Article
Chemistry, Applied
Tian-Qi Zhou, Xue-Chen Wang, Ling-Yi Gao, Jia-Nan Yan, Hai-Tao Wu
Summary: This study investigated the synergetic gelation of curdlan gum (CG) and gellan gum (GG) at different ratios. The optimal gelation was achieved at a mass ratio of 1:1 and a total concentration of 0.6%. The gel properties were influenced by the CG/GG ratio, with the strongest gel observed at a ratio of 5:5. The improved gel properties were attributed to hydrogen bonds between CG and GG. The CG/GG binary composite gel exhibited increased water holding capacity as the CG/GG ratio decreased. Furthermore, the microstructure of the CG/GG gel was denser and more homogeneous, supporting its stronger gel rigidity and water holding capacity.
FOOD HYDROCOLLOIDS
(2024)
Article
Biochemistry & Molecular Biology
Joo Hee Choi, Soo In Kim, Jin Sol Seo, Normin-Erdene Tumursukh, Se Eun Kim, Seung Ho Choe, Seung Jae Kim, Sunjae Park, Jeong Eun Song, Gilson Khang
Summary: This study demonstrates the potential of tunable stress relaxing gellan gum hydrogel for enhanced cell growth and regenerative medicine. The researchers tuned the molecular weight and physical crosslinking density of the hydrogel and found that it showed active viability, proliferation, and remodeling of human-derived bone marrow stem cells. The hydrogel also had an enhanced release profile of growth factors and exosomes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Yulin Li, Xin Qi, Liyuan Rong, Jinwang Li, Mingyue Shen, Jianhua Xie
Summary: This study investigated the improvement of heat-induced pea protein isolate (PPI) gel using gellan gum (GG). The addition of GG significantly enhanced the gel strength, water holding capacity, and rheological properties of GG-PPI gels. Scanning electron microscopy revealed the promotion of a dense and homogeneous gel network structure by GG.
FOOD HYDROCOLLOIDS
(2024)
Article
Food Science & Technology
Juanjuan Wang, Xue Zhao, Changyu Zhou, Chong Wang, Yanyan Zheng, Keping Ye, Chunbao Li, Guanghong Zhou
Summary: The study aimed to investigate the properties and interaction mechanisms of the mixed-gel system containing gelatin (GL), gellan gum (GG), and inulin (IL). Results showed that addition of GG-IL improved the hardness, chewiness, and cohesiveness of the mixed-gel, while maintaining appropriate springiness. Water mobility of the mixed-gel decreased, viscoelasticity increased, and the melting temperature of the gel significantly increased at GG:IL = 2:8.
FOOD SCIENCE & NUTRITION
(2021)
Article
Chemistry, Applied
Kaoru Kohyama, Sayaka Ishihara, Makoto Nakauma, Takahiro Funami
Summary: This study aimed to investigate the effects of mechanical properties of soft food gels on breakability with the human tongue. The results suggest that fracture deformation of food gels alone is a more important factor for gel fracture during compression between the tongue and hard palate.
FOOD HYDROCOLLOIDS
(2021)
Article
Environmental Sciences
Nandakumar Selvasudha, Joseph PushpaSweety, Thekkila-Veedu Saranya, Kandasamy Ruckmani, Loganathan Gayathri
Summary: This study aimed to adapt a simple protein estimation method for detecting nisin and to formulate and evaluate site-specific nanoformulation for therapeutic applications. Among the three nanoformulations prepared and characterized, the one with gellan gum showed the best characteristics. Interaction and stability patterns were confirmed using FT-IR and DSC, and CD demonstrated the stability of nisin in an alkaline environment. The formulated gellan gum-nisin colloidal nanoparticles showed significant effectiveness against colon cancer cells and antimicrobial activity against Staphylococcus aureus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Lyda Halbaut, Victor Garcia-Torra, Marta Espina, Amanda Cano, Miren Ettcheto, Antoni Camins, Eliana B. Souto, Maria Luisa Garcia, Elena Sanchez-Lopez
Summary: A novel in situ gelling system dispersing RLZ-loaded nanoparticles has been successfully developed as an innovative neuroprotective strategy for potential topical treatment of glaucoma, achieving a more delayed distribution in the posterior eye segment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Agronomy
Roohallah Saberi-Riseh, Mojde Moradi-Pour
Summary: This study successfully developed a new formulation using microcapsules loaded with bacteria and nanoparticles on chitosan-gellan gum to control wheat take-all disease. The results showed that this formulation had high efficiency, promoting plant growth and improving soil health.
