Article
Surgery
Hannah Kaminski, Nassim Kamar, Olivier Thaunat, Nicolas Bouvier, Sophie Caillard, Isabelle Garrigue, Dany Anglicheau, Jean-Philippe Rerolle, Yannick Le Meur, Antoine Durrbach, Thomas Bachelet, Helene Savel, Roxane Coueron, Jonathan Visentin, Arnaud Del Bello, Isabelle Pellegrin, Julie Dechanet-Merville, Pierre Merville, Rodolphe Thiebaut, Lionel Couzi
Summary: This study found that everolimus can decrease the incidence of CMV DNAemia and disease in CMV seropositive solid organ transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Ravi Dhital, Shashi Anand, Brianna Graber, Qiang Zeng, Victoria M. Velazquez, Srinivasa R. Boddeda, James R. Fitch, Ranjana W. Minz, Mukut Minz, Ashish Sharma, Rachel Cianciolo, Masako Shimamura
Summary: Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. CMV promotes allograft damage via cytokine-mediated Th1/17 cell recruitment. Pharmacologic inhibition of the Th17 cell signature cytokine, IL-17A, ameliorates CMV-associated allograft damage.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Cristina Hernandez, Curtis Mabilangan, Catherine Burton, Karen Doucette, Jutta Preiksaitis
Summary: This study found that the risk of cytomegalovirus (CMV) transmission in solid organ transplant recipients is influenced by the type of allograft, and that the use of antiviral prophylaxis may not alter the transmission risk. Additionally, factors related to the donor may also impact the transmission outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Nathalie Chavarot, Juliette Gueguen, Guillaume Bonnet, Mariam Jdidou, Antonin Trimaille, Carole Burger, Lucile Amrouche, Orianne Weizman, Thibaut Pommier, Olivier Aubert, Joffrey Celier, Rebecca Sberro-Soussan, Laura Geneste, Vassili Panagides, Michel Delahousse, Wassima Marsou, Claire Aguilar, Antoine Deney, Julien Zuber, Charles Fauvel, Christophe Legendre, Delphine Mika, Theo Pezel, Dany Anglicheau, Willy Sutter, Mohamad Zaidan, Renaud Snanoudj, Ariel Cohen, Anne Scemla
Summary: This study aimed to compare the outcomes of kidney transplant recipients and non-transplant patients in terms of survival and severity of COVID-19. The findings suggest that the severity of COVID-19 in kidney transplant recipients is related to their associated comorbidities and not to chronic immunosuppression.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Robin K. Avery, Jennifer D. Motter, Kyle R. Jackson, Robert A. Montgomery, Allan B. Massie, Edward S. Kraus, Kieren A. Marr, Bonnie E. Lonze, Nada Alachkar, Mary J. Holechek, Darin Ostrander, Niraj Desai, Madeleine M. Waldram, Shmuel Shoham, Seema Mehta Steinke, Aruna Subramanian, Janet M. Hiller, Julie Langlee, Sheila Young, Dorry L. Segev, Jacqueline M. Garonzik Wang
Summary: Desensitization for incompatible living donor kidney transplantation increases the risk of infections, especially in highly desensitized recipients, leading to prolonged hospitalization and graft loss. Strategies are needed to protect patients from recurrent infections and extend the survival benefit of ILDKT.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Pavithra Natarajan, Shawn R. Lockhart, Sridhar Basavaraju, Shweta Anjan, Mark D. Lindsley, Martina M. McGrath, David H. Oh, Brendan R. Jackson
Summary: Cryptococcus gattii infection, a rare but severe pulmonary disease and meningoencephalitis, recently emerged in the southeastern United States. An organ transplant-related outbreak involved an immunosuppressed donor and three recipients, with positive CrAg testing in the donor. Two recipients developed severe infection, resulting in one death and one survival following treatment for cryptococcal meningitis. The outbreak highlights the importance of considering cryptococcosis in patients with clinical findings suggestive of CNS pathology and the potential benefit of routine pre-transplant donor CrAg screening.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Ivy Melgarejo, Dana Jorgensen, Sundaram Hariharan, Chethan M. Puttarajappa
Summary: A strategy of bimonthly CMV screening was effective in monitoring high-risk CMV kidney transplant recipients, with higher adherence associated with lower viral counts at diagnosis and a trend towards lower risk of CMV-related hospitalization.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
David Cucchiari, Natalia Egri, Marta Bodro, Sabina Herrera, Jimena Del Risco-Zevallos, Joaquim Casals-Urquiza, Frederic Cofan, Asuncion Moreno, Jordi Rovira, Elisenda Banon-Maneus, Maria J. Ramirez-Bajo, Pedro Ventura-Aguiar, Anna Perez-Olmos, Marta Garcia-Pascual, Mariona Pascal, Anna Vilella, Antoni Trilla, Jose Rios, Eduard Palou, Manel Juan, Beatriu Bayes, Fritz Diekmann
Summary: The study on 148 kidney transplant recipients showed that the mRNA SARS-CoV-2 vaccine elicited either cellular or humoral response in 65.0% of the patients. Approximately 20.9% of patients were considered to have prior immunization against SARS-CoV-2, while 79.1% were deemed naïve to the virus.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Alicja Sadowska-Klasa, Wendy M. Leisenring, Ajit P. Limaye, Michael Boeckh
