Journal
AGING CELL
Volume 18, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/acel.12929
Keywords
dynamin 1; endocytosis; miR-132; Tau
Categories
Funding
- National Natural Science Foundation of China [31571039, 31721002, 81761138043, 81771150, 81771492, 81829002, 81871108, 91632114]
- Academic Frontier Youth Team of Huazhong University of Science and Technology
- Top-Notch Young Talents Program of China of 2014
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Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced expression of human tau (hTau) in mouse cortical neurons impairs endocytosis by decreasing the level of the GTPase dynamin 1 via disruption of the miR-132-MeCP2 pathway; this process can also be detected in the brains of Alzheimer's patients and hTau mice. Our results provide evidence for a novel role of tau in the regulation of presynaptic function.
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