Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Adel Hajj Ali, Michael Nakhla, Leslie Cho, Raul Seballos, Richard Lang, Steve Feinleib, Scott Flamm, Paul Schoenhagen, Tom Wang, Milind Y. Desai
Summary: In this study, the risk reclassification provided by multiethnic study on subclinical atherosclerosis coronary artery calcium scoring (CACS) was compared with atherosclerotic cardiovascular disease (ASCVD) and Reynolds risk score (RRS) in a large screening program. The use of MESA-CACS, along with CACS distribution, resulted in significant reclassification of traditional scores, with RRS underestimating and ASCVD overestimating the cardiovascular disease risk.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Sport Sciences
Charles A. German, Jason Fanning, Matthew J. Singleton, Michael D. Shapiro, Peter H. Brubaker, Alain G. Bertoni, Joseph Yeboah
Summary: This study found that high levels of physical activity are negatively correlated with cardiovascular disease and all-cause mortality, indicating that high PA can reduce the risk of CVD and overall death. The research also suggests that even among individuals at high risk of CVD, high levels of PA do not pose additional risks.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Cardiac & Cardiovascular Systems
Omar Dzaye, Alexander C. Razavi, Zeina A. Dardari, Leslee J. Shaw, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Alan Rozanski, John A. Rumberger, Carl E. Orringer, Sidney C. Jr Jr Smith, Ron Blankstein, Seamus P. Whelton, Martin Bodtker Mortensen, Michael J. Blaha
Summary: This study aimed to determine the optimal age for a first CAC scan based on ASCVD risk factors, with the optimal age being 36.8 years in men and 50.3 years in women with diabetes, 42.3 years in men without risk factors, and 57.6 years in women without risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Miguel Cainzos-Achirica, Renato Quispe, Reed Mszar, Ramzi Dudum, Mahmoud Al Rifai, Raimund Erbel, Andreas Stang, Karl-Heinz Jockel, Nils Lehmann, Sara Schramm, Borge Schmidt, Peter P. Toth, Jamal S. Rana, Joao A. C. Lima, Henrique Doria de Vasconcellos, Donald Lloyd-Jones, Parag H. Joshi, Colby Ayers, Amit Khera, Michael J. Blaha, Philip Greenland, Khurram Nasir
Summary: This study assessed the ability of coronary artery calcium (CAC) to stratify ASCVD risk under three non-familial hypercholesterolemia PCSK9i allocation paradigms. The results showed that CAC=0 was associated with lower incident ASCVD rates, and CAC burden was independently associated with ASCVD events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Peripheral Vascular Disease
Ayman Haq, Michael D. Miedema
Summary: This review examines the prognostic significance and clinical utility of coronary artery calcium (CAC) for risk assessment of atherosclerotic cardiovascular disease (ASCVD) in younger adults. The findings suggest that CAC provides clear prognostic value in this population and can be considered in individuals with uncertainties about their ASCVD risk or the benefit of preventive therapies.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Joseph Rigdon, Matthew C. Tattersall, Charles A. German, Thomas A. Barringer, Parag H. Joshi, Laurence S. Sperling, Matthew J. Budoff, Alain Bertoni, Erin D. Michos, Michael J. Blaha, James H. Stein, Michael D. Shapiro
Summary: This study found that the presence and extent of carotid plaque were associated with long-term coronary heart disease risk and incident CAC in middle-aged asymptomatic individuals with initial CAC score of 0.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Wanda Y. Wu, David W. Biery, Adam N. Berman, Grace Hsieh, Sanjay Divakaran, Sumit Gupta, Michael L. Steigner, Ayaz Aghayev, Hicham Skali, Donna M. Polk, Jorge Plutzky, Christopher P. Cannon, Marcelo F. Di Carli, Ron Blankstein
Summary: CAC scoring can help identify prevention strategies for coronary heart disease patients and provide important guidance for patient management. Higher CAC scores are associated with increased medication use and lifestyle changes, while CAC = 0 is not. In patients with higher CAC scores, most are prescribed lipid-lowering therapies.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2022)