Summary: A systematic review of randomized and observational studies from 2013-2023 indicated that antiviral preemptive therapy initiated at cytomegalovirus viral load thresholds between 2 and 3 log10 IU/mL had comparable cytomegalovirus disease rates. Thus, viral thresholds within this range appeared to effectively safeguard patients who did not receive prophylaxis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Surgery
Gaurav Gupta, Idris Yakubu, Yiran Zhang, Pamela Kimball, Le Kang, Kimberly Mitchell, Stephen Ijioma, Norman Carroll, Julie Patterson, Meagan Shinbashi, Dhiren Kumar, Irfan Moinuddin, Layla Kamal, Anne King, Chandra Bhati, Marlon Levy, Adrian Cotterell, Aamir Khan, Amit Sharma, Richard Sterling
Summary: Trials of short-course DAAs for HCV transmission in kidney transplant recipients showed promising results in reducing transmission rates, with all cases of transmission achieving sustained virologic response after full-course therapy. However, cost and access to treatment remain potential barriers to real-world application.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Patricia Suarez-Fernandez, Alberto Utrero-Rico, Virginia Sandonis, Estefani Garcia-Rios, Daniel Arroyo-Sanchez, Mario Fernandez-Ruiz, Amado Andres, Natalia Polanco, Cecilia Gonzalez-Cuadrado, Patricia Almendro-Vazquez, Pilar Perez-Romero, Jose Maria Aguado, Estela Paz-Artal, Rocio Laguna-Goya
Summary: Primary CMV infection/reactivation in kidney transplant recipients may lead to rejection and mortality. T follicular helper cells (TFH) could play a protective role against CMV, with circulatory TFH (cTFH) levels affecting CMV infection rates. Monitoring cTFH levels pre- and post-transplant could improve CMV risk stratification and benefit high-risk patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Maria Magicova, Martina Fialova, Ivan Zahradka, Silvie Rajnochova-Bloudickova, David Hackajlo, Petr Raska, Ilja Striz, Ondrej Viklicky
Summary: Kidney transplant recipients show a lower anti-SARS-CoV-2 IgG seroprevalence compared to healthcare workers, with those who had SARS-CoV-2 infection being younger and more likely to receive CNI-based immunosuppression. Interestingly, kidney transplant recipients had higher levels of anti-SARS-CoV-2 IgG antibodies compared to healthcare workers, with the presence of moderate to severe symptoms being the main factor affecting IgG levels in kidney transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Mehdi Maanaoui, Dulciane Baes, Aghiles Hamroun, Kahina Khedjat, Fanny Vuotto, Emmanuel Faure, Benjamin Lopez, Sebastien Bouye, Thomas Caes, Arnaud Lionet, Celine Lebas, Francois Provot, Francois Glowacki, Jean-Baptiste Gibier, Remi Lenain, Marc Hazzan
Summary: This study found that acute graft pyelonephritis is associated with graft failure in kidney transplant recipients, but not with mortality or acute rejection. Recurrent AGPN does not appear to have an additional detrimental impact on graft loss.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Camille Lanaret, Dany Anglicheau, Vincent Audard, Mathias Buchler, Sophie Caillard, Lionel Couzi, Paolo Malvezzi, Laurent Mesnard, Dominique Bertrand, Franck Martinez, Vincent Pernin, Didier Ducloux, Coralie Poulain, Antoine Thierry, Arnaud Del Bello, Jean P. Rerolle, Clarisse Greze, Charlotte Uro-Coste, Julien Aniort, Celine Lambert, Nicolas Bouvier, Betoul Schvartz, Nicolas Maillard, Johnny Sayegh, Julie Oniszczuk, Marie-Pascale Morin, Christophe Legendre, Nassim Kamar, Anne E. Heng, Cyril Garrouste
Summary: The combination of RTX with SOC can improve treatment outcomes without increasing the risk of infection after kidney transplantation. RTX can be used in cases of SOC failure or remission for early discontinuation of PP.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Ilkka Helantera, Mika Gissler, Ruska Rimhanen-Finne, Niina Ikonen, Mari Kanerva, Marko Lempinen, Patrik Finne
Summary: Compared to the general population, kidney transplant recipients have a significantly higher risk of laboratory-confirmed influenza, with incidence increased fivefold, and more than fourfold risk of hospitalization due to influenza. The impact of influenza on transplant recipients is substantial.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Immunology
Sukhdeep S. Jatana, Hedi Zhao, Laurine M. Bow, Emanuele Cozzi, Ibrahim Batal, Tillie Horak, Alexandre Amar-Zifkin, Carrie Schinstock, Medhat Askar, Darshana M. Dadhania, Matthew Cooper, Maarten Naesens, Edward S. Kraus, Ruth Sapir-Pichhadze
Summary: This study systematically assessed the definition and prognostic implications of HLA incompatibility in transplant outcomes, finding heterogeneity in the definition and incomplete reporting of variables. The risk of bias in studies examining the association between death-censored graft failure and HLA incompatibility was high. Therefore, optimizing HLA compatibility assessment and standardizing the reporting of variables are necessary for improving transplant outcomes and promoting international collaboration.
