Article
Radiology, Nuclear Medicine & Medical Imaging
Nelisa Helena Rocha, Samara Riguete Zacchi, Heitor Naoki Sado, Carlos Alberto Buchpiguel, Paulo Schiavom Duarte, Marcelo Tatit Sapienza
Summary: This study aimed to compare the effectiveness of oral and IV administration of F-18-NaF PET/CT in detecting bone metastatic lesions of breast and prostate cancers. The results showed that there was no significant difference in TBR between the two administration routes, and there was a high consistency between the two routes. Therefore, oral administration can be considered in patients with difficult venous access.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Feng Xu, Frank Liu, Wen Chen
Summary: This article presents different findings in a patient with prostate cancer metastasis using F-18-fluciclovine (Axumin) PET/CT and F-18-NaF PET/CT images. The F-18-fluciclovine PET/CT scan showed intense uptake in left adrenal gland metastasis, while multiple sclerotic osseous metastasis showed only faint to mild uptake. In contrast, F-18-NaF bone PET/CT demonstrated intense uptake at these sites. Both examinations are necessary for accurately evaluating visceral and osseous metastasis from prostate cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Xiongjian Hu, Yiming Cao, Bin Ji, Min Zhao, Qiang Wen, Bin Chen
Summary: This study aimed to compare the diagnostic efficiency of F-18-DCFPyL PET/CT imaging and Tc-99m-MDP SPECT/CT bone imaging for detecting bone metastases in prostate cancer. The results showed that F-18-DCFPyL PET/CT imaging had superior diagnostic performance compared to Tc-99m-MDP SPECT/CT bone imaging at both the patient and lesion levels. It is concluded that F-18-DCFPyL PET/CT imaging is an important supplement to imaging examination for prostate cancer patients and has great potential and broad application prospects.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Kalevi Kairemo, S. Cheenu Kappadath, Timo Joensuu, Homer A. Macapinlac
Summary: In this study, the quantitative differences between Fluorocholine-18 (FCH) and sodium fluoride-18 (NaF) in assessing skeletal disease in prostate cancer patients were characterized. The results suggest that a combination of NaF and FCH provides complementary information about the activity of skeletal disease, improving diagnosis and disease staging in PCa.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keith L. Spinali, David J. Papke, Hina J. Shah
Summary: F-18-DCFPyl is used to detect recurrent or metastatic prostate cancer and can target nonprostatic disease entities that mimic prostate cancer. The interpreting physician needs to consider serum prostate-specific antigen levels and uptake distribution to avoid misdiagnosis of metastatic prostate cancer. We describe the association of F-18-DCFPyl uptake with a previously undescribed hepatic small vessel neoplasm.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kenichi Tanaka, Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kengo Fujimoto, Yasukage Takami, Mariko Ishimura, Hanae Arai-Okuda, Yoichiro Tohi, Nobuyuki Kudomi, Mikio Sugimoto, Yoshihiro Nishiyama
Summary: This study aimed to investigate the correlation between standardized uptake value (SUV) and volume-based parameters measured by quantitative SPECT/CT and PET/CT in the assessment of bone metastases in patients with prostate cancer. The results showed a strong correlation between SPECT/CT and PET/CT, with the SUV and volume-based parameters being significantly higher for metastatic lesions compared to benign lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela-Elena Oprea-Lager, Eric Gontier, Lina Garcia-Canamaque, Mathieu Gauthe, Pierre Olivier, Mercedes Mitjavila, Pilar Tamayo, Philippe Robin, Ana Maria Garcia Vicente, Anne-Charlotte Bouyeure, Alban Bailliez, Antonio Rodriguez-Fernandez, Sinan Ben Mahmoud, Juan Antonio Vallejo-Casas, Philippe Maksud, Charles Merlin, Paul Blanc-Durand, Clement Drouet, Hubert Tissot, Irina Vierasu, Thierry Vander Borght, Evelyne Boos, Florence Chossat, Marina Hodolic, Caroline Rousseau
