Updates of Recent Aortic Aneurysm Research

MicroRNA-21 Knockout Exacerbates Angiotensin II–Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β–SMAD3 SignalingHighlights

(2018) Xiaofan Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD40L Deficiency Protects Against Aneurysm FormationHighlights

(2018) Pascal J.H. Kusters et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TIMPing the Aorta

(2018) Carla Winter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies—Statement From ATVB CouncilHighlights

(2018) Peggy Robinet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cilostazol Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E–Deficient MiceHighlights

(2018) Ryoko Umebayashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic AneurysmsHighlights

(2018) Akshaya K. Meher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic AneurysmsHighlights

(2018) Jenny Lutshumba et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm

(2018) Matti Adam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix RemodelingHighlights

(2018) Marika Fava et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm DevelopmentHighlights

(2018) Li He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Renin-Angiotensin System and Cardiovascular Functions

(2018) Chia-Hua Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insights Into the Role of Regional Proteoglycan Metabolism in Thoracic Aortic Aneurysms

(2018) Allan R. Brasier   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell Type–Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease—Brief ReportHighlights

(2018) Josephine Galatioto et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Abdominal Aortic Aneurysms Growth Is Associated With High Concentrations of Plasma Proteins in the Intraluminal Thrombus and Diseased Arterial Tissue

(2018) Carsten Behr-Rasmussen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

(2018) Paul A. Mueller et al.   CIRCULATION

Osteopontin may be a driver of abdominal aortic aneurysm formation

(2018) S. Keisin Wang et al.   JOURNAL OF VASCULAR SURGERY

The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm

(2018) Elliot L. Chaikof et al.   JOURNAL OF VASCULAR SURGERY

Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study

(2018) Lu-Chen Weng et al.   PLoS One

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm

(2018) Seamus C. Harrison et al.   JAMA Cardiology

A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms

(2018) Cristina Patuzzo et al.   Balkan Journal of Medical Genetics

Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm—Brief Report

(2018) Diego Martínez-López et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LRP1 (Low-Density Lipoprotein Receptor–Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca 2+ Signaling and Expression of Cytoskeleton-Related Proteins

(2018) Dianaly T. Au et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monocytes and macrophages in abdominal aortic aneurysm

(2017) Juliette Raffort et al.   Nature Reviews Cardiology

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

(2017) Xunde Xian et al.   eLife

Transforming Growth Factor‐β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

(2017) Alan Daugherty et al.   Journal of the American Heart Association

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

(2017) Hao Wei et al.   Journal of the American Heart Association

X Marks the Spot

(2017) Siddharth K. Prakash et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II–Induced Aortic Pathology

(2017) Yasir Alsiraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-1β (Interleukin-1β) and TNF-α (Tumor Necrosis Factor-α) Impact Abdominal Aortic Aneurysm Formation by Differential Effects on Macrophage Polarization

(2017) Rishi Batra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lifetime Risk and Risk Factors for Abdominal Aortic Aneurysm in a 24-Year Prospective StudyHighlights

(2016) Weihong Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm FormationHighlights

(2016) Yun-Fei Yan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and AtherosclerosisHighlights

(2016) Smriti Murali Krishna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Focal Adhesion Kinase Promotes the Progression of Aortic Aneurysm by Modulating Macrophage BehaviorHighlights

(2016) Takasuke Harada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell ActivationHighlights

(2016) Huimin Yan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and DissectionsHighlights

(2016) Dianna M. Milewicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II–Induced Abdominal Aortic AneurysmsClinical Perspective

(2016) Yasir Alsiraj et al.   CIRCULATION

Oxidative stress and abdominal aortic aneurysm: potential treatment targets

(2016) T. I. Emeto et al.   CLINICAL SCIENCE

Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation

(2016) Zeina El Asmar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization

(2016) Matthew A. Dale et al.   JOURNAL OF IMMUNOLOGY

Sex- and Disease-Specific Inflammasome Signatures in Circulating Blood Leukocytes of Patients with Abdominal Aortic Aneurysm

(2016) Xiaoyu Wu et al.   MOLECULAR MEDICINE

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

(2016) Xiaofeng Chen et al.   PLoS One

Inflammatory Cell Phenotypes in AAAsSignificance

(2015) Matthew A. Dale et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential expression of Hedgehog/Notch and transforming growth factor-β in human abdominal aortic aneurysms

(2015) Adam J. Doyle et al.   JOURNAL OF VASCULAR SURGERY

Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1·9 million people

(2015) Anoop Dinesh Shah et al.   LANCET

ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression

(2015) Pedro Molina-Sánchez et al.   THROMBOSIS AND HAEMOSTASIS

Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies

(2014) Frank M Davis et al.   HEART

LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1

(2013) Selen C. Muratoglu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves

(2013) Loren E. Dupuis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms

(2012) M. J. Sweeting et al.   BRITISH JOURNAL OF SURGERY

The Strange Relationship between Diabetes and Abdominal Aortic Aneurysm

(2012) F.A. Lederle   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Effects of Statin Therapy on Abdominal Aortic Aneurysm Growth: A Meta-analysis and Meta-regression of Observational Comparative Studies

(2012) H. Takagi et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Arterial stiffness and novel biomarkers in patients with abdominal aortic aneurysms

(2012) Nikolaos P.E. Kadoglou et al.   REGULATORY PEPTIDES

MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion

(2012) L. Maegdefessel et al.   Science Translational Medicine

The Rise and Fall of Abdominal Aortic Aneurysm

(2011) Frank A. Lederle   CIRCULATION

The Impact of Intraluminal Thrombus Failure on the Mechanical Stress in the Wall of Abdominal Aortic Aneurysms

(2011) S. Polzer et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Management of Abdominal Aortic Aneurysms Clinical Practice Guidelines of the European Society for Vascular Surgery

(2011) F.L. Moll et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Complex pathologies of angiotensin II-induced abdominal aortic aneurysms

(2011) Alan Daugherty et al.   Journal of Zhejiang University-SCIENCE B

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

(2011) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans

(2010) J.-B. Michel et al.   CARDIOVASCULAR RESEARCH

Wnt Signaling and Aging-Related Heart Disorders

(2010) Atsuhiko T. Naito et al.   CIRCULATION RESEARCH

TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

(2010) Yu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β signaling in aortic aneurysm: another round of controversy

(2010) Fuyu Lin et al.   Journal of Genetics and Genomics

Hyperglycemia limits experimental aortic aneurysm progression

(2010) Noriyuki Miyama et al.   JOURNAL OF VASCULAR SURGERY

Proteomics Characterization of Extracellular Space Components in the Human Aorta

(2010) Athanasios Didangelos et al.   MOLECULAR & CELLULAR PROTEOMICS

Risk Factors for Abdominal Aortic Aneurysms

(2009) Signe Helene Forsdahl et al.   CIRCULATION

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice

(2009) Brian C. Tieu et al.   JOURNAL OF CLINICAL INVESTIGATION

SVS practice guidelines for the care of patients with an abdominal aortic aneurysm: Executive summary

(2009) Elliot L. Chaikof et al.   JOURNAL OF VASCULAR SURGERY

Androgen Increases AT1a Receptor Expression in Abdominal Aortas to Promote Angiotensin II–Induced AAAs in Apolipoprotein E–Deficient Mice

(2008) Tracy Henriques et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endovascular Repair of Abdominal Aortic Aneurysm

(2008) Roger M. Greenhalgh et al.   NEW ENGLAND JOURNAL OF MEDICINE