Article
Oncology
Francois Gernier, Djihane Ahmed-Lecheheb, Patricia Pautier, Anne Floquet, Cedric Nadeau, Sophie Frank, Jerome Alexandre, Frederic Selle, Dominique Berton-Rigaud, Elsa Kalbacher, Hubert Orfeuvre, Alain Lortholary, Paule Augereau, Fabien Labombarda, Lionel Perrier, Jean-Michel Grellard, Idlir Licaj, Benedicte Clarisse, Aude-Marie Savoye, Heloise Bourien, Thibaut De La Motte Rouge, Jean-Emmanuel Kurtz, Katia Kerdja, Anais Lelaidier, Amandine Charreton, Isabelle Ray-Coquard, Florence Joly
Summary: The study aims to assess the potential long-term physical side-effects of chemotherapy in survivors of Germ Cell Tumors (GCT) and Sex Cord Stromal Tumors (SCST), especially cardiovascular and pulmonary disorders. The results will contribute to adjusting treatment and follow-up management with adapted recommendations to reduce toxicity while maintaining efficacy. Intervention strategies based on the results could improve patient management during treatment and in the long term.
Article
Oncology
Martina E. Schmidt, Siri Goldschmidt, Silke Hermann, Karen Steindorf
Summary: Significant efforts have been made in cancer treatment, leading to improved survival rates. However, research and care for long-term problems and late effects in cancer survivors are inadequate. This study found that while cancer survivors' overall health-related quality of life and physical function were comparable or better than the general population, emotional and cognitive function were worse, particularly among women. Commonly reported problems with moderate burden included loss of physical performance, fatigue, sexual problems, sleep problems, and anxiety. Survivors often rated the support they received as poor, especially for non-threatening medical issues or issues without effective medication or treatment. Factors such as older age, female gender, history of chemotherapy, and overweight/obesity were associated with higher burdens. These findings highlight the need for increased awareness and targeted care for the long-term and late effects experienced by cancer survivors.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Nutrition & Dietetics
Sylvia L. Crowder, Zonggui Li, Kalika P. Sarma, Anna E. Arthur
Summary: The study found that head and neck cancer survivors with lower nutrition impact symptom (NIS) burden have higher lean muscle mass, better quality of life, and improved functional status. Compared to healthy controls, head and neck cancer survivors reported lower diet quality scores.
Article
Oncology
F. Gernier, A. Gompel, C. Rousset-Jablonski, E. Kalbacher, A. Floquet, D. Berton-Rigaud, O. Tredan, J. Alexandre, P. Follana, A. Zannetti, N. Dohollou, J-M Grellard, B. Clarisse, I Licaj, D. Ahmed-Lecheheb, R. Fauvet, P. Pautier, F. Joly
Summary: The study found that menopausal symptoms and sexual disorders are frequently reported by epithelial ovarian cancer survivors, especially among those who underwent surgical menopause. Most survivors with menopausal symptoms could benefit from hormone replacement therapy.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Valentin H. Meissner, Cornelia Peter, Donna P. Ankerst, Stefan Schiele, Juergen E. Gschwend, Kathleen Herkommer, Andreas Dinkel
Summary: This longitudinal study investigates the course and predictors of prostate cancer-related anxiety in long-term survivors treated by radical prostatectomy. The study found that prostate cancer-related anxiety remains stable over 5 years, and factors such as initial anxiety levels, biochemical recurrence, and psychological well-being predict future anxiety.
