Article
Cardiac & Cardiovascular Systems
Thomas F. Deering, John N. Catanzaro, David A. Woodard
Summary: This study found that the use of antibiotics, especially gentamicin, in biologic envelope hydration solution may reduce infection risk in CIED procedures. Additionally, utilizing antibacterial envelopes without adjunct IV ABX may not be sufficient to reduce infection rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Simone Gulletta, Giulio Falasconi, Lorenzo Cianfanelli, Alice Centola, Gabriele Paglino, Manuela Cireddu, Andrea Radinovic, Giuseppe D'Angelo, Alessandra Marzi, Simone Sala, Nicolai Fierro, Caterina Bisceglia, Giovanni Peretto, Nadia Di Muzio, Paolo Della Bella, Pasquale Vergara, Italo Dell'Oca
Summary: This study reports the ten-year real-world experience of a tertiary multidisciplinary teaching hospital in managing patients with cardiac implantable electronic devices (CIEDs) undergoing radiotherapy (RT). The results show infrequent changes in device parameters and occurrence of arrhythmias, with no clinically significant adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Vaibhav R. Vaidya, Roshini Asirvatham, Gurukripa N. Kowlgi, Ming-Yan Dai, Jordan J. Cochuyt, David O. Hodge, Abhishek J. Deshmukh, Yong Mei Cha
Summary: This study examines the trends in cardiovascular implantable electronic device (CIED) insertion in Olmsted County over the past three decades. The incidence of permanent pacemaker and implantable cardioverter-defibrillator (ICD) implants is declining, while the incidence of cardiac resynchronization therapy (CRT) implants is increasing.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Grzegorz Slawinski, Maciej Kempa, Andrzej Przybylski
Summary: The importance of CIEDs in treating cardiac rhythm disturbances, heart failure, and preventing sudden cardiac death is undeniable. However, CIED therapy is associated with complications, particularly infections, which have a significant impact on prognosis. This review summarizes current knowledge on diagnosing and managing CIED infections and also discusses alternative methods like subcutaneous defibrillators, leadless pacemakers, and wearable cardioverter defibrillators.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Fozia Z. Ahmed, Carina Blomstrom-Lundqvist, Heather Bloom, Christopher Cooper, Christopher Ellis, Andreas Goette, Arnold J. Greenspon, Charles J. Love, Jens Brock Johansen, Francois Philippon, Khaldoun G. Tarakji, Reece Holbrook, Lou Sherfesee, Ying Xia, Swathi Seshadri, Daniel R. Lexcen, Andrew D. Krahn
Summary: The PADIT infection risk score, developed from a large dataset, identified five independent predictors of CIED infection. A validation study using U.S. healthcare claims data confirmed the predictive value of the risk score, especially when combined with prior CIED infection history, in identifying high-risk patients for targeted interventions to reduce CIED infection risk.
Article
Medicine, General & Internal
Vincenzo Livio Malavasi, Jacopo Francesco Imberti, Alberto Tosetti, Giulio Francesco Romiti, Marco Vitolo, Massimo Zecchin, Ercole Mazzeo, De Marco Giuseppina, Frank Lohr, Teresa Lopez-Fernandez, Giuseppe Boriani
Summary: The prevalence of radiotherapy-induced CIEDs malfunctions ranges from 4% to 20%. The use of neutron-producing energies and more complex devices (ICD/CRT-D) are associated with a higher risk of device malfunction, while the radiation dose at CIED does not significantly impact the risk unless higher doses (>10 Gy) are used.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kasun De Silva, Natasha Nassar, Tim Badgery-Parker, Saurabh Kumar, Lee Taylor, Pramesh Kovoor, Sarah Zaman, Andrew Wilson, Clara K. Chow
Summary: This study analyzed data from cardiovascular hospitalizations in New South Wales, Australia and found that women had lower rates of implantation and use of cardiac implantable electronic devices (CIEDs) compared to men. This difference existed across nearly all indications, and men and women had similar 30-day survival rates among those who received devices.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Hui-Chen Han, Nathaniel M. Hawkins, Charles M. Pearman, David H. Birnie, Andrew D. Krahn
Summary: CIED infection is a serious complication with a 1% infection rate, influenced by technical, patient, and procedural factors. Considering these factors is essential for minimizing infection risk.