Article
Medicine, General & Internal
Dariusz Kalka, Jana Gebala, Malgorzata Biernikiewicz, Aneta Mrozek-Szetela, Krystyna Rozek-Piechura, Malgorzata Sobieszczanska, Ewa Szuster, Marzena Majchrowska, Anna Mietka, Agnieszka Rusiecka
Summary: This study investigated the impact of familial occurrence of CAD on the presence of ED and classic risk factors for ED in men with CAD. The findings showed that while familial CAD increased the incidence of certain risk factors for ED, it did not increase the incidence of ED itself.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michael J. Blaha, Isaac N. Naazie, Miguel Cainzos-Achirica, Zeina A. Dardari, Andrew P. DeFilippis, Robyn L. McClelland, Mohammadhassan Mirbolouk, Olusola A. Orimoloye, Omar Dzaye, Khurram Nasir, John H. Page
Summary: The study introduced the concept of coronary age as a more effective way to communicate coronary heart disease (CHD) risk to patients. By calculating an individual's coronary age based on MESA 10-year CHD risk score equations and coronary artery calcium (CAC), the study found that coronary age had similar predictive ability to MESA CHD Risk Score and outperformed chronological age and CAC alone in predicting CHD events. The newly derived coronary age could potentially help in routine risk communication between patients and clinicians.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Aamir Javaid, Zeina A. Dardari, Joshua D. Mitchell, Seamus P. Whelton, Omar Dzaye, Joao A. G. Lima, Donald M. Lloyd-Jones, Matthew Budoff, Khurram Nasir, Daniel S. Berman, John Rumberger, Michael D. Miedema, Todd C. Villines, Michael J. Blaha
Summary: This study investigated coronary artery calcium (CAC) in asymptomatic Black and White individuals aged 30-45 years and found that the prevalence of CAC >0 varied by age, sex, and race. The estimated percentiles from the study may assist in interpreting CAC scores and comparing them to age-sex-race matched peers.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Oncology
Kyle Wang, Hayley E. Malkin, Nicholas D. Patchett, Kevin A. Pearlstein, Hillary M. Heiling, Sean D. McCabe, Allison M. Deal, Panayiotis Mavroidis, Mary Oakey, Jeffrey Fenoli, Carrie B. Lee, J. Larry Klein, Brian C. Jensen, Thomas E. Stinchcombe, Lawrence B. Marks, Ashley A. Weiner
Summary: This study found that computed tomography (CT) coronary calcifications are associated with cardiac toxicity and can help ascertain baseline heart disease. The presence of coronary calcifications can identify high-risk patients and guide clinicians in taking measures before potentially cardiotoxic cancer treatments.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander C. Razavi, S. M. Iftekhar Uddin, Zeina A. Dardari, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Albert D. Osei, Olufunmilayo H. Obisesan, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee J. Shaw, Laurence S. Sperling, Seamus P. Whelton, Martin Bodtker Mortensen, Michael J. Blaha, Omar Dzaye
Summary: Coronary artery calcium (CAC) is associated with the risk of incident sudden cardiac death (SCD), particularly among primary prevention patients with low-intermediate risk. Stratification of SCD risk through CAC measurement can identify patients who are most likely to benefit from further downstream testing in the early stages of coronary heart disease (CHD).
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Albert D. Osei, Mohammadhassan Mirbolouk, Daniel Berman, Matthew J. Budoff, Michael D. Miedema, Alan Rozanski, John A. Rumberger, Leslee Shaw, Mahmoud Al Rifai, Omar Dzaye, Garth N. Graham, Maciej Banach, Roger S. Blumenthal, Zeina A. Dardari, Khurram Nasir, Michael J. Blaha
Summary: The study shows that coronary artery calcium scoring remains a strong predictor of cardiovascular disease mortality and coronary heart disease mortality in statin users, with a slightly different relationship between density and outcomes.
