Article
Nutrition & Dietetics
Yang Liu, Simin Li, Liqing Jiang, Yuchong Zhang, Zhi Li, Jing Shi
Summary: The study found no significant correlation between total intake of solanaceous vegetables and colorectal cancer risk, but certain specific types of solanaceous vegetables showed a negative association with colorectal cancer risk, such as eggplant and sweet pepper. Potato was positively correlated with colorectal cancer risk.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Francesca Privitera, Rossella Gioco, Alba Ilari Civit, Daniela Corona, Simone Cremona, Lidia Puzzo, Salvatore Costa, Giuseppe Trama, Flavia Mauceri, Aurelio Cardella, Giuseppe Sangiorgio, Riccardo Nania, Pierfrancesco Veroux, Massimiliano Veroux
Summary: Kidney transplant recipients do not have an increased risk of developing colorectal cancer compared to the healthy population, but they have a higher risk of developing colorectal adenomas.
Review
Food Science & Technology
Ashraful Alam, Abdullah Al Arif Jahan, Md Sazzadul Bari, Labony Khandokar, Md Hasan Mahmud, Muhammed Junaid, Mohammed Salahuddin Chowdhury, Mohammad Forhad Khan, Veronique Seidel, Md Areeful Haque
Summary: This review provides an overview of the traditional uses, phytoconstituents, anti-inflammatory and anticancer activity of Allium species. These plants contain a wide range of chemical constituents and show potential for anti-inflammatory and anticancer effects. Garlic and onion, in particular, have been extensively studied, suggesting that other Allium species may also possess similar bioactive constituents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Oncology
Masoud Amini Kahrizsangi, Zohreh Ebrahimi, Zainab Shateri, Fatemeh Mansouri, Ali Zangene, Milad Rajabzadeh-Dehkordi, Mehran Nouri, Bahram Rashidkhani
Summary: This study found that there is a positive correlation between high glycemic load, high insulin load, and high glycemic index with the odds of developing colorectal cancer. On the other hand, high carbohydrate quality index and low-carbohydrate diet score are significantly negatively associated with the odds of colorectal cancer. Therefore, it is recommended to follow a diet with high-quality carbohydrates, low glycemic index, and low glycemic load to minimize the risk of developing colorectal cancer.
Article
Multidisciplinary Sciences
Huijie Wang, Huanwei Zheng, Xu Cao, Ping Meng, Jinli Liu, Caihua Zheng, Haiying Zuo, Zhichao Wang, Teng Zhang
Summary: This study explored the association between β2-microglobulin and colorectal cancer (CRC) among inpatients who underwent colonoscopy. After adjusting for baseline characteristics and laboratory parameters, a positive association was found between β2-M and CRC. Monitoring β2-M levels may be important for predicting CRC.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Amparo Belltall, Guido Mazzinari, Iris Garrido-Cano, Francisco Giner, Anabel Marques Mari, Pilar Eroles, Maria Pilar Argente-Navarro, Juan Pablo Cata, Oscar Diaz-Cambronero
Summary: This study aimed to assess the differential expression of opioid receptors between healthy and tumor tissues in patients with stage II and III colorectal cancer undergoing elective surgery. The results showed significant differences in the expression of opioid receptors between tumor and control tissue, but no significant differences in the expression of cAMP-PKA metabolic pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Xiang-Qian Su, Zhou-Yi Yin, Qiu-Yu Jin, Zong-Chao Liu, Xuan Han, Zhi-Qiang Hu, Lian Zhang, Jun-Ling Ma, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Dong Liu, Wei-Cheng You, Kai-Feng Pan, Leiyu Shi, Wen-Qing Li
Summary: In a prospective study, researchers found that the intake of allium vegetables, such as garlic and onion, can reduce the risk of gastric cancer. The study also suggested that the effects of allium vegetable intake may be modified by vitamin supplementation, garlic supplementation, and Helicobacter pylori treatment. These findings have important implications for dietary recommendations and public health.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Soheila Shekari, Soroor Fathi, Zahra Roumi, Mohammad Esmail Akbari, Shirin Tajadod, Maryam Afsharfar, Naeemeh Hasanpour Ardekanizadeh, Fatemeh Bourbour, Seyed Ali Keshavarz, Mahtab Sotoudeh, Maryam Gholamalizadeh, Shiva Nemat Gorgani, Hanieh Shafaei Kachaei, Atiyeh Alizadeh, Saeid Doaei
Summary: This study found a negative association between dietary intake of oleic acid, linoleic acid and alpha-linolenic acid with colorectal cancer risk.
