Article
Surgery
Nicolo Pecorelli, Giovanni Guarneri, Marco Palucci, Lorenzo Gozzini, Alessia Vallorani, Stefano Crippa, Stefano Partelli, Massimo Falconi
Summary: This study evaluated the impact of early biochemical markers on the occurrence of clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy. The findings suggest that postoperative serum amylase and C-reactive protein trajectory can serve as useful early predictors for CR-POPF, in addition to drain fluid amylase. Incorporating these laboratory tests into clinical practice can aid in the management of postoperative patients and drainage.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Ziyun Shen, Haoda Chen, Weishen Wang, Wei Xu, Yiran Zhou, Yuanchi Weng, Zhiwei Xu, Xiaxing Deng, Chenghong Peng, Xiongxiong Lu, Baiyong Shen
Summary: In this study, machine learning algorithms were used to predict clinically relevant postoperative pancreatic fistula (CR-POPF) and guide drain removal after pancreaticoduodenectomy (PD). The best-performing algorithm was CatBoost, which achieved a mean area under the receiver operating characteristic curve (AUC) of 0.81 in cross-validation and a mean AUC of 0.83 in the test dataset. The most important parameter was the mean drain fluid amylase (DFA) in the first seven postoperative days.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Surgery
Masahiro Fukada, Katsutoshi Murase, Toshiya Higashi, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Shigeru Kiyama, Yoshihiro Tanaka, Naoki Okumura, Takao Takahashi, Nobuhisa Matsuhashi
Summary: This study aimed to identify the most reliable indicator related to postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). The study found that the drain and serum amylase concentration ratio (DSACR) on postoperative day 3 (POD3) is the most accurate indicator for predicting POPF.
Article
Gastroenterology & Hepatology
Katsunori Sakamoto, Kohei Ogawa, Kei Tamura, Miku Iwata, Takashi Matsui, Yusuke Nishi, Tomoyuki Nagaoka, Naotake Funamizu, Akihiro Takai, Yasutsugu Takada
Summary: This study identified high CRP levels and high DFA output on postoperative day 3 as independent predictors of clinically relevant POPF after distal pancreatectomy. Postoperative CRP values and DFA output may help guide postoperative management for patients undergoing this procedure.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yosuke Mukai, Kei Asukai, Hirofumi Akita, Masahiko Kubo, Shinichiro Hasegawa, Hiroshi Wada, Hiroshi Miyata, Masayuki Ohue, Masato Sakon, Hidenori Takahashi
Summary: Combining postoperative fluid collection and drain amylase levels can provide a more precise assessment of the intra-abdominal status related to postoperative pancreatic fistula. C-reactive protein levels can also be used as a risk factor for clinically relevant postoperative pancreatic fistula after distal pancreatectomy.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Surgery
Pongsatorn Tangtawee, Somkit Mingphruedhi, Narongsak Rungsakulkij, Wikran Suragul, Watoo Vassanasiri, Paramin Muangkaew
Summary: This study compared surgical complications and the incidence of clinically relevant postoperative pancreatic fistula (CR-POPF) between distal pancreatectomy (DP) with extended organ resection and standard DP. The results showed that patients in the extended DP group had greater blood loss, higher incidence of major complications, and longer hospital stay compared to the DP group. However, there were no differences in the incidence of CR-POPF, readmission rate, or the need for postoperative intervention drainage between the two groups.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Stefano Andrianello, Elisa Bannone, Giovanni Marchegiani, Giuseppe Malleo, Salvatore Paiella, Alessandro Esposito, Roberto Salvia, Claudio Bassi
Summary: It was found that postoperative acute pancreatitis is a common event after distal pancreatectomy and it is closely associated with postoperative pancreatic fistula. Factors influencing postoperative acute pancreatitis include neoadjuvant therapy, age, duct size, pancreatic thickness, resection level, and histology type. Postoperative acute pancreatitis may increase the risk of further complications for patients.
Article
Surgery
Naoki Ikenaga, Takao Ohtsuka, Kohei Nakata, Yusuke Watanabe, Yasuhisa Mori, Masafumi Nakamura
Summary: The study found a high incidence of postoperative acute pancreatitis after pancreatoduodenectomy and distal pancreatectomy, with different impacts on patients. Patients with clinically relevant postoperative acute pancreatitis were more likely to develop severe complications.