PEST MANAGEMENT SCIENCE
(2021)
Article
Chemistry, Medicinal
Ting Shen, Zijian Yang
Summary: The study demonstrated that the pemirolast potassium ocular in situ gels have good stability and sustained release ability, effectively suppressing inflammatory symptoms and improving drug bioavailability in the therapy of allergic conjunctivitis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Applied
K. M. Kanyuck, A. B. Norton-Welch, T. B. Mills, I. T. Norton
Summary: The study found that the mixed-gel of high acyl gellan gum and maltodextrin formed an interpenetrating network, combining soft and flexible properties with firm and brittle properties. With maltodextrin dominating small deformation rheology and high acyl gellan gum dominating the fracture point, the material properties indicated the type of structural organization in the mixed gel network.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Jin Sol Seo, Nomin-Erdene Tumursukh, Joo Hee Choi, Youngeun Song, Gayeong Jeon, Na Eun Kim, Seung Jae Kim, Nahyeon Kim, Jeong Eun Song, Gilson Khang
Summary: The increasing number of individuals suffering from visual loss due to eye diseases has led to a need for corneal replacement. However, the shortage of donors and immune responses pose challenges. This study developed a GM/LAP hydrogel by blending methacrylated gellan gum (GM) with gellan gum (GG) and adding a crosslinking initiator (LAP). The GM/LAP hydrogel showed improved compressive strength and better cell viability, proliferation, and gene expression compared to the GM hydrogel, making it a promising candidate for corneal tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Yi-Nan Du, Jia-Nan Yan, Shi-Qi Xu, Yu-Qiao Wang, Xue-Chen Wang, Hai-Tao Wu
Summary: The aim of this study was to investigate the effect of gellan gum (GG) on the cold gelation of large yellow croaker roe protein isolate (pcRPI). The water-holding ability and storage modulus of the pcRPI-GG binary gels increased with the GG concentration, where the storage modulus of the pcRPI-0.2% GG gel was approximately 30.7 times that of the pure pcRPI gel. Compare to the other binary gels, pcRPI-0.2% GG gels exhibited a lower lacunarity and higher junction density, with a denser, more aggregated microstructure. Consequently, curcumin was embedded in pcRPI-0.2% GG gels, and simulated gastrointestinal digestion test results showed that GG addition effectively protected and slowed curcumin release in the gastrointestinal environment. These findings may contribute to elucidating the interaction of pcRPI with GG and demonstrate the potential of binary gels for the embedding and delivery of active substances.
Article
Agriculture, Multidisciplinary
Na Guo, Ying Ma, Fangyan Zhang, Guilan Zhu, Zhenyu Yu, Huanhuan Dai, Ziying Wang
Summary: This study investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate high acyl gellan gum. The pH had a strong effect on the gel hardness, water-holding capacity, free sulfhydryl groups, and other properties of the composite gel. The rheological analysis demonstrated that the pH affected the gel formation time and the gel's storage modulus.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Pharmacology & Pharmacy
Guiting Huang, Jin Xie, Shuyuan Shuai, Shaofeng Wei, Yingchong Chen, Zhiyu Guan, Qin Zheng, Pengfei Yue, Changhong Wang
Summary: This study successfully utilized a carbohydrate polymer deacetylated gellan gum (DGG) as matrix to design nanocrystals-based intranasal in situ gel (IG) for nose-to-brain drug delivery, showing excellent therapeutic efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Annalisa Martorana, Giovanna Pitarresi, Fabio Salvatore Palumbo, Giuseppe Barberi, Calogero Fiorica, Gaetano Giammona
Summary: This study focuses on improving the processability of bioprinting by using a bioink-based gellan gum. By mixing an amino derivative of gellan gum with a mono-functionalized aldehyde polyethyleneglycol, the viscoelastic properties of the bioink are improved. The study also explores the effect of cell density on printing quality.