Article
Oncology
Francisco Alvarez-Salvago, Jose Daniel Jimenez-Garcia, Antonio Martinez-Amat, Clara Pujol-Fuentes, Sandra Atienzar-Aroca, Cristina Molina-Garcia, Agustin Aibar-Almazan
Summary: The study aims to assess whether the effects of therapeutic exercise programs are sustained over time (>= 5 years) in long-term breast cancer survivors (LTBCS). It also examines the impact of current physical activity (PA) levels on cancer-related fatigue (CRF) in these patients. The results indicate that the positive effects of therapeutic exercise programs are not maintained over time and that more than half of LTBCS remain inactive >= 5 years after completing the program, which is associated with higher levels of CRF.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Adriaan Penson, Iris Walraven, Ewald Bronkhorst, Heleen Maurice-Stam, Martha A. Grootenhuis, Margriet Van der Heiden-van der Loo, Wim J. E. Tissing, Helena J. H. Van der Pal, Andrica C. H. De Vries, Dorine Bresters, Cecile Ronckers, Marry M. Van den Heuvel, Sebastian J. C. M. M. Neggers, Birgitta A. B. Versluys, Marloes Louwerens, Saskia M. F. Pluijm, Leontien C. M. Kremer, Nicole Blijlevens, Eline Van Dulmen-den Broeder, Hans Knoop, Jacqueline Loonen
Summary: The study found that fatigue in childhood cancer survivors can negatively impact vitality, general health, and role limitations. Therefore, timely treatment of fatigue is crucial for the quality of life of survivors.
Article
Psychology, Multidisciplinary
Marianne Nilsen, Ragna Stalsberg, Kari Sand, Gorill Haugan, Randi Johansen Reidunsdatter
Summary: The study found that many breast cancer patients reported various health problems in the aftermath of the disease, which could lead to meaning discrepancies. In dealing with the breast cancer experience, patients engaged in a variety of coping techniques to change overall meaning and cultivate a more positive view of the cancer experience.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Britta Lohmann, Katharina Kuba, Heide Goetze, Anja Mehnert-Theuerkauf, Svenja Heyne, Peter Esser
Summary: This research investigated the situation of hematological cancer survivors regarding partnership, sexuality, and fertility-related communication. The results showed that most survivors were satisfied with their partnership and sexual life, but some experienced sexual impairments due to physical or mental symptoms. Factors related to quality of life included satisfaction with partnership, satisfaction with sexual life, and conversation about fertility with physicians. These findings need to be confirmed in longitudinal studies.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Health Care Sciences & Services
Kathrin Sommer, Marco Vignetti, Francesco Cottone, Massimo Breccia, Ombretta Annibali, Mario Luppi, Tamara Intermesoli, Erika Borlenghi, Paola Carluccio, Francesco Rodeghiero, Francesco Fabbiano, Claudio Romani, Marco Sborgia, Bruno Martino, Monica Crugnola, Fabio Efficace
Summary: This study aimed to investigate the association between fatigue and severity of other key cancer symptoms, as well as the interference with daily activities and outlook on life in long-term survivors of acute promyelocytic leukaemia (APL). The results showed a higher fatigue burden was associated with increased affective symptoms, memory problems, sleep disturbances, and pain. Fatigue also had a significant impact on the overall interference with daily activities and enjoyment of life among APL survivors.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Oncology
Cecilie E. Kiserud, Sandra Lockmer, Idun Baerug, Alv A. Dahl, Eva Kimby, Bjorn Ostenstad
Summary: The study aims to describe the health-related quality of life (HRQoL) and fatigue in long-term indolent lymphoma survivors compared to normal data, as well as examine factors related to impaired HRQoL among the survivors. The results indicate that lymphoma survivors have higher fatigue levels and lower HRQoL in certain domains compared to the normative data. Somatic comorbidities, unemployment, and chronic fatigue were significantly associated with reduced physical HRQoL, while anxiety and depressive symptoms were associated with reduced mental HRQoL. These findings emphasize the importance of monitoring HRQoL and fatigue in long-term follow-up of lymphoma survivors, as there are treatment and rehabilitation options available.
LEUKEMIA & LYMPHOMA
(2023)
Article
Oncology
Martina E. Schmidt, Marvin Chong, Oliver Klassen, Joachim Wiskemann, Karen Steindorf
Summary: Cancer-related fatigue is still not well understood, leading to undifferentiated treatment. This study investigated the potential use of bioelectrical phase angle (PhA) as a marker to identify specific fatigue subtypes. PhA was measured in breast cancer patients, and its association with fatigue severity and response to strength training was analyzed. The results showed that a decrease in PhA was significantly associated with increased physical and emotional fatigue. The association was stronger in patients with normal BMI and low pre-diagnosis exercise level. Furthermore, PhA was related to chemotherapy and strength training. These findings indicate that PhA may be a useful marker in classifying fatigue subtypes and tailoring treatments accordingly.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Grace M. M. Spiro, Philip C. C. Doyle, Nedeljko Jovanovic, Melissa Nash, Kevin Fung, Danielle MacNeil, Anthony Nichols, John Yoo
Summary: This study investigated the degree of perceived fatigue in individuals treated for head and neck cancer (HNCa). Results showed that more than half of the participants reported clinically significant levels of fatigue. There was an inverse relationship between fatigue and overall health-related quality of life, suggesting that as fatigue increases, perceived HRQOL decreases.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Rachel Vogel, Broderick Yoerg, Patricia Jewett, Nathan Rubin, Megan Olson, Ashley E. Stenzel, Rehana L. Ahmed, DeAnn Lazovich
Summary: This study examined sex differences in cancer-specific psychosocial quality of life among long-term melanoma survivors. Females were more likely to report changes in appearance and fear of recurrence, but also perceived a positive impact from melanoma. Males were more likely to acknowledge life's limited duration. Unique quality of life concerns for males and females following a melanoma diagnosis may require diverse support methods.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Pierre Heudel, Bertrand Favier, Marie-Laure Solodky, Souad Assaad, Natacha Chaumard, Olivier Tredan, Thomas Bachelot, Isabelle Ray-Coquard, Bruno Russias, Marie-Line Fournier, Benedicte Mastroianni, Virginie Avrillon, Anne-Sophie Michallet, Philippe Zrounba, Sylvie Chabaud, David Perol, Jean-Yves Blay
Summary: This study investigated the impact of SARS-COV-2 vaccination on the risk of developing COVID-19 in cancer patients from a comprehensive cancer center. The results showed that vaccination played a positive role in reducing the risk of COVID-19 infection among cancer patients.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Olivier Tredan, Magali Provansal, Cyril Abdeddaim, Audrey Lardy-Cleaud, Anne-Claire Hardy-Bessard, Elsa Kalbacher, Anne Floquet, Laurence Venat-Bouvet, Alain Lortholary, Oana Pop, Jean-Sebastien Frenel, Mathilde Cancel, Remy Largillier, Christophe Louvet, Benoit You, Alain Zannetti, Amelie Anota, Isabelle Treilleux, Daniel Pissaloux, Aurelie Houlier, Aude-Marie Savoye, Marie-Ange Mouret-Reynier, Jerome Meunier, Charles-Briac Levache, Fabien Brocard, Isabelle Ray-Coquard
Summary: This study evaluated the efficacy and safety of regorafenib versus tamoxifen in platinum-sensitive ovarian cancer biological recurrence. The results showed regorafenib had a less favorable safety profile compared to tamoxifen, but no superior efficacy in this population of patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Aurelien Francois, Nadine Dermit-Richard, Daniel Plumley, Rob Wilson, Natacha Heutte
Summary: The study analyzes the effectiveness of UEFA's Financial Fair Play under the break-even requirement using data from English and French football clubs from 2008-2018. Results show an increase in clubs' profitability in the EPL, while in Ligue 1, the improvement is only significant for certain clubs.