Article
Surgery
Conrad K. Blunck, Selwyn M. Vickers, Thomas N. Wang, Vikas Dudeja, Sushanth Reddy, J. Bart Rose
Summary: The study aimed to investigate whether adjusting drain fluid amylase (DFA) for volume corrected drain fluid amylase (vDFA) could improve the prediction of clinically relevant postoperative pancreatic fistula (CR-POPF). The results showed that vDFA did not contribute to a superior CR-POPF predictive model compared to DFA, indicating that postoperative DFA remains the preferred method for predicting CR-POPF.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Jenny H. Chang, Kathryn Stackhouse, Fadi Dahdaleh, Mir Shanaz Hossain, Robert Naples, Chase Wehrle, Toms Augustin, Robert Simon, Daniel Joyce, R. Matthew Walsh, Samer Naffouje
Summary: This study evaluated the predictive value of drain amylase on day 1 (DA-D1) after pancreaticoduodendectomy for the occurrence of postoperative pancreatic fistula (POPF). The results showed that DA-D1 < 720 U/L can be considered as a clinically useful predictor of clinically relevant POPF. Surgeons should consider removing the drain on the first postoperative day for patients with low risk.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Matteo Palmeri, Niccolo Furbetta, Gregorio Di Franco, Desiree Gianardi, Simone Guadagni, Matteo Bianchini, Lorenzo Maria Fatucchi, Annalisa Comandatore, Andrea Moglia, Giulio Di Candio, Luca Morelli
Summary: In robot-assisted distal pancreatectomy, different strategies for pancreatic stump management have not shown significant advantages in reducing the occurrence of postoperative pancreatic fistula (POPF). The hand-sewn technique is more time-consuming, but remains essential in situations where staplers cannot be used.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Review
Gastroenterology & Hepatology
Kai Chen, Zonghao Liu, Bohan Yang, Yongsu Ma, Shupeng Zhang, Zhijiang Shao, Yinmo Yang, Xiaodong Tian
Summary: A meta-analysis was conducted to evaluate the efficacy and safety of early drain removal (EDR) after pancreatic surgery. The results showed that EDR significantly reduced the incidence of postoperative pancreatic fistula and total complications, especially in patients with low postoperative drain fluid amylase concentration.
Article
Surgery
Kota Sahara, Samantha M. M. Ruff, Kentaro Miyake, Junya Toyoda, Yasuhiro Yabushita, Yuki Homma, Takafumi Kumamoto, Ryusei Matsuyama, Itaru Endo, Timothy M. M. Pawlik
Summary: Although routine drain placement is common among surgeons, early drain removal (EDR) after pancreatoduodenectomy (PD) has shown increased over time and is associated with lower post-operative complications and shorter length of stay. However, only a small portion of patients undergo EDR despite its safety and potential benefits.
WORLD JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Brian C. Brajcich, Rebecca M. Platoff, Vanessa M. Thompson, Bruce Hall, Clifford Y. Ko, Henry A. Pitt
Summary: This study evaluated the association of postoperative hyperamylasemia (POHA) grade with clinically relevant postoperative pancreatic fistula (CR-POPF) and compared its prognostic utility against postoperative day 1 drain fluid amylase (DFA-1). The study found that POHA grade is associated with CR-POPF and outperforms DFA-1 in predicting its occurrence.
