The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension

Three new case reports of Arteriovenous malformation-related Amyotrophic Lateral Sclerosis

(2018) Maria Chondrogianni et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis

(2018) Bastien Paré et al.   Scientific Reports

Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis

(2018) Elaheh Ekhtiari Bidhendi et al.   ACTA NEUROPATHOLOGICA

A standardized protocol for comparable analysis of GSH/GSSG by UHPLC-ESI-MSMS for human plasma

(2018) Anna-Sara Claeson et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis

(2018) Marcel Maier et al.   Science Translational Medicine

Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site

(2017) Morgan M. Fetherolf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Comprehensive analysis to explain reduced or increased SOD1 enzymatic activity in ALS patients and their relatives

(2017) Isil Keskin et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Dissecting Redox Biology Using Fluorescent Protein Sensors

(2016) Markus Schwarzländer et al.   ANTIOXIDANTS & REDOX SIGNALING

Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis

(2016) Nikolas Santamaria et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

(2016) Valentina Gallo et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis–like disease

(2016) Elaheh Ekhtiari Bidhendi et al.   JOURNAL OF CLINICAL INVESTIGATION

Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy

(2016) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel cases of amyotrophic lateral sclerosis after treatment of cerebral arteriovenous malformationss

(2016) M Linnebank et al.   SWISS MEDICAL WEEKLY

Mapping oxygen concentration in the awake mouse brain

(2016) Declan G Lyons et al.   eLife

Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

(2016) Isil Keskin et al.   PLoS One

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

(2015) Jacob I. Ayers et al.   ACTA NEUROPATHOLOGICA

The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation

(2015) Madhuri Chattopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis: Table 1

(2015) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping

(2015) Johan Bergh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental transmissibility of mutant SOD1 motor neuron disease

(2014) Jacob I. Ayers et al.   ACTA NEUROPATHOLOGICA

Neurotrophic Requirements of Human Motor Neurons Defined Using Amplified and Purified Stem Cell-Derived Cultures

(2014) Nuno Jorge Lamas et al.   PLoS One

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

(2014) Jacob I Ayers et al.   Acta Neuropathologica Communications

Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice

(2013) Lei Cao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Can lesions to the motor cortex induce amyotrophic lateral sclerosis?

(2013) Angela Rosenbohm et al.   JOURNAL OF NEUROLOGY

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells

(2013) M. W. Amoroso et al.   JOURNAL OF NEUROSCIENCE

Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS

(2012) Matthis Synofzik et al.   HUMAN MOLECULAR GENETICS

Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis

(2012) K. S. Graffmo et al.   HUMAN MOLECULAR GENETICS

Genetic analysis and SOD1 mutation screening in Iranian amyotrophic lateral sclerosis patients

(2012) Afagh Alavi et al.   NEUROBIOLOGY OF AGING

Composition of Soluble Misfolded Superoxide Dismutase-1 in Murine Models of Amyotrophic Lateral Sclerosis

(2012) Per Zetterström et al.   NEUROMOLECULAR MEDICINE

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

(2012) Edward Pokrishevsky et al.   PLoS One

Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS

(2012) T. E. Brotherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium

(2012) L. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis

(2011) Karin Forsberg et al.   ACTA NEUROPATHOLOGICA

Superoxide dismutases: Ancient enzymes and new insights

(2011) Anne-Frances Miller   FEBS LETTERS

Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients

(2011) Per Zetterström et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

A novel SOD1 splice site mutation associated with familial ALS revealed by SOD activity analysis

(2010) Anna Birve et al.   HUMAN MOLECULAR GENETICS

Superoxide dismutase-1 and other proteins in inclusions from transgenic amyotrophic lateral sclerosis model mice

(2010) Daniel Bergemalm et al.   JOURNAL OF NEUROCHEMISTRY

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients

(2010) Karin Forsberg et al.   PLoS One

Smoking and risk for amyotrophic lateral sclerosis: Analysis of the EPIC cohort

(2009) Valentina Gallo et al.   ANNALS OF NEUROLOGY

Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q†

(2009) Duane D. Winkler et al.   BIOCHEMISTRY

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

(2009) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Superoxide dismutase in amyotrophic lateral sclerosis patients homozygous for the D90A mutation

(2009) P. Andreas Jonsson et al.   NEUROBIOLOGY OF DISEASE

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis

(2008) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

(2008) M. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA