Lung-Endothelium-Targeted Nanoparticles Based on a pH-Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer

Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

(2018) Kalina Paunovska et al.   ACS Nano

Synergism between a cell penetrating peptide and a pH-sensitive cationic lipid in efficient gene delivery based on double-coated nanoparticles

(2018) Ikramy A. Khalil et al.   JOURNAL OF CONTROLLED RELEASE

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

An experimental study of menopause induced by bilateral ovariectomy and mechanistic effects of mesenchymal stromal cell therapy on the parotid gland of a rat model

(2018) Nesma Ibraheim El-naseery et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Optimization of siRNA delivery to target sites: issues and future directions

(2018) Ikramy A. Khalil et al.   Expert Opinion on Drug Delivery

PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA

(2017) Sarochin Santiwarangkool et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

(2016) Xinwei Cheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

(2016) Miriam Colombo et al.   Nature Communications

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Delivery of platinum(IV) drug to subcutaneous tumor and lung metastasis using bradykinin-potentiating peptide-decorated chitosan nanoparticles

(2014) Xin Wang et al.   BIOMATERIALS

An apolipoprotein E modified liposomal nanoparticle: Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells

(2014) Mina Tamaru et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors

(2014) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations

(2014) Zixiu Du et al.   Scientific Reports

Lipid Envelope-Type Nanoparticle Incorporating a Multifunctional Peptide for Systemic siRNA Delivery to the Pulmonary Endothelium

(2013) Kenji Kusumoto et al.   ACS Nano

Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: Interplay between nanostructure and composition

(2013) D. Pozzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

The effect of neutral helper lipids on the structure of cationic lipid monolayers

(2011) A. P. Dabkowska et al.   Journal of the Royal Society Interface

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma

(2010) Hiroto Hatakeyama et al.   ADVANCED DRUG DELIVERY REVIEWS

Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models

(2010) A. Santel et al.   CLINICAL CANCER RESEARCH

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression

(2010) H. DeLisser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

(2009) Akin Akinc et al.   MOLECULAR THERAPY