Article
Multidisciplinary Sciences
Masayuki Watanabe, Tomohito Higashi, Kana Ozeki, Atsuko Y. Higashi, Kotaro Sugimoto, Hayato Mine, Hironori Takagi, Yuki Ozaki, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Yutaka Shio, Hiroyuki Suzuki, Hideki Chiba
Summary: This study identified claudin-15 as a potential positive marker for malignant pleural mesotheliomas, with high expression levels in 83% of MPM tissue samples. The specificity of CLDN15 was comparable to other markers in lung adenocarcinoma sections. CLDN15 showed low expression in non-mesothelial tumors, suggesting its potential clinical utility for MPM diagnosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Zhenying Guo, Li Shen, Ningning Li, Xiaoxiao Wu, Canming Wang, Zheng Gu, Zhongjian Chen, Junping Liu, Weimin Mao, Yuchen Han
Summary: This study used bioinformatics to identify key genes in malignant mesothelioma, finding that Aurora-A could be an optimal diagnostic biomarker and a potential prognostic marker. Additionally, seven genes were identified as potential prognostic markers for MM.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pinar cakilkaya, Rikke Raagaard Sorensen, Henrik Jessen Jurgensen, Oliver Krigslund, Henrik Gardsvoll, Christoffer F. Nielsen, Eric Santoni-Rugiu, Niels Behrendt, Lars H. Engelholm
Summary: The study found significant upregulation of uPARAP in malignant mesothelioma, independent of asbestos exposure and chemotherapy. Internalization of anti-uPARAP monoclonal antibody led to specific eradication of MM cells with antibody-drug conjugate at sub-nanomolar concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Ping Lin, Yuean Zhao, Xiaoqian Li, Zongan Liang
Summary: This study identified several hub genes relevant to Malignant Pleural Mesothelioma (MPM), including NUSAP1, PLOD2, and KIAA0101. Among these genes, KIAA0101 appears to be a useful diagnostic and prognostic biomarker for MPM, which may provide new clues for MPM diagnosis and therapy.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Review
Oncology
Alex Dipper, Nick Maskell, Anna Bibby
Summary: Malignant pleural mesothelioma (MPM) presents diagnostic challenges, with ancillary diagnostic tests such as immunocytochemical markers, molecular techniques, diagnostic biomarkers, and imaging discussed in cases where histological samples are unavailable or inconclusive. While no single adjunctive test has the sensitivity and specificity to diagnose MPM in isolation, correlation of pleural fluid cytology with radiology and biomarkers can help make an MDT-consensus diagnosis when invasive tests are not feasible.
Review
Medicine, General & Internal
Jacopo Moro, Simona Sobrero, Carlotta Francesca Cartia, Simona Ceraolo, Roberta Rapana, Federico Vaisitti, Stefano Ganio, Federica Mellone, Stefano Rudella, Federico Scopis, Danilo La Paglia, Carola Crystel Cacciatore, Enrico Ruffini, Francesco Leo
Summary: Malignant pleural mesothelioma is a rare cancer with a very poor prognosis, primarily caused by asbestos exposure. Current research focuses on identifying treatable phases of the disease, particularly preinvasive lesions and mesothelial hyperplasia. Recent studies discuss the role of BAP-1 and MTAP in diagnosing mesothelioma in situ and predicting prognosis. However, managing preinvasive lesions in mesothelioma remains unclear and controversial, including diagnosis, disease staging, and comprehensive patient assessment.
Review
Oncology
Shigeki Kusamura, Dario Baratti, Michele De Simone, Enrico Maria Pasqual, Luca Ansaloni, Daniele Marrelli, Manuela Robella, Fabio Accarpio, Mario Valle, Stefano Scaringi, Daniele Biacchi, Carmen Palopoli, Sergio Gazzanelli, Marcello Guaglio, Marcello Deraco
Summary: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare cancer that originates in the peritoneum and has a poor prognosis. Cytoreductive surgery and HIPEC are currently the standard treatments, but selecting suitable patients and managing the perioperative period is challenging.
Article
Immunology
Ismail Hendaoui, Ahlem Lahmar, Luca Campo, Sihem Mebarki, Sandrine Bichet, Daniel Hess, Martin Degen, Nidhameddine Kchir, Leila Charrada-Ben Farhat, Rania Hefaiedh, Christian Ruiz, Luigi M. Terracciano, Richard P. Tucker, Lotfi Hendaoui, Ruth Chiquet-Ehrismann
Summary: The study found that tenascin-C and tenascin-W were expressed in all biliary tract tumors, with tenascin-W not detected in normal hepatobiliary tissue. Additionally, the formation and organization of tenascin-W required co-culture of Huh-28 cells with bone marrow-derived stromal cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Koki Nakashima, Yasuhiro Sakai, Hitomi Hoshino, Yukihiro Umeda, Hiroto Kawashima, Yoshitaka Sekido, Tamotsu Ishizuka, Motohiro Kobayashi
Summary: In this study, a monoclonal antibody named S1 was found to have a high positivity rate in immunostaining of malignant pleural mesothelioma (MPM). Additionally, a unique glycan structure was identified in MPM cells. Therefore, the S1 glycoepitope could potentially serve as a new diagnostic marker for MPM.
