Article
Multidisciplinary Sciences
Mitchell G. Bryski, Lydia G. Frenzel-Sulyok, E. James Delikatny, Charuhas Deshpande, Leslie A. Litzky, Sunil Singhal
Summary: The development and validation of a molecular imaging capable cryostat called Smart-Cut was reported, showing that it can accurately identify cancer cells in frozen tissue sections in a murine model and clinical application. With a small footprint, Smart-Cut proved to be effective in detecting lesions and providing valuable information for surgical oncology.
Article
Oncology
Huanyu Zhao, Yudie Lu, Jingrong Zheng, Yuyao Xie, Qingchang Li
Summary: This article presents a rare case of primary thyroid PGL and highlights its distinct characteristics in frozen section analysis. Proper diagnostic and differential diagnostic management strategies are recommended.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Amanda Marsch, Rita Khodosh, Martina Porter, Jason H. Raad, Sara Samimi, Brittney Schultz, Lindsay Chaney Strowd, Laura Vera, Emily Wong, Gideon P. Smith
Summary: This article outlines the steps and methods for quality improvement in medicine, emphasizing the importance of teamwork and core principles, as well as how to embed improvements into the healthcare system.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Oncology
Mark L. Urken, Jun Yun, Michael P. Saturno, Lily A. Greenberg, Raymond L. Chai, Kayvon Sharif, Margaret Brandwein-Weber
Summary: Frozen section remains the gold standard for intraoperative pathological evaluation of surgical margins in head and neck specimens. However, there is a lack of standardization and debates regarding the role and method of intraoperative pathological consultation. This review summarizes the historical and contemporary practice of frozen section analysis and margin mapping in head and neck cancer, and introduces 3D scanning as a groundbreaking technology to improve the workflow for intraoperative frozen section analysis.
Article
Gastroenterology & Hepatology
Richard Zheng, Jillian Bonaroti, Beverly Ng, Geetha Jagannathan, Wei Jiang, Harish Lavu, Charles J. Yeo, Jordan M. Winter
Summary: The study found that intraoperative frozen section (IFS) during pancreaticoduodenectomy is highly accurate in determining histological malignancy, with a sensitivity of 97.2% and specificity of 95.3%. Positive resection margins were the key factor in predicting revised resection, while selective omission of IFS may be justified in cases of suspected benign disease.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Pathology
Rachel Jug, Adam L. Booth, Anne F. Buckley, Jordan Newell, Joshua Kesterson, Jerad M. Gardner, Lerna Ozcan, Beiyu Liu, Cynthia L. Green, Lija Joseph, Thomas J. Cummings
Summary: Patients benefited from personalized clinical encounters with pathologists in improving their understanding of their health condition and their satisfaction with their care experience. Most patients found it important to learn as much as possible about their health condition, although some faced difficulty despite having completed high school and/or further education. Patients rated their pathologists highly in terms of communication metrics.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Clinical Neurology
Johanna Waltraud Anita Harms, Eileen Maria Susanne Streckert, Nora Maren Kiolbassa, Christian Thomas, Oliver Grauer, Michael Oertel, Hans Theodor Eich, Walter Stummer, Werner Paulus, Benjamin Brokinkel
Summary: This study compared frozen section pathology (FSP) with final diagnosis in surgeries for glioma-suspicious lesions. Diagnostic shift occurred in 18% of cases, with FSP showing high sensitivity but moderate negative predictive value. Repeated sampling may increase accuracy, and diagnostic shift rarely alters postoperative treatment strategy.
NEUROSURGICAL REVIEW
(2023)
Article
Medical Laboratory Technology
Rahaf Alkhateb, Preethi Dileep Menon, Hamza Tariq, Sarah Hackman, Alia Nazarullah, Daniel D. Mais
Summary: This study assessed the accuracy of frozen section analysis in patients with clinically suspected AIFRS, showing a sensitivity of 88.5% and specificity of 100%. These findings are valuable for guiding intraoperative decision-making.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Joshua Kong, Sudeshna Bandyopadhyay, Wei Chen, Faisal Al-Mufarrej, Lydia Choi, Mary A. Kosir
Summary: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer with a poor survival rate. Intraoperative frozen section analysis (FSA) can decrease the number of positive margins in IBC patients undergoing modified radical mastectomy (MRM), potentially reducing the need for re-operation, allowing immediate wound closure, and preventing delays in adjuvant radiation therapy.
Article
Oncology
Ze-Rui Zhao, Ying-Hong Yu, Zhi-Chao Lin, De-Hua Ma, Yao-Bin Lin, Jian Hu, Qing-Quan Luo, Gao-Feng Li, Chun Chen, Yu-Lun Yang, Jian-Cheng Yang, Yong-Bin Lin, Hao Long
Summary: This study aims to evaluate the performance of an artificial intelligence (AI) algorithm in assessing the malignancy and invasiveness of pulmonary nodules. The results show that the deep learning system based on a 3D convolutional neural network can discriminate malignant diseases in pulmonary nodules measuring no more than 3 cm, and has a high positive predictive value for invasive adenocarcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Pathology
Hiroshi Miyamoto
Summary: Intraoperative pathology consultation with frozen section assessment (FSA) plays a critical role in urological surgeries, providing key information for immediate decision-making. The evaluation of surgical margins during surgery is important, and further research is needed to determine the contribution of FSA to reducing the risk of final positive margins.
PATHOLOGY INTERNATIONAL
(2021)
Article
Surgery
J. I. Staubitz, I. Elmrich, P. B. Musholt, R. J. A. Camara, F. Watzka, H. Dralle, C. Sekulla, K. Lorenz, T. J. Musholt
Summary: The study indicates that intraoperative frozen section (iFS) analysis is useful for determining the appropriate surgical management of thyroid disease. Targeted use of iFS is associated with significantly higher sensitivity for detecting malignancy and significantly reduced necessity for completion surgery.
Article
Oncology
Tamaki Tamanuki, Maki Namura, Tomoyoshi Aoyagi, Sinichirou Shimizu, Tomoko Suwa, Hiroshi Matsuzaki
Summary: The combination of imprint cytology followed by frozen section for intraoperative margin assessment significantly reduces the positive margin rate. The false-positive rate decreased from 13.4% with imprint cytology alone to 2.5% when frozen section was added. The overall positive margin rate based on permanent sections was 2.9%.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Otorhinolaryngology
Ellen S. Deutsch, Sonya Malekzadeh, Cecelia E. Schmalbach
Summary: Simulation training plays a significant role in ensuring patient safety and quality improvement in OTO-HNS, extending beyond resident training to team-based learning. Part III provides an overview of simulation in medicine and its specific applications in the field of OTO-HNS, presenting evidence-based impact assessments and outlining steps for developing simulation programs focused on PS/QI with future opportunities.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Urology & Nephrology
Lorenzo Bianchi, Francesco Chessa, Andrea Angiolini, Laura Cercenelli, Simone Lodi, Barbara Bortolani, Enrico Molinaroli, Carlo Casablanca, Matteo Droghetti, Caterina Gaudiano, Angelo Mottaran, Angelo Porreca, Rita Golfieri, Daniele Romagnoli, Francesca Giunchi, Michelangelo Fiorentino, Pietro Piazza, Stefano Puliatti, Stefano Diciotti, Emanuela Marcelli, Alexandre Mottrie, Riccardo Schiavina
Summary: The novel technique of using augmented reality three-dimensional (AR-3D) models for intraoperative frozen section (IFS) analysis may help reduce positive surgical margins (PSMs) at the level of the index lesion during robot-assisted radical prostatectomy.
