4.2 Article

Mortality of lead smelter workers: A follow-up study with exposure assessment

Journal

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
Volume 59, Issue 11, Pages 979-986

Publisher

WILEY
DOI: 10.1002/ajim.22618

Keywords

mortality cohort study; lead exposure

Funding

  1. National Institute for Occupational Safety and Health

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BackgroundLead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS). MethodsWe extended vital status follow-up on a cohort of 1,990 lead smelter workers by 25 years and computed standardized mortality ratios and rate ratios (RR) stratified by cumulative lead exposure. ResultsThe update added 13,823 person-years at risk and 721 deaths. Increased risk of mortality was observed for the a priori outcomes of lung cancer, cardiovascular disease (including cerebrovascular disease), chronic kidney disease, and ALS. However, of these outcomes, only cardiovascular, cerebrovascular, and chronic kidney diseases were associated with a positive exposure-response in RR analyses. ConclusionsThis study reaffirms the association of lead exposure with cardiovascular and kidney diseases; however, increased mortality observed for certain cancers is not likely to be due to lead exposure. Am. J. Ind. Med. 59:979-986, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

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