Article
Health Care Sciences & Services
Veronica Filetti, Carla Loreto, Luca Falzone, Claudia Lombardo, Emanuele Cannizzaro, Sergio Castorina, Caterina Ledda, Venerando Rapisarda
Summary: This study aimed to validate the diagnostic significance of hsa-miR-323a-3p, hsa-miR-101-3p, and hsa-miR-20b-5p in MM patients exposed to FE. Results showed the down-regulation of these miRNAs in MM cases, with hsa-miR-323a-3p and hsa-miR-20b-5p having diagnostic value for MM. Computational analysis suggested a potential prognostic role of hsa-miR-101-3p in MM patients, correlating higher expression with increased overall survival.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Toxicology
Zubeyde Tanriverdi, Fatih Meteroglu, Hande Yuce, Abdurrahman Senyigit, Mumtaz Iscan, Songul Unuvar
Summary: The study showed that neopterin, periostin, YKL-40, TNC, and IDO were significantly elevated in patients with malignant pleural mesothelioma (MPM) and were positively correlated with each other. These non-invasive biomarkers can contribute to the early diagnosis of MPM.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Rudy Foddis, Maria Franzini, Alessandra Bonotti, Riccardo Marino, Roberto Silvestri, Poupak Fallahi, Dante Chiappino, Michele Emdin, Aldo Paolicchi, Alfonso Cristaudo
Summary: This study evaluated the role of specific GGT fractional enzymatic activity patterns in the diagnosis of MPM and found a specific profile of GGT fractions activity significantly associated with MPM. Combining GGT activity with serum SMRP levels improved the diagnostic accuracy.
Article
Biotechnology & Applied Microbiology
Valeria Panzetta, Ida Musella, Sabato Fusco, Paolo A. Netti
Summary: Malignant pleural mesothelioma is a rare but devastating tumor that is difficult to diagnose and treat effectively. Effusion cytology, although used for diagnosis, is time-consuming and has limited sensitivity. Therefore, alternative research methods are needed to support early diagnosis. Mechanobiology offers new perspectives and diagnostic tools for the mechanical and biophysical characterization of malignant pleural mesothelioma cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
R. Taylor Ripley, Nihanth Palivela, Shawn S. Groth, Eugene A. Choi, Lorraine D. Cornwell, Philip W. Carrott, George Van Buren, Taylor G. Splawn, David J. Sugarbaker, Bryan M. Burt
Summary: This study investigated whether DL improves staging for patients with malignant pleural mesothelioma and found that DL can provide more accurate prediction for patient selection and preoperative assessment. According to the results, the majority of patients were able to undergo successful surgical resection after DL.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Cai-Pu Chun, Lin-Xie Song, Hong-Pan Zhang, Dan -Dan Guo, Gui-Xuan Xu, Ya Li, Xin Xin, Jiachen Cao, Feng Li
Summary: This article presents a rare case of malignant peritoneal mesothelioma (MPM) in a 67-year-old male patient, with severe abdominal pain, bloating, and bloody ascites. The diagnosis was confirmed through cytology and laparoscopic exploratory biopsy. The characteristics of signs and clinical manifestations in this case are less common.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Oncology
Masaru Matsumoto, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Susumu Takeuchi, Akihiko Miyanaga, Kazuhiro Kitamura, Kaoru Kubota, Akihiko Gemma
Article
Oncology
Susumu Takeuchi, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Fenfei Zou, Haruka Uesaka, Nobuhiko Nishijima, Masaru Matsumoto, Yuji Minegishi, Kaoru Kubota, Akihiko Gemma
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Multidisciplinary Sciences
Akiko Takahashi, Masahiro Seike, Mika Chiba, Satoshi Takahashi, Shinji Nakamichi, Masaru Matsumoto, Susumu Takeuchi, Yuji Minegishi, Rintaro Noro, Shinobu Kunugi, Kaoru Kubota, Akihiko Gemma
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Aya Fukuizumi, Yuji Minegishi, Miwako Omori, Kenichiro Atsumi, Natsuki Takano, Kakeru Hisakane, Satoshi Takahashi, Kenichi Kobayashi, Teppei Sugano, Susumu Takeuchi, Rintaro Noro, Masahiro Seike, Kaoru Kubota, Arata Azuma, Akihiko Gemma
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Teppei Sugano, Masahiro Seike, Yoshinobu Saito, Takeru Kashiwada, Yasuhiro Terasaki, Natsuki Takano, Kakeru Hisakane, Satoshi Takahashi, Toru Tanaka, Susumu Takeuchi, Akihiko Miyanaga, Yuji Minegishi, Rintaro Noro, Kaoru Kubota, Akihiko Gemma
Editorial Material
Respiratory System
Remi Yoneyama, Hisashi Saji, Susumu Takeuchi, Norihiko Ikeda
JOURNAL OF THORACIC DISEASE
(2020)
Article
Multidisciplinary Sciences
Yoshihisa Shimada, Jun Matsubayashi, Yujin Kudo, Sachio Maehara, Susumu Takeuchi, Masaru Hagiwara, Masatoshi Kakihana, Tatsuo Ohira, Toshitaka Nagao, Norihiko Ikeda
Summary: This study found a significant correlation between serum exosomal PD-L1 levels and tumor PD-L1 levels as well as the number of CD8+TILs in non-small cell lung cancer patients. This suggests that measuring serum exosomal PD-L1 could be a valuable factor in predicting the response to anti-PD-1 therapy and clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kumi Chubachi, Junko Umihara, Akiko Yoshikawa, Shinji Nakamichi, Susumu Takeuchi, Masaru Matsumoto, Akihiko Miyanaga, Yuji Minegishi, Kazuo Yamamoto, Masahiro Seike, Akihiko Gemma, Kaoru Kubota
Summary: The study shows that using a treatment selection check sheet as a decision support tool positively influenced communication between patients and physicians. Patients generally found the check sheets helpful for decision-making, while some physicians felt it may increase their administrative burden.
