Article
Gastroenterology & Hepatology
Eva Roman, Marc Parramon, Montserrat Flavia, Cristina Gely, Maria Poca, Adolfo Gallego, Rosalia Santesmases, Elvira Hernandez, Juan C. Nieto, Eulalia Urgell, Edilmar Alvarado-Tapias, Silvia Vidal, Andreu Ferrero-Gregori, Victor Vargas, Carlos Guarner, German Soriano
Summary: Frailty was more common in outpatients with cirrhosis than in controls, mainly due to decreased muscle strength. Frail cirrhotic patients had a higher likelihood of hospitalization and falls during follow-up, but similar mortality rates.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Xiaoyu Wang, Hongjuan Feng, Yangyang Hui, Tianming Zhao, Lihong Mao, Xiaofei Fan, Binxin Cui, Lin Lin, Jie Zhang, Bangmao Wang, Qingxiang Yu, Xingliang Zhao, Chao Sun
Summary: This study aimed to develop a personalized prediction tool for 2-year mortality in cirrhosis for primary care physicians. A nomogram incorporating parameters like 5-meter gait speed was shown to effectively predict survival rates in cirrhotic patients, demonstrating good utility in clinical settings.
POSTGRADUATE MEDICINE
(2021)
Article
Geriatrics & Gerontology
Shannon Mance, Andrea Rosso, Joshua Bis, Stephanie Studenski, Nico Bohnen, Caterina Rosano
Summary: The study aimed to examine the association between dopamine-related genotype and gait speed according to frailty status or race. The results showed a stronger association between dopamine-related genotype and gait speed among adults with frailty compared to those without frailty. However, the association did not differ significantly among individuals of different races.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Tetsuya Ozawa, Masashi Yamashita, Satoshi Seino, Kentaro Kamiya, Nobuyuki Kagiyama, Masaaki Konishi, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Emi Maekawa, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo, Hiroshi Wada, Takatoshi Kasai, Shin-ichi Momomura, Nobuaki Hamazaki, Kohei Nozaki, Hunkyung Kim, Shuichi Obuchi, Hisashi Kawai, Akihiko Kitamura, Shoji Shinkai, Yuya Matsue
Summary: This study aimed to define an event-driven cut-off for the relative decline in gait speed against age-adjusted reference values and evaluate its prognostic implications in elderly patients with heart failure. The results showed that a standardized gait speed ratio of 0.527 was independently associated with mortality in this population.
Article
Geriatrics & Gerontology
Kensuke Ueno, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Takumi Noda, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: This study found that slower maximal gait speed in CVD patients was associated with higher mortality, and evaluating maximal gait speed in conjunction with usual gait speed could further improve risk stratification for prognosis.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Oncology
Andrew Hantel, Clark DuMontier, Oreofe O. Odejide, Marlise R. Luskin, Adam S. Sperling, Tammy Hshieh, Richard Chen, Robert Soiffer, Jane A. Driver, Gregory A. Abel
Summary: Measuring gait speed in older adults with blood cancer can predict survival but does not impact oncologists' treatment intensity recommendations. Therefore, incorporating gait speed into decision-making may help improve optimal treatment selection.
Article
Geriatrics & Gerontology
Yong-Hao Pua, Laura Tay, Ross Allan Clark, Julian Thumboo, Ee-Ling Tay, Shi-Min Mah, Yee-Sien Ng
Summary: This study aimed to examine the screening accuracy of an optimal GS% predicted threshold for prefrailty/frailty. The study found that a GS% predicted threshold of 0.93 provided higher screening accuracy than the traditional 1.0 m/s threshold for gait speed. Additionally, replacing gait speed with GS% predicted improved the overall discrimination of the Physical Frailty Phenotype.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Karolina Piotrowicz, Hanna Kujawska-Danecka, Kacper Jagiello, Adam Hajduk, Anna Skalska, Malgorzata Mossakowska, Tomasz Zdrojewski, Tomasz Grodzicki, Jerzy Gasowski
Summary: This study conducted a survey among older Poles and found that slow gait speed is the predominant component of frailty. Among older adults, at least 72% have at least one frailty component. The overall prevalence of frailty is 15.9% and pre-frailty is 55.8%.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Marta Tonon, Silvia Rosi, Carmine Gabriele Gambino, Salvatore Piano, Valeria Calvino, Antonietta Romano, Andrea Martini, Patrizia Pontisso, Paolo Angeli
Summary: The study found that AKD is common in patients with cirrhosis, has a significant negative impact on the clinical course and survival of patients, can be reversible, but may recur and progress to CKD.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Reilly D. Hobbs, Elizabeth L. Norton, Xiaoting Wu, Cristen J. Willer, Scott L. Hummell, Richard L. Prager, Jonathan Afilalo, Whitney E. Hornsby, Bo Yang
Summary: The study aimed to evaluate whether 5-m gait speed is associated with postoperative events after elective proximal aortic surgery. The results showed that slow walkers had a higher risk of in-hospital mortality, prolonged ventilation, renal failure, and were less likely to be discharged home. Gait speed may complement existing operative risk models.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Chisato Saeki, Mitsuru Saito, Akihito Tsubota
Summary: Plasma pentosidine levels in patients with cirrhosis are associated with sarcopenia, low gait speed, and mortality, and may serve as a useful surrogate biomarker for these clinical events.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Li Siyu, Yuan Yuan, An Ran, Li Minyan
Summary: Frailty is common in out-patient patients with cirrhosis in China. Elderly, reduced gait speed, lack of physical activity, and low educational level are risk factors for frailty and prefrailty, and early identification and intervention are necessary.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Arthur Berger, Federico Ravaioli, Oana Farcau, Davide Festi, Horia Stefanescu, Francois Buisson, Pierre Nahon, Christophe Bureau, Nathalie Ganne-Carrie, Annalisa Berzigotti, Victor de Ledinghen, Salvatore Petta, Paul Cales
Summary: The study aimed to improve strategies to rule out varices needing treatment in patients with chronic liver disease by including data on the ratio of platelets to liver stiffness. VariScreen algorithm was found to be safe and effective in ruling out varices in patients with chronic liver disease of any etiology or severity, making it a valuable tool for clinical practice.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Respiratory System
Claire M. Nolan, Susie J. Schofield, Matthew Maddocks, Suhani Patel, Ruth E. Barker, Jessica A. Walsh, Oliver Polgar, Peter M. George, Philip L. Molyneaux, Toby M. Maher, Paul Cullinan, William D. -C. Man
Summary: This study aimed to investigate the longitudinal change of four-metre gait speed (4MGS) in newly diagnosed individuals with idiopathic pulmonary fibrosis (IPF) and its association with adverse outcome. The study found that 4MGS declined over 6 months, and a decline of 0.07 m/s or more was significantly associated with increased risk of hospitalization/death. Therefore, 4MGS change has the potential to serve as a surrogate endpoint for interventions targeting hospitalization/death risk.
Article
Geriatrics & Gerontology
H. Domergue, S. C. Regueme, O. L. Zafra, L. Manaz-Rodriguez, A. Sinclair, I Bourdel-Marchasson
Summary: The study found that in frail or prefrail older adults with diabetes, slower walking speed was associated with a faster decline in category fluency.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)