FRONTIERS IN NUTRITION
(2022)
Article
Medical Laboratory Technology
Leila Jamali, Hossein Sadeghi, Mohammad-Reza Ghasemi, Roohollah Mohseni, Ehsan Nazemalhosseini-Mojarad, Vahid Reza Yassaee, Pegah Larki, Mohammad Reza Zali, Reza Mirfakhraie
Summary: This study evaluated the association between ATG16L1 rs2241880 and ATG5 rs1475270 variants with CRC risk in an Iranian population. The T allele of ATG16L1 rs2241880 was significantly associated with increased CRC risk, while no significant differences were found in ATG5 rs1475270 alleles and genotypes between cases and controls. Further investigations among different populations and ethnicities are needed to refine these conclusions.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Nutrition & Dietetics
Juan Flich-Carbonell, Antoni Alegre-Martinez, Jose L. Alfonso-Sanchez, Maria T. Torres-Sanchez, Segundo Gomez-Abril, Maria I. Martinez-Martinez, Jose M. Martin-Moreno
Summary: The study found that high, frequent consumption of capsaicin, followed by ethanol, eugenol, caffeine/theine/theobromine, and acids increase the risk of diverticulitis and hemorrhoidal proctitis.
Article
Multidisciplinary Sciences
Zheying Zhang, Huijie Jia, Yuhang Wang, Baoshun Du, Jiateng Zhong
Summary: The study found that increased MACC1 levels may be associated with lymphatic metastasis in colorectal cancer patients, especially in the middle-aged group of 64-75 years old.
Article
Nutrition & Dietetics
Monireh Sadat Seyyedsalehi, Giulia Collatuzzo, Inge Huybrechts, Maryam Hadji, Hamideh Rashidian, Roya Safari-Faramani, Reza Alizadeh-Navaei, Farin Kamangar, Arash Etemadi, Eero Pukkala, Marc J. Gunter, Veronique Chajes, Paolo Boffetta, Kazem Zendehdel
Summary: This study investigated the association between fatty acid intake and colorectal cancer (CRC) in a large Iranian case-control study. The results showed a positive association between high intakes of dietary total fat, cholesterol, and palmitoleic acid and CRC, and an inverse association with high intake of dietary heptanoic acid and low intake of palmitic acid. The study suggests that limiting fat consumption may decrease the risk of CRC in the Iranian population.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Mona Jonoush, Soroor Fathi, Naeemeh Hassanpour Ardekanizadeh, Golsa Khalatbari Mohseni, Nazanin Majidi, Seyed Ali Keshavarz, Soheila Shekari, Shiva Nemat Gorgani, Saheb Abbas Torki, Mahtab Sotoudeh, Fatemeh Habibi, Maryam Gholamalizadeh, Atiyeh Alizadeh, Saeid Doaei
Summary: This study found that CRC patients had higher dietary intake of carbohydrates, sugars, fructose, sucrose, and maltose. Moderating the intake of these components in the diet may help prevent CRC.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Kyle Staller, Ola Olen, Jonas Soderling, Bjorn Roelstraete, Hans Tornblom, Mingyang Song, Jonas F. Ludvigsson
Summary: Chronic constipation was not found to be directly associated with later CRC according to the study, and the association disappeared when using sibling comparators for comparison.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Environmental Sciences
Samira Negrichi, Salima Taleb
Summary: Colorectal carcinoma (CRC) is the second most common cancer diagnosed in Algeria, with an increasing incidence and mortality rate. Factors such as high education level, family history of cancer, occupational exposures, obesity, alcohol consumption, and dietary factors were found to be associated with CRC risk in this study. Public health campaigns to raise awareness about CRC and promote healthy dietary choices may help in prevention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Hongfei Yan, Yang Chen, Zichang Yang, Zhi Li, Xiaofang Che, Jiawen Xiao, Yunpeng Liu, Xiujuan Qu
Summary: An immune signature based on infiltrating immune cells composition was established to predict survival and chemotherapy benefits for gastric cancer patients after surgery. The IS classifier consisting of eight immune cells showed significant prognostic value, especially when combined with TNM stage. Patients with high-IS were more likely to benefit from a specific chemotherapy regimen, and two nomograms were established to screen for suitable patients for adjuvant chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chuan Liu, Chuan Hu, Jiale Huang, Kanghui Xiang, Zhi Li, Jinglei Qu, Ying Chen, Bowen Yang, Xiujuan Qu, Yunpeng Liu, Guangwei Zhang, Ti Wen
