Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
Volume 181, Issue 2, Pages 262-268Publisher
WILEY
DOI: 10.1002/ajmg.c.31696
Keywords
association studies; East Asian; genetic susceptibility; population differences; systemic lupus erythematosus
Categories
Funding
- Chinese Precision Medicine Project on autoimmune diseases [2017YFC0909001]
- General Research Fund, Hong Kong [17125114, 17146616]
- National Natural Science Foundation of China [81801636]
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Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with extreme clinical heterogeneity and significant differences between populations. East Asian populations are known to have higher prevalence and more severe clinical manifestations for SLE than Europeans. The difference could be the result of genetic and environmental factors, and the interactions between them. Thus, identifying genetic associations from diverse populations provides an opportunity to better understand the genetic architecture of this heterogeneous disease. It is also necessary to elucidate population differences and to apply the findings in future stratified treatment of the disease, with ethnicity likely a major factor to consider. Indeed, it has shown that there are significant differences between East Asians and European populations in several genetic loci for SLE. Genetic studies on SLE are very active in East Asian countries and there have been close collaborations among scientists in this region. Here, we document some work done in this region on SLE genetic research and discuss the aspect of population differences.
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