Article
Nanoscience & Nanotechnology
Kerstin Schirrmann, Gabriel Caceres-Aravena, Anne Juel
Summary: Coated droplets self-assemble into regular clusters at the sudden expansion of a microfluidic channel. The assembly is achieved through droplet coalescence at the expansion point, forming clusters of finite size. Observations suggest that cluster size is limited by experimental fluctuations, and this self-assembly method offers a robust alternative for encapsulating multiple cores in a single coating film.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Engineering, Chemical
Yanyin Zhang, Jiamin Wang, Jiawei Wu, Huanming Xia
Summary: In this study, the control of droplet generation through pulsatile continuous-phase flow is numerically investigated. Different modes of droplet generation and their underlying mechanisms are identified. This method is significant for improving control and manipulation of droplet microfluidic systems.
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Rutvik Lathia, Krishnadas Narayanan Nampoothiri, Nitish Sagar, Shubhi Bansal, Chandantaru Dey Modak, Prosenjit Sen
Summary: Microscale droplet generation and manipulation are widely used in various fields, from biochemical assays to printing and additive manufacturing. Most techniques are limited in the range of droplet sizes they can handle, as well as the variety of fluid properties they can work with. Recent advancements have focused on overcoming these limitations and this feature article discusses the developments in this area that cover a wide range of droplet sizes from subpicoliter to microliter.
Article
Nanoscience & Nanotechnology
Kunkun Tu, Simon Buechele, Sharon Mitchell, Laura Stricker, Chun Liu, Christian Goldhahn, Julien Allaz, Yong Ding, Roman Guenther, Zhidong Zhang, Jianguo Sun, Sandro Stucki, Guido Panzarasa, Samuel C. Zeeman, Ingo Burgert, Javier Perez-Ramirez, Tobias Keplinger
Summary: The development of flow-through wood-based catalytic microreactors enables continuous and controllable hydrogen production. These structured catalysts exhibit highly adjustable hydrogen productivity and scalability, making them suitable for catalytic reactions and applications in the energy-water nexus.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Physics, Multidisciplinary
Farrokh Mobadersani, Araz Rezavand Hesari
Summary: Pulsating heat pipes are crucial for high-performance cooling systems, and this study focuses on numerical modeling of a single-turn PHP considering flow boiling and condensation under constant temperature boundary condition. The research shows improved accuracy in modeling and demonstrates the impact of pipe diameter on PHP performance. Additionally, entropy generation analysis reveals an increase in the share of heat transfer in entropy generation with larger pipe diameters.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
Article
Engineering, Chemical
Noureddine Lebaz, Fouad Azizi, Nida Sheibat-Othman
Summary: This work investigates droplet breakage during continuous emulsification in static mixers, introducing a full spectrum-based model within a population balance model to describe the time evolution of droplet size distribution. The model, tested against experimental data, shows predictive capabilities and improved computational efficiency compared to CFD simulations. The full spectrum-based model requires knowledge of mean turbulent kinetic energy and energy dissipation rate, which can be estimated through pressure drop measurements for rapid implementation.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Metallurgy & Metallurgical Engineering
Qingrui Lai, Zhiguo Luo, Yongjie Zhang, Yang You, Zongshu Zou
Summary: In this study, a new method is used to simulate the three-phase flow in a continuous casting mold, considering various interactions between bubbles and inclusions. The effects of simulation factors on the results are studied, and the importance of different factors is determined.
