Article
Engineering, Biomedical
Hanchen Zhang, Li Deng, Haiqing Liu, Siyao Mai, Ziliang Cheng, Guangzi Shi, Hong Zeng, Zhuo Wu
Summary: A gene delivery system using self-assembled multifunctional nanoparticles was constructed for hepatocellular carcinoma (HCC) therapy. The nanoparticles showed good size distribution, high RNA condensation and transfection ability. They exhibited excellent fluorescence and magnetic resonance imaging properties. The targeted nanoparticles improved cellular uptake and effectively inhibited tumor growth.
MATERIALS TODAY BIO
(2022)
Article
Nanoscience & Nanotechnology
Bong Han Lee, Md Tanvir Hasan, Denise Lichthardt, Roberto Gonzalez-Rodriguez, Anton Naumov
Summary: Novel Mn2+ or Gd3+ doped nitrogen-containing graphene quantum dots (NGQDs) have been developed to provide deep tissue MRI capabilities to graphene quantum dots (GQDs) and render contrast agents biocompatible. These dual-modal contrast agents exhibit high in vitro biocompatibility and effective internalization in cells, showing potential for both T1 and T2 contrast imaging.
Article
Pharmacology & Pharmacy
Songbai Zhang, Vega Lloveras, Yufei Wu, Juan Tolosa, Joaquin C. Garcia-Martinez, Jose Vidal-Gancedo
Summary: Dual or multimodal imaging probes, such as metal-free organic species based on dendrimers, have been developed as powerful tools for disease diagnosis using magnetic resonance imaging (MRI) and optical fluorescence imaging (OFI). In this study, six radical dendrimers were synthesized and characterized, demonstrating their paramagnetic properties for MRI contrast generation and fluorescence emission. This represents a significant development in the field of macromolecules with bimodal magnetic and fluorescent properties using organic radicals as the magnetic probe.
Article
Chemistry, Multidisciplinary
Franz Wegner, Kerstin Luedtke-Buzug, Sjef Cremers, Thomas Friedrich, Malte M. Sieren, Julian Haegele, Martin A. Koch, Emine U. Saritas, Paul Borm, Thorsten M. Buzug, Joerg Barkhausen, Mandy Ahlborg
Summary: The purpose of this study was to develop instrument markers that are visible in both MPI and MRI. Coatings containing different types of magnetic nanoparticles were fabricated, and their MPI performance was evaluated using MPS. These coatings were then applied on a nonmetallic guidewire for imaging experiments. MPI image reconstruction was performed using system matrices measured with different coatings. The bimodal markers were clearly visible in both MRI and MPI, but the signal voids and areas of high signal intensity were larger than the real marker size. Insufficient MPI signal was observed when using a specific coating.
Article
Chemistry, Multidisciplinary
Bo Song, Mengyan Li, Junyu Ren, Qi Liu, Xinyi Wen, Wenzhu Zhang, Jingli Yuan
Summary: This study presents a novel tumor-targetable bimodal time-gated luminescence (TGL)-MRI nanoprobe for tracing cancer cells, achieved by coating superparamagnetic Fe3O4 nanoparticles with functional silica shells encapsulating luminescent Eu3+ complexes and decorated with tumor-targeting molecules.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Bo Song, Huinan Yan, Jiao Jiang, Jin Yu, Shengjun Huang, Jingli Yuan
Summary: In this study, an activatable nanoprobe for bimodal TGLI and MRI has been developed, which shows rapid, sensitive, and selective turn-on responses towards GSH and H2O2. The nanoprobe can be used for the identification and tracing of cancer cells in vitro and in vivo.
Article
Nanoscience & Nanotechnology
Fujie Jiang, Lu Wang, Yu Tang, Yaotai Wang, Ningshan Li, Disen Wang, Zhong Zhang, Li Lin, Yan Du, Xia Ou, Jianzhong Zou
Summary: This study described a novel anaerobic bacteria-mediated nanoplatform, employing US and MR bimodal imaging for synergistic HIFU therapy of breast cancer. B. bifidum-mediated PFH@CL/Fe3O4 NPs enhanced tumor targeting ability and promoted therapeutic effect.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Xueyang Xiao, Hao Cai, Qiaorong Huang, Bing Wang, Xiaoming Wang, Qiang Luo, Yinggang Li, Hu Zhang, Qiyong Gong, Xuelei Ma, Zhongwei Gu, Kui Luo
Summary: In this study, a dual-modality contrast agent, Gd-DOTA-TPBP, was successfully synthesized using an amphiphilic block polymer as a carrier. The contrast agent exhibited high resolution and sensitivity, making it a promising tool for early-stage tumor diagnosis.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
J. Typek, K. Wardal, G. Zolnierkiewicz, G. Leniec, D. Sibera, U. Narkiewicz
Summary: The study synthesized nanocrystalline samples of ZnO doped with MnO, revealing magnetic inhomogeneity due to the competition of different magnetic states and ions.