Article
Cardiac & Cardiovascular Systems
Garima Sharma, Pamela S. Douglas, Sharonne N. Hayes, Roxana Mehran, Anne Rzeszut, Robert A. Harrington, Athena Poppas, Mary Norine Walsh, Toniya Singh, Ranna Parekh, Roger S. Blumenthal, Laxmi S. Mehta
Summary: The study found a high global prevalence of HWE in cardiology, with women, Blacks, and North Americans being the most affected groups. HWE includes emotional harassment, discrimination, and sexual harassment, and has a negative impact on professional and patient interactions.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
David Feldman, Jacqueline Latina, Jana Lovell, Roger S. Blumenthal, Armin Arbab-Zadeh
Summary: The treatment of coronary artery disease focuses on managing symptoms and preventing cardiovascular events. Coronary CTA has emerged as the first line noninvasive imaging modality for evaluating coronary atherosclerosis, improving diagnostic accuracy and patient outcomes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Miguel Cainzos-Achirica, Dixitha Anugula, Reed Mszar, Gowtham Grandhi, Kershaw Patel, Marcio S. Bittencourt, Ron Blankstein, Michael J. Blaha, Roger S. Blumenthal, Kausik K. Ray, Deepak L. Bhatt, Khurram Nasir
Summary: The article discusses using the CAC score to enhance prognostic enrichment in RCTs of add-on therapies, with a focus on risk stratification and cost reduction. Various approaches are suggested to maximize the advantages of a CAC-based enrichment strategy in future RCTs.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Michael J. Blaha, Vijay Nambi, Steven J. C. Shea, Erin D. Michos, Roger S. Blumenthal, Christie M. Ballantyne, Moyses Szklo, Philip Greenland, Michael D. Miedema, Khurram Nasir, Jerome I. Rotter, Xiuqing Guo, Jie Yao, Wendy S. Post, Salim S. Virani
Summary: Current cigarette smoking, diabetes, and hypertension are independently associated with incident ASCVD over a 16-year follow-up among those with CAC=0.
Review
Cardiac & Cardiovascular Systems
Brent Gudenkauf, Allison G. Hays, Jacqueline Tamis-Holland, Jeffrey Trost, Daniel Ambinder, Katherine C. Wu, Armin Arbab-Zadeh, Roger S. Blumenthal, Garima Sharma
Summary: Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a complex disease requiring multiple imaging techniques for diagnosis. Cardiac magnetic resonance can exclude nonischemic causes and invasive coronary imaging can evaluate plaque formation and the presence of disruption or dissection. The application of noninvasive imaging techniques is also being studied.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Cardiac & Cardiovascular Systems
Carine E. Hamo, Lucia Kwak, Dan Wang, Roberta Florido, Justin B. Echouffo-Tcheugui, Roger S. Blumenthal, Laura Loehr, Kunihiro Matsushita, Vijay Nambi, Christie M. Ballantyne, Elizabeth Selvin, Aaron R. Folsom, Gerardo Heiss, Josef Coresh, Chiadi E. Ndumele
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Yaa A. Kwapong, Ellen Boakye, Olufunmilayo H. Obisesan, Lochan M. Shah, S. Michelle Ogunwole, Allison G. Hays, Roger S. Blumenthal, Andreea A. Creanga, Michael J. Blaha, Miguel Cainzos-Achirica, Khurram Nasir, Pamela S. Douglas, Xiaobin Wang, Garima Sharma
Summary: This study analyzed data from the Boston Birth Cohort on non-Hispanic Black, non-Hispanic White, and Hispanic women, and found disparities in preterm birth related to nativity and duration of U.S. residence. Foreign-born women had better cardiovascular risk profiles and lower odds of preterm birth in the non-Hispanic Black and Hispanic groups.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Oluseye Ogunmoroti, Olatokunbo Osibogun, Lena Mathews, Olumuyiwa A. Esuruoso, Chiadi E. Ndumele, Victor Okunrintemi, Gregory L. Burke, Roger S. Blumenthal, Matthew J. Budoff, Erin D. Michos
Summary: This study found that favorable cardiovascular health is associated with a lower risk of extracoronary atherosclerosis. These findings emphasize the importance of primordial prevention as an intervention to reduce the burden of cardiovascular disease.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Pharmacology & Pharmacy