Summary: The purpose of this study was to compare the per-patient detection rates of [F-18]DCFPyL and [F-18]fluoromethylcholine PET/CT in patients with first prostate cancer biochemical recurrence. The results showed that [F-18]DCFPyL had a significantly higher detection rate compared to [F-18]fluoromethylcholine.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aloyse Fourquet, Adrian Rosenberg, Esther Mena, Joanna J. Shih, Baris Turkbey, Maxime Blain, Ethan Bergvall, Frank Lin, Stephen Adler, Ilhan Lim, Ravi A. Madan, Fatima Karzai, James L. Gulley, William L. Dahut, Bradford J. Wood, Richard Chang, Elliot Levy, Peter L. Choyke, Liza Lindenberg
Summary: This study compared the use of different PET tracers (F-18-DCFPyL, F-18-NaF, and F-18-FDG) in men with metastatic prostate cancer. The results showed that F-18-DCFPyL was the most effective in detecting metastatic lesions, while F-18-NaF was better at detecting bone metastases. The study also found that there were differences in the detection rates of the same lesion using different tracers.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sharjeel Usmani, Najeeb Ahmed, Muhammad Waqas Ilyas, Sarah Murad, Fareeda Al Kandari
Summary: Metastatic involvement of the thyroid cartilage is rare due to the absence of vessels within the cartilaginous tissue. This case highlights the significance of thyroid cartilage metastasis in breast cancer patients, which may have prognostic implications.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ediz Beyhan, Sevim Baykal Koca, Ugur Yucetas, Tevfik Fikret Cermik, Nurhan Ergul
Summary: This article presents a rare case of urethral metastasis of bladder cancer after surgery. The patient had undergone surgery for invasive bladder carcinoma and prostate adenocarcinoma and presented with urethral hemorrhage. F-18-FDG PET/CT restaging showed intense linear F-18-FDG activity in the proximal urethra. Urethrectomy was performed and histopathology confirmed urethral metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Siying Dong, Yanmei Li, Jian Chen, Yongliang Li, Pengfei Yang, Juan Li
Summary: This study evaluated the value of semi-quantitative parameters derived from F-18-PSMA-1007 PET/CT imaging for risk stratification in newly diagnosed prostate cancer. TL-PSMAp was found to have a superior ability to identify high-risk prostate cancer. These imaging parameters can serve as objective reference indices for determining prostate cancer risk stratification.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianluca Bottoni, Arnoldo Piccardo, Francesco Fiz, Giacomo Siri, Federica Matteucci, Andrea Rocca, Oriana Nanni, Manuela Monti, Etienne Brain, Jean Louis Alberini, Bassam Dib, Gian Mauro Sacchetti, Chiara Saggia, Valentina Rossi, Nadia Harbeck, Rachel Wuerstlein, Tom Degenhardt, Andrea DeCensi, Gian Andrea Rollandi, Alessandra Gennari
Summary: The study shows that the combined use of [18F]FES PET/CT and [18F]FDG PET/CT can evaluate the heterogeneity of estrogen receptor in bone metastases of breast cancer, which is significantly associated with survival. Additionally, the extension of the FDG-avid component correlates with the risk of disease progression.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Denise Bianchi, Alessio Rizzo, Mattia Bonacina, Alberto Zaniboni, Giordano Savelli
Summary: F-18-Fluorocholine (F-18-FCH) PET/CT is commonly used for prostate cancer patients, but its sensitivity for certain organs may be limited. This case report describes a patient with oligometastatic prostate cancer and a rare penile metastasis detected through F-18-FCH PET/CT.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Luca Urso, Giovanni Christian Rocca, Francesca Borgia, Federica Lancia, Antonio Malorgio, Mauro Gagliano, Mauro Zanetto, Licia Uccelli, Corrado Cittanti, Carmelo Ippolito, Laura Evangelista, Mirco Bartolomei