Article
Cardiac & Cardiovascular Systems
Michele Malagu, Francesco Vitali, Alessandro Brieda, Paolo Cimaglia, Martina De Raffele, Enea Tazzari, Cristina Musolino, Cristina Balla, Matteo Serenelli, Rosario Cultrera, Claudio Rapezzi, Matteo Bertini
Summary: In a study involving patients undergoing CIED surgery, stratification of infective risk guided antibiotic prophylaxis with similar infection rates observed between high and low-risk groups after 250 days of follow-up. Active neoplasia, haematoma, and reintervention were identified as independent risk factors for CIED-related infection.
Article
Cardiac & Cardiovascular Systems
Khaldoun G. Tarakji, Panagiotis Korantzopoulos, Francois Philippon, Mauro Biffi, Suneet Mittal, Jeanne E. Poole, Charles Kennergren, Daniel R. Lexcen, Jeff D. Lande, Swathi Seshadri, Bruce L. Wilkoff
Summary: Among WRAP-IT patients, the risk of hematoma was 2.2%. Control patients with hematoma had a significantly higher risk of developing major CIED infection, which was effectively reduced by 82% with antibacterial envelope use compared to control patients.
Review
Cardiac & Cardiovascular Systems
Tanyanan Tanawuttiwat, Mithilesh K. Das, John M. Miller, Maya E. Guglin
Summary: The design of an innovative left ventricular assist device (LVAD) utilizes magnetic levitation technology to suspend the device's rotors, reducing friction and damage to blood or plasma. However, this magnetic field can cause electromagnetic interference (EMI) with other cardiac implantable electronic devices (CIEDs), particularly implantable cardioverter-defibrillators (ICDs). EMI-induced interactions have been reported, leading to inappropriate shocks, connection issues, premature battery depletion, undersensing, and other malfunctions. This article addresses the impact of LVAD-induced EMI on CIED functionality and provides management options for different types of CIEDs.
Article
Cardiac & Cardiovascular Systems
Andrew Y. Lin, Tatiana Saul, Omar M. Aldaas, Florentino Lupercio, Gordon Ho, Travis Pollema, Victor Pretorius, Ulrika Birgersdotter-Green
Summary: This study compared the impact of early versus delayed infected CIED extraction on patient outcomes. The results showed that delayed extraction was associated with worse outcomes. This underscores the importance of early detection and prompt management strategies.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Vassil Traykov, Carina Blomstrom-Lundqvist
Summary: Infections related to cardiac implantable electronic devices (CIED) are increasing despite preventive strategies. Antibiotic-eluting envelopes (AEEs) have shown promise in preventing CIED infections and are cost-effective.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Henrike A. K. Hillmann, Claudius Hansen, Oliver Przibille, David Duncker
Summary: This study aims to analyze the patient perspectives on the remote monitoring of cardiac devices in Germany. The survey found that most patients felt well informed and remote monitoring helped them cope with their disease. Some patients experienced technical problems with remote monitoring, and younger patients are more interested in using smartphones for data transfer.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Seungbong Han, Gyung-Min Park, Yong-Giun Kim, Ki Won Hwang, Chang Hee Kwon, Jae-Hyung Roh, Sangwoo Park, Ki-Bum Won, Soe Hee Ann, Shin-Jae Kim, Sang-Gon Lee
Summary: This study compared the characteristics and mortality of new implantation of cardiac implantable electronic device (CIED) between tertiary and non-tertiary hospitals in Korea. The findings showed that there was no significant difference in mortality between the two types of hospitals for patients undergoing first and new implantation of CIED.