Article
Surgery
Haoda Chen, Ziyun Shen, Xiayang Ying, Yuanchi Weng, Yu Jiang, Hao Chen, Zhiwei Xu, Xiaxing Deng, Junjie Xie, Baiyong Shen
Summary: Visceral obesity is associated with higher CR-POPF rate and worse perioperative outcomes in pancreatic surgery, but for non-visceral obesity patients, RDP shows better outcomes compared to ODP.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Surgery
Thomas F. Seykora, Brett L. Ecker, Matthew T. McMillan, Laura Maggino, Joal D. Beane, Zhi Ven Fong, Robert H. Hollis, Nigel B. Jamieson, Ammar A. Javed, Stacy J. Kowalsky, John W. Kunstman, Giuseppe Malleo, Katherine E. Poruk, Kevin Soares, Vicente Valero, Lavanniya K. P. Velu, Ammara A. Watkins, Charles M. Vollmer, William E. Fisher, Mark P. Callery, Tara S. Kent, Michael G. House, Adam C. Berger, Christopher L. Wolfgang, Carlos Fernandez-del Castillo, Horacio J. Asbun, John A. Stauffer, Mark Bloomston, Ericka Haverick, Carl R. Schmidt, John D. Christein, Chad G. Ball, Elijah Dixon, Steven J. Hughes, Jeffrey A. Drebin, Michael Sprys, Amer H. Zureikat, Stephen W. Behrman, Claudio Bassi, Euan J. Dickson, Ronald R. Salem
Article
Multidisciplinary Sciences
Jeongyun Seo, David Conegliano, Megan Farrell, Minseon Cho, Xueting Ding, Thomas Seykora, Danielle Qing, Nilam S. Mangalmurti, Dongeun Huh
SCIENTIFIC REPORTS
(2017)
Article
Gastroenterology & Hepatology
Thomas F. Seykora, Laura Maggino, Giuseppe Malleo, Major K. Lee, Robert Roses, Roberto Salvia, Claudio Bassi, Charles M. Vollmer
JOURNAL OF GASTROINTESTINAL SURGERY
(2019)
Article
Surgery
Brett L. Ecker, Charles M. Vollmer, Stephen W. Behrman, Valentina Allegrini, John Aversa, Chad G. Ball, Courtney E. Barrows, Adam C. Berger, Martha N. Cagigas, John D. Christein, Elijah Dixon, William E. Fisher, Mollie Freedman-Weiss, Francisco Guzman-Pruneda, Robert H. Hollis, Michael G. House, Tara S. Kent, Stacy J. Kowalsky, Giuseppe Malleo, Ronald R. Salem, Roberto Salvia, Carl R. Schmidt, Thomas F. Seykora, Richard Zheng, Amer H. Zureikat, Paxton Dickson
Article
Surgery
Maxwell T. Trudeau, Fabio Casciani, Brett L. Ecker, Laura Maggino, Thomas F. Seykora, Priya Puri, Matthew T. McMillan, Benjamin Miller, Wande B. Pratt, Horacio J. Asbun, Chad G. Ball, Claudio Bassi, Stephen W. Behrman, Adam C. Berger, Mark P. Bloomston, Mark P. Callery, Carlos Fernandez-del Castillo, John D. Christein, Mary E. Dillhoff, Euan J. Dickson, Elijah Dixon, William E. Fisher, Michael G. House, Steven J. Hughes, Tara S. Kent, Giuseppe Malleo, Ronald R. Salem, Christopher L. Wolfgang, Amer H. Zureikat, Charles M. Vollmer
Summary: This study aims to present different patient presentations of pancreatic fistula risk and define the effectiveness of mitigation strategies in the most prevalent and vulnerable scenarios for surgeons. Through analysis of data from multiple international institutions, specific scenarios and optimal mitigation approaches associated with CR-POPF occurrence were identified.
Article
Surgery
Maxwell T. Trudeau, Fabio Casciani, Laura Maggino, Thomas F. Seykora, Horacio J. Asbun, Chad G. Ball, Claudio Bassi, Stephen W. Behrman, Adam C. Berger, Mark P. Bloomston, Mark P. Callery, Carlos Fernandez-Del Castillo, John D. Christein, Mary E. Dillhoff, Euan J. Dickson, Elijah Dixon, William E. Fisher, Michael G. House, Steven J. Hughes, Tara S. Kent, Giuseppe Malleo, Ronald R. Salem, Christopher L. Wolfgang, Amer H. Zureikat, Charles M. Vollmer
Summary: This study aims to investigate the impact of intraoperative estimated blood loss (EBL) on the development of clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy (PD). The results showed that increased EBL was associated with the occurrence of CR-POPF, and significant reductions in CR-POPF occurrence could be achieved by minimizing EBL.
Meeting Abstract
Gastroenterology & Hepatology
Maxwell T. Trudeau, Fabio Casciani, Thomas Seykora, Laura Maggino, Charles Vollmer