IEEE TRANSACTIONS ON MAGNETICS
(2021)
Article
Chemistry, Multidisciplinary
Wenhui Zeng, Luyan Wu, Yusuke Ishigaki, Takashi Harimoto, Yuxuan Hu, Yidan Sun, Yuqi Wang, Takanori Suzuki, Hong-Yuan Chen, Deju Ye
Summary: The study introduces a novel H2S-activatable bimodal probe F1-GdNP for accurate detection of hepatic hydrogen sulfide, showing high sensitivity and specificity for monitoring acute hepatitis through evaluation of CSE activity in living mice. The probe demonstrates potential for sensitive afterglow imaging of increased hepatic H2S levels and correlates well with upregulated CSE activity in the liver.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Physical
Tao Tang, Baisong Chang, Mingxi Zhang, Taolei Sun
Summary: Gliomas are the most common primary brain tumors in adults, and the difficulty in accurately imaging and determining the malignancy grade of gliomas has significant impact on diagnostic accuracy and subsequent surgery or therapy. The rapid development of emerging nanoprobes provides a promising opportunity for the precise imaging and therapy of gliomas, enabling efficient crossing of the blood-brain barrier and targeted treatment. Challenges and future directions in nanoprobe-based diagnosis and treatment of gliomas are also discussed.
NANOSCALE HORIZONS
(2021)
Article
Nanoscience & Nanotechnology
Weibing Xu, Jia Zhang, Minzhi Zhao, Zhijie Yang, Qingfeng Wu, Fang Nian
Summary: A novel MR/FI bimodal imaging probe was successfully fabricated in this study, with high quantum yield and excellent imaging performance, demonstrating good biocompatibility for potential further applications.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Review
Polymer Science
Baharak Divband, Nahideh Gharehaghaji, Samad Hassani
Summary: Early detection and appropriate treatment methods are crucial in reducing cancer mortality. Nanotheranostics, which combines imaging and therapeutic capabilities, can significantly improve cancer diagnosis and treatment efficacy. Magnetic resonance imaging (MRI) and fluorescence imaging (FI) have been widely explored as imaging modalities in nanotheranostics. The integration of superparamagnetic Fe3O4 with graphene derivatives as imaging nanomaterials shows promising physicochemical and biological properties for cancer diagnosis and monitoring.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Kyohei Okubo, Ryuta Takeda, Shuhei Murayama, Masakazu Umezawa, Masao Kamimura, Kensuke Osada, Ichio Aoki, Kohei Soga
Summary: Rare-earth-doped nanoparticles offer promising bimodal imaging capabilities for both NIR fluorescence and MRI. By controlling particle size, PEG-modified NaGdF4:Yb3+,Er3+ NPs demonstrate high relaxometric ratios for MRI contrast enhancement and OTN-NIR fluorescence imaging.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Minchuan Luo, Hiroshi Yukawa, Kazuhide Sato, Makoto Tozawa, Masato Tokunaga, Tatsuya Kameyama, Tsukasa Torimoto, Yoshinobu Baba
Summary: This study presents a multifunctional nanoprobe for bimodal imaging and photothermal-enhanced targeted therapy. The nanoprobe exhibits intense fluorescence and magnetic resonance imaging capabilities for sensitive and high-resolution imaging of tumors in living mice. Additionally, it can generate localized heat and reactive oxygen species, achieving excellent therapeutic efficacy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Balakrishnan Nagarajan, Yingnan Wang, Maryam Taheri, Simon Trudel, Steven Bryant, Ahmed Jawad Qureshi, Pierre Mertiny
Summary: The study establishes a methodology to combine magnetic field induced particle alignment along with a dual-cure resin to create anisotropic magnetic composites through polymer casting and additive manufacturing.
Article
Materials Science, Multidisciplinary
Piotr Pawlik, Barbara Blasiak, Joanna Depciuch, Marcin Pruba, Diana Kitala, Svetlana Vorobyova, Malgorzata Stec, Maxim Bushinsky, Artem Konakov, Jaroslaw Baran, Julia Fedotova, Oleg Ivashkevich, Magdalena Parlinska-Wojtan, Alexey Maximenko
Summary: The novel iron-oxide nanoparticles stabilized with triethanolammonium oleate were found to have potential applications in MRI-guided hyperthermia and regenerative medicine.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Physical
Nicholas M. Randell, Renaud Miclette Lamarche, Franceso Tintori, Roman Chernikov, Gregory C. Welch, Simon Trudel
Summary: The study reports the fabrication of amorphous aCuOx thin films using a UV-based thin-film deposition method from commercially available starting materials, which exhibit p-type semiconductor behavior after thermal annealing and can be used as HTLs in organic photovoltaic devices.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Physical
M. Taheri, S. Maaref, A. Kantzas, S. Bryant, S. Trudel
Summary: This study investigated the effect of different surfactants on the stability of PEGylated BaTiO3 nanoparticles in water and ethylene glycol. The results showed that the anionic surfactant acted as the best stabilizer, while the cationic surfactant was the least favorable stabilizer.