Article
Critical Care Medicine
Thomas Leclerc, Tom Potokar, Amy Hughes, Ian Norton, Calin Alexandru, Josef Haik, Naiem Moiemen, Stian Kreken Almeland
Summary: The TWGB formula appears to be effective in estimating fluid requirements for burn patients in mass casualty situations, providing appropriate fluid resuscitation for most salvageable burned patients in disasters. This simple formula can simplify patient management, reduce early complications, and optimize disaster response when tailored resuscitation is given with specialized care.
Article
Critical Care Medicine
Dean M. Thompson, Clare Thomas, Lisa Hyde, Yvonne Wilson, Naiem Moiemen, Jonathan Mathers
Summary: According to a survey in the UK, most pediatric burns services support parents in administering dressing changes at home. However, the lack of formal eligibility criteria and the open interpretation of informal criteria may lead to inequity in the support received by children and their families.
Article
Critical Care Medicine
Dean M. Thompson, Clare Thomas, Lisa Hyde, Yvonne Wilson, Naiem Moiemen, Jonathan Mathers
Summary: This study explores parents' experiences of administering dressing changes in paediatric burns aftercare. The findings suggest that parents want to be involved in their child's care by administering dressing changes at home, provided they receive sufficient reassurance and support.
Review
Critical Care Medicine
Athina Lavrentieva, Nadia Depetris, Naiem Moiemen, Michael Joannidis, Tina Louise Palmieri
Summary: This study aimed to explore the diagnostic approach and clinician's attitudes towards the management of acute kidney injury (AKI) and renal replacement therapy (RRT) in burn patients worldwide. The majority of burn specialists use specific consensus classifications to detect AKI and continuous renal replacement therapy is the most preferred option. The expertise to deliver a particular modality and the availability of resources play a significant role in modality selection. However, the use of ultrasound and specific biomarkers for AKI evaluation is infrequent in routine clinical practice.
Article
Critical Care Medicine
Liam David Cato, Khaled Al-Tarrah, Naiem Moiemen
Summary: This study investigates the association between healthcare infrastructure, geography, and time on burn wound colonization. Results show that after the relocation of the burn center, the prevalence of methicillin resistant Staph. aureus, Coliform spp., and Aci. baumanni decreased, while Candida spp. colonization increased.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Surgery
Khaled Altarrah, Poh Tan, Animesh Acharjee, Jon Hazeldine, Barbara Torlinska, Yvonne Wilson, Tomasz Torlinski, Naiem Moiemen, Janet M. Lord
Summary: The use of steroids following major thermal injury may have a significant impact on patient prognosis. Corticosteroid use is associated with increased odds of in-hospital mortality, multiple organ failure, and sepsis, while oxandrolone use is associated with reduced odds of mortality and sepsis. However, oxandrolone is also associated with increased odds of multiple organ failure and reduced days free from multiple organ failure.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Review
Critical Care Medicine
Hadyn K. N. Kankam, Kwang Chear Lee, Amanda V. Sardeli, Janine Dretzke, Janet M. Lord, Naiem Moiemen
Summary: Burn injuries may lead to higher long-term mortality rates. The underlying mechanism is still unclear and further research is needed to improve outcomes for burn patients.
Article
Critical Care Medicine
Stian Kreken Almeland, Evelyn Depoortere, Serge Jennes, Folke Sjoberg, J. Alfonso Lozano Basanta, Sofia Zanatta, Calin Alexandru, Jose Ramon Martinez-Mendez, Cornelis H. van der Vlies, Amy Hughes, Juan P. Barret, Naiem Moiemen, Thomas Leclerc
Summary: This study aims to provide insights into developing a response plan for burn mass casualties within the EU Civil Protection Mechanism. The findings indicate that only 35% of burn centers in Europe have a burn-specific plan. Therefore, it is crucial to develop and implement response plans for burn mass casualties.