Summary: Liver metastasis is a deadly phenomenon in colon cancer patients, and a nomogram integrating various prognostic factors can accurately predict the prognosis of these patients. The nomogram showed favorable effects in predicting the overall survival of CCLM patients in training, internal validation, and external validation sets, suggesting its suitability for different patient populations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dan Zou, Zhi Li, Fei Lv, Yi Yang, Chunjiao Yang, Jincheng Song, Yang Chen, Zi Jin, Jinpeng Zhou, Yang Jiang, Yanju Ma, Zhitao Jing, Yu Tang, Ye Zhang
Summary: NOS3, a member of the NOS enzyme family, plays a role in NO generation and has been shown to influence apoptosis, angiogenesis, proliferation, and invasiveness. High expression of NOS3 in stomach adenocarcinoma is associated with poor prognosis, and it may affect the occurrence and development of the cancer through various cancer-related pathways. NOS3 could be a potential target for gastric cancer treatment as drug response analysis suggests drugs that suppress NOS3.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Wenqing Lu, Xiaofang Che, Xiujuan Qu, Chunlei Zheng, Xianghong Yang, Bowen Bao, Zhi Li, Duo Wang, Yue Jin, Yizhe Wang, Jiawen Xiao, Jianfei Qi, Yunpeng Liu
Summary: This study comprehensively analyzed the role of succinylation regulators in ccRCC and suggested their specific and critical impact on tumor prognosis. By clustering patients based on the expression patterns of regulators, distinct clusters with different survival outcomes and clinicopathological features were identified, indicating their potential mechanisms in promoting malignant progression. The study provided new insights into the understanding of succinylation modification and its clinical implications in ccRCC treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shuo Wang, Xiujuan Qu, Zhi Li, Xiaofang Che, Lili Cao, Xianghong Yang, Xuejun Hu, Ling Xu, Kezuo Hou, Yibo Fan, Ti Wen, Yunpeng Liu
Summary: The study revealed that PD-L1 in ADC and PD-1+ TILs in SCC respectively indicate T-cell function, playing a crucial role in prognosis determination. PD-L1 was considered an independent predictor of overall survival for ADC patients, while PD-1+ TILs were deemed a poor prognostic predictor in SCC patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Hao Quan, Xiaosong Xu, Tingting Zheng, Zhi Li, Mingfang Zhao, Xiaoyu Cui
Summary: A new deep learning framework DenseCapsNet is proposed, which integrates DenseNet and CapsNet to achieve high accuracy and sensitivity detection of novel coronavirus pneumonia CXR images.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Pathology
Jin Wang, Xinye Shao, Yang Liu, Ruichuan Shi, Bowen Yang, Jiawen Xiao, Yunpeng Liu, Xiujuan Qu, Zhi Li
Summary: This study identified four key driver genes (TP53, PIK3CA, APC, and ARID1A) associated with the risk of gastric cancer metastasis. Mutations in TP53 and APC were found to be significantly linked to lymph node and distant metastasis in gastric cancer, particularly in the Asian population. Further prospective studies are needed to validate these findings.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Pharmacology & Pharmacy
Yiting Sun, Liqing Jiang, Ti Wen, Xiaoyu Guo, Xinye Shao, Hui Qu, Xi Chen, Yujia Song, Fang Wang, Xiujuan Qu, Zhi Li
Summary: This study provides a comprehensive bibliometric analysis of literature on anti-PD1/PDL1, revealing major research themes, emergent hotspots, and top contributors from different perspectives. Through co-occurrence overlay of keywords, the progress from discovery of the PD1/PDL1 molecule to its clinical application is reflected, with immune-related adverse events forming a unique cluster. The study also outlines the historical development and transformation of cancers and therapy strategies through a direct citation network of RCT, indicating potential future research focus on irAEs and combination therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Yang Liu, Simin Li, Liqing Jiang, Yuchong Zhang, Zhi Li, Jing Shi
Summary: The study found no significant correlation between total intake of solanaceous vegetables and colorectal cancer risk, but certain specific types of solanaceous vegetables showed a negative association with colorectal cancer risk, such as eggplant and sweet pepper. Potato was positively correlated with colorectal cancer risk.
