Article
Cell & Tissue Engineering
Jun-Ho Kim, Kang-Il Kim, Wan Keun Yoon, Sang-Jun Song, Wook Jin
Summary: This randomized controlled trial assessed the effects of intra-articular injection of adipose-derived mesenchymal stem cells (ADMSCs) after medial open-wedge high tibial osteotomy (MOWHTO) on cartilage defect regeneration, functional improvement, and safety in osteoarthritic knee with varus malalignment. The results showed that the ADMSC group had significantly better cartilage regeneration, arthroscopic assessment, and functional improvement compared to the control group, without any treatment-related adverse events.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Orthopedics
Jun-Gu Park, Seung-Beom Han, Ki-Mo Jang
Summary: The study compared clinical and radiologic outcomes after OWHTO in patients with and without tibial varus deformity, finding that patients without tibial varus deformity had inferior functional scores. However, radiologic outcomes and symptomatic improvement post-OWHTO were comparable regardless of preoperative tibial varus deformity.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Lisa Bode, Jan Kuehle, Anna-Sophie Brenner, Viola Freigang, Helge Eberbach, Philipp Niemeyer, Norbert P. Suedkamp, Hagen Schmal, Gerrit Bode
Summary: This study evaluated the influence of patellofemoral cartilage defects on the postoperative outcome of high tibial osteotomy (HTO) in patients with varus medial compartment osteoarthritis. The results showed that the long-term outcomes of HTO remained good to excellent even in the presence of patellofemoral defects. Overcorrection should be avoided, and distal biplanar HTO should be considered for patients with trochlear or kissing lesions of the patellofemoral joint.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Zheng Zhang, Hai Tao, Yingchun Zhao, Wei Xiang, Hui Cao, Fenghua Tao
Summary: This study evaluated the impact of high tibial osteotomy (HTO) on balance control in patients with knee osteoarthritis (OA) and varus deformity. The results showed that balance control improved in patients one year after HTO. Furthermore, HTO improved the alignment and function of the affected knee.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Multidisciplinary Sciences
Xingchen Li, Yang Xu, Changjun Guo, Chonglin Yang, Yuan Zhu, Xiangyang Xu
Summary: In this study, 21 patients with posttraumatic ankle osteoarthritis underwent intra-articular osteotomy, showing significant improvements in clinical outcomes. With an average follow-up of 34 months, the procedure effectively alleviated ankle pain and improved mobility, making it a valuable treatment option for this condition.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Hayden F. Atkinson, Trevor B. Birmingham, Jenna M. Schulz, Codie A. Primeau, Kristyn M. Leitch, Stephany L. Pritchett, D. W. Holdsworth, J. R. Giffin
Summary: The study demonstrated that medial opening wedge HTO can improve articular cartilage composition in the medial compartment of the knee without negatively affecting the lateral compartment or patella. Furthermore, there were low associations between radiographic measures and T2 values of cartilage composition.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Orthopedics
Yunfei Liu, Ruiyang Li, Yu Zhan, Xuetao Xie, Congfeng Luo
Summary: Combined proximal tibial osteotomy (CPTO) is a novel surgical technique that is suitable for KBD patients with severe knee varus deformity and intra-articular instability. This procedure can improve knee function, pain, and joint stability in patients.
ORTHOPAEDIC SURGERY
(2022)
Article
Computer Science, Interdisciplinary Applications
Ye Huang, Yetong Tan, Xiangdong Tian, Jian Wang, Guangyu Zhu, Rongtian Wang, Zhipeng Xue, Sheng Ma, Yuanyi Hu, Tiansong Ding
Summary: The study evaluated the clinical efficacy of DTT-HTO using a new patented pi-shaped plate in obese patients with varus knee osteoarthritis. Results showed that DTT-HTO yielded excellent clinical outcomes in obese patients, with no correlation between BMI and postoperative results.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yunpeng Bai, Binhui Lin, Miao Wang, Haoliang Ding, Weibing Sun, Jian Sun
Summary: This study demonstrated that MOWHTO combined with arthroscopic microfracture can effectively improve clinical outcomes in the treatment of varus medial compartmental knee osteoarthritis. Cartilage regeneration can be promoted by correcting varus deformities, which affects clinical outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Matthieu Ollivier, Jae-Sung An, Kristian Kley, Raghbir Khakha, Levi Reina Fernandes, Gregoire Micicoi
Summary: This study analyzed patients who underwent isolated opening wedge high tibial osteotomy (OWHTO) before the ESSKA guidelines, and found a significant rate of post-operative tibial overcorrection and an increase in knee joint line obliquity (JLO). Pre-operative planning that considers the ESSKA guidelines allows for better identification of patients requiring a distal femoral osteotomy (DFO) or double level osteotomy (DLO) and avoids post-operative deformities.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Mario Hevesi, Ryan R. Wilbur, Lucas K. Keyt, Matthew P. Abdel, Bruce A. Levy, Daniel B. F. Saris, Michael J. Stuart, Aaron J. Krych
Summary: This study compared the outcomes of patients who underwent total knee arthroplasty (TKA) following unilateral proximal tibial osteotomy (PTO). The results showed that PTO did not significantly affect the subsequent TKA. Patients who had undergone PTO-TKA had comparable clinical function, subjective outcomes, and knee preference to those who had undergone TKA-only.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Engineering, Biomedical
Jake Bowd, Sam Van Rossom, David Williams, David Elson, Chris Wilson, Gemma Whatling, Cathy Holt, Ilse Jonkers
Summary: This study evaluated the knee loading and contact location of a control group, a pre-surgery group, and the same group 12 months post-surgery using a musculoskeletal modeling approach. The results showed that surgery changed the contact force in the medial compartment during gait, with a reduction in contact force post-surgery despite increased walking speed. This study provides insight into the effects of high tibial osteotomy on knee loading and supports the aim of surgery to unload the medial knee compartment.
