Article
Chemistry, Analytical
Eleni Koukouviti, Christos Kokkinos
Summary: The study presents a novel miniature all-3D-printed 4-electrode biochip capable of simultaneous determination of different biomarkers, showcasing high sensitivity and transferability.
ANALYTICA CHIMICA ACTA
(2021)
Review
Biochemical Research Methods
Linan Zhang, Chunchuan Gu, Jiajun Wen, Guangxian Liu, Hongying Liu, Lihua Li
Summary: Exosomes, actively secreted by eukaryotic cells, are promising biomarkers for cancer diagnosis and therapeutic response evaluation. The incorporation of nanomaterials into sensing systems can enhance sensitivity, selectivity, and stability, improving detection methods for exosomes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yousif Saleh Ibrahim, Andres Alexis Ramirez-Coronel, Dinesh Kumar Sain, Zahraa Haleem Al-qaim, Zanko Hassan Jawhar, Aya Yaseen Mahmood Alabdali, Saad Hayif Jasim Ali, Raed H. Althomali, Yasser Fakri Mustafa, Rosario Mireya Romero-Parra
Summary: Foodborne pathogenic bacteria pose a significant threat to public health and require rapid identification to prevent the spread of illness. Chemiluminescence, with its simplicity and sensitivity, has become a dominant method for bacterial detection. Nanomaterials such as noble metal NPs, LDHs, MoS2, MOFs, CDs, and QDs have been employed to enhance chemiluminescence radiation due to their reactive and unique photoelectric properties. However, a comprehensive review on the application of nanomaterial-based chemiluminescence for tracing foodborne pathogenic bacteria is still lacking.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Applied
Quanliang Li, Xiyu Wang, Xiaomeng Wang, Lin Zheng, Ping Chen, Biying Zhang
Summary: Detrimental contamination of zearalenone (ZEN) in crops and foodstuffs poses an ongoing threat to global food security and human health. Conventional detection methods for ZEN have deficiencies, while nanomaterial-based biosensors have emerged as superior substitutes due to their high sensitivity, portability, and miniaturization. This review provides an overview of the fabrication strategies and applications of nanomaterial-based biosensors for ZEN detection, highlighting sensing mechanisms, response types, and analytical performance as well as the integration of diverse recognition elements to enhance sensing capabilities. Critical challenges and future perspectives for expedited ZEN detection are also discussed.
Review
Chemistry, Analytical
B. M. Azizur Rahman, Charusluk Viphavakit, Ratchapak Chitaree, Souvik Ghosh, Akhilesh Kumar Pathak, Sneha Verma, Natsima Sakda
Summary: The increasing use of nanomaterials and scalable, high-yield nanofabrication process is revolutionizing the development of novel biosensors. This review provides a comprehensive overview of major scientific achievements in nano-biosensors based on optical fiber, nanomaterials and terahertz-domain metasurface-based refractometric, labelled and label-free nano-biosensors.
Article
Biophysics
Abdelmonaim Azzouz, Lamia Hejji, Christian Sonne, Ki-Hyun Kim, Vanish Kumar
Summary: Aptamers, with beneficial properties, are widely used in biodetection platforms. Advanced biosensors combining aptamers and diverse nanomaterials can be utilized for recognizing cardiovascular disease biomarkers. Researchers are also focusing on evaluating the performance of aptasensors in terms of key quality assurance metrics and developing signal amplification technologies for enhanced portability.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Asha P. Johnson, Chinnu Sabu, N. Kumara Swamy, Annstephy Anto, H. V. Gangadharappa, K. Pramod
Summary: Graphene nanoribbons (GNRs) are considered a promising platform for biomedical applications due to their unique properties. By altering the edge functionalities and geometry, their properties can be significantly reformed and controlled. GNRs are extensively explored in the field of biosensing.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Analytical
Theo Lienard-Mayor, Myriam Taverna, Stephanie Descroix, Thanh Duc Mai
Summary: This study provides a comprehensive overview of different strategies for combining droplet-based sample handling and preparation with electrophoretic separation. It focuses on three principal interfacing strategies, including droplets in immiscible phases, digital microfluidics with electrowetting-on-dielectric principle, and inkjet droplet generation. Different instrumental developments, pros and cons of designs, and application demonstrations of droplet-interfaced electrokinetic strategies are discussed.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Yunho Choi, Younseong Song, Yong Tae Kim, Hogi Kim, Yoo Min Park, Seok Jae Lee, Sung Gap Im, Kyoung G. Lee
Summary: Chip-scale microfluidic technologies have the potential to provide rapid and low-cost POCT diagnostics, but integrating functional steps into POCT remains a crucial and unsolved issue.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Materials Science, Multidisciplinary
Dewang Li, Yaqian Deng, Jingyi Xia, Zhitan Wu, Tongxin Shang, Pei Li, Junwei Han, Ying Tao, Quan-Hong Yang
Summary: A new gelation approach can produce mechanically stable polystyrene gel from microemulsion, and pore structures can be effectively tuned by changing gelation time and solvent exchange. This simple method avoids shaping tools and chemical templates, making it a promising alternative for designing polymer materials.
