zheng, Qianbing Zhang, Yuxia Zhong, Ruoshui Chang, Sha Wu, Yaomu Xiao, Chufeng Liu
Summary: Memory CD8+T cells exhibit efficient immune response, long-term survival, and continuous differentiation. Enhanced glycolytic metabolism can generate sufficient energy for the formation of these cells. The mammalian target of rapamycin (mTOR) signaling pathway regulates memory CD8+T cell formation, maintenance, and function through glycometabolism. Different subpopulations of memory CD8+T cells show metabolic flexibility during different stages, and energy metabolism may play a critical role.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ning Wei, James Burnett, Desirae L. Crocker, Yixian Huang, Song Li, Peter Wipf, Edward Chu, John C. Schmitz
Summary: Cellular protein synthesis is accelerated in human colorectal cancer, and inhibition of protein synthesis may be an effective therapeutic strategy. The quassinoid bruceantinol (BOL) showed antitumor activity and STAT3 inhibition in mouse models. BOL-resistant cell lines were sensitive to standard CRC therapeutic agents and known STAT3 inhibitors but resistant to homoharringtonine, indicating the potential of quassinoids as protein synthesis inhibitors in CRC treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Dayong Zheng, Jun Li, Han Yan, Gang Zhang, Wei Li, Edward Chu, Ning Wei
Summary: Aurora-A kinase plays a pivotal role in cancer progression by affecting multiple cancer hallmarks and resistance to various therapies. This review highlights the mechanisms through which Aurora-A kinase promotes therapy resistance and discusses potential strategies for targeting this kinase in combination with other therapeutic agents. Additionally, the review provides insights into the development of novel Aurora-A inhibitors for precision cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemistry & Molecular Biology
Fernand Bteich, Mahshid Mohammadi, Terence Li, Muzaffer Ahmed Bhat, Amalia Sofianidi, Ning Wei, Chaoyuan Kuang
Summary: Colorectal cancer is a heterogeneous disease with various alterations at the cellular and molecular levels. KRAS mutations are found in up to 40% of CRCs and serve as both a prognostic and predictive biomarker. Targeting KRAS mutations in CRC is being explored through both indirect and direct strategies, with several KRAS allele-specific inhibitors in late-phase clinical trials and newer agents and targeting strategies undergoing preclinical and early-phase clinical testing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)