Article
Pharmacology & Pharmacy
Qiwen Shi, Mengxia Lin, Xiang Cheng, Ziyuan Zhang, Shufen Deng, Ke Lang, Zhikun Yang, Xuanrong Sun
Summary: Dysregulation of nucleocytoplasmic shuttling impairs cellular homeostasis and promotes cancer development. KPNB1 is a member of the karyopherin β family, mediating the transportation of proteins from the cytoplasm to the nucleus. Upregulation of KPNB1 expression in various cancers facilitates tumor growth and progression. Inhibiting KPNB1 activity prevents cancer-related transcription factors from entering the nucleus, thereby suppressing cancer cell proliferation and metastasis. This paper provides an overview of KPNB1's role and mechanism in different cancers, as well as promising KPNB1-targeted anticancer compounds.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
AnnaMaria Maraschi, Valentina Gumina, Jessica Dragotto, Claudia Colombrita, Miguel Mompean, Emanuele Buratti, Vincenzo Silani, Marco Feligioni, Antonia Ratti
Summary: Research indicates that SUMOylation can regulate TDP-43 splicing activity and sub-cellular localization, promoting or inhibiting SUMOylation may influence the cytoplasmic localization and aggregation formation of TDP-43.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hsiang-Pu Feng, Yu -Chin Liu, Chih-Liang Wang, Wei -Chao Liao, Jau-Song Yu, Chia-Jung Yu
Summary: KPNA2 is a nucleoplasmic protein responsible for nuclear import. Aberrant nuclear accumulation of KPNA2 has been observed in cancer tissues. AMPK is involved in the phosphorylation and acetylation of KPNA2, but its impact on the nucleocytoplasmic distribution of KPNA2 and its oncogenic role is unclear.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yang Sun, Liqin Wang, Jiameng Niu, Ting Ma, Lili Xing, Aowei Song, Wenhua Wang, Yuan Shen, Jiangcun Yang
Summary: There are significant geographical differences in the distribution of ABO blood groups in China, with a lower frequency of the r [O] gene in the north and a lower frequency of the q [B] gene in the south.
Article
Medicine, General & Internal
Aurore Collet, Christophe Zawadzki, Emmanuelle Jeanpierre, Caroline Kitel, Sylvain Dubucquoi, Eric Hachulla, Sophie Susen, David Launay
Summary: Systemic sclerosis (SSc) is associated with endothelial activation and fibrosis. Non-O blood group is linked to higher risk of thrombosis, fibrosis and autoimmune diseases. The distribution of ABO groups in SSc patients is similar to the general population, but non-O groups are associated with inflammation and endothelial activation, and a slightly higher frequency of pulmonary and vascular complications in SSc.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Giovanna Azzarito, Michele Visentin, Brigitte Leeners, Raghvendra K. Dubey
Summary: Vascular and lymphatic vessels play a crucial role in breast cancer growth and metastasis. The study found that the secretome of estrogen receptor-positive breast cancer cells can stimulate vascular angiogenesis and inhibit lymphatic growth, which has significant pathological and physiological implications for breast cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yuan Gao, Yingfang Feng, Shaochuan Liu, Yan Zhang, Jing Wang, Tingting Qin, Peng Chen, Kai Li
Summary: Despite the benefits of cancer immunotherapies, many patients develop resistance and the underlying mechanism is still unknown. This study reveals the role of cell-intrinsic PD-L1 in immunotherapeutic resistance and provides insights into the immune-independent acquired resistance mechanism to PD-L1 antibodies.
Article
Anatomy & Morphology
Jie Pan, Xiaoping Cai, Xiao Zheng, Xiaoyu Zhu, Jihong Feng, Xiaoqiu Wang
Summary: Luteolin inhibits the migration and invasion of NSCLC-VECs through the miR-133a-3p/PURB-mediated MAPK and PI3K/Akt pathways.
Article
Biology
Jing Zhang, Ming-yan Yao, Guo-rui Zhang, Xian-ru Chen, Qi Liu, Yifang Guo, Xin-wei Jia
Summary: The study found that different enantiomers of amlodipine did not affect lipid profiles and eNOS levels in the rabbit atherosclerosis model, but were able to decrease ET-1 expression. Serum NO and iNOS levels were significantly reduced in the drug intervention groups.
OPEN LIFE SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Yuefei Liu, Lisa Haeussinger, Juergen M. Steinacker, Alexander Dinse-Lambracht
Summary: This study found a significant positive correlation between the growth factor of infection and death cases and the proportion of population with blood type A, and a negative correlation with the proportion of population with blood type B. Higher proportion of blood type A population showed more infection and death cases, higher growth factors, and shorter case doubling times, indicating higher epidemic dynamics.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Cell Biology
Clara Agudo-Rios, Amber Rogers, Isaiah King, Virali Bhagat, Le My Tu Nguyen, Carlos Cordova-Fletes, Diego Krapf, Jerome F. Strauss III, Lena Arevalo, Gina Esther Merges, Hubert Schorle, Eduardo R. S. Roldan, Maria Eugenia Teves
Summary: This study found that SPAG17 protein is involved in the transport of protamines during spermiogenesis. The research validated the interaction of SPAG17 and protamines and discovered abnormal protamination and transport defects in Spag17 knockout mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Yaw-Dong Lang, Yuh-Shan Jou
Summary: The dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers, leading to the development of novel anticancer therapeutic strategies. By targeting the aberrant contextual determinants of nucleocytoplasmic shuttling, innovative therapeutic biomarkers and agents can be developed to improve cancer therapy. This approach holds potential for enhancing tumor suppression and developing more effective treatments for cancer.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Plant Sciences
Yuanyuan Nie, Yang Li, Menghui Liu, Binran Ma, Xinying Sui, Jiacai Chen, Yanchong Yu, Chun-Hai Dong
Summary: This study reveals the involvement of Arabidopsis nucleoporins NUP160 and NUP96 in nucleocytoplasmic transport of mRNAs related to ethylene signaling pathway, advancing our understanding of the regulatory mechanisms of nucleoporin proteins in ethylene signaling and response.
PLANT CELL REPORTS
(2023)
Article
Plant Sciences
Jiacai Chen, Xinying Sui, Binran Ma, Yuetong Li, Na Li, Longfei Qiao, Yanchong Yu, Chun-Hai Dong
Summary: This study elucidates the regulatory mechanism of Arabidopsis CPR5 in ethylene signaling, including its interaction with the ETR1 receptor and its control over the nucleocytoplasmic transport of ethylene-related mRNAs. These findings have significant implications for our understanding of the role of CPR5 in ethylene signaling.
PLANT CELL REPORTS
(2022)
Article
Multidisciplinary Sciences
Ruiju Wang, Ruixuan Wang, Mengmeng Liu, Weiwei Yuan, Zhiying Zhao, Xiaoqian Liu, Yameng Peng, Xiaorui Yang, Yu Sun, Wenqiang Tang
Summary: BZR1, a key transcription factor in the brassinosteroid signaling pathway, is tightly regulated by phosphorylation and subcellular localization; it can be rapidly recruited from the cytoplasm to the nucleus by BR treatment, and its protein abundance is regulated by two distinct turnover mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)