Journal
AUTOIMMUNITY REVIEWS
Volume 18, Issue 4, Pages 426-432Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2018.12.004
Keywords
Neuropsychiatric systemic lupus erythematosus; Autoantibodies; Cytokines; Complement; Blood-brain barrier and mechanisms
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Funding
- Comite para el Desarrollo de la Investigacidn (CODI) - Universidad de Antioquia, through the program: Convocatoria Programatica Ciencias de la Salud 2013-2014
- Comite para el Desarrollo de la Investigacidn (CODI) - Universidad de Antioquia, through the program: Programa de Sostenibilidad para Grupos de Investigacion
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Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE.
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