Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne M. Wong, Phoebe Luo, Benjamin Keunen, Samuel Pichardo, James M. Drake, Adam C. Waspe
Summary: An adaptive targeting algorithm was developed for real-time correction of misplanned hyperthermia treatments, improving the accuracy and precision of MRgHIFU therapy.
Article
Nanoscience & Nanotechnology
Hui Gao, Zhaoxia Wang, Mixiao Tan, Weiwei Liu, Liang Zhang, Ju Huang, Yang Cao, Pan Li, Zhigang Wang, Jiexin Wen, Tingting Shang, Haitao Ran
Summary: This study successfully constructed pH-responsive Ca@H nanoparticles for photoacoustic imaging-guided/monitored HIFUT combined with SDT therapy. This method has potential in the treatment of non-invasive tumors in the future.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Laura de los Rios Cardenas, Leonardo A. Bermeo Varon, Wagner Coelho de Albuquerque Pereira
Summary: This study investigates the hyperthermia therapy for cancer treatment using HIFU through numerical simulation and parameter estimation. By analyzing acoustic and bioheat transfer models, the temperature distribution in the heat field can be determined and appropriate treatment parameters can be estimated. The results suggest that this method provides personalized treatment options for each patient.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Janggun Jo, M. Laird Forrest, Xinmai Yang
Summary: The combination of laser and ultrasound can significantly improve the efficiency of thrombolysis, with lower ultrasound threshold pressures observed as laser powers increase in the in vitro blood clot model.
Article
Chemistry, Physical
Yingyan Zheng, Dejun She, Huihui Huang, Lin Lin, Sunhui Chen, Yiping Lu, Li Liu, Zhiqing Pang, Bo Yin
Summary: A versatile nanoplatform called BMP was synthesized, which can generate tumoricidal reactive oxygen species (ROS) under high-intensity focused ultrasound (HIFU) exposure. BMP also has specific T-1-weighted magnetic resonance imaging (MRI) capability and can alleviate the hypoxic environment, leading to improved glioma treatment.
Article
Nanoscience & Nanotechnology
Moslem Sadeghi-Goughari, Soo Jeon, Hyock-Ju Kwon
Summary: The study evaluated the potential of carbon nanotubes (CNTs) as effective absorption-enhancing agents for HIFU treatment, showing that CNTs significantly enhanced the thermal effect of HIFU. Increasing ultrasonic power and driving frequency was found to improve the performance of CNTs.
Article
Acoustics
Eric K. Juang, Lance H. De Koninck, Kaleb S. Vuong, Aswin Gnanaskandan, Chao-Tsung Hsiao, Michalakis A. Averkiou
Summary: This study aimed to investigate the use of HIFU with microbubble injections under image guidance to enhance thermal therapy. The results showed that inertial cavitation of microbubbles led to temperature elevation in non-perfused liver, while local injections of microbubbles were necessary to achieve significant temperature enhancement in perfused liver.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Computer Science, Information Systems
Yongkui Tang, Leng-Ying Chen, Ailin Zhang, Chun-Peng Liao, Mitchell Eric Gross, Eun Sok Kim
Summary: The study evaluated the therapeutic effects of a new pulsed high-frequency medium-intensity focused ultrasound in selective cancer treatment with promising results, demonstrating reduced tumor size without thermal damage for potentially safer cancer treatment.
Review
Oncology
David Cranston, Tom Leslie, Gail ter Haar
Summary: High-intensity focused ultrasound is a novel and non-invasive treatment method that is similar to focusing the sun's rays with a magnifying glass. It has shown promising results in trials for the treatment of renal and prostate cancers in urological surgery. The technology is rapidly evolving and has the potential to become a standard treatment for various diseases as it improves over time.
