Article
Multidisciplinary Sciences
Florian Schmitz, Jessica Glas, Richard Neutze, Kristina Hedfalk
Summary: This study introduces a screening approach that utilizes BiFC and flow cytometry to characterize membrane protein interaction partners, allowing for distinguishable constructive complexes from random interactions with statistical confidence. This method potentially enables an efficient high-throughput screen for protein:protein interactions in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Marine & Freshwater Biology
A. L. Drozdov, A. Yu Zhuravlev, A. A. Karpenko, K. A. Kolesnikov, A. Yu Ivantsov
Summary: Based on the study of the debatable fossil Lenica unica Gorjansky, 1977 from the Siberian Platform, the chemical composition of sponge spicules was analyzed. The findings reveal that the skeleton of this giant sponge is composed of a complex carbonate-silica-organic compound. The data obtained support the idea that early Cambrian sponges formed skeletal elements with a mixed carbonate-biosilica composition, suggesting it as the initial skeleton composition for all spiculate sponges.
RUSSIAN JOURNAL OF MARINE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christopher P. Cutler, Sasha Mainer, Tolulope Ojo
Summary: This study identified the cDNA sequence of aquaporin 8 (AQP8) in dogfish and found that it is only expressed in the brain. This suggests that AQP8 does not play a role in the transport of water, ammonia and urea in the gill, kidney or gastrointestinal tract.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alaa Alghanimy, Conor Martin, Lindsay Gallagher, William M. M. Holmes
Summary: The compound TGN-073 can enhance glymphatic function in the brain by improving the function of AQP4 channels, which may protect against neurodegenerative diseases such as Alzheimer's disease.
Article
Multidisciplinary Sciences
Ralph Rose, Bjorn Kemper, Albrecht Schwab, Eberhard Schlatter, Bayram Edemir
Summary: Research has shown that primary cultured renal inner medullary collecting duct (IMCD) cells exhibit collective migration behavior, with no differences in migration speed between cells cultivated at either 300 or 600 mosmol/kg. Acute changes in osmolality from 300 to 600 mosmol/kg led to a significant reduction in migration speed, while the reverse led to an increase. Interestingly, AQPs were not localized at the leading edge, with AQP3 disappearing within the first 2-3 rows of cells and AQP4 being enriched at the rear end.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Simone Mader, Lior Brimberg, An Vo, Joshua J. Strohl, James M. Crawford, Alexandre Bonnin, Joseph Carrion, Delcora Campbell, Tomas S. Huerta, Andrea La Bella, Roseann Berlin, Stephen L. Dewey, Matthew Hellman, David Eidelberg, Irena Dujmovic, Jelena Drulovic, Jeffrey L. Bennett, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond
Summary: The exposure of the fetal brain to maternal IgG before the formation of an effective blood-brain barrier can have consequences on brain development. In this study, the researchers found that exposure to an antibody against AQP4 protein in the fetal brain led to abnormal cortical vasculature, impaired WNT signaling, increased blood flow, and leakiness of the blood-brain barrier in adult mice. These mice also exhibited behavioral impairments and disturbances in the grid cell system within the entorhinal cortex.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Norman B. Javitt
Summary: This article discusses the hypothesis proposed in 1959 regarding bile formation, highlighting the current research that supports the initial proposal of water flow in response to an osmotic gradient. The article also emphasizes the need to modify the initial proposal based on the discovery of water-containing vesicles unrelated to osmotic gradient. The introduction of the fluorescent localization after photobleaching technique is also mentioned as a recent development to study hepatic duct flow and biomarkers for quantifying water flow.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Minqi Xiang, Xu Qian, Luyu Han, Hui Wang, Jiqiu Wang, Weiren Liu, Yanyun Gu, Shuangshuang Yao, Jian Yang, Yifei Zhang, Ying Peng, Zhiguo Zhang
Summary: Aquaporin-8(AQP8), a transmembrane channel protein, plays a role in water transport and bile acid formation in the liver. The expression of AQP8 was found to be reduced in liver specimens of patients with NAFLD, high-fat diet-induced mice, and genetically obese db/db mice. Knockdown of AQP8 in hepatocytes exacerbated intracellular lipid accumulation, while AQP8 overexpression activated the FXR pathway, reducing intrahepatic triglyceride overload in obese mice. The ameliorating effect of AQP8 overexpression on NAFLD was abolished in FXR knockout mice.
