Article
Gastroenterology & Hepatology
Brigida Barberio, Lesley A. Houghton, Yan Yiannakou, Edoardo Savarino, Christopher J. Black, Alexander C. Ford
Summary: The study found that among individuals self-identifying as having IBS, the diagnosis and subtype of IBS were less stable, and starting new treatments did not affect symptom stability.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Mais Khasawneh, Orla F. Craig, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: The study suggests that diagnosing IBS according to the Rome IV criteria and conducting limited investigation is safe and durable. Among IBS patients, although 1 in 6 were referred again due to gastrointestinal symptoms, missed organic gastrointestinal disease occurred in only 1% of patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Lesley A. Houghton, Yan Yiannakou, Christopher J. Black, Alexander C. Ford
Summary: This study found that the natural history of irritable bowel syndrome (IBS) defined according to the Rome IV criteria is more severe compared to IBS defined by the Rome III criteria. Approximately 60% of the participants met the Rome IV criteria, while approximately 40% met the Rome III criteria. Individuals with Rome IV IBS were more likely to seek medical care, start new treatments, and have more treatment cycles compared to those with Rome III IBS. Additionally, Rome IV IBS patients had more severe symptoms, greater impact on daily activities, and poorer psychological health.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jie Wu, Imke Masuy, Jessica R. Biesiekierski, Heather E. Fitzke, Chinar Parikh, Laurel Schofield, Hafsa Shaikh, Anisha Bhagwanani, Qasim Aziz, Stuart A. Taylor, Jan Tack, Lukas Van Oudenhove
Summary: Fructans induce similar changes in small bowel motility and colon gas and volume in patients with irritable bowel syndrome (IBS) and healthy controls (HCs). Increased symptom responses to fructans in IBS are associated with altered brain responses in pain-related regions, indicating a dysregulation of the gut-brain axis in FODMAP-induced symptom generation in IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Nutrition & Dietetics
Esther Colomier, Lukas Van Oudenhove, Jan Tack, Lena Boehn, Sean Bennet, Sanna Nybacka, Stine Stoersrud, Lena oehman, Hans Toernblom, Magnus Simren
Summary: This study investigated predictors of symptom improvement in patients with irritable bowel syndrome following low FODMAP and traditional IBS diets, finding that psychological, nutritional, and microbial factors play a role in symptom improvement.
Article
Nutrition & Dietetics
Sanna Nybacka, Stine Storsrud, Helen M. Lindqvist, Hans Tornblom, Magnus Simren, Anna Winkvist
Summary: The study found subtle differences in FODMAP intake among IBS patients with different subtypes, with the association between IBS symptoms and FODMAP intake being most prominent in unsubtyped IBS patients. However, patients intolerant to certain FODMAPs may have already reduced their intake, requiring future cohort or experimental studies for further investigation.
Article
Gastroenterology & Hepatology
Adrienne Lenhart, Tien Dong, Swapna Joshi, Nancee Jaffe, Charlene Choo, Cathy Liu, Jonathan P. Jacobs, Venu Lagishetty, Wendy Shih, Jennifer S. Labus, Arpana Gupta, Kirsten Tillisch, Emeran A. Mayer, Lin Chang
Summary: This study found that restrictive diets are more likely to be consumed by irritable bowel syndrome (IBS) patients than healthy controls (HCs) to reduce the severity of gastrointestinal symptoms. Dietary patterns influence the composition of the fecal microbiota and may explain some of the differences between IBS and HCs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Pei-Lin Yang, Kendra J. Kamp, Robert L. Burr, Hsin-Yi (Jean) Tang, Adrian Dobra, Robert J. Shulman, Margaret M. Heitkemper
Summary: This study found that fatigue is a critical target for symptom management in adults with IBS, regardless of age. Comorbid anxiety is likely an important treatment focus for young adults with IBS. The study also found that intestinal gas and bloating symptoms exert considerable influences in both age groups. Overall, the symptom structure and connectivity were found to be similar regardless of age.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Pr. Benoit Coffin, Henri Duboc
Summary: Persistent abdominal pain is a challenging condition often misdiagnosed as functional disorders. This article provides an update on less well-known causes of abdominal pain and their diagnosis and management.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Christian Bojarski, Paul Tangermann, Christian Barmeyer, Juliane Buchkremer, Ralf Kiesslich, Mark Ellrichmann, Stefan Schreiber, Carsten Schmidt, Andreas Stallmach, Robert Roehle, Christoph Loddenkemper, Severin Daum, Britta Siegmund, Michael Schumann, Reiner Ullrich
Summary: The study evaluated the diagnostic accuracy of confocal laser endomicroscopy for identifying wheat sensitivity in patients with IBS, showing low sensitivity and specificity.