SCIENCE CHINA-MATERIALS
(2021)
Article
Biochemical Research Methods
Supat Chupradit, Mahyuddin K. M. Nasution, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Dmitry Bokov, Alexander Markov, Irina N. Fardeeva, Gunawan Widjaja, Mohammed Nader Shalaby, Marwan Mahmood Saleh, Yasser Fakri Mustafa, A. Surendar, Ramtin Bidares
Summary: Leukemia is a disease caused by dysfunctions in hematopoietic stem cells lineages, and different types of leukemia require different diagnosis and treatment options. Early detection is crucial for effective treatment, and genosensors and electrochemical sensors can help detect cancer cells and leukemia-related genes. The use of nanomaterials can increase the sensitivity of detection.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Hongyu Nie, Zhihui Li, Xiaokun Wang, Rongmeng Gu, Hongyan Yuan, Yong Guo, Dan Xiao
Summary: In this study, a multi-input capacitively coupled contactless conductivity detector (MICD)-D-4 was proposed with high sensitivity, and further improved by combining it with differential detection to form (DFMICD)-D-4. The new detector showed improved performance compared to traditional single-input and double-input detectors, with a higher response-to-baseline ratio and a low limit of detection (0.7 nM). It can be applied to the detection of low-conductivity solutions and total dissolved solids (TDS) analysis, demonstrating its versatility and superiority over standard conductivity meters.
Article
Chemistry, Analytical
Zhenfeng Lin, Xin Liu, Yangzi Li, Changxiang Li, Liu Yang, Keke Ma, Zhenwei Zhang, Huayu Huang
Summary: Two-dimensional Mo2C/Mo2N composites were successfully synthesized and used for fabricating a biosensor with ultra-low detection limit for CPF. The biosensor showed satisfactory recoveries for CPF in real samples with acceptable relative standard deviations.
Article
Chemistry, Analytical
Miaoron Zhamg, Yan Zhang, Chuankai Yang, Chunyun Ma, Yuhang Zhang, Jianguo Tang
Summary: The novel colorimetric biosensor based on La-MFs fabricated via biomineralization showed enhanced detection performance for EP, with a wide linear detection range and good selectivity. The La-MFs exhibited satisfactory storage stability and reusability for EP detection.