Article
Medicine, Research & Experimental
Chao Li, Yao Lu, Lili Cheng, Xiaoge Zhang, Jun Yue, Jie Liu
Summary: Combining HIFU with nanodroplets showed enhanced anticancer efficacy by triggering anticancer immune responses, inducing immunogenic cell death, activating DCs maturation, and enhancing effector T-cell infiltration within tumors.
MOLECULAR PHARMACEUTICS
(2021)
Article
Urology & Nephrology
Matthew G. Parry, Arunan Sujenthiran, Julie Nossiter, Melanie Morris, Brendan Berry, Arjun Nathan, Ajay Aggarwal, Heather Payne, Jan van der Meulen, Noel W. Clarke
Summary: This observational cohort study examines the 5-year failure-free survival (FFS) of 1381 men who received high-intensity focused ultrasound (HIFU) for localized prostate cancer. The study finds that four in five men were free from local salvage treatment at 5 years, but treatment failure rates varied significantly based on ISUP Grade Group.
Article
Acoustics
Che-Chou Shen, Ri-Cheng Lin, Nien-Hung Wu
Summary: This study proposes a Golay-encoded ultrasound (US) monitoring method to address the difficulties in monitoring high-intensity focused ultrasound (HIFU) treatment caused by strong HIFU interference. By effectively removing HIFU interference patterns, this method improves the image quality metrics and increases the echo magnitude in real-time B-mode imaging. Experimental results show that Golay decoding significantly increases the PSNR of US monitoring images and improves the SSIM index, making the B-mode image with HIFU transmission visually indistinguishable from the one without HIFU transmission.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Review
Biochemistry & Molecular Biology
Loreto B. Feril, Rodney L. Fernan, Katsuro Tachibana
Summary: High-intensity focused ultrasound (HIFU) is a non-invasive method of ablating malignant tumors, with growing interest in its clinical application for breast cancer treatment. Despite technical challenges and limited clinical studies, HIFU is considered safe and potentially the preferred treatment option for most breast cancer patients in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sunao Shoji, Satoshi Kuroda, Kohei Uemura, Kazuya Oda, Tatsuo Kano, Takahiro Ogawa, Tatsuya Umemoto, Mayura Nakano, Masayoshi Kawakami, Masahiro Nitta, Masanori Hasegawa, Akira Miyajima
Summary: The study showed that lower pre-procedural erectile function and treatment in proximity to the NVB were significant risk factors for severe ED after focal therapy.
Article
Surgery
Julene B. Samuels, Bruce Katz, Robert A. Weiss
Summary: This study investigated the efficacy of a novel device for abdominal toning and fat reduction. The results showed that the active treatment group, which utilized simultaneous application of radiofrequency and HIFEM therapy, had a significant increase in rectus abdominis thickness and reduction in subcutaneous fat, exceeding previously published results for separate HIFEM and radiofrequency treatments.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Acoustics
Jonathan M. Rubin, Sibo Li, J. Brian Fowlkes, Shriram Sethuraman, Oliver D. Kripfgans, William Shi, Marjorie C. Treadwell, James R. Jago, Ronald D. Leichner, Stephen Z. Pinter
Summary: The study compared a new method for estimating blood volume flow with the standard 1-dimensional spectral Doppler method in the umbilical vein, finding significantly less variation in estimates with the new 3-dimensional ultrasound method.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Gema Valles, Eduardo Garcia-Rey, Laura Saldana, Eduardo Garcia-Cimbrelo, Nuria Vilaboa
Summary: Aseptic loosening involves inflammation and bone resorption processes. The study found higher serum IGFBP-1 levels in revision surgery patients compared to primary total hip arthroplasty patients, possibly due to increased local IGFBP-1 production in the inflammatory environment of the periprosthetic bed.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Daniel Fernandez-Villa, Gerardo Asensio, Manuel Silva, Rosa Ana Ramirez-Jimenez, Laura Saldana, Nuria Vilaboa, Ana Leite-Oliveira, Julio San Roman, Blanca Vazquez-Lasa, Luis Rojo
Summary: The study presented novel vitamin B9 derivatives with divalent cations, which demonstrated bioactivity in modulating osteogenic-like or fibrocartilaginous-like phenotypes. These compounds show potential for further in vivo studies for musculoskeletal regeneration applications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Khaled Sinjab, Oliver D. Kripfgans, Alice Ou, Hsun-Liang Chan
Summary: This study aimed to investigate the feasibility of ultrasound in assessing bone ridge width and crestal bone surface quality. The results showed a high correlation and agreement between ultrasound and cone beam computed tomography in evaluating BRW and CBSQ.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Engineering, Biomedical
Easton Farrell, Mitra Aliabouzar, Carole Quesada, Brendon M. Baker, Renny T. Franceschi, Andrew J. Putnam, Mario L. Fabiilli
Summary: A novel composite hydrogel, called an acoustically-responsive scaffold (ARS), has been developed for non-invasive, spatiotemporally controlled modulation of mechanical and morphological properties using focused ultrasound. The study demonstrates that ARS can effectively control the differentiation of fibroblasts into myofibroblasts and induce matrix compaction and stiffening.
ACTA BIOMATERIALIA
(2022)
Article
Acoustics
Jonathan M. Rubin, J. Brian Fowlkes, Stephen Z. Pinter, Marjorie C. Treadwell, Oliver D. Kripfgans
Summary: Placental blood flow analysis using Fast Fourier Transform of umbilical venous pulse wave spectra can assess maternal/fetal blood flow simultaneously, distinguishing between normal and complications like IUGR and pre-eclampsia. Differences in maternal/fetal spectral peaks and weight-normalized umbilical venous blood flows may act synergistically in cases with both conditions. This new marker in umbilical venous flow has the potential to identify primary causes of IUGR and pre-eclampsia when combined with umbilical cord blood flow analysis.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Polymer Science
Maria Aguado, Laura Saldana, Eduardo Perez del Rio, Judith Guasch, Marc Parera, Alba Cordoba, Joaquin Seras-Franzoso, Olivia Cano-Garrido, Esther Vazquez, Antonio Villaverde, Jaume Veciana, Imma Ratera, Nuria Vilaboa, Nora Ventosa
Summary: This study demonstrates for the first time the use of Freon R134a for generating porous polymer matrices with larger pore sizes and better mechanical properties compared to conventional scCO(2) processing. MSCs attached to PLA scaffolds processed with Freon R134a exhibited good metabolic activity and displayed spread morphology with a well-organized actin cytoskeleton. Functionalization of Freon R134a-processed PLA scaffolds with protein nanoparticles significantly enhanced the scaffolds' cytocompatibility.
Review
Pharmacology & Pharmacy
Maria I. Falguera Uceda, Silvia Sanchez-Casanova, Clara Escudero-Duch, Nuria Vilaboa
Summary: This review provides an overview of current developments in cell-based strategies for enhancing the surgical armamentarium to regenerate cranial vault defects. The review focuses on cell-based approaches, delivery strategies for extracellular matrix, conditioned media, and extracellular vesicles, as well as recent advances in 3D printing and bioprinting techniques for cranial reconstruction. It also discusses cell-based gene therapy approaches with regulated and unregulated gene switches.
Article
Dentistry, Oral Surgery & Medicine
Mustafa Tattan, Omar Tattan, Jad Majzoub, Ali Salami, Hsun-Liang Chan, Oliver D. Kripfgans
Summary: This study demonstrates the feasibility of using 3D ultrasound to measure ridge width of the jawbone. 3D ultrasound can provide a larger field of view and more accurate positioning, making it a promising tool to supplement CBCT.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lorenzo Tavelli, Shayan Barootchi, Maria Vera Rodriguez, Leonardo Mancini, Jad Majzoub, Suncica Travan, Jim Sugai, Hsun-Liang Chan, Oliver Kripfgans, Hom-Lay Wang, William Giannobile
Summary: This study evaluated the efficacy of recombinant human platelet-derived growth factor (rhPDGF)-BB combined with a cross-linked collagen matrix (CCM) for the treatment of multiple adjacent gingival recession type 1 defects (MAGRs). The results showed that rhPDGF could improve mean root coverage, increase gingival thickness, and enhance aesthetic outcomes for patients.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Rheumatology
Alexander J. Knights, Easton C. Farrell, Olivia M. Ellis, Lindsey Lammlin, Lucas M. Junginger, Phillip M. Rzeczycki, Rachel F. Bergman, Rida Pervez, Monique Cruz, Eleanor Knight, Dennis Farmer, Alexa A. Samani, Chia-Lung Wu, Kurt D. Hankenson, Tristan Maerz
Summary: Through studying a PTOA mouse model, we found that synovial fibroblasts assume distinct functional identities during PTOA, and Prg4(hi) lining fibroblasts secrete Rspo2 that may drive pathological joint crosstalk after injury.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Acoustics
Jonathan M. Rubin, Oliver D. Kripfgans, J. Brian Fowlkes, Gary M. Weiner, Marjorie C. Treadwell, Stephen Z. Pinter
Summary: Measurement of blood flow to the brain in neonates is valuable but challenging in clinical settings. Researchers have developed an ultrasound blood volume flow technique that can safely and conveniently assess cerebral blood flow in newborns, offering potential for monitoring and evaluating blood flow in various clinical conditions.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mitra Aliabouzar, Oliver D. Kripfgans, J. Brian Fowlkes, Mario L. Fabiilli
Summary: The development of phase-shift droplets has expanded the possibilities of ultrasound-based biomedical applications. Acoustic droplet vaporization (ADV), where the perfluorocarbon phase undergoes a phase transition to a gaseous state under sufficient acoustic pressures, has been extensively researched. This review covers experimental approaches, theoretical models, and recent advancements in tissue regeneration using ADV, as well as potential future applications in microrheology and pressure estimation.
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2023)
Article
Acoustics
Hsi-Chien Yu, Oliver D. Kripfgans, Amanda B. Rodriguez, Ankita Samal, Carole Quesada, Liana P. Webber, John P. Mazzocco, I-Ching Wang, Jaeman Woo, Hsun-Liang Chan
Summary: This study investigated the biomechanical properties of porcine oral tissues using in vivo ultrasonography, comparing the differences between oral alveolar mucosa and gingival tissue in terms of compressional and tensile mechanical strain. The results showed significant differences in strain between the two types of tissues, with alveolar mucosa exhibiting greater longitudinal strain and slightly greater tensile strain than gingiva. These findings may have important clinical implications for the diagnosis and treatment of oral diseases.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Physics, Applied
Mitra Aliabouzar, Bachir A. Abeid, Oliver D. Kripfgans, J. Brian Fowlkes, Jonathan B. Estrada, Mario L. Fabiilli
Summary: Phase-shift droplets generated a range of bioeffects via the mechanism of acoustic droplet vaporization (ADV), which could be applied in therapeutic and diagnostic ultrasound. This study visualized ADV-induced mechanics and sonoporation in fibrin-based hydrogels using ultra-high-speed microscopy, confocal microscopy, and focused ultrasound. The results showed that fibrin gels containing perfluoropentane (PFP) droplets exhibited significantly higher radial expansion, expansion velocity, induced strain, and displacement of tracer particles compared to gels containing perfluorohexane (PFH) or perfluorooctane (PFO) droplets. Cell membrane permeabilization was dependent on the distance between the droplet and cell, decreasing rapidly with increasing distance. The hyper-local region of influence by an ADV bubble correlated inversely with the boiling point of the phase-shift droplets. These findings provide insights for the development of optimal approaches for therapeutic applications of ADV.
APPLIED PHYSICS LETTERS
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.