SPORT BUSINESS AND MANAGEMENT-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Elsa Caumette, Antonio Di Meglio, Ines Vaz-Luis, Cecile Charles, Julie Havas, Garazi Ruiz de Azua, Elise Martin, Laurence Vanlemmens, Suzette Delaloge, Sibille Everhard, Anne-Laure Martin, Asma Dhaini Merimeche, Olivier Rigal, Charles Coutant, Marion Fournier, Christelle Jouannaud, Patrick Soulie, Paul-Henri Cottu, Olivier Tredan, Gwenn Menvielle, Agnes Dumas
Summary: The return to work after breast cancer recovery is influenced by psychosocial factors, including a shift in life values towards more emphasis on private life. Clinical determinants, work-related factors, and psychosocial factors all play a role in this change. Depressive symptoms are negatively associated with this shift.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Florence Oberkampf, Maya Gutierrez, Olfa Trabelsi Grati, Emilie Le Rhun, Olivier Tredan, Isabelle Turbiez, Amir Kadi, Coraline Dubot, Sophie Taillibert, Sophie Vacher, Claire Bonneau
Summary: This study aimed to evaluate the efficacy of intrathecal trastuzumab in HER2 + BC patients with leptomeningeal metastasis. The results showed that weekly administration of 150 mg of intrathecal trastuzumab was effective in controlling neurological progression.
Article
Oncology
Olivier Tredan, Caroline Robert, Antoine Italiano, Fabrice Barlesi
Summary: Genome-wide testing plays a crucial role in advancing precision medicine in oncology; however, current recommendations lack specificity regarding its indications and utility for different types of cancer. To address this, a national consensus approach using a modified Delphi methodology was employed in France to provide expert opinions on the use of genome-wide testing in clinical practice. Consensus was reached through multiple rounds of rating, resulting in 24 statements agreed upon by the expert panel. While genome-wide testing was recommended for non-small cell lung cancer (NSCLC) and cancer of unknown primary (CUP), its routine use was not recommended for breast cancer and melanoma. The standardization of broad molecular screening in oncology may be facilitated by improved access to innovation in France.
BULLETIN DU CANCER
(2023)
Article
Oncology
Idlir Licaj, Elodie Coquan, Tienhan Sandrine Dabakuyo-Yonli, Sarah Dauchy, Ines Vaz Luis, Cecile Charles, Cedric Lemogne, Olivier Tredan, Laurence Vanlemmens, Christelle Jouannaud, Christelle Levy, Olivier Rigal, Marion Fournier, Thierry Petit, Florence Dalenc, Philippe Rouanet, Jerome Lemonnier, Sibille Everhard, Paul Cottu, Florence Joly
Summary: This study used the CANTO cohort to study the associations between baseline quality of life and chemotherapy dose-reductions (CDRs) or post-chemotherapy toxicities (PCTs). The results showed that baseline physical functioning and fatigue were associated with CDRs and PCTs.
Article
Otorhinolaryngology
Mathieu Cesaire, Audrey Rambeau, Florian Clatot, Alisson Johnson, Natacha Heutte, Juliette Thariat
Summary: This study evaluated the impact of lymphopenia on the efficacy of nivolumab immunotherapy in patients with head and neck cancer. The results showed that lymphopenia upon initiation of nivolumab did not affect patients' survival, but persistent lymphopenia during immunotherapy might be a prognostic marker of patient survival.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Pauline Corbaux, Catherine Terret, Claire Cropet, Sylvie Chabaud, Chiara Russo, Christelle Faure, Olivier Tredan, Thomas Bachelot, Pierre-Etienne Heudel
Summary: This study aimed to examine the effect of additional chemotherapy on overall survival in patients aged 70 years or older with early breast cancer, as well as the impact of comorbidities on chemotherapy benefit. The results showed that additional chemotherapy was associated with improved overall survival, while chronic obstructive pulmonary disease and polypharmacy were associated with worse overall survival. These findings support the importance of chemotherapy considerations in elderly patients with early breast cancer.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Gisele Chvetzoff, Carole Bouleuc, Audrey Lardy-Cleaud, Pierre Saltel, Veronique Dieras, Magali Morelle, Jean-Paul Guastalla, Olivier Tredan, Paul Rebattu, Simona Pop, Isabelle Ray-Coquard, Jean-Yves Pierga, Laurent Mignot, Valerie Laurence, Valerie Bourne-Branchu, David Perol, Thomas Bachelot