MICROCHEMICAL JOURNAL
(2022)
Article
Energy & Fuels
Nagi M. El-Shafai, Mohamed S. Ramadan, Ibrahim M. El-Mehasseb
Summary: This study focuses on the design of a novel composite nanomaterial for supercapacitors, biosensors, and photocatalysis. The incorporation of two metal oxides on the surface of a synthetic self-assembly enhances electron transfer and improves photocatalytic efficiency. The results suggest that the composite nanomaterial has the potential for applications in supercapacitors and biosensors.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Review
Chemistry, Analytical
Tingting Hong, Xi Yang, Yujing Xu, Yibing Ji
ANALYTICA CHIMICA ACTA
(2016)
Article
Biochemical Research Methods
Tingting Hong, Xueping Chen, Yujing Xu, Xiaoqin Cui, Ruihan Bai, Can Jin, Ruijun Li, Yibing Ji
JOURNAL OF CHROMATOGRAPHY A
(2016)
Article
Biochemical Research Methods
Tingting Hong, Yan Zheng, Wenwen Hu, Yibing Ji
ANALYTICAL BIOCHEMISTRY
(2014)
Article
Chemistry, Analytical
Tingting Hong, Cuijie Chi, Yibing Ji
JOURNAL OF SEPARATION SCIENCE
(2014)
Article
Biochemical Research Methods
Si Peng, Tingting Hong, Wenbin Liang, Wenfang Liu, Chuanpin Chen
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2019)
Article
Biochemical Research Methods
Tingting Hong, Lin Qiu, Wen Rui, Ying Li, Ronghui Zheng, Qianqian Guo, Shuwen Zhou, Pengfei Cui, Jingyu Sheng, Xinye Ni, Jianhao Wang, Pengju Jiang
Summary: A novel peptide containing antimicrobial sequence and gelatinase cleavage sites was designed for Staphylococcus aureus detection. The results showed that capillary electrophoresis was efficient for determining Staphylococcus aureus content, with higher efficiency, enhanced sensitivity, and low sample consumption compared to traditional approaches. Moreover, the proposed peptide also exhibited desirable antimicrobial activity, indicating a new path for Staphylococcus aureus detection by capillary electrophoretic method.
Review
Pharmacology & Pharmacy
Cheng Wang, Tingting Hong, Pengfei Cui, Jianhao Wang, Jiang Xia
Summary: This article reviews recent studies on the delivery and formulation of antimicrobial peptides, categorizing strategies driven by physical interactions or chemical conjugation reactions, and covering carriers from inorganic solid nanoparticles to organic micelles, liposomes, and hydrogels. Targeted delivery, responsive release, and strategies to increase oral bioavailability of antimicrobial peptides are discussed, highlighting the recent progress towards clinical application.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Analytical
Tingting Hong, Ronghui Zheng, Lin Qiu, Shuwen Zhou, Hufei Chao, Ying Li, Wen Rui, Pengfei Cui, Xinye Ni, Songwen Tan, Pengju Jiang, Jianhao Wang
Summary: A strategy based on fluorescence coupled capillary electrophoresis (CE-FL) was developed for analyzing tetrahedron DNA (TD) and TD-doxorubicin (DOX) conjugate. The optimized method showed satisfactory repeatability and accuracy. CE-FL is a sensitive and specific method for TD assay, with potential applications in DNA nanomaterials research.
Review
Chemistry, Analytical
Tingting Hong, Xing Liu, Qi Zhou, Yilian Liu, Jing Guo, Wenhu Zhou, Songwen Tan, Zhiqiang Cai
ANALYTICAL CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Xiaolin Zhu, Kaiyao Hou, Peiyang Zheng, Wenya Zhong, Jing Guo, Xiyue Zhao, Tingting Hong, Zhiqiang Cai
Summary: In this study, a novel approach involving exogenous oxygen vectors was developed to improve the production of biosynthetic Ansamitocin P-3 (AP-3). The addition of soybean oil was found to be the most effective in promoting AP-3 generation. Metabolomics analysis further revealed the influence of dissolved oxygen levels on AP-3 production.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Chemistry, Analytical
Tingting Hong, Lin Qiu, Shuwen Zhou, Zhiqiang Cai, Pengfei Cui, Ronghui Zheng, Jianhao Wang, Songwen Tan, Pengju Jiang
Summary: DNA possesses various properties that make it important in biological analysis, and its combination with capillary-based microsystems offers great potential in applications such as DNA aptamer selection, amplification, and digestion. The meeting between DNA and capillary-based microsystems has the potential to advance further in the field of analytical chemistry.
Review
Chemistry, Analytical
Chuanpin Chen, Wenfang Liu, Tingting Hong
Review
Chemistry, Analytical
Tingting Hong, Wenfang Liu, Ming Li, Chuanpin Chen
Article
Biochemical Research Methods
Yujing Xu, Tingting Hong, Xueping Chen, Yibing Ji
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