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Gastroenterology & Hepatology
Elton Dajti, Leonardo Frazzoni, Veronica Iascone, Matteo Secco, Amanda Vestito, Lorenzo Fuccio, Leonardo Henry Eusebi, Pietro Fusaroli, Fernando Rizzello, Carlo Calabrese, Paolo Gionchetti, Franco Bazzoli, Rocco Maurizio Zagari
Summary: Faecal calprotectin is a reliable test with high sensitivity and specificity for distinguishing patients with inflammatory bowel disease from those with irritable bowel syndrome. It seems to have a better sensitivity in Western countries and at a cut-off of <= 50 mu g/g.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Paula Ma Rodriguez-Castillejo, Cesar Fernandez-de-las-Penas, Francisco Alburquerque-Sendin, Daiana P. Rodrigues-de-Souza
Summary: The comorbidity between FM and IBS is not considered in the eligibility criteria of clinical trials evaluating physical therapy. Improvements in the selection criteria are necessary to avoid selection bias in clinical trials involving FM patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Brigida Barberio, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: This study conducted a network meta-analysis to compare the relative efficacy of various biological therapies and small molecules in the treatment of luminal Crohn's disease. The results showed differences in the effectiveness of different drugs in inducing and maintaining clinical remission, and previous exposure to biologics also had an impact on treatment outcomes.
Article
Education & Educational Research
Vanessa Botan, Despina Laparidou, Viet-Hai Phung, Peter Cheung, Adrian Freeman, Richard Wakeford, Meiling Denney, Graham R. R. Law, Aloysius Niroshan Siriwardena
Summary: This study evaluated examiner perceptions of the Recorded Consultation Assessment (RCA) as a replacement for the Clinical Skills Assessment (CSA) in the UK general practice licensing exam. The results showed that the RCA was considered feasible and broadly acceptable by examiners, although challenges were experienced in candidate case selection, case content, and judgments.
BMC MEDICAL EDUCATION
(2023)
Letter
Gastroenterology & Hepatology
Vivek C. Goodoory, Elspeth A. Guthrie, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho E. Ng, Christopher J. Black, Alexander C. Ford
Summary: This article is associated with Goodoory et al papers. Click the link to access these articles.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Alexander C. Ford, Colin W. Howden
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mais Khasawneh, Orla F. Craig, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: The study suggests that diagnosing IBS according to the Rome IV criteria and conducting limited investigation is safe and durable. Among IBS patients, although 1 in 6 were referred again due to gastrointestinal symptoms, missed organic gastrointestinal disease occurred in only 1% of patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Maria rosa Ingrosso, Christopher j. Black, Alexander c. Ford
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christopher J. Black, David J. Gracie, Alexander C. Ford
Summary: Using latent class analysis, this study identified novel clusters of patients with inflammatory bowel disease (IBD) and found that patients with higher gastrointestinal and psychological symptoms were at a higher risk of adverse disease outcomes and were also high-volume users of healthcare.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Brigida Barberio, Giulio Del Corso, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford, Edoardo Savarino
Summary: A network meta-analysis was conducted to compare the efficacy of different drugs for active eosinophilic esophagitis (EoE). The results showed that most available drugs were more effective than placebo in treating EoE. However, significant heterogeneity among the trials hindered the establishment of a solid therapeutic hierarchy.
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christian P. Selinger, David J. Gracie, Alexander C. Ford
Summary: The use of opioids in patients with inflammatory bowel disease (IBD) is associated with psychological comorbidity and an increased risk of intestinal resection, particularly with stronger formulations. Future studies should classify the risks of different opioids to develop reliable prescribing algorithms, and evaluate the effectiveness of addressing psychological factors as an opioid avoidance strategy in routine IBD care.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Brigida Barberio, Keeley M. Fairbrass, David J. Gracie, Alexander C. Ford
Summary: In this 12-month longitudinal study, one-third of patients with IBD reported presence of Rome III IBS-type symptoms at any point in time. Reporting such symptoms was associated with significant impacts on psychological health and/or quality of life.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Mais Khasawneh, Orla F. Craig, David J. Gracie, Christopher J. Black, Alexander C. Ford