STEEL RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Applied
Kevin Simon, Desiree Znidar, Julien Boutet, Gerard Guillamot, Jean-Yves Lenoir, Doris Dallinger, C. Oliver Kappe
Summary: A proof-of-concept study for the synthesis of 1,2-difluorobenzene from 2-fluoroaniline via the Balz-Schiemann reaction using HF/pyridine as the fluorinating reagent is reported. The key to success was the photochemically induced fluorodediazoniation of the in situ-generated diazonium salt performed in a continuous flow mode. The use of a high-power 365 nm light-emitting diode improved the reaction performance and allowed the generation of 1,2-difluorobenzene within a 10 min residence time and a product selectivity of >= 95% at full conversion.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Automation & Control Systems
Ebtesam Sharghi, Ali Farzadi
Summary: This study investigated the temperature field and heat generation during dissimilar friction stir welding of Al-Mg2Si metal matrix composite and AA6061 aluminum alloy using 3D computational fluid dynamics model and FLUENT software. The experiments validated that about 70% of heat is generated at the shoulder and workpiece interface, with the peak temperature predicted on the advancing side. The asymmetrical temperature distribution across cross-sections is attributed to different material velocities on the advancing and retreating sides.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Alexey Polukeev, Reine Wallenberg, Jens Uhlig, Christian P. Hulteberg, Ola F. Wendt
Summary: Convenient methods for on-board hydrogen storage and release are necessary for the large-scale use of hydrogen fuel cells. This study demonstrates the use of a continuous flow reactor and a heterogenized iridium pincer complex to significantly increase the dehydrogenation rates of liquid organic hydrogen carriers (LOHCs). This advancement holds potential for applications in fuel-cell powered cars.
Article
Chemistry, Multidisciplinary
Hiroyuki Miyamura, Aya Suzuki, Zhiyuan Zhu, Shu Kobayashi
Summary: A highly active Pt/MPPSi-Al2O3 catalyst was developed for the dehydrogenation of organic hydrides, leading to complete conversion into aromatic compounds. The reaction reached maximum equilibrium conversion at specific temperature conditions.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Physical
Xingyu Ai, Xiaolei Cai, Jiaqing Chen, Guodong Ding, Shun Guan, Yipeng Ji
Summary: This study investigates the gas-liquid two-phase mixing process and microbubble formation in a jet flow field. A self-designed on-line measurement system is used to measure bubble generation characteristics and the Volume of Fluid (VOF) model in numerical simulation methods is used to analyze flow field distribution characteristics. The effect of turbulence intensity on microbubble size distribution is considered. The study analyzes the characteristics and duration of the three stages during the bubble breaking process. Results show that increasing turbulence intensity promotes the breaking probability of bubble but decreases significantly when the bubble breaks to a small size. The increase in turbulence intensity greatly promotes the bubble coalescence process, affecting the bubble size distribution.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Chemical
Mingyao Mou, Loren dela Rosa, Jethrine H. Mugumya, Mo Jiang
Summary: In this study, a slug flow generation device based on in-line imaging was used to study slug size uniformity. Modified gas flow control significantly improved slug uniformity. The type of gas used to generate slugs did not affect slug size uniformity. Narrow slug size distribution can improve product quality.
CHEMICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Engineering, Multidisciplinary
Michal Zelenak, Zdenek Riha, Andreas Fech, Kamil Soucek, Frank Pude, Petr Hlavacek, Fernando Kevin Miranda
Summary: This study investigated the functionality of a newly developed micro hydrodynamic nozzle and its ability to generate a modulated water jet used for the erosion of soft materials. The study included nozzle design, numerical flow modelling, quality testing, and evaluation of the nozzle's functionality. The test results showed that the nozzle with a 45-degree orientation relative to the traverse direction achieved the best erosion effect.
Article
Physics, Applied
D. N. Gabyshev, D. N. Medvedev, K. Misiiuk
Summary: The results of a ballistic experiment showing the levitation of microdroplets due to a convective steam-air flow over a heated region of water are presented. The resistance of the flow to the motion of the droplets is estimated, along with the maximum size of the levitated droplets. It is concluded that stationary levitation of droplets is not possible in a linearly nonuniform flow.
Article
Chemistry, Analytical
Yuchen Dai, Haotian Cha, Michael J. Simmonds, Hedieh Fallahi, Hongjie An, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang, Antony P. McNamee
Summary: This study investigates the effects of altering fluid viscoelasticity on blood plasma extraction. Poly (ethylene oxide) (PEO) was added to increase blood viscoelasticity, resulting in improved cell focusing performance. The optimal PEO concentration was found to be in the range of 100 to 200 ppm, and the optimal flow rate was determined to be between 1 and 15 mu L/min.