JOURNAL OF NIPPON MEDICAL SCHOOL
(2021)
Article
Oncology
Rintaro Noro, Kazufumi Honda, Kengo Nagashima, Noriko Motoi, Shinobu Kunugi, Jun Matsubayashi, Susumu Takeuchi, Hideaki Shiraishi, Tetsuya Okano, Ayumi Kashiro, Xue Meng, Yukihiro Yoshida, Shunichi Watanabe, Jitsuo Usuda, Tatsuya Inoue, Huang Wilber, Norihiko Ikeda, Masahiro Seike, Akihiko Gemma, Kaoru Kubota
Summary: This study aimed to provide predictive biomarkers for selecting postoperative adjuvant chemotherapy. The results showed that ACTN4 gene amplification was associated with better recurrence-free survival in the adjuvant chemotherapy group in patients aged 65 or older.
Article
Cardiac & Cardiovascular Systems
Yujin Kudo, Yoshihisa Shimada, Jun Matsubayashi, Yoshiro Kitamura, Yojiro Makino, Sachio Maehara, Masaru Hagiwara, Jinho Park, Takafumi Yamada, Susumu Takeuchi, Masatoshi Kakihana, Toshitaka Nagao, Tatsuo Ohira, Jun Masumoto, Norihiko Ikeda
Summary: This study used three-dimensional imaging analysis with artificial intelligence (AI) technology to identify unfavourable prognostic factors for patients with solid-predominant lung adenocarcinoma with a radiological size <= 2 cm. The study found that high AI-SV, high SUVmax, and abnormal carcinoembryonic antigen level were associated with worse recurrence-free survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Yukari Tsubata, Kana Watanabe, Ryota Saito, Atsushi Nakamura, Hiroshige Yoshioka, Mami Morita, Ryoichi Honda, Nobuhiro Kanaji, Satoshi Ohizumi, Daisuke Jingu, Taku Nakagawa, Kensuke Nakazawa, Atsuto Mouri, Susumu Takeuchi, Naoki Furuya, Yuki Akazawa, Kiyotaka Miura, Eiki Ichihara, Makoto Maemondo, Satoshi Morita, Kunihiko Kobayashi, Takeshi Isobe
Summary: Osimertinib demonstrated effectiveness in EGFR-TKI-resistant, poor performance status patients with T790M mutation-positive advanced NSCLC. The response rate was 53.1%, with a median progression-free survival of 5.1 months and median overall survival of 10.0 months. The most common adverse event was lymphopenia, with interstitial lung disease observed in a subset of patients.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Kuno Suzuki, Hideyoshi Igata, Motoki Abe, Yusuke Yamamoto
Summary: Liquid biopsy is a promising cancer screening method due to its low invasiveness and ability to detect multiple types of cancer. Small RNAs can be used for cancer type classification in samples from a single facility, but interfacility biases can affect the classification of samples from multiple facilities.
Article
Oncology
Susumu Takeuchi, Kaoru Kubota, Shunichi Sugawara, Satoshi Teramukai, Rintaro Noro, Kei Fujikawa, Takashi Hirose, Shinji Atagi, Seigo Minami, Shinichiro Iida, Hiroshi Kuraishi, Tomoiki Aiba, Yuji Minegishi, Masaru Matsumoto, Masahiro Seike, Akihiko Gemma, Masaaki Kawahara
Summary: A randomized phase II trial showed that both standard dose and low dose of nab-paclitaxel monotherapy had similar efficacy in previously treated advanced non-small cell lung cancer patients, with better safety profile in the low dose group.
Article
Oncology
Takeru Kashiwada, Yoshinobu Saito, Yasuhiro Terasaki, Kakeru Hisakane, Susumu Takeuchi, Teppei Sugano, Akihiko Miyanaga, Rintaro Noro, Yuji Minegishi, Masahiro Seike, Kaoru Kubota, Akihiko Gemma
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2019)