Summary: This study compared the impact of early palliative care and usual oncology care on the decision for additional chemotherapy. The results showed no significant difference in the prescription rate of chemotherapy between the two groups, but the early palliative care group had less deterioration in physical functioning and improved information exchange and communication.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Gwenn Le Gall, Sabine Noal, Natacha Heutte, Benedicte Clarisse, Alexandra Leconte, Francois Cherifi, Corinne Delcambre, Florence Joly, Benedicte Clin
Summary: The study aimed to analyze the impact of adjuvant trastuzumab on fatigue, emotional status, and quality of personal and work life in patients with localized breast cancer. The results showed that trastuzumab did not affect fatigue and return to work, but patients treated with trastuzumab may experience a stronger feeling of helplessness in terms of emotional well-being. Therefore, emotional support should be provided for patients receiving trastuzumab.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Environmental Sciences
I. Benjelloun, N. Merlet-Machour, F. Portet-Koltalo, N. Heutte, D. Garon, F. Baraud, L. Leleyter
Summary: Soil contamination is a significant issue due to urbanization and industrialization. This paper introduces the bioaugmentation effect of fungal strain Absidia cylindrospora on co-contaminated industrial soil for the first time. The study investigates the evolution of metals and PAHs content in the soil over time, as well as the adsorption and/or accumulation of metals within the mycelium of Absidia cylindrospora. The results show that the fungal strain can simultaneously accumulate Cd, Co, Cu, Ni, and Zn, even in the presence of high levels of PAHs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Oncology
Houssein El Hajj, Domenico Ferraioli, Pierre Meus, Frederic Beurrier, Olivier Tredan, Isabelle Ray-Coquard, Nicolas Chopin
Summary: ObjectiveSplenectomy is performed in a significant percentage of cytoreductive surgeries for ovarian cancer. This study aimed to evaluate the impact of splenectomy on overall and disease-free survival in patients with epithelial ovarian cancer. MethodsA retrospective study was conducted on patients who underwent cytoreduction for ovarian cancer between January 2000 and December 2016. Patients were stratified into splenectomy and non-splenectomy groups, and postoperative complications and survival outcomes were analyzed. ResultsA total of 464 patients were included in the study. The splenectomy group had higher disease stages, peritoneal carcinomatosis scores, and radical surgery rates. However, there was no significant difference in complete cytoreduction rates between the two groups. Splenectomy was associated with extensive surgical procedures and increased risk of abdominopelvic lymphocele and blood transfusion. The average length of hospital stay and delay in adjuvant chemotherapy were longer in the splenectomy group. Overall and disease-free survival rates were not significantly different between the groups. ConclusionSplenectomy may be a safe procedure with no impact on overall or disease-free survival in patients with ovarian cancer. However, it is associated with longer hospital stay and delay in chemotherapy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Otorhinolaryngology
E. Babin, N. Heutte, M. Humbert, O. Laccourreye
Summary: This study analyzed the impact of total laryngectomy on the quality of sexual life for cancer patients and the methods used to assess it. The results showed that the quality of sexual life was severely affected, including issues like erectile dysfunction, decreased ejaculatory function, and low libido. Lack of postoperative support was also reported. Therefore, these factors should be taken into account before performing total laryngectomy, and there is a need for a common information tool to improve the management of sexuality based on patient demand.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Oncology
Khalil Hodroj, David Pellegrin, Cindy Menard, Thomas Bachelot, Thierry Durand, Philippe Toussaint, Armelle Dufresne, Benoite Mery, Olivier Tredan, Thibaut Goulvent, Pierre Heudel
Summary: This study describes the implementation of an MDT application prototype based on structured data for ABC MDT meetings, which improved the quality and confidence of clinical decisions, and could support sustained improvements to patient care.