Review
Surgery
Ronald F. Parsons, Ekamol Tantisattamo, Wisit Cheungpasitporn, Arpita Basu, Yee Lu, Krista L. Lentine, Kenneth J. Woodside, Neeraj Singh, Joseph Scalea, Tarek Alhamad, Ty B. Dunn, Franco H. Cabeza Rivera, Sandesh Parajuli, Martha Pavlakis, Matthew Cooper
Summary: Well-selected patients with kidney disease and diabetes mellitus who undergo simultaneous kidney-pancreas transplantation often experience improved quality of life and long-term survival. Frailty has become increasingly important in the pancreas transplant candidate and recipient populations. This review discusses the risk factors, measurement, outcomes, and interventions related to frailty in pancreas transplant patients.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Brian K. Lindner, Shahzia A. Lakhani, Matthew Cooper, Brian M. Nguyen, Gayle Vranic, Soo Y. Yi, Peter Abrams
Summary: Implementation of a multimodal, multidisciplinary pain management protocol significantly reduced opioid use in patients after pancreatic transplantation. The combination of non-opioid analgesics, patient education, and discharge planning may be beneficial in pain management for pancreatic transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Beatrice P. Concepcion, Meera Harhay, Jay Ruterbories, Jan Finn, Alex Wiseman, Matthew Cooper, Sumit Mohan, Mona D. Doshi
Summary: Organ procurement organizations (OPOs) in the United States face barriers in obtaining kidney biopsies and pumping due to lack of available staff and transportation. Moreover, the new allocation system has worsened transportation challenges, increased provisional acceptances of kidneys, and communication challenges with transplant centers, and worsened the efficiency of organ allocation. OPOs suggest making transplant centers more accountable, developing reliable transportation options, and removing the requirement for national sharing.
CLINICAL TRANSPLANTATION
(2023)
Article
Biology
Luke T. Slater, John A. Williams, Paul N. Schofield, Sophie Russell, Samantha C. Pendleton, Andreas Karwath, Hilary Fanning, Simon Ball, Robert Hoehndorf, Georgios V. Gkoutos
Summary: Annotation of biomedical entities with ontology classes facilitates semantic analysis and utilization of background knowledge. We have developed a new tool called Klarigi, which introduces multiple scoring heuristics to identify compositional and discriminatory classes for annotated entity groups. Klarigi utilizes semantic inference, classification, and significance testing to provide characteristic and explanatory explanations for biomedical datasets, offering a distinct perspective compared to traditional enrichment methods.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Health Care Sciences & Services
Tanya Pankhurst, Laurie Lucas, Steve Ryan, Chris Ragdale, Helen Gyves, Louise Denner, Ian Young, Laura Rathbone, Anwar Shah, Deborah McKee, Jamie J. Coleman, Felicity Evison, Jolene Atia, David Rosser, Mark Garrick, Richard Baker, Suzy Gallier, Simon Ball
Summary: This study aims to describe the benefits of implementing electronic observation charting in intensive care units (ICU). The study evaluated error reduction, time-savings, and costs associated with the transition from paper to digital records. Staff opinions were assessed during the COVID-19 pandemic to determine the efficacy of the electronic system.