SCIENTIFIC REPORTS
(2021)
Retraction
Health Care Sciences & Services
Arif H. Kamal, Janet H. Bull, Steven P. Wolf, Keith M. Swetz, Tait D. Shanafelt, Katherine Ast, Dio Kavalieratos, Christian T. Sinclair
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2020)
Review
Medicine, General & Internal
Halena M. Gazelka, Janette C. Leal, Maria I. Lapid, Teresa A. Rummans
MAYO CLINIC PROCEEDINGS
(2020)
Article
Medicine, General & Internal
Halena M. Gazelka, Casey M. Clements, Julie L. Cunningham, Holly L. Geyer, Jenna K. Lovely, Cheri L. Olson, Lindsey M. Philpot, Steven B. Porter, Terrence J. Witt, Kathryn W. Zavaleta, Elizabeth B. Habermann
MAYO CLINIC PROCEEDINGS
(2020)
Article
Oncology
Dario Pasalic, Eric A. Strom, Pamela K. Allen, Tyler D. Williamson, Falk Poenisch, Richard A. Amos, Wendy A. Woodward, Michael C. Stauder, Simona F. Shaitelman, Benjamin D. Smith, George H. Perkins, Welela Tereffe, Karen E. Hoffman
Summary: The study conducted a planned interim analysis of acute and late toxicities as well as cosmetic outcomes after proton accelerated partial breast irradiation for breast cancer. Results show high local control, favorable cosmetic outcomes, and high treatment satisfaction among patients and physicians. The most commonly reported late cosmetic effect was telangiectasis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Alexander Augustyn, L. Jeffrey Medeiros, Ethan B. Ludmir, Jillian Gunther, Penny Fang, Shaoying Li, Chi Young Ok, Mikaela E. Bankston, Vivek Verma, Dario Pasalic, Sairah Ahmed, Loretta J. Nastoupil, Jason R. Westin, Paolo Strati, Sattva S. Neelapu, Ranjit Nair, Raphael E. Steiner, Swaminathan P. Iyer, Alma Rodriguez, Luis E. Fayad, Christopher R. Flowers, Bouthaina S. Dabaja, Chelsea C. Pinnix
Summary: The study found that COO, MYC, and Bcl-2 overexpression, as well as MYC rearrangement, had minimal impact on the prognosis of DLBCL patients treated with consolidative radiation therapy. Consolidative RT achieved excellent local control regardless of DLBCL biology.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Dario Pasalic, Daniel A. Barocas, Li-Ching Huang, Zhiguo Zhao, Tatsuki Koyama, Chad Tang, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Lisa E. Paddock, Antoinette M. Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O'Neil, Sherrie H. Kaplan, Sheldon Greenfield, David F. Penson, Karen E. Hoffman
Summary: This study compared disease-specific function in prostate cancer patients undergoing external-beam radiotherapy (EBRT) alone versus EBRT with a low-dose-rate (LDR) brachytherapy boost (EBRT-LDR). The results showed that EBRT-LDR was associated with worse urinary irritative and bowel function over 3 years post-treatment, but symptoms resolved after 5 years. Men who received EBRT-LDR continued to report moderate-to-big problems with urinary function bother through 5 years.
Review
Medicine, General & Internal
Michael J. O'Rourke, Maureen C. Keshock, Christine E. Boxhorn, Darin J. Correll, Avital Y. O'Glasser, Halena M. Gazelka, Richard D. Urman, Karen Mauck
Summary: There is a lack of guidelines for preoperative dosing of opioid and nonopioid pain medications for surgical patients, but the Society for Perioperative Assessment and Quality Improvement has developed consensus recommendations in this area to improve patient care.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Medicine, General & Internal
Dario Pasalic, C. David Fuller, Walker Mainwaring, Timothy A. Lin, Austin B. Miller, Amit Jethanandani, Andres F. Espinoza, Aaron J. Grossberg, Reshma Jagsi, Prajnan Das, Albert C. Koong, Claus Roedel, Emmanouil Fokas, Charles R. Thomas, Bruce D. Minsky, Ethan B. Ludmir
Summary: The study found that approximately 1 in 15 clinical oncology RCTs are unpublished, which has a profound impact on the research enterprise. Factors associated with unpublished trials included lack of cooperative group sponsorship and supportive care investigation.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Oncology
Joseph Abi Jaoude, Ramez Kouzy, Marc Ghabach, Roshal Patel, Dario Pasalic, Elie Ghossain, Austin B. Miller, Timothy A. Lin, Vivek Verma, C. David Fuller, Vivek Subbiah, Bruce D. Minsky, Ethan B. Ludmir, Cullen M. Taniguchi
Summary: The majority of FDA approvals are based on data generated from trials analyzing surrogate primary endpoints and trials receiving industry funding. In addition, increased pre-hoc power and meeting patients' accrual target are associated with FDA approvals.
