Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Daniel L. Cohen, Anton Bermont, Vered Richter, Narjes Azzam, Haim Shirin, Ram Dickman, Amir Mari
Summary: The study found that integrated relaxation pressure (IRP) can distinguish between the reflux-predominant and dysphagia-predominant phenotypes in patients with absent contractility (AC). This may have important clinical implications, as procedures such as fundoplication may benefit patients with reflux and a low IRP, while procedures like peroral endoscopic myotomy (POEM) may benefit patients with dysphagia and a relatively high IRP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Eun Jeong Gong, Soo In Choi, Bong Eun Lee, Yang Won Min, Yu Kyung Cho, Kee Wook Jung, Ji Hyun Kim, Moo In Park
Summary: This study investigated the current practice of esophageal high-resolution manometry (HRM) in Korea and found variations among centers, although there was general agreement in data analysis. Efforts are needed to develop a standardized protocol for HRM measurement.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Taher Omari, Ali Zifan, Charles Cock, Ravinder K. Mittal
Summary: Esophageal peristalsis is a complex process involving both inhibition and excitation. Abnormalities in this process can lead to dysphagia and other swallowing difficulties. Studying the distensibility and contraction characteristics of the esophagus during peristalsis can provide valuable insights for the development of new treatments for patients with swallowing disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Otorhinolaryngology
Daniel L. Cohen, Basem Hijazi, Ali Omari, Anton Bermont, Haim Shirin, Helal Said Ahmad, Narjes Azzam, Fahmi Shibli, Ram Dickman, Amir Mari
Summary: This study compared the demographic, clinical, endoscopic, and manometric findings of achalasia patients between Israeli Arabs and Israeli Jews. It found that Israeli Arab achalasia patients had different clinical symptoms and higher integrated relaxation pressure compared to Israeli Jewish patients.
Article
Gastroenterology & Hepatology
Isis K. Araujo, Sabine Roman, Marie Napoleon, Francois Mion
Summary: The study found that using solid food swallows (SFS) during esophageal motility assessment can improve diagnostic accuracy and is important for diagnosing clinically relevant disorders. The application of solid food swallows in HRM has a significant impact on changing diagnoses and can be widely used in daily clinical practice.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Sawangpong Jandee, Kasemsak Jandee
Summary: This study evaluated the diagnostic yield of high-resolution manometry in Thai patients, finding the highest yield in dysphagia patients. However, the test was not as beneficial in detecting clinically relevant esophageal motor disorders in patients presenting with non-dysphagia symptoms.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Shiko Kuribayashi, Junichi Akiyama, Haruo Ikeda, Kazue Nagai, Hiroko Hosaka, Mariko Hamada, Manabu Onimaru, Noriyuki Kawami, Kunihiko Hayashi, Katsuhiko Iwakiri, Haruhiro Inoue, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to evaluate the accuracy of a new automated diagnostic program for HREM, which showed high diagnostic accuracy and time-saving benefits in clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Sudarshan R. Jadcherla, Kathryn A. Hasenstab, Erika K. Osborn, Deborah S. Levy, Haluk Ipek, Roseanna Helmick, Zakia Sultana, Nicole Logue, Vedat O. Yildiz, Hailey Blosser, Summit H. Shah, Lai Wei
Summary: This study demonstrates that an integrated approach with parent-preferred therapy based on mechanistic understanding of VFSS and HRM metrics improves oral feeding outcomes, despite evidence of penetration or aspiration. The application of new knowledge of the physiology of swallowing and airway protection may contribute to these findings.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Jennifer Wellington, Joseph Kim, Donald O. Castell, Guofeng Xie
Summary: Dysphagia lusoria is a rare condition caused by impingement of the esophagus by an aberrant right subclavian artery, leading to progressive difficulty in swallowing. Diagnosis is typically made through various imaging studies and high-resolution impedance manometry, which can help strengthen the diagnosis of true dysphagia lusoria.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Editorial Material
Medicine, Research & Experimental
Fernando A. M. Herbella, Leonardo M. Del Grande, Francisco Schlottmann, Marco G. Patti
Summary: The Chicago Classification 4.0 introduces new concepts for the diagnosis of achalasia, potentially reducing unnecessary treatment. Conditions such as esophagogastric junction outflow obstruction, distal esophageal spasm, and hypercontractile esophagus are now considered clinically significant only in certain conditions, leading to a potential decrease in treatment, especially peroral endoscopic myotomy, solely based on manometric diagnosis.
