How May Proton Pump Inhibitors Impair Cardiovascular Health?

Conflicting Results Between Randomized Trials and Observational Studies on the Impact of Proton Pump Inhibitors on Cardiovascular Events When Coadministered With Dual Antiplatelet Therapy

(2015) Chiara Melloni et al.  

Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension

(2015) Lucas C. Pinheiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proton pump inhibitors and vascular function: A prospective cross-over pilot study

(2015) Yohannes T Ghebremariam et al.   VASCULAR MEDICINE

Conflicting Results Between Randomized Trials and Observational Studies on the Impact of Proton Pump Inhibitors on Cardiovascular Events When Coadministered With Dual Antiplatelet Therapy

(2015) Chiara Melloni et al.   Circulation-Cardiovascular Quality and Outcomes

Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population

(2015) Nigam H. Shah et al.   PLoS One

Rising rates of proton pump inhibitor prescribing in US emergency departments

(2014) Maryann Mazer-Amirshahi et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Letter by Montenegro and Lundberg Regarding Article, “Unexpected Effect of Proton Pump Inhibitors: Elevation of the Cardiovascular Risk Factor Asymmetric Dimethylarginine”

(2014) Marcelo F. Montenegro et al.   CIRCULATION

Letter by Pinheiro et al Regarding Article, “Unexpected Effect of Proton Pump Inhibitors: Elevation of the Cardiovascular Risk Factor Asymmetric Dimethylarginine”

(2014) Lucas C. Pinheiro et al.   CIRCULATION

Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update

(2014) Ralph-Steven Wedemeyer et al.   DRUG SAFETY

Revising the link between proton-pump inhibitors and risk of acute myocardial infarction—a case-crossover analysis

(2014) Aleksandra Turkiewicz et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Proton pump inhibitor use represents an independent risk factor for myocardial infarction

(2014) Chia-Jen Shih et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction

(2014) J P Depta et al.   PHARMACOGENOMICS JOURNAL

Proton-Pump Inhibitor Use and the Risk for Community-Acquired Pneumonia

(2013) Monika Sarkar et al.   ANNALS OF INTERNAL MEDICINE

Proton-Pump Inhibitors Are Associated With Increased Cardiovascular Risk Independent of Clopidogrel Use

(2013) Mette Charlot   ANNALS OF INTERNAL MEDICINE

Unexpected Effect of Proton Pump Inhibitors

(2013) Yohannes T. Ghebremariam et al.   CIRCULATION

TEMPOL enhances the antihypertensive effects of sodium nitrite by mechanisms facilitating nitrite-derived gastric nitric oxide formation

(2013) Jefferson H. Amaral et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of lysosomal enzyme activities by proton pump inhibitors

(2013) Wensheng Liu et al.   JOURNAL OF GASTROENTEROLOGY

Proton pump inhibitors and hypomagnesemia: a rare but serious complication

(2013) Mark A. Perazella   KIDNEY INTERNATIONAL

Proton Pump Inhibitors and the Risk of Adverse Cardiac Events

(2013) David N. Juurlink et al.   PLoS One

Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors

(2013) Jai Moo Shin et al.   Journal of Neurogastroenterology and Motility

Systematic review: hypomagnesaemia induced by proton pump inhibition

(2012) M. W. Hess et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Association of Proton Pump Inhibitor Use on Cardiovascular Outcomes With Clopidogrel and Ticagrelor

(2012) Shaun G. Goodman et al.   CIRCULATION

Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats

(2012) Lucas C. Pinheiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy and safety of loop diuretic therapy in acute decompensated heart failure: a clinical review

(2012) Laura Leto et al.   HEART FAILURE REVIEWS

No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: Meta-analysis

(2012) Chun Shing Kwok et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Proton Pump Inhibitors

(2012) Saman Chubineh et al.   SOUTHERN MEDICAL JOURNAL

Concomitant use of clopidogrel and proton pump inhibitors is not associated with major adverse cardiovascular events following coronary stent implantation

(2011) M. Schmidt et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

DDAH Says NO to ADMA

(2011) John P. Cooke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proton pump inhibitor side effects and drug interactions: Much ado about nothing?

(2011) R. D. MADANICK   CLEVELAND CLINIC JOURNAL OF MEDICINE

Proton Pump Inhibitor Discontinuation in Long-Term Care

(2011) Amy Linsky et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors

(2010) V. E. Valkhoff et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Nitrate-Nitrite-Nitric Oxide Pathway

(2010) Eddie Weitzberg et al.   ANESTHESIOLOGY

Proton Pump Inhibitor Use, Hip Fracture, and Change in Bone Mineral Density in Postmenopausal Women

(2010) Shelly L. Gray   ARCHIVES OF INTERNAL MEDICINE

Failing the Acid Test

(2010) Mitchell H. Katz   ARCHIVES OF INTERNAL MEDICINE

Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis

(2010) C.-S. Eom et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension

(2010) Mattias Carlström et al.   CARDIOVASCULAR RESEARCH

Patterns and Predictors of Proton Pump Inhibitor Overuse among Academic and Non-Academic Hospitalists

(2010) Shaker M. Eid et al.   INTERNAL MEDICINE

Clopidogrel with or without Omeprazole in Coronary Artery Disease

(2010) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Use of Acid-Suppressing Drugs Before the Occurrence of Ischemic Events: A Potential Source of Confounding in Recent Observational Studies

(2010) David F Blackburn et al.   PHARMACOTHERAPY

Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease

(2010) Andrew M Wilson et al.   VASCULAR MEDICINE

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

(2010) M L Marino et al.   Cell Death & Disease

Proton Pump Inhibitor Use and Enteric Infections

(2009) M Sandra Dial   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effect of Proton Pump Inhibitors on Vitamins and Iron

(2009) Kenneth E L McColl   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Comprehensive Review of the Loop Diuretics: Should Furosemide Be First Line?

(2009) Kurt A Wargo et al.   ANNALS OF PHARMACOTHERAPY

A population-based study of the drug interaction between proton pump inhibitors and clopidogrel

(2009) D. N. Juurlink et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome

(2009) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint

(2009) Helge L. Waldum et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Use of proton pump inhibitors and risk of osteoporosis-related fractures

(2008) L. E. Targownik et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Proton pump inhibitors: an update of their clinical use and pharmacokinetics

(2008) Shaojun Shi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

(2008) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

The gastric HK-ATPase: structure, function, and inhibition

(2008) Jai Moo Shin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY