Article
Environmental Sciences
Ewelina Krol, Zbigniew Krejpcio
Summary: Diabetes mellitus is a metabolic disease that affects carbohydrate and lipid levels, as well as the body's mineral balance. This study found that Cr(III) is a potential hypoglycaemic element. Supplementation with Cr(III) complexes partially normalized the levels of magnesium and phosphorus in the heart, liver, and spleen of diabetic rats. However, these compounds did not influence the antioxidant status.
JOURNAL OF ELEMENTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Enas A. Abdel-Hady
Summary: Chronic hypoxia can cause cardiovascular complications. This study found that hypoxia leads to abnormal cardiac activities and increased oxidative stress in cardiac tissue. However, chromium supplementation can improve these abnormalities and enhance cardiovascular function.
Article
Chemistry, Analytical
Missael Antonio Arroyo Negrete, Kazimierz Wrobel, Eunice Yanez Barrientos, Alma Rosa Corrales Escobosa, Israel Enciso Donis, Katarzyna Wrobel
Summary: In this study, flow injection analysis (FIA) was used as a sample introduction method for an electrospray ionization - ion trap mass spectrometer (ESI-ITMS) to quantify CrPic(3) in commercial supplements. The FIA system operated with ammonium formate as a carrier solution, and cobalt picolinate was used as an internal standard (IS). The results showed that the proposed FIA-ESI-ITMS/MS procedure is a suitable method for the determination of CrPic(3) in such products.
Article
Endocrinology & Metabolism
Nombuso Xulu, Phikelelani Ngubane, Andile Khathi, Irvin Booysen, Ntethelelo Sibiya
Summary: The study showed that the anti-hyperglycaemic dioxidovanadium(V) complex improved haematological parameters, cell survival, and antioxidant status in diabetic rats, suggesting its potential as an effective alternative therapeutic drug for hyperglycaemia in diabetes mellitus.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Chemistry, Medicinal
Jakub Kurek, Ewelina Krol, Halina Staniek, Zbigniew Krejpcio
Summary: The study evaluated the effects of stevioside combined with L-arginine and chromium(III) on mild type 2 diabetic rats. The results showed improvements in blood glucose levels, insulin resistance indices, and VLDL-C concentrations with stevioside supplementation. Stevioside was more effective than rebaudioside A in reducing these markers.
Article
Biochemistry & Molecular Biology
Shivam Khare, Muneendra Kumar, Vinod Kumar, Raju Kushwaha, Shalini Vaswani, Avinash Kumar, Rajkumar Singh Yadav, Shanker Kumar Singh, Yajuvendra Singh, Pankaj Kumar Shukla
Summary: The study aimed to assess the effect of Cr supplementation on insulin sensitivity and health status in Hariana calves during their transition period. The results showed that Cr supplementation improved insulin sensitivity and glucose utilization in calves, leading to better health status.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Narayan Sinha, Juan-Ramon Jimenez, Bjorn Pfund, Alessandro Prescimone, Claude Piguet, Oliver S. Wenger
Summary: By combining pi-donating amido with pi-accepting pyridine coordination units in a tridentate chelate ligand, a strong nephelauxetic effect was achieved in a homoleptic Cr-III complex, shifting its luminescence to the NIR-II spectral range. This study focuses on increasing metal-ligand bond covalence to shift the ruby-like E-2 emission of Cr-III to 1067 nm at 77 K, taking a fundamentally different approach from previous ligand design strategies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Plant Sciences
Eman Zekry Attia, Marwa Fathy Khalifa, John Refaat Fahim, Mohamed Salah Kamel
Summary: The study found that the crude mucilage of Hippeastrum vittatum bulbs, belonging to the Amaryllidaceae family, has potential hypoglycemic effects in diabetic rats. The results suggest the possibility of developing natural hypoglycemic agents from this plant and other Amaryllidaceae species as alternative or complementary therapies for type-2 diabetes.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Engineering, Chemical
Xiande Xie, Jingxia Li, Jing Liu, Zhuo Chen, Xiaoqing Yuan, Tao Chen, Lin Luo
Summary: Chromium picolinate (Cr(pic)3), widely used in animal feeding, can be introduced to the environment through animal waste, leading to chromium contamination risk. Direct adsorption and precipitation methods for removing chromium in Cr(pic)3 form are difficult. This study investigated the treatment of Cr(pic)3 using the Fenton process and found that it can effectively degrade Cr(pic)3 and remove chromium simultaneously, making it promising for treating Cr(pic)3-containing wastewater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Fisheries
Qixia Chan, Fuqiang Wang, Yuzhe Han, Tongjun Ren, Lidong Shi, Xue Ren, Fanshuang Zeng, Muzi Li, Wenbo Chen
Summary: The study found that dietary chromium picolinate supplementation at 0.6 mg/kg greatly improves food utilization, growth-related gene expressions, immune and antioxidant capacity in juvenile sea cucumbers.