ADVANCES IN THERAPY
(2021)
Article
Medicine, General & Internal
Daniel L. Cohen, Ram Dickman, Anton Bermont, Vered Richter, Haim Shirin, Amir Mari
Summary: Patients with absent contractility (AC) have more esophageal symptoms and require more intense gastrointestinal follow-up than controls. Only a minority of patients with AC have underlying rheumatologic disease. Those without rheumatologic disease at baseline did not subsequently develop one, suggesting that a rheumatologic evaluation is likely unnecessary. The clinical course of AC in patients with rheumatologic disease and those without appears to be similar.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
V. Vitton, C. Andrianjafy, L. Luciano, J. M. Gonzalez, L. Padovani
Summary: This study aimed to assess the prevalence of esophageal motility disorders (EMD) diagnosed by high-resolution esophageal manometry (HREM) after cervical or thoracic radiation therapy. The results showed that dysphagia was the most frequent symptom, 60% of patients had abnormal esophageal motility, with 15% presenting with major motility disorder.
CANCER RADIOTHERAPIE
(2021)
Article
Surgery
Chloe W. Caudell, Ethan P. Covil, John W. Gilpin, Brian Hodgens, Alex Ewing, Shanu N. Kothari
Summary: The study evaluates the use of Minimally Invasive Marshmallow Swallow Study (MSS) as a screening technique and its correlation with High Resolution Manometry (HRM) results and post-operative dysphagia. The results suggest that MSS is effective in ruling out major esophageal motility disorders and reducing the need for invasive HRM.
AMERICAN JOURNAL OF SURGERY
(2022)
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Matteo Ghisa, Brigida Barberio, Elisa Marabotto, Nicola de Bortoli, Edoardo Savarino
Summary: Esophageal motor abnormalities are common in patients with eosinophilic esophagitis (EoE) and may contribute to symptoms. Eosinophils influence esophageal motility, and some motility abnormalities can be improved after medical treatment.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Surgery
Charlotte Desprez, Henri Damon, Guillaume Meurette, Diane Mege, Jean-Luc Faucheron, Charlene Brochard, Elsa Lambrescak, Guillaume Gourcerol, Francois Mion, Vincent Wyart, Igor Sielezneff, Laurent Siproudhis, Isabelle Etienney, Nadine Ajamie, Paul-Antoine Lehur, Thomas Duflot, Valerie Bridoux, Anne-Marie Leroi
Summary: The effectiveness of sacral nerve modulation (SNM) was assessed in a large cohort of patients implanted for at least 10 years. The study found that approximately half of the patients with fecal incontinence maintained long-term efficacy after SNM treatment.
Article
Gastroenterology & Hepatology
Wei-Yi Lei, C. Prakash Gyawali, Wei-Chuan Chang, Sabine Roman, Ming Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Jui-Sheng Hung, Shu-Wei Liang, Chien-Lin Chen
Summary: The study showed that performing water swallows during straight leg raise can improve esophageal peristaltic performance and predict esophageal contraction reserve.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Jan Tack, Ans Pauwels, Sabine Roman, Edoardo Savarino, Andre Smout
Summary: A European consensus was developed on the clinical application of esophageal high-resolution manometry (HRM), providing guidance on when to consider HRM, how to perform it, and how to interpret the results. Areas of uncertainty and lack of consensus were identified, particularly in terms of treatment implications, highlighting the need for future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Otorhinolaryngology
Sabine Roman, Livia Anna Guadagnoli, Audrey Hastier, Estelle Becam, Meredith Ruth Ann Craven, John E. Pandolfino, Marie Napoleon, Dustin A. Carlson, Francois Mion, Tiffany Taft
Summary: The study found that the esophageal dysphagia questionnaire (BEDQ) is a valid clinical assessment tool in French, accurately reflecting the frequency and intensity of dysphagia in patients, and showing good correlation with other scoring tools. For patients undergoing examination, the BEDQ score is significantly higher in the dysphagia group compared to the GERD or other symptom groups.
Article
Gastroenterology & Hepatology
Barrett Rogers, Benjamin Rogers, Marzio Frazzoni, Edoardo Savarino, Sabine Roman, Daniel Sifrim, C. Prakash Gyawali
Summary: In pH-impedance studies, acidic reflux episodes in upright position with high proximal extent and longer acid clearance times have the highest concordance for identification by expert reviewers. Reflux episode identification may be influenced by reviewer opinions despite the availability of established criteria.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Ophthalmology
Laurent Kodjikian, Ramin Tadayoni, Eric H. Souied, Stephanie Baillif, Solange Milazzo, Stephane Dumas, Joel Uzzan, Lorraine Bernard, Evelyne Decullier, Laure Huot, Thibaud Mathis
Summary: This study evaluated the mean change in visual acuity at 52 weeks in patients with idiopathic choroidal neovascularization treated with aflibercept. The results showed significant functional and anatomical treatment effect of aflibercept, suggesting that the treat-and-extend regimen proposed after the first injection may be suitable for most cases.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Oncology
Bastien Collomb, Amelie Dubromel, Anne Gaelle Caffin, Chloe Herledan, Virginie Larbre, Amandine Baudouin, Ariane Cerutti, Laurence Couturier, Magali Maire, Lionel Karlin, Delphine Maucort-Boulch, Laure Huot, Stephane Dalle, Emmanuel Bachy, Herve Ghesquieres, Gilles Salles, Sebastien Couraud, Benoit You, Gilles Freyer, Veronique Trillet-Lenoir, Florence Ranchon, Catherine Rioufol
Summary: This study assessed symptoms potentially related to adverse events experienced by cancer outpatients treated with OAAs using patient-reported outcomes (PROs). The results showed that almost three-quarters of the patients reported at least one high-level symptom, with fatigue, various psychological disorders, and general pain being the most commonly experienced symptoms. This study highlights the importance of close coordination between community and hospital health professionals and the integration of patient self-reporting systems in oncology clinical practice.
