Article
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Congzhen Wang, Xiucai Fang
Summary: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders that often overlap with each other. The pathogenesis of these disorders is complex, involving various factors, with limited studies focusing on the inflammatory mechanism in patients with overlap syndrome of IBS-FD.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Gastroenterology & Hepatology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Kwangwoo Nam, Nayoung Kim, Hyun Joo Song, Gwang Ho Baik, Suck Chei Choi, Hyun Jin Kim, Ju Yup Lee, Kyung Sik Park, Sun-Young Park, Seun Ja Park
Summary: The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe upper gastrointestinal symptoms and depression compared to non-overlap patients. Women with FD-IBS overlap experience more severe gastrointestinal and depression symptoms than men.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Simon Keely, Gerald Holtmann, Nicholas J. Talley
Summary: The study found that both IBS and FD, along with most of their major subtypes, are associated with a range of sleep disturbances. These sleep problems are unlikely to be explained by psychological factors and may play an independent role in the pathophysiology.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Letter
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This article is connected to Marasco et al papers. To view these articles, visit and...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Chunmei Wang, Yue Yin, Le Wang, Xiaozhong Guo, Lu Liu, Xingshun Qi
Summary: This study found that Helicobacter pylori infection is associated with an increased risk of irritable bowel syndrome (IBS) and that H. pylori eradication treatment can improve IBS symptoms.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Tadayuki Oshima, Kewin Tien Ho Siah, Takanori Yoshimoto, Ko Miura, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
Summary: This study investigated the impact of the COVID-19 pandemic on gastrointestinal and psychological symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS). Results showed that during the pandemic, respondents with FD-IBS overlap syndrome had the worst symptoms, followed by IBS-alone and FD-alone respondents. 11.9% reported deterioration and 2.8% reported improvement of gastrointestinal symptoms.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Michael P. Jones, Ayesha Shah, Marjorie M. Walker, Natasha A. Koloski, Gerald Holtmann, Nicholas J. Talley
Summary: This study found that there is an overlap between irritable bowel syndrome (IBS), functional dyspepsia (FD), and heartburn (GERD), which is considered as a distinct entity with features of psychological morbidity, sleep disturbance, and elevated rates of atopy.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Surgery
Judith J. de Jong, Carmen S. S. Latenstein, Djamila Boerma, Eric J. Hazebroek, David Hirsch, Joost T. Heikens, Joop Konsten, Fatih Polat, Marten A. Lantinga, Cornelis J. H. M. van Laarhoven, Joost P. H. Drenth, Philip R. de Reuver
Summary: This study investigated the prevalence of FD and IBS in patients eligible for cholecystectomy and their association with resolution of biliary colic and pain-free state. The results showed that one third of eligible patients had FD/IBS, and only a few patients experienced biliary colic after cholecystectomy, while nonbiliary abdominal pain persisted in over 40% of patients, especially those with pre-existing FD/IBS.
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Antonina Mikocka-Walus, Yan Yiannakou, Lesley A. Houghton, Christopher J. Black, Alexander C. Ford
Summary: The prognosis of individuals with Rome IV-defined IBS worsens according to incremental increases in psychological comorbidity. This finding has significant implications for clinical practice and research.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Yamini S. Yadav, Guy D. Eslick, Nicholas J. Talley
Summary: Symptoms of IBS fluctuate over time with a portion experiencing resolution and new cases developing; significant movement between subtypes of IBS, with IBS-M group being the least stable; fluctuations in intestinal immune activity may explain symptom variability over time.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Gastroenterology & Hepatology
Mohamed G. Shiha, Imran Aziz
Summary: Patients with irritable bowel syndrome commonly have various extraintestinal complaints, such as anxiety, depression, and fibromyalgia. The presence of comorbidities poses a diagnostic and therapeutic challenge, leading to unnecessary investigations and interventions, including surgery. Shared pathophysiological mechanisms and potential management strategies are discussed in this review.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Christopher J. Black, Yan Yiannakou, Elspeth Guthrie, Robert West, Lesley A. Houghton, Alexander C. Ford
Summary: The study conducted a longitudinal follow-up on IBS patients, finding that cluster membership stratified according to psychological burden was more stable and predictive of disease course. Those with high psychological burden at baseline had more severe symptoms, received more treatments, and were more likely to consult a doctor.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Zachary E. McPherson, Henrik T. Sorensen, Erzsebet Horvath-Puho, Ashish Agar, Minas T. Coroneo, Andrew White, Ian C. Francis, Louis R. Pasquale, Jae H. Kang, Sven Pettersson, Nicholas J. Talley, Mark A. McEvoy
Summary: Two large European cohort studies suggest that individuals with irritable bowel syndrome (IBS) may have an increased risk of developing glaucoma.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Erin R. Shanahan, Seungha Kang, Heidi Staudacher, Ayesha Shah, Anh Do, Grace Burns, Veronique S. Chachay, Natasha A. Koloski, Simon Keely, Marjorie M. Walker, Nicholas J. Talley, Mark Morrison, Gerald J. Holtmann
Summary: This study indicates a link between duodenal microbiota, gastric emptying, and FD symptoms, and this link is largely independent of long-term dietary intake.