Summary: By analyzing data from a multidisciplinary approach, [F-18]F-choline PET/CT plays an important role in the diagnosis and prognosis of PCa patients, helping to select initial treatment plans and being associated with longer biochemical recurrence-free survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liam Widjaja, Rudolf A. Werner, Elke Krischke, Hans Christiansen, Frank M. Bengel, Natalia Bogdanova, Thorsten Derlin
Summary: This study aims to evaluate the predictive potential of DNA damage response (DDR) markers in peripheral blood lymphocytes (PBLs) for the outcome of metastatic castration-resistant prostate cancer (mCRPC) patients receiving [Lu-177]Lu-prostate-specific membrane antigen (PSMA) radioligand therapy (RLT). The results suggest that low baseline DDR markers in PBLs tend to predict poor outcome, providing a foundation for exploring radiosensitizing or treatment intensification in high-risk individuals scheduled for RLT.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aleksander Kosmala, Sebastian E. Serfling, Wiebke Schlotelburg, Thomas Lindner, Kerstin Michalski, Andreas Schirbel, Takahiro Higuchi, Philipp E. Hartrampf, Andreas K. Buck, Alexander Weich, Rudolf A. Werner
Summary: The purpose of this study was to compare the impact of FAPI-directed molecular imaging with GCI on staging and therapeutic management in patients with digestive system tumors. The results showed that 68Ga-FAPI-04 PET/CT resulted in staging changes in 46.9% of patients and therapeutic modifications in 25.0% of patients. These findings may favor a more widespread adoption of FAP-directed imaging, especially in patients with HCC and PDAC.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ralph A. Bundschuh, Susanne Luetje, Lena Bundschuh, Constantin Lapa, Takahiro Higuchi, Philipp E. Hartrampf, Michael A. Gorin, Aleksander Kosmala, Andreas K. Buck, Martin G. Pomper, Steven P. Rowe, Markus Essler, Gabriel T. Sheikh, Rudolf A. Werner
Summary: This study assessed the concordance of PSMA-directed PET/CT using the PSMA reporting and data system (RADS). The results showed excellent agreement for general parameters and minimal modifications were observed after providing clinical data. These findings indicate that standardized frameworks can provide guidance for reading PSMA PETs, even in the absence of patient information.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alexander Weich, Sebastian E. Serfling, Heqing Yi, Andreas K. Buck, Takahiro Higuchi, Rudolf A. Werner
Summary: We presented the case of a 52-year-old man with metastasized neuroendocrine tumor (G2) of the pancreas. After surgical removal, follow-up imaging showed liver lesions, which were positive for somatostatin receptors. Peptide receptor radionuclide therapy achieved complete remission, indicating that hot somatostatin analogs can be effective for pancreatic G2 neuroendocrine tumors. However, such cases with complete remission after this therapy are extremely rare and require further investigation.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rudolf A. Werner, Cyrus Sayehli, Heribert Haenscheid, Takahiro Higuchi, Sebastian E. Serfling, Martin Fassnacht, Maria-Elisabeth Goebeler, Andreas K. Buck, Matthias Kroiss
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sara Sheikhbahaei, Ricardo Bello Martinez, Mark C. Markowski, Mario A. Eisenberger, Kenneth J. Pienta, Diane Reyes, Mary Katherine Brosnan, Ergi Spiro, Rehab AbdAllah, Daniel P. Holt, Robert F. Dannals, Rudolf A. Werner, Martin G. Pomper, Michael A. Gorin, Lilja B. Solnes, Steven P. Rowe
Summary: This study investigated the utility of a novel PSMA-targeted PET radiotracer, [F-18]F-Florastamin, compared to conventional imaging for lesion detection and evaluated the effect of multi-timepoint imaging on lesion detectability. The results showed that [F-18]F-Florastamin PET was superior to CT in detecting osseous metastases and small-sized metastatic lymph nodes. Multi-timepoint imaging also improved tumor-to-background ratio.