Article
Health Care Sciences & Services
Mathias Schloegl, Anand S. Iyer, Florian Riese, David Blum, Lanier O'Hare, Tejaswini Kulkarni, Sophie Pautex, Jan Schildmann, Keith M. Swetz, Pallavi Kumar, Christopher A. Jones
Summary: Prognostication is considered as an essential component in medical care, but it becomes increasingly challenging as research advances bring new treatments for complex conditions like cancer and dementia. This article, written by palliative care clinicians with expertise in geriatrics, pulmonology, and oncology, aims to provide a helpful framework for prognostication in these illnesses.
JOURNAL OF PALLIATIVE MEDICINE
(2021)
Article
Health Care Sciences & Services
Mathias Schloegl, Esther S. Pak, Amar D. Bansal, Jane O. Schell, Sabha Ganai, Arif H. Kamal, Keith M. Swetz, Jennifer M. Maguire, Aristotelis Perrakis, Haider J. Warraich, Christopher A. Jones
Summary: This article presents 10 tips for PC clinicians to consider when caring and discussing prognosis for seriously ill patients, emphasizing the importance of broad understanding of treatments for serious diseases and collaboration in prognostication with specialists.
JOURNAL OF PALLIATIVE MEDICINE
(2021)
Editorial Material
Oncology
David Boyce-Fappiano, Matthew S. Ning, Olsi Gjyshi, Shane Mesko, Dario Pasalic, Albert J. Chang, Peter F. Orio, Nikhil G. Thaker
JCO ONCOLOGY PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Melisa Wilson, Rebekah H. Anguiano, Rana L. A. Awdish, James C. Coons, Amy Kimber, Melissa Morrison, Sara Paulus, Ann Schmit, Frank Spexarth, Keith M. Swetz, Nathan J. Verlinden, Mary E. Whittenhall, Margaret R. Sketch, Meredith Broderick, Jacqueline Brewer
Summary: Referral to palliative or supportive care services is challenging for patients with pulmonary arterial hypertension (PAH). Experts reached a consensus that patients should be referred to these services when disease symptoms become unmanageable or for end-of-life care. Pain management techniques, end-of-life care, and psychosocial recommendations were identified as important services. Discussing palliative or supportive care with patients, focusing on their overall health and treatment adherence, as well as prioritizing psychosocial aspects of care, was found to be important.
PULMONARY CIRCULATION
(2022)
Article
Oncology
Alexander D. Sherry, Dario Pasalic, G. Brandon Gunn, C. David Fuller, Jack Phan, David Rosenthal, William H. Morrison, Erich M. Sturgis, Neil D. Gross, Maura L. Gillison, Renata Ferrarotto, Adel K. El-Naggar, Adam S. Garden, Steven J. Frank
Summary: PRT for HNCUP was associated with highly favorable dosimetric and clinical outcomes, including minimal oral mucositis, xerostomia, and dysphagia. Toxicity and QOL may be superior with PRT compared with conventional radiation therapy and PRT maintains equivalent oncologic control.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
Article
Oncology
Nikhil G. Thaker, David Boyce-Fappiano, Matthew S. Ning, Dario Pasalic, Alexis Guzman, Grace Smith, Emma B. Holliday, James Incalcaterra, Adam S. Garden, Simona F. Shaitelman, G. Brandon Gunn, C. David Fuller, Pierre Blanchard, Thomas W. Feeley, Robert S. Kaplan, Steven J. Frank
Summary: In this study, time-driven activity-based costing was used to compare the costs of delivering IMPT and IMRT. The results showed that while the single-fraction costs for IMPT were higher than IMRT, the average full cycle cost of IMPT was not significantly higher than IMRT.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