Article
Ophthalmology
Laurent Kodjikian, Amro Abukhashabah, Christine Fardeau, Ramin Tadayoni, Antoine Brezin, Stephane Dumas, Michel Weber, Lorraine Bernard, Olivier Loria, Evelyne Decullier, Laure Huot, Thibaud Mathis
Summary: This study evaluated the mean change in best-corrected visual acuity in patients with inflammatory choroidal neovascularization treated with aflibercept. The results showed that aflibercept was clinically effective in treating inflammatory CNV both anatomically and functionally.
ACTA OPHTHALMOLOGICA
(2023)
Article
Gastroenterology & Hepatology
Guillaume Gourcerol, Benoit Coffin, Bruno Bonaz, Helene Hanaire, Stanislas Bruley Des Varannes, Frank Zerbib, Robert Caiazzo, Jean Charles Grimaud, Francois Mion, Samy Hadjadj, Paul Valensi, Lucine Vuitton, Guillaume Charpentier, Alain Ropert, Romain Altwegg, Philippe Pouderoux, Etienne Dorval, Michel Dapoigny, Henri Duboc, Pierre Yves Benhamou, Aurelie Schmidt, Nathalie Donnadieu, Philippe Ducrotte, Bruno Guerci
Summary: The study aimed to evaluate the efficacy, safety, and medico-economic impact of Enterra therapy for chronic medically refractory nausea and vomiting. The results showed that Enterra therapy significantly improved the gastrointestinal quality of life index score and reduced vomiting frequency. It also decreased healthcare costs and resulted in savings for the patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Ophthalmology
Laurent Kodjikian, Catherine Creuzot-Garcher, Jean-Francois Korobelnik, Ramin Tadayoni, Ivan Delafoy, Cecilia Leal, Lorraine Bernard, Evelyne Decullier, Laure Huot, Thibaud Mathis
Summary: The aim of this study was to determine if microperimetric parameters could predict the progression of an eye at high risk of age-related macular degeneration. The results showed that mean retinal sensitivity was the only predictive parameter associated with progression.
ACTA OPHTHALMOLOGICA
(2023)
Article
Gastroenterology & Hepatology
Morgane Sallette, Jamila Lenz, Francois Mion, Sabine Roman
Summary: This study compared the frequency of motility disorders diagnosed with CCv3.0 and CCv4.0 and evaluated the severity of symptoms. The results showed that while the diagnoses remained mainly unchanged with both versions, CCv4.0 had a lower frequency of ineffective esophageal motility (IEM) compared to CCv3.0.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Health Care Sciences & Services
Pascale Guerre, Laure Huot, Cyrille Colin, Adrien Marrel, Hugo Rabier
Summary: Depending on countries and health systems, medico-economic assessment guidelines recommend to adopt one or several perspectives. We conducted a systematic literature review to assess the fit between the country guidelines and the perspectives announced in the published studies.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Medicine, General & Internal
Hassan Serrier, Laure Huot, Sophie Brosset, Cecile Batailler, Tristan Ferry
Summary: The study aims to evaluate the cost-effectiveness of using Cerament-G compared to standard of care in the treatment of chronic long bone osteomyelitis. The study is a prospective, multicenter, randomized, single blind study conducted in 14 French Reference Centers for Complex Osteoarticular infections. The results will support the recommendation for the use of Cerament-G and its reimbursement through the French Health Insurance scheme.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Tess Martin, Alessandra Guercio, Helene Besseau, Laure Huot, Pascale Guerre, Jamal Atfeh, Laurent Piazza, Judith Pineau, Brigitte Sabatier, Isabelle Borget, Nicolas Martelli
Summary: A national survey was conducted to assess the implementation of hospital-based health technology assessment (HB-HTA) in French hospitals and to identify its level of formalization.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2023)
Article
Ophthalmology
Laurent Kodjikian, Amina Rezkallah, Evelyne Decullier, Gilles Aulagner, Laure Huot, Thibaud Mathis
Summary: The study aims to evaluate early predictive factors of visual loss in patients treated with anti-VEGF injections for neovascular AMD. The study found that a larger CNV area at baseline and the presence of fluid at 3 months were associated with visual loss.
OPHTHALMOLOGY RETINA
(2022)