AQUACULTURE REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Simon Trzmiel, Jan Langmann, Daniel Werner, Caecilia Maichle-Moessmer, Wolfgang Scherer, Reiner Anwander
Summary: The reaction of CHI3 with six equivalents of CrCl2 at low temperatures resulted in the first isolable high-yield Cr-III mu(3)-methylidyne complex. Substitution of terminal chlorido ligands with alkali-metal cyclopentadienides produced isostructural half-sandwich chromium(III)-mu(3)-methylidynes. Side and decomposition products of the Cl/Cp(R) exchange reactions were identified and characterized.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Ruben Moreira, Ana D. Martins, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira
Summary: Low testosterone levels are a major cause of male infertility, and endocrine-disrupting chemicals such as chromium (Cr) can affect testicular steroidogenesis and male fertility. In particular, Cr(III) picolinate (CrPic(3)) has been found to inhibit enzymes involved in steroidogenesis and impact reactive oxygen species (ROS) levels, testosterone levels, and sperm motility and count. However, further research is needed to fully understand the effects of CrPic(3) on male fertility and ensure its safety for use by men.
Article
Biochemistry & Molecular Biology
Abhay Kumar Giri, Narottam Prasad Sahu, Gyanaranjan Dash
Summary: The study found that supplementing Labeo rohita fingerlings' diet with 800 μg/kg Cr-Pic significantly improved growth and carbohydrate utilization, as indicated by various growth and enzyme activity parameters.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Ibrahim M. Alhazza, Hossam Ebaid, Mohamed S. Omar, Iftekhar Hassan, Mohamed A. Habila, Jameel Al-Tamimi, Mohamed Sheikh
Summary: The study found that selenium nanoparticles (SeNPs) have a protective effect against kidney injury in streptozocin-induced diabetic rats, improving symptoms such as polyuria, delayed gestation, and abnormal pancreatic beta-cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Veterinary Sciences
Rudolf Dupak, Jana Hrnkova, Nikoleta Simonova, Jan Kovac, Eva Ivanisova, Anna Kalafova, Monika Schneidgenova, Marta Soltesova Prnova, Jan Brindza, Katarina Tokarova, Marcela Capcarova
Summary: Sea buckthorn, known for its antioxidant effects, can effectively suppress hyperglycemia, reduce water intake, and lower sorbitol levels in the lens of the eyes in diabetic rats.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pandora E. White, Ewelina Krol, Artur Szwengiel, Malgorzata Tubacka, Dawid Szczepankiewicz, Halina Staniek, John B. Vincent, Zbigniew Krejpcio
Summary: The study investigated the combined effects of trivalent chromium and bitter melon in high-fat-fed streptozotocin-induced diabetic rats, revealing a potential nutritional antagonistic effect between the two substances. While bitter melon showed some improvement in body mass gain, blood glucose, and LDL cholesterol values, trivalent chromium did not significantly impact glucose and lipid metabolism in the experimental rats. This suggests that the combination of trivalent chromium and bitter melon may not provide additive benefits in treating insulin resistance and diabetes in this animal model.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Katarzyna Szkudelska, Monika Okulicz, Tomasz Szkudelski
Summary: BPA enhances insulin action and lipolysis response to epinephrine in adipocytes, but has no effect on adipokine secretion.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Jakub Michal Kurek, Ewelina Krol, Zbigniew Krejpcio
Summary: The study found that dietary supplementation with steviol glycosides can normalize lipid metabolism, alleviate internal organ damage in diabetic rats, and have no significant effect on blood glucose, insulin, and insulin resistance indices.