Review
Chemistry, Analytical
Malihe Farasat, Ehsan Aalaei, Saeed Kheirati Ronizi, Atin Bakhshi, Shaghayegh Mirhosseini, Jun Zhang, Nam-Trung Nguyen, Navid Kashaninejad
Summary: Separation and detection of cells and particles in a suspension are essential for various applications, including biomedical investigations and clinical diagnostics. Microfluidics has enabled the miniaturization of analytical devices by controlling the motion of fluid in micrometer-sized channels and chambers. Among different microfluidic methods, dielectrophoresis (DEP) offers advantages for manipulating neutral bioparticles using unique dielectric characteristics. This review focuses on signal-based DEP methods that utilize signal parameters such as frequency, amplitude, phase, and shape for cell/particle separation and manipulation.
Article
Materials Science, Biomaterials
Fahima Akther, Jun Zhang, Huong D. N. Tran, Hedieh Fallahi, Hossein Adelnia, Hoang-Phuong Phan, Nam-Trung Nguyen, Hang Thu Ta
Summary: This study presents a unique microfluidic device that mimics and studies atherothrombosis, a condition caused by atherosclerotic plaque disruption and thrombosis. The device successfully explains the correlation between vessel geometry and thrombus formation and demonstrates sensitivity to aspirin and targeted drug carriers.
Article
Chemistry, Analytical
Yuchen Dai, Haotian Cha, Nhat-Khuong Nguyen, Lingxi Ouyang, Fariba Galogahi, Ajeet Singh Yadav, Hongjie An, Jun Zhang, Chin Hong Ooi, Nam-Trung Nguyen
Summary: This study investigated the formation process of double emulsion under a dripping regime in a capillary device through experimental, analytical, and numerical methods. The results showed that mismatches between core and shell droplets can be captured experimentally and numerically. A semi-analytical model was proposed to describe the match ratio and the mismatch issue can be avoided if the ratio is lower than unity. The model with the wall effect predicted the size of the matched double emulsion and showed good agreement with experimental data under certain flow conditions.
Article
Engineering, Chemical
Meng Wang, Huanming Xia, Li Zhu, Yanyin Zhang
Summary: This work demonstrates an active approach using pulsatile perturbations to control gas-liquid slug flow. By applying a rotating valve to produce high-frequency pulsating air flow, either Taylor bubbles or liquid-in-gas droplets can be generated in a hydrophilic or hydrophobic channel, respectively. The gas and liquid slug lengths can be independently tuned via the air inlet pressure and the liquid flow rate, providing an efficient method to regulate gas-liquid slug flow in multiphase microreactors or microfluidic analytical systems.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Review
Biochemical Research Methods
Samith Hettiarachchi, Haotian Cha, Lingxi Ouyang, Amith Mudugamuwa, Hongjie An, Gregor Kijanka, Navid Kashaninejad, Nam-Trung Nguyen, Jun Zhang
Summary: This paper comprehensively studies the latest progress in microfluidic technology for submicron and nanoparticle manipulation and separation. It summarizes the principles of traditional techniques and explores the physics, device design, working mechanism, and applications of different microfluidic approaches. The merits and demerits of microfluidic techniques are compared to conventional technologies. Seven standard post-separation detection techniques for nanoparticles are summarized, and current challenges and future perspectives on microfluidic technology for nanoparticle manipulation are discussed.
Review
Chemistry, Analytical
Dimple Palanilkunnathil Thomas, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
Summary: This review covers the physiology of the human gut and the engineering approaches of gut-on-a-chip (GOC) models, including materials and fabrication, cell types, stimuli, and gut microbiota. The applications, challenges, possible solutions, and prospects for GOC models and technology are thoroughly discussed.
Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
Review
Biotechnology & Applied Microbiology
Jialin Wu, Hui Fang, Jun Zhang, Sheng Yan
Summary: The advancement of microfluidics has led to significant discoveries and technologies in life sciences. However, the lack of industry standards and configurability has made the design and fabrication of microfluidic devices challenging. Modular microfluidics, which integrates standardized microfluidic modules into a complex platform, offers portability, on-site deployability, and high customization. In this review, we discuss the working mechanisms of basic microfluidic modules, their feasibility as modular components, connection approaches, advantages over integrated microfluidics, and future perspectives.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Zixuan Jia, Jialin Wu, Xiuru Wu, Qingwei Yuan, Yue Chan, Bin Liu, Jun Zhang, Sheng Yan
Summary: Haematococcus pluvialis is a valuable source of astaxanthin, which has antioxidant, anti-inflammatory, and anticancer properties. Size-based microalgal separation plays an important role in the extraction of high-value algae and directed evolution. In this study, a size-tunable elasto-inertial sorting method for H. pluvialis was developed using Ecoflex ultrastretchable microfluidic devices. The effects of velocity, channel elongation, and particle size on particle migration were systematically investigated. The results demonstrated that channel elongation significantly influenced particle focusing, and the continuous regulation of sorting threshold by stretching the channel provided technical support for the extraction and directed evolution of high-yield microalgae.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Chemical
Yanyin Zhang, Jiamin Wang, Jiawei Wu, Huanming Xia
Summary: In this study, the control of droplet generation through pulsatile continuous-phase flow is numerically investigated. Different modes of droplet generation and their underlying mechanisms are identified. This method is significant for improving control and manipulation of droplet microfluidic systems.
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Engineering, Chemical
Haotian Cha, Hoseyn A. Amiri, Sima Moshafi, Ali Karimi, Ali Nikkhah, Xiangxun Chen, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics is a technique that uses the finite inertia of fluid at high flow speed to manipulate and separate microparticles. Embedding periodic micro-obstacles into curvilinear channels has been found to be an effective strategy to improve inertial focusing and separation. This study systematically investigated the influence of micro-obstacles on inertial focusing and developed a high-resolution microfluidic device for particle and cell separation. The results showed that concave obstacles were more effective in tuning particle inertial focusing and separation compared to convex obstacles, and the square concave obstacle channel offered the highest separation resolution. The developed microfluidic device showed high-efficiency separation of polystyrene beads and U87MG cancer cells from blood.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Chaochao Yuan, Qinqin Gu, Hongchun Fang, Huanming Xia
Summary: The preparation of aluminum phosphate (AP) adjuvant through a microfluidic approach is investigated, using a chaotic micromixer to enhance the mixing between the reactants. The effects of magnetic stirring and continuous-flow shearing during the settling of the AP precipitate are compared. The method provides better control over the particle size distribution, with tunable median particle size and uniformity index.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Engineering, Biomedical
Haotian Cha, Yuchen Dai, Helena H. W. B. Hansen, Lingxi Ouyang, Xiangxun Chen, Xiaoyue Kang, Hongjie An, Hang Thu Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics utilizes fluid inertia to manipulate particles and cells in a simple and precise manner. This study introduces an innovative way to adjust inertial focusing by embedding asymmetrical obstacle microstructures, resulting in unilateral focusing. The influence of obstacle size and asymmetrical patterns on unilateral inertial focusing is characterized, and this approach is successfully applied for the separation of particles and cancer cells from white blood cells.
CYBORG AND BIONIC SYSTEMS
(2023)
Article
Engineering, Biomedical
Qianbin Zhao, Sheng Yan, Boran Zhang, Kai Fan, Jun Zhang, Weihua Li
Summary: There are many non-Newtonian fluids in our daily life, which are viscoelastic and heterogeneous liquids containing cells, ions, metabolites, and hormones. The viscoelasticity of biological fluids is often ignored, but it actually affects the behavior of microparticles. A reliable and easy-to-use on-chip viscoelasticity sensor is therefore highly desired for various applications. In this study, stable non-Newtonian fluid-polyethylene oxide (PEO) solutions were used to investigate the effects of weak fluidic viscoelasticity on microparticle behavior. A database of fluidic patterns for viscoelasticity sensing and relaxation time measurement was established. The sensor was tested with different biological fluids and showed promising results.
CYBORG AND BIONIC SYSTEMS
(2023)