Article
Gastroenterology & Hepatology
Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Michael Horowitz, Gerald Holtmann, Nicholas J. Talley
Summary: Diabetes is an independent risk factor for an increased frequency of gastrointestinal symptoms, adjusting for lifestyle and psychological factors.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Michelle Bosman, Fabienne Smeets, Sigrid Elsenbruch, Jan Tack, Magnus Simren, Nicholas Talley, Bjorn Winkens, Ad Masclee, Daniel Keszthelyi
Summary: This study conducted a systematic review and meta-analysis to investigate the placebo response in pharmacological trials for functional dyspepsia (FD). The study found that the pooled placebo response rate ranged from 35.5% to 39.6% depending on the responder definition used. Lower baseline symptom scores were significantly associated with higher placebo response rates. The study suggests considering entry criteria based on symptom severity and separate reporting of core FD symptoms in future trials.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
M. H. Simon, P. E. Heenan, C. Frampton, S. Bayer, J. Keenan, de N. K. Boer, N. C. Roy, N. J. Talley, R. B. Gearry
Summary: This study examines the association between functional gastrointestinal disorders (FGIDs) and depression and anxiety, and identifies the covariates influencing this association. The study finds that economic standard of living, pain, and IBS phenotype are significant independent factors associated with depression and anxiety in FGID cases.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Michael P. Jones, Gerald Holtmann
Summary: Placebo responses provide insights into mechanisms beyond the intervention and affect the potential efficacy of new interventions in clinical trials. This mini-review discusses the systematic review and meta-analysis conducted by Bosman and colleagues on placebo response in functional dyspepsia clinical trials. It also explores potential mechanisms of placebo response in the context of brain-gut interaction disorders and extra-gastrointestinal disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Adam I. I. Kaplan, Yoav Mazor, Gillian M. M. Prott, Carol Sequeira, Michael P. Jones, Allison Malcolm
Summary: Recent community-based studies have found that having multiple concurrent functional gastrointestinal disorders (FGIDs) is associated with increased somatization, worse quality of life (QoL), and greater healthcare utilization. However, the presence of multiple overlapping FGIDs specifically in chronic constipation and functional defecation disorders (FDD) has not been studied. This study investigated the prevalence and impact of additional nonconstipation FGIDs on constipation severity, anorectal physiology, anxiety and depression, and QoL in patients with chronic constipation and FDD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Nick Goelen, Mike Jones, I-Hsuan Huang, Florenca Carbone, Pieter Janssen, Jan Tack
Summary: Gastroparesis and functional dyspepsia are disorders characterized by upper gastrointestinal symptoms and multifaceted etiologies. The association between symptom improvement and acceleration of gastric emptying (GE) by prokinetic agents is not clear. This meta-analysis aimed to provide a transparent update on the association between symptom improvement and GE acceleration in patients with gastroparesis.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Letter
Gastroenterology & Hepatology
Lucas Wauters, Paul R. Harris, Marjorie M. Walker, Carolina A. Serrano, Andrea Villagran, Gurpreet S. Rakhra, Jean E. Crabtree, Nicholas J. Talley
Summary: This article is connected to the paper by Broeders et al. To access this article, visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Allergy
Grace L. Burns, Simon Keely
Summary: This article evaluates the contribution of local enteric neuroimmune interactions to the immune response in food allergies, and discusses considerations for targeting neuroimmune pathways in the treatment of food allergies.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Brandon Stretton, Joshua Kovoor, Stephen Bacchi, Shantel Chang, Benjamin Ngoi, Tess Murray, Thomas C. Bristow, Jonathan Heng, Aashray Gupta, Christopher Ovenden, Guy Maddern, Campbell H. Thompson, Leonie Heilbronn, Mark Boyd, Christopher Rayner, Nicholas J. Talley, Michael Horowtiz
Summary: This review summarizes the direct comparisons between subcutaneous semaglutide and other GLP-1 RAs in individuals with type 2 diabetes, focusing on their efficacy for inducing weight loss and improving metabolic health markers. Five studies which fulfilled the inclusion criteria were identified. Randomized trials support the superior efficacy of semaglutide over other GLP-1 RAs in terms of weight loss, but tirzepatide is more effective than semaglutide.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Veterinary Sciences
Leandro Abreu da Fonseca, Fabiano Montiani-Ferreira, Jeny Soto, Michael P. Jones, Nancy Zagaya, Carolyn Cray
Summary: This study compared agarose gel electrophoresis (AGE) and capillary zone electrophoresis (CZE) methods and determined reference intervals for CZE using plasma from bald eagles. The results showed that these two methods are not equivalent, and CZE demonstrated better resolution and reproducibility for protein fraction quantitation.
VETERINARY CLINICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Raquel Cameron, Marjorie M. Walker, Michael Jones, Guy D. Eslick, Simon Keely, Peter Pockney, Carolina C. Cosentino, Nicholas J. Talley
Summary: This study examined the changes of eosinophils and other immune cells in the mucosa of colonic diverticula through quantitative histology. The results showed a significant increase in eosinophil counts at the base and neck of the diverticula. These findings provide new clues for understanding the role of eosinophils and chronic inflammation in the pathophysiology of colonic diverticulosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Psychiatry
Anastasia Ejova, Michael P. Jones, Alissa P. Beath, Sarah L. Mckerchar, Akiko Okifuji
Summary: There is evidence that people with both fibromyalgia and functional gastrointestinal disorders experience more severe psychological symptoms. Using Ecological Momentary Assessment (EMA), this study found that for individuals with fibromyalgia, accompanying GI symptoms lead to stronger bidirectional relationships between distress and bodily pain or fatigue.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Marguerite J. Kutyla, Jessica J. McMaster, Adam Haig, Natasha Koloski, Luke Hourigan, Vera Meeusen, Ayesha Shah, Nicholas J. Talley, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to develop and validate a patient-reported experience measure for GI endoscopy. The Comprehensive Endoscopy Satisfaction Tool captures relevant domains that influence the patient's experience and identifies factors that shape satisfaction. The tool was tested in a large number of patients and found to be valid and responsive.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)