Shiavax J. Rao, Seth Shay Martin, Shari M. Lawson, Tigist Hailu, Dorothy M. Davis, Khurram Nasir, Miguel Cainzos-Achirica, Roger S. Blumenthal, Garima Sharma
Summary: Pregnant women with gestational hypertension and/or preeclampsia have abnormal lipid profiles that contribute to the development of atherosclerosis. Changes in maternal lipids can promote atherogenesis through endothelial injury, and these alterations have been associated with adverse pregnancy outcomes and maternal morbidity and mortality. Statin therapies, with their effects on endothelial dysfunction, inflammation, and plaque stabilization, may be useful in the prevention and treatment of preeclampsia.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rishav Adhikari, Kunal Jha, Zeina Dardari, James Heyward, Roger S. Blumenthal, Robert H. Eckel, G. Caleb Alexander, Michael J. Blaha
Summary: While the use of SGLT2is and GLP-1RAs by cardiologists in the United States has increased significantly over a 6-year period, they still account for a small proportion of overall usage, leading to underutilization in the treatment of individuals with type 2 diabetes at high cardiovascular risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Hematology
Nadia R. Sutton, Rajeev Malhotra, Cynthia St. Hilaire, Elena Aikawa, Roger S. Blumenthal, Grace Gackenbach, Parag Goyal, Adam Johnson, Sagar U. Nigwekar, Catherine M. Shanahan, Dwight A. Towler, Brooke N. Wolford, Yabing Chen
Summary: Cardiovascular disease is the leading cause of death globally, particularly in individuals over the age of 65, with myocardial infarction and stroke being the primary contributors. The development of vascular aging and vascular calcification with aging is not fully understood, but is believed to be influenced by genetic risk, environmental factors, and the ability of vascular smooth muscle cells to acquire an osteogenic phenotype. Understanding the molecular mechanisms behind age-associated vascular pathology may lead to strategies for promoting healthy vascular aging. This article provides a summary of current knowledge on age-associated vascular disease, with a focus on vascular calcification.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gemma A. Figtree, Philip D. Adamson, Charalambos Antoniades, Roger S. Blumenthal, Michael Blaha, Matthew Budoff, David S. Celermajer, Mark Y. Chan, Clara K. Chow, Damini Dey, Girish Dwivedi, Nicola Giannotti, Stuart M. Grieve, Christian Hamilton-Craig, Bronwyn A. Kingwell, Jason C. Kovacic, James K. Min, David E. Newby, Sanjay Patel, Karlheinz Peter, Peter J. Psaltis, Stephen T. Vernon, Dennis T. Wong, Stephen J. Nicholls
Summary: Coronary artery disease (CAD) is the leading cause of adult mortality globally. Improvements in imaging techniques have provided a better understanding of different phenotypes of coronary atherosclerosis, which are associated with different risks for acute ischemic events. Noninvasive coronary imaging techniques have the potential to accelerate cardiovascular drug development and reduce costs and timelines.
Article
Cardiac & Cardiovascular Systems
Yaa A. Kwapong, Ellen Boakye, Sadiya S. Khan, Michael C. Honigberg, Seth S. Martin, Chigolum P. Oyeka, Allison G. Hays, Pradeep Natarajan, Mamas A. Mamas, Roger S. Blumenthal, Michael J. Blaha, Garima Sharma
Summary: Depression and poor mental health are associated with increased risk of cardiovascular disease and suboptimal cardiovascular health among young adults.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Christeen Samuel, Jihwan Park, Aparna Sajja, Erin D. Michos, Roger S. Blumenthal, Steven R. Jones, Seth S. Martin
Summary: This study compared the accuracy of 23 available LDL-C equations with ultracentrifugation measurement and found that most alternatives to the Friedewald equation have lower accuracy. The Martin/Hopkins equation demonstrated the highest accuracy overall and across subgroups.