FRONTIERS IN NUTRITION
(2021)
Article
Computer Science, Artificial Intelligence
Hui Qu, Ruichuan Shi, Shuqin Li, Fengying Che, Jian Wu, Haoran Li, Weixing Chen, Hao Zhang, Zhi Li, Xiaoyu Cui
Summary: The traditional static radiology feature extraction method is insufficient to fully evaluate a patient's condition. This study proposes a new dynamic radiomics feature extraction method, which achieves higher accuracy and robustness in predicting different clinical questions.
APPLIED INTELLIGENCE
(2022)
Article
Cell Biology
Jiaxi Yao, Yuchong Zhang, Mengling Li, Zuyu Sun, Tao Liu, Mingfang Zhao, Zhi Li
Summary: This study investigated the relationship between epithelial-mesenchymal transition (EMT) and ferroptosis in tumor cells using single-cell RNA sequencing. The results showed a positive correlation between EMT and ferroptosis tendency. The analysis of transcription factors and cell communication networks revealed that ferroptosis has a regulatory effect on EMT, and high propensities of ferroptosis and EMT may lead to poor prognosis and non-response to immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Chaoyi Yin, Yangkun Cao, Peishuo Sun, Hengyuan Zhang, Zhi Li, Ying Xu, Huiyan Sun
Summary: The study introduces a novel framework for cancer molecular subtyping based on multi-omics data integration, showing superior classification performance in predicting molecular subtypes of breast and stomach cancer compared to existing methods.
FRONTIERS IN GENETICS
(2022)
Correction
Oncology
Li-Bao Gong, Ti Wen, Zhi Li, Xing Xin, Xiao-Fang Che, Jin Wang, Yun-Peng Liu, Xiu-Juan Qu
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Hui Qu, Ruichuan Shi, Bowen Yang, Xi Chen, Yujia Song, Lingzi He, Yiting Sun, Yujing Yang, Zhi Li, Xiujuan Qu
Summary: Using a gene expression database, this study performed univariate Cox regression analysis to identify three genes potentially associated with the risk of peritoneal metastasis in diffuse-type gastric cancer patients. Propensity score matching analysis confirmed the significant correlation of these genes with short-term peritoneal disease-free survival in this patient group. Additionally, gene set enrichment analysis suggested these genes may promote early peritoneal metastasis through glucose metabolism pathways.
Article
Biology
Mengyi Tang, Bowen Yang, Chuang Zhang, Chaoxu Zhang, Dan Zang, Libao Gong, Yunpeng Liu, Zhi Li, Xiujuan Qu
Summary: This study investigated key prognostic factors in distal gastric cancer (DGC) using bioinformatic methods, revealing that high coagulation factor V (F5) expression was associated with poor prognosis and may affect the prognosis by modulating the Wnt and/or TGF-beta signaling pathways.