Article
Biochemical Research Methods
Christopher J. Sedlock, Aaron R. Purchase, Boguslaw Tomanek, Jonathan C. Sharp
Summary: Transmit array spatial encoding (TRASE) is an MR imaging technique that utilizes phase gradients in the RF transmit field for k-space encoding. It allows for TRASE MRI to be performed with cheaper bi-planar permanent magnets or Halbach arrays, without the need for B0 gradient fields. A new truncated design for the RF transmit coil was introduced to increase the usable imaging volume relative to the coil length. Testing with an un-shimmed 2.84 MHz Halbach array showed that the truncated design could achieve similar imaging volume and quality to the untruncated version while significantly reducing the coil length by as much as a half.
JOURNAL OF MAGNETIC RESONANCE
(2023)
Article
Chemistry, Physical
Katelynn M. Daly, Santiago Jimenez-Villegas, Benjamin Godwin, Martin A. W. Schoen, Oliver Calderon, Ning Chen, Simon Trudel
Summary: The storage of renewable energy is a challenge in transitioning to a power grid based on intermittent energy supplies. The electrocatalytic conversion of water to hydrogen fuel is an attractive option, but requires better catalysts for better performance. This study evaluated different RuOx catalysts and found that nanocrystalline RuOx catalysts outperform their amorphous counterparts and are more stable under alkaline conditions, which is a significant step towards using RuOx for alkaline water electrolysis.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Renaud Miclette Lamarche, Akpeko Gasonoo, Anderson Hoff, Roman Chernikov, Gregory C. Welch, Simon Trudel
Summary: This study demonstrates the formation of vanadium oxide films using a room-temperature, ambient photochemical deposition route. The films consist of V2O5 with a significant amount of V4+. The films become nanocrystalline after annealing and show no improvement in device performance when used as hole-transport layers in organic photovoltaic cells and organic light-emitting diodes.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Piotr Pawlik, Barbara Blasiak, Marcin Pruba, Arkadiusz Miaskowski, Oskar Moraczynski, Justyna Miszczyk, Boguslaw Tomanek, Joanna Depciuch
Summary: This work presents a new aerosol-based technique for synthesizing magnetite nanoparticles (Fe3O4 NPs) and explores their potential medical applications. The refinement of processing conditions resulted in monodispersed NPs with narrow size distribution. The NPs were coated with TEA-oleate for stability in water dispersion. The study also discovered diverse mechanisms of interaction between cancer and normal cell lines and Fe3O4 NPs, suggesting potential applications in magnetic hyperthermia and magnetic resonance imaging (MRI).
Review
Chemistry, Physical
Abhinandan Banerjee, Barbara Blasiak, Armita Dash, Boguslaw Tomanek, Frank C. J. M. van Veggel, Simon Trudel
Summary: There is a need for non-invasive diagnostic tools, which has led to the use of magnetic resonance imaging (MRI). High-field MRI offers advantages in terms of signal-to-noise ratio and spectral resolution. This review discusses the development of new contrast agents for high-field MRI.
CHEMICAL PHYSICS REVIEWS
(2022)
Article
Computer Science, Information Systems
Aaron R. Purchase, Logi Vidarsson, Keith Wachowicz, Piotr Liszkowski, Hongwei Sun, Gordon E. Sarty, Jonathan C. Sharp, Boguslaw Tomanek
Summary: Traditional Halbach magnets are widely used in MRI, but improvements in manufacturing techniques and designs are needed to reduce weight. This study successfully reduces the weight and size of Halbach magnets by optimizing the design and using high-coercivity ferromagnets, while maintaining good magnetic field homogeneity.
Article
Chemistry, Physical
Martin A. W. Schoen, Oliver Calderon, Nicholas M. Randell, Santiago Jimenez-Villegas, Katelynn M. Daly, Roman Chernikov, Simon Trudel
Summary: Amorphous nickel-iron mixed metal oxides are efficient oxygen evolution reaction catalysts that offer an economical alternative to traditional platinum- or iridium-based catalysts. The synergistic effect between Fe and Ni plays a crucial role in their superior OER performance, with potential- and rate-determining steps occurring at Ni and Fe sites, respectively. However, at higher annealing temperatures, this synergistic effect is suppressed, possibly due to phase separation into NiOx and FeOx phases.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Nanoscience & Nanotechnology
Armita Dash, Barbara Blasiak, Boguslaw Tomanek, Abhinandan Banerjee, Simon Trudel, Peter Latta, Frank C. J. M. van Veggel
Summary: The article demonstrates the synthesis of stable Fe NPs for MRI applications. Different sizes of Fe NPs show high stability against oxidation when dispersed in chloroform and deionized water, exhibiting strong contrast enhancement in MRI. Fe NPs are promising contrast agents for medical imaging.
ACS APPLIED NANO MATERIALS
(2021)