Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 14, Pages 4690-4694Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813801
Keywords
carbonylation; difluoromethylated esters; fluoroalkenes; palladium; selectivity
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Funding
- State of Mecklenburg-Vorpommern
- Chinese Scholarship Council (CSC)
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The first catalyst for the alkoxycarbonylation of gem-difluoroalkenes is described. This novel catalytic transformation proceeds in the presence of Pd(acac)(2)/1,2-bis((di-tert-butylphosphan-yl)methyl)benzene (btbpx) (L4) and allows for an efficient and straightforward access to a range of difluoromethylated esters in high yields and regioselectivities. The synthetic utility of the protocol is showcased in the practical synthesis of a Cyclandelate analogue using this methodology as the key step.
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