Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Soeren Mattke, Hankyung Jun, Emily Chen, Ying Liu, Andrew Becker, Christopher Wallick
Summary: This study aimed to compare the actual diagnosis rates of mild cognitive impairment (MCI) and dementia in the full Medicare population with the predicted diagnosis rates. The study found that the detection rate for MCI was low, especially among Black and Hispanic beneficiaries. Dementia was diagnosed more frequently, particularly in non-Hispanic White beneficiaries.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Clinical Neurology
Dana Pourzinal, Jihyun Yang, Rachael A. Lawson, Katie L. McMahon, Gerard J. Byrne, Nadeeka N. Dissanayaka
Summary: This review evaluates the literature on data-driven subtypes of cognition in Parkinson's disease (PD), finding that there are subtype structures either showing a spectrum of severity or specific domains of impairment. Neuroimaging evidence provides insight into distinct patterns of brain alterations among subtypes. The clinical relevance of certain cognitive subtypes in PD is highlighted, but further research is needed to explore the underlying neural mechanisms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jacqueline M. Torres, Karla Renata Flores Romero, Ashwin A. Kotwal, Ruijia Chen, Tanisha Hill-Jarrett, Uchechi A. Mitchell, Medellena Maria Glymour
Summary: Little is known about the population of individuals who live with a spouse with cognitive impairment or dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Hannah Gardener, Bonnie Levin, Janet DeRosa, Tatjana Rundek, Clinton B. Wright, Mitchell S. Elkind, Ralph L. Sacco
Summary: The study suggests that social connections may have a protective effect on cognitive health, especially in disadvantaged populations.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Xiao Deng, Yilin Ning, Seyed Ehsan Saffari, Bin Xiao, Chenglin Niu, Samuel Yong Ern Ng, Nicole Chia, Xinyi Choi, Dede Liana Heng, Yi Jayne Tan, Ebonne Ng, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Adeline Ng, Eng-King Tan, Nan Liu, Louis C. S. Tan
Summary: Using a machine learning approach, this study found a strong association between high triglyceride and apolipoprotein A1 levels and Parkinson's disease mild cognitive impairment (PD-MCI), while SNCA rs6826785 may be a novel therapeutic target for PD-MCI. ShapleyVIC-assisted variable selection is a novel and robust alternative for prioritizing variables of interest in future clinical studies.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Zhang, Yuyuan Gao, Xuetao He, Shujun Feng, Jinlong Hu, Qingxi Zhang, Jiehao Zhao, Zhiheng Huang, Limin Wang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Summary: PD-MCI is characterized by widespread structural and EEG abnormalities. Composite markers could be valuable for the individualized diagnosis of PD-MCI through machine learning. The SVM model based on qEEG and structural MR features showed high accuracy in identifying PD-MCI.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Pei-Hao Chen, Ya-Yuan Yang, Ying-Yi Liao, Shih-Jung Cheng, Pei-Ning Wang, Fang-Yu Cheng
Summary: This study explored factors associated with fear of falling in individuals with mild cognitive impairment due to Alzheimer's disease and Parkinson's disease, finding that FOF in different types of cognitive impairment was determined by different factors.
Article