Article
Medicine, General & Internal
Daren K. Heyland, Lucy Wibbenmeyer, Jonathan A. Pollack, Bruce Friedman, Alexis F. Turgeon, Niknam Eshraghi, Marc G. Jeschke, Sylvain Belisle, Daisy Grau, Samuel Mandell, Sai R. Velamuri, Gabriel Hundeshagen, Naiem Moiemen, Kayvan Shokrollahi, Kevin Foster, Fredrik Huss, Declan Collins, Alisa Savetamal, Jennifer M. Gurney, Nadia Depetris, Christian Stoppe, Luis Ortiz-Reyes, Dominique Garrel, Andrew G. Day
Summary: This study suggests that supplemental glutamine does not reduce the time to discharge alive from the hospital in patients with severe burns.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Thomas Leclerc, Folke Sjoberg, Serge Jennes, Jose Ramon Martinez Mendez, Cornelis H. van der Vlies, Anna Battistutta, Alfonso Lozano-Basanta, Naiem Moiemen, Stian Kreken Almeland
Summary: A European response plan has been developed to deal with mass casualty incidents, providing international assistance to affected countries. Burn Assessment Teams are deployed to assess and triage patients, and casualties are transported to foreign burn centers based on their recommendations. The plan also includes guidelines for national preparedness, specialized in-hospital triage, and medical evacuations.
Review
Surgery
Bilal Gani Taib, A. Karwath, K. Wensley, L. Minku, G. Gkoutos, N. Moiemen
Summary: Artificial Intelligence (AI) has shown successful application in burns care and can assist in interpreting various aspects of burns care. This systematic review and diagnostic test accuracy meta-analyses aim to evaluate and summarize the current research direction in this field. The results focus on burn depth, burn segmentation, and burn-related mortality, with neural networks being the most common machine learning algorithm utilized.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Dermatology
Poh Tan, Razan A. Basonbul, Joanne Lim, Naiem Moiemen
Summary: Accurate wound assessment is crucial and portable wound assessment devices are useful in providing accurate evaluations. This study compared the performance of various portable wound assessment techniques and found that 2D-based devices were the most studied and demonstrated good performance, while further studies are needed for 3D and application-based devices.
JOURNAL OF WOUND CARE
(2023)
Article
Critical Care Medicine
Ezekwe Amirize, Hadyn K. N. Kankam, Abdulrazak Abdulsalam, Rajan Choudhary, Harriet Walker, Naiem Moiemen
Summary: This study retrospectively analyzed self-inflicted burn cases in a regional burns center in the UK over almost 2 decades. The majority of patients were male with pre-existing psychiatric disorders, and flame burns were the most frequent type of injury. Survivors were younger and had less severe burns, while the inpatient mortality rate was significantly higher than the rest of the cohort.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Review
Emergency Medicine
Kate Price, Kwang Chear Lee, Katherine E. Woolley, Henry Falk, Michael Peck, Richard Lilford, Naiem Moiemen
Summary: A lack of published literature exists regarding large-scale burn prevention programs in LMIC that can demonstrate sustained reductions in burn incidence. Most initiatives focus on education-based interventions, with limited involvement of environmental modification interventions. While education-based initiatives generally improve knowledge on burn safety or first aid, few measure the impact on reducing burn incidence effectively.
Article
Emergency Medicine
Liam D. Cato, Benjamin Bailiff, Joshua Price, Christos Ermogeneous, Jon Hazeldine, William Lester, Gillian Lowe, Christopher Wearn, Jonathan R. B. Bishop, Janet M. Lord, Naiem Moiemen, Paul Harrison
Summary: The anticoagulant effect of low molecular-weight heparin in burn patients may be influenced by nucleosomes, potentially leading to heparin resistance. Therefore, accurate monitoring and appropriate therapy escalation plans are recommended following severe burn injury.