CLINICAL BIOMECHANICS
(2023)
Article
Orthopedics
Koji Iwasaki, Eiji Kondo, Shinji Matsubara, Masatake Matsuoka, Kaori Endo, Isao Yokota, Tomohiro Onodera, Norimasa Iwasaki
Summary: This study evaluated the distribution of subchondral bone density across the proximal tibia in nonarthritic knees and knees of patients with osteoarthritis before and after high tibial osteotomy (HTO). Results showed that HTO shifted the high-density areas of the medial compartment of the proximal tibial articular surface toward the lateral compartment, with an increase in the most lateral region of the medial compartment.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Yong Sang Kim, Dong Suk Suh, Dae Hyun Tak, Pill Ku Chung, Yoo Beom Kwon, Tae Yong Kim, Yong Gon Koh
Summary: The study aimed to investigate the outcomes of MSC implantation with concomitant HTO for varus knee OA. Results showed significant improvements in clinical and radiographic outcomes, with encouraging cartilage regeneration. Patient age and number of MSCs were found to be important factors influencing the outcomes.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Review
Orthopedics
Marcello Capella, Salvatore Risitano, Luigi Sabatini, Carlotta Faccenda, Luca Barberis, Daniele Camazzola, Francesco Bosco, Fortunato Giustra, Alessandro Masse
Summary: The increasing incidence and distribution of primary and post-traumatic knee osteoarthritis (OA) in the young, active population has renewed interest in joint-preserving procedures. High tibial osteotomy (HTO) is the most common treatment for medial knee OA associated with varus tibial deformity, while tibial condylar valgus osteotomy (TCVO) is used for advanced medial knee OA with lateral joint subluxation. However, there are limited studies on the use of TCVO, with various indications and operative techniques. This paper summarizes and discusses the indications, surgical techniques, and outcomes of intra-articular osteotomies based on an extensive search of databases, while also reporting the preoperative planning and surgical procedure performed at our institution. Intra-articular osteotomies can effectively correct intra-articular defects in the lower limbs and provide benefits such as restoring joint congruence, improving mechanical axis, and load distribution.
Article
Critical Care Medicine
Yukai Wang, Congfeng Luo, Yi Zhu, Qilin Zhai, Yu Zhan, Weijian Qiu, Yafeng Xu
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2016)
Article
Orthopedics
Y. Zhan, C. F. Luo, Y. J. Chen
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2018)
Article
Orthopedics
Qi-fang He, Hui Sun, Lin-yuan Shu, Yu Zhan, Chun-yan He, Yi Zhu, Bin-bin Zhang, Cong-feng Luo
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2018)
Article
Orthopedics
Qi-fang He, Han-xu Wang, Hui Sun, Yu Zhan, Xue-tao Xie, Cong-feng Luo
ORTHOPAEDIC SURGERY
(2019)
Article
Critical Care Medicine
Zhu Yi, Sun Hui, Zhang Binbin, Tang Jianfei, Shi Huipeng, Mei Jiong, Luo Congfeng
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2020)
Article
Critical Care Medicine
Bin-bin Zhang, Hai Hu, Shi Zhan, Jiong Mei, Yi Zhu, Cong-feng Luo
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2020)
Article
Orthopedics
Qi-fang He, Guo-biao Pan, Ze-feng Yu, Wang-xiang Yao, Liu-long Zhu, Cong-feng Luo, Xiao-shan Guo
Summary: This study introduced a novel fixation technique for the treatment of inferior pole fracture of the patella, which achieved satisfactory outcomes through the use of a rim plating technique.
ORTHOPAEDIC SURGERY
(2021)
Article
Medicine, Research & Experimental
Ruiyang Li, Pingping Sun, Yu Zhan, Xuetao Xie, Weibing Yan, Congfeng Luo
Summary: This study aims to determine an effective physiotherapy for knee osteoarthritis by comparing two different home-based exercise programs among 114 patients. The research will provide more evidence on the effects of traditional Chinese exercise on improving physical function and relieving joint pain in knee OA patients.
Review
Orthopedics
Yunfei Liu, Ruiyang Li, Yu Zhan, Xuetao Xie, Congfeng Luo
Summary: Combined proximal tibial osteotomy (CPTO) is a novel surgical technique that is suitable for KBD patients with severe knee varus deformity and intra-articular instability. This procedure can improve knee function, pain, and joint stability in patients.
ORTHOPAEDIC SURGERY
(2022)
Article
Orthopedics
Xuetao Xie, Yu Zhan, Minjie Dong, Qifang He, Justin F. Lucas, Yingqi Zhang, Yukai Wang, Congfeng Luo
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2017)