Article
Surgery
Caroline C. Jadlowiec, Benjamin Hippen, John Gill, Raymond Heilman, Darren Stewart, Kunam S. Reddy, Sumit Mohan, Alex Wiseman, Matthew Cooper
Summary: This article investigates the variation in attitudes and management of delayed graft function (DGF) in the field of kidney transplantation, revealing that DGF occurs at a rate of 20%-40% in most centers. Despite its commonality, only half of the centers reported having an established protocol to manage DGF. Kidney allograft biopsies were the only consistent management strategy observed, although the use of machine perfusion was also favored. The research suggests that sharing best practices, redefining terminology, establishing DGF dialysis guidelines, and improving access to machine perfusion across OPOs may help reduce discard and improve utilization of kidneys at risk for DGF.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Anjana Pillai, Elizabeth. C. C. Verna, Neehar. D. D. Parikh, Matthew Cooper, Carrie Thiessen, Julie Heimbach, Elisa. J. J. Gordon, Gonzalo Sapisochin, Nazia Selzner, Amit Mathur, Emily. R. R. Perito, Michelle Jesse, AnnMarie Liapakis, Vineeta Kumar
Summary: In October 2021, the American Society of Transplantation (AST) held a virtual consensus conference to address barriers preventing the expansion of living donor liver transplantation (LDLT) in the United States. A multidisciplinary group of experts identified financial implications on donors, crisis management, policies and regulations, and ethical considerations as significant barriers. They proposed strategies to overcome these barriers and highlighted the importance of donor safety and the need for appropriate crisis management plans in transplant programs.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Charat Thongprayoon, Pradeep Vaitla, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Prakrati C. Acharya, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: This study characterized kidney retransplant recipients into three distinct clusters using an unsupervised machine-learning approach. The clusters had different patient and graft survival outcomes. The findings suggest opportunities for improvement in the kidney retransplantation process, particularly for recipients with moderate allosensitization.
CLINICAL TRANSPLANTATION
(2023)
Article
Immunology
Garrett R. Roll, Robert A. Bray, Matthew Cooper, Todd N. Eagar, Howard M. Gebel, Gayle M. Vranic, Kelley M. K. Hitchman, Julie Houp, Malek Kamoun, John Killian, Jim Kim, Vineeta Kumar, Matthew Levine, Brendan P. Lovasik, Tyler Lunow-Luke, Ronald F. Parsons, Vikram Pattanayak, Daniel Ranch, Anushi Shah, Peter G. Stock, Olga A. Timofeeva, Jennifer Trofe-Clark, Chelsey Wongjirad, Heidi Yeh, Stephanie Yi, Raja Rajalingam
Summary: Infection or vaccination with SARS-CoV-2 does not increase the specificities and strength of HLA antibodies in the majority of cases and sensitized patients, indicating minimal impact on organ transplantation.
Article
Medicine, General & Internal
Justin D. Smith, Akansha Agrawal, Catherine Wicklund, Debra Duquette, John Friedewald, Luke V. Rasmussen, Jessica Gacki-Smith, S. Darius Tandon, Lutfiyya N. Muhammad, Clyde W. Yancy, Siyuan Dong, Matthew Cooper, Alexander Gilbert, Aneesha Shetty, Elisa J. Gordon
Summary: This study aims to evaluate the impact of culturally competent APOL1 testing, chatbot, and counseling on decisional conflict, decision preparedness, willingness to donate, and satisfaction with informed consent among living kidney donor candidates. It also aims to longitudinally assess the implementation of this intervention in clinical practice using the RE-AIM framework.
Article
Health Care Sciences & Services
Charat Thongprayoon, Jing Miao, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: Using unsupervised machine learning, the study identified three clinically distinct clusters of recipients in diabetic deceased donor kidney transplants with differing outcomes. The findings highlight opportunities to improve utilization of high KDPI kidneys from diabetic donors for recipients with survival-limiting comorbidities, as observed in Cluster 1.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Charat Thongprayoon, Jing Miao, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Pradeep Vaitla, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: The aim of this study was to categorize highly sensitized kidney transplant recipients based on pre-transplant panel reactive antibody (PRA)= 98% using unsupervised machine learning. The study found two distinct clusters with different post-transplant outcomes, highlighting the importance of individualized management strategies for these vulnerable recipients.
MEDICINA-LITHUANIA
(2023)
Article
Surgery
Caroline C. Jadlowiec, Charat Thongprayoon, Supawit Tangpanithandee, Rachana Punukollu, Napat Leeaphorn, Matthew Cooper, Wisit Cheungpasitporn
Summary: Unsupervised machine learning identified two clinically distinct clusters among deceased donor kidney transplant recipients with prolonged CIT, highlighting differences in patient and donor characteristics and outcomes. Despite differences, both clusters showed good survival rates, providing opportunities for transplant centers to explore ways to increase CIT.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Charat Thongprayoon, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: This study used a machine learning approach to cluster very elderly kidney transplant recipients into three distinct categories and evaluated their post-transplant outcomes. The results showed that different categories had different clinical characteristics and post-transplant outcomes.
BMJ SURGERY INTERVENTIONS & HEALTH TECHNOLOGIES
(2023)