Article
Biochemistry & Molecular Biology
Christopher P. Cutler, Keith Kurt, Karen E. Campbell, Tolulope Ojo
Summary: Immunohistochemical localization of three aquaporin water channel proteins (AQP3, AQP4, and AQP15) in the kidney of the spiny dogfish revealed that AQP4/2 and AQP15 are primarily located in the late distal tubule loop, while AQP3 is mainly located at the end of the late distal tubule loop. The strong staining of AQP4/2, AQP15, and Na+,K+-ATPase antibodies was found at the beginning of the late distal tubule loop.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christopher P. Cutler, Debra Murray, Tolulope Ojo, Sheena Harmon, Bryce MacIver, Gordon Cramb, Mark L. Zeidel
Summary: cDNAs for aquaporin genes AQP3 and AQP15 were cloned and sequenced to initiate the study. Northern blot analysis confirmed mRNA sizes, showing significant decrease in AQP15 expression with higher salinity. Microinjection of full length cDNAs into Xenopus oocytes increased water permeability, particularly in the presence of mercury and at neutral pH. Antibody staining and localization studies in fish tissues revealed specific membrane distributions of AQP3 and AQP15, suggesting a potential water absorption pathway in the intestine.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Review
Immunology
Nazila V. Jafari, Jennifer L. Rohn
Summary: The urothelium, a highly specialized layer of cells lining the inner surface of the bladder, plays a crucial barrier role in preventing the diffusion of urine components. This article summarizes recent research on the structure, function, development, and regeneration of the urothelium, with a focus on the role of umbrella cells in barrier formation and maintenance. It also discusses the use of human urothelial in vitro models in complementing traditional animal studies.
MUCOSAL IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Siyang He, Zheng Wang, Xiaosong Zhang, Zitang Yuan, Yushan Sun, Tinghai Cheng, Zhong Lin Wang
Summary: In this study, a monitoring method based on triboelectric nanogenerators for non-full pipe fluidic flow of large pipelines is proposed. By fabricating a special sensor, flow velocity and liquid level can be simultaneously monitored, enabling accurate flow measurement. The experimental results demonstrate that this method has high accuracy and good responsiveness in real-time flow monitoring.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Baofeng Zhang, Chuguo Zhang, Wei Yuan, Ou Yang, Yuebo Liu, Lixia He, Yuexiao Hu, Linglin Zhou, Jie Wang, Zhong Lin Wang
Summary: This study proposes a self-charging marine power system that utilizes a conductive polymer with hollow morphology and seawater to achieve stable high power density and energy density, overcoming the challenges of corrosion and environmental friendliness.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jens Gravesen, Morten Willatzen, Jiajia Shao, Zhong Lin Wang
Summary: A general theoretical analysis of a 3D generic TENG structure is presented in this paper. It is found that the optimal TENG geometry is independent of the frequency of the moving dielectric, but the external ohmic impedance for maximum power output is inversely proportional to the frequency. The energy of the TENG is proportional to the cube of its size, the square of the triboelectric charge density, and the angular frequency of the moving dielectric.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Ziming Wang, Andy Berbille, Yawei Feng, Site Li, Laipan Zhu, Wei Tang, Zhong Lin Wang
Summary: Research has shown that electrons transferred through contact-electrification can be used for catalyzing reactions without conventional catalysts. This new catalytic principle, termed contact-electro-catalysis, has been proven effective for various dielectric materials, such as Teflon, Nylon-6,6, and rubber. This expands the range of catalytic materials and offers a new approach for catalytic processes through mechano-induced contact-electrification.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Mingli Zheng, Shiquan Lin, Laipan Zhu, Zhen Tang, Zhong Lin Wang
Summary: Energy harvesters based on the tribovoltaic effect show increased tribo-voltage and tribo-current at liquid-solid interfaces with higher temperatures. The coupling effect of liquid pH value and temperature on the tribovoltaic effect is also demonstrated. A proposed energy band model suggests that the generation of tribovoltaic effect is attributed to the energy released by the formation of chemical bonds between the liquid and solid surfaces.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Hao Luo, Hanqing Wang, Lijun Yang, Han Wu, Shenglin Kang, Shun Yong, Ruijin Liao, Jiyu Wang, Zhong Lin Wang