ANNALS OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Weich, Sebastian E. Serfling, Wiebke Schloetelburg, Takahiro Higuchi, Philipp E. Hartrampf, Andreas Schirbel, Marieke Heinrich, Andreas K. Buck, Steven P. Rowe, Aleksander Kosmala, Rudolf A. Werner
Summary: This study investigates the influence of CXCR4-directed imaging on staging and oncologic management in patients with digestive system tumors compared with guideline-appropriate imaging. The results show that CXCR4-directed PET/CT altered the staging results and impacted subsequent clinical algorithm in a significant number of patients.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian E. Serfling, Philipp E. Hartrampf, Yingjun Zhi, Takahiro Higuchi, Aleksander Kosmala, Julia Serfling, Andreas Schirbel, Anna Hoerning, Andreas K. Buck, Alexander Weich, Rudolf A. Werner
Summary: A study found that SSTR-targeted PET/CT can lead to changes in therapeutic management in patients with small cell lung cancer (SCLC), resulting in disease control and prolonged survival.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Philipp E. Hartrampf, Aleksander Kosmala, Sebastian E. Serfling, Lena Bundschuh, Takahiro Higuchi, Constantin Lapa, Steven P. Rowe, Yohji Matsusaka, Alexander Weich, Andreas K. Buck, Ralph A. Bundschuh, Rudolf A. Werner
Summary: In this study, we evaluated the agreement rates between observers in patients scanned with CXCR4-targeted PET/CT, including the percentage of patients eligible for CXCR4-targeted RLT based on the scan results. Fair to excellent agreement rates were observed for both visual and quantitative assessments, indicating the potential widespread adoption of [Ga-68]pentixafor in the clinic.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aleksander Kosmala, Sebastian E. Serfling, Kerstin Michalski, Thomas Lindner, Andreas Schirbel, Takahiro Higuchi, Philipp E. Hartrampf, Thorsten Derlin, Andreas K. Buck, Alexander Weich, Rudolf A. Werner
Summary: The purpose of this study was to assess the prevalence, distribution, and intensity of in-vivo arterial wall fibroblast activation protein (FAP) uptake, and its correlation with calcified plaque burden, cardiovascular risk factors (CVRFs), and FAP-avid tumor burden. The study found a significant correlation between FAP uptake and calcified plaque burden, but inconsistent correlation with cardiovascular risk factors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Weich, Dorothea Rogoll, Melissa Peschka, Wolfgang Weich, Judit Pongracz, Markus Brand, Matthias Froehlich, Sebastian E. Serfling, Steven P. Rowe, Aleksander Kosmala, Florian P. Reiter, Alexander Meining, Rudolf A. Werner, Michael Scheurlen
Summary: This study investigates the effect of Wnt/beta-catenin signaling pathway alterations on the expression and function of somatostatin receptors (SSTRs) in neuroendocrine tumors (NETs). The results show that inhibiting the Wnt pathway can increase SSTR expression and enhance the efficacy of a targeted therapy approach for certain neuroendocrine tumors.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wojciech Cytawa, Robin Hendel, Bartlomiej Tomasik, Franz-Xaver Weinzierl, Thorsten Bley, Jacek Jassem, Andreas Schirbel, Andreas K. Buck, Ralph A. Bundschuh, Philipp E. Hartrampf, Rudolf A. Werner, Constantin Lapa
Summary: The purpose of this study was to investigate the radiographic PSMA PET response after one cycle of [Lu-177]Lu-PSMA I & T RLT in mCRPC patients and to assess its role in predicting overall response and survival. The results showed that early PSMA PET radiographic response was not associated with overall survival, indicating that treatment should not be discontinued prematurely. However, early PSA progression after one cycle of [Lu-177]Lu-PSMA I & T RLT was an indicator of overall progression and poor clinical outcome.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Urology & Nephrology
Rudolf A. Werner, Philipp E. Hartrampf, Wolfgang P. Fendler, Sebastian E. Serfling, Thorsten Derlin, Takahiro Higuchi, Kenneth J. Pienta, Andrei Gafita, Thomas A. Hope, Martin G. Pomper, Matthias Eiber, Michael A. Gorin, Steven P. Rowe
Summary: PSMA-RADS is a standardized reporting and data system for classifying prostate cancer lesions. Studies have shown that the different categories of PSMA-RADS reflect their actual meanings, and there is high concordance among observers. This system can also assist in clinical decision-making, such as avoiding overtreatment in oligometastatic disease. However, there are also limitations to PSMA-RADS, which need to be updated to optimize lesion-level characterization.
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthias Froehlich, Marc Schmalzing, Andreas Buck, Thorsten A. Bley, Konstanze V. Guggenberger, Rudolf A. Werner
Summary: Using [ 18 F]fluorodeoxyglucose ([ 18 F]FDG)-PET parameters, it is possible to predict relapse in patients with giant cell arteritis (GCA). Blood-based inflammatory markers and clinical parameters are not effective in distinguishing between relapse and no-relapse. However, the FDG-PET parameter TBR liver can differentiate between patients with and without relapse.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sandra M. Ihne-Schubert, Malte Kircher, Rudolf A. Werner, Constantin Lapa, Hermann Einsele, Andreas Geier, Torben Schubert
Summary: This study uses time series analysis to predict organ response in patients with the rare disease AA amyloidosis and demonstrates the comparative utility of blood, functional, and imaging markers in monitoring disease development and regression.