Article
Food Science & Technology
Monika Okulicz, Iwona Hertig, Tomasz Szkudelski
Summary: Allyl isothiocyanate (AITC), a compound found in Brassica family plants, has shown diverse effects including anti-cancer, cardioprotective, neuroprotective, and anti-obesity abilities. However, in a diabetic rat model induced by a high fat diet and streptozotocin, AITC caused adverse effects such as decreased thyroid hormones, lipid disorders, and pancreatic hypertrophy. Although AITC lowered blood glucose levels and improved insulin sensitivity, its adverse effects on lipids and hormones may limit its potential as an anti-diabetic compound.
Article
Engineering, Chemical
Hanna Smigielska, Wioletta Blaszczak, Grazyna Lewandowicz
Summary: The growth in the human population and intensive farming have led to a decline in the quality of nutrition, often resulting in a deficiency in micronutrients. To address this issue, the food industry has introduced products enriched with bioactive substances. This study focused on evaluating the use of native potato starch and modified starches as carriers for microelements. The results showed that both native and modified starches were effective in adsorbing copper, iron, and zinc ions, with the modified starches containing hydrophilic carboxyl groups showing higher efficiency.
Article
Nutrition & Dietetics
Aleksandra Szlas, Jakub Michal Kurek, Zbigniew Krejpcio
Summary: L-arginine is a safe endogenous amino acid involved in various regulatory functions in the body. It may be helpful in managing disturbed metabolism, regulating blood pressure, and alleviating type 2 diabetes symptoms, but the mechanisms underlying these effects are not fully understood.
Article
Food Science & Technology
Jakub Michal Kurek, Joanna Zielinska-Wasielica, Katarzyna Kowalska, Zbigniew Krejpcio, Anna Olejnik
Summary: This study demonstrates the inhibitory effect of stevioside and steviol on adipogenesis and lipogenesis, leading to decreased lipid accumulation. Additionally, they can enhance glucose uptake in insulin-resistant cells and alleviate symptoms of insulin resistance.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Monika Okulicz, Iwona Hertig, Ewelina Krol, Tomasz Szkudelski
Summary: Oxidative stress and inflammation have a crucial role in the development of diabetes. This study found that allyl isothiocyanate (AITC) exacerbates oxidative and inflammation status in diabetic rats.
Article
Chemistry, Medicinal
Jakub Kurek, Ewelina Krol, Halina Staniek, Zbigniew Krejpcio
Summary: The study evaluated the effects of stevioside combined with L-arginine and chromium(III) on mild type 2 diabetic rats. The results showed improvements in blood glucose levels, insulin resistance indices, and VLDL-C concentrations with stevioside supplementation. Stevioside was more effective than rebaudioside A in reducing these markers.
Article
Biochemistry & Molecular Biology
Kinga Stuper-Szablewska, Tomasz Szablewski, Anna Przybylska-Balcerek, Lidia Szwajkowska-Michalek, Michal Krzyzaniak, Dariusz Swierk, Renata Cegielska-Radziejewska, Zbigniew Krejpcio
Summary: Plant extracts are valuable sources of bioactive compounds that can be used in various industries. This study investigated the content of selected bioactive compounds in extracts from different plant materials, and found that they have potential antimicrobial activity. The tested plant materials, including bitter melon, elderberry, wild rose, mountain ash, guelder rose, and sea buckthorn, contain various bioactive compounds and exhibit antibacterial effects.
Article
Medicine, Research & Experimental
Jakub Michal Kurek, Joanna Mikolajczyk-Stecyna, Zbigniew Krejpcio
Summary: This study reveals the potential of steviol glycosides in regulating lipid metabolism and shows their impact on specific gene expression. However, further research, including human trials, is needed to confirm these effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Ewelina Krol, Zbigniew Krejpcio
Summary: Diabetes mellitus is a metabolic disease that affects carbohydrate and lipid levels, as well as the body's mineral balance. This study found that Cr(III) is a potential hypoglycaemic element. Supplementation with Cr(III) complexes partially normalized the levels of magnesium and phosphorus in the heart, liver, and spleen of diabetic rats. However, these compounds did not influence the antioxidant status.
JOURNAL OF ELEMENTOLOGY
(2023)