Summary: An in situ measurement system based on a variable frequency liquid-solid triboelectric nanogenerator (VFLS-TENG) is developed to quantify and measure nanofluid dispersion (NFD). The system utilizes VFLS-TENG as a passive probe and proposes an equivalent capacitance circuit model based on the electric double layer model. Through parameter identification and separation algorithms, the system can accurately calculate the particle size and spacing of nanoparticles. The experimental results show that this method provides a more accurate and sensitive measurement of nanoparticle size compared to traditional methods.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Zhaoxu Jing, Jiacheng Zhang, Jianlong Wang, Mingkang Zhu, Xinxian Wang, Tinghai Cheng, Jianyang Zhu, Zhong Lin Wang
Summary: This study reports a three-dimensional fully-enclosed triboelectric nanogenerator with bionic fish-like structure for harvesting hydrokinetic energy in low flow velocity and shallow water areas. The bionic structure enables zero head power generation, and the effects of external excitations and bionic structures on the electrical performance are studied. Experimental results demonstrate high peak power density and excellent water durability for long-term service in river currents.
Article
Chemistry, Physical
Yaokun Pang, Xianchen Xu, Shoue Chen, Yuhui Fang, Xiaodong Shi, Yiming Deng, Zhong-Lin Wang, Changyong Cao
Summary: Inspired by human skin, a textile-based tactile sensor capable of multifunctional sensing for personalized healthcare monitoring and soft robotic control is reported. The sensor can mimic the function of fast adapting mechanoreceptors and slow adapting mechanoreceptors, enabling real-time recognition of voice, monitoring physiological signals and human motions, as well as accurate perception of surface textures and material types. The sensor has potential applications in various fields.
Article
Thermodynamics
Xin Yu, Jianwei Ge, Zhenjie Wang, Jianlong Wang, Da Zhao, Zhong Lin Wang, Tinghai Cheng
Summary: This paper proposes a charge handling triboelectric nanogenerator (CH-TENG) with synchronous mechanism to effectively improve output performance. The cooperation of the pump-TENG and charge handling module allows for rapid charge accumulation, resulting in significant improvements in performance.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Dongjie Jiang, Minxing Du, Xuecheng Qu, Yansong Gai, Wei Sun, Jiangtao Xue, Yusheng Li, Zhou Li, Zhong Lin Wang
Summary: Improving the safety and usability of blind movement is crucial. This study introduces a distributed self-powered intelligent voice navigation tactile pavement (SVP) that utilizes a hybrid nanogenerator to achieve unconscious interaction and high navigation accuracy. The SVP addresses the challenges of GPS navigation delay and lack of map information, while also providing energy supply for future IoT and smart city construction.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Mousa AlTarabeen, Qosay Al-Balas, Amgad Albohy, Werner Ernst Georg Mueller, Peter Proksch
Summary: Manzamines are a group of compounds extracted from Acanthostrongylophora ingens species. We have identified and characterized seven compounds. Based on previous screening work by Mayer et al., who suggested that manzamine A could be an inhibitor of RSK1 kinase, our work focused on targeting the RSK1 N-terminal kinase domain. Docking using Autodock Vina software showed that Manzamine A N-oxide (5) exhibited the highest activity with an IC50 value of 3.1 μM.
Article
Pharmacology & Pharmacy
Shunfeng Wang, Meik Neufurth, Hadrian Schepler, Rongwei Tan, Zhending She, Bilal Al-Nawas, Xiaohong Wang, Heinz C. Schroeder, Werner E. G. Mueller
Summary: Amorphous calcium carbonate (ACC) precipitated in the presence of inorganic polyphosphate (polyP) has shown potential as a material for bone regeneration. ACC center dot PP particles, stabilized by polyP, have enzymatic activity that promotes the transformation of ACC into crystalline polymorphs. In experiments conducted in vitro and in vivo, ACC center dot PP was found to stimulate cell migration and accelerate wound healing, particularly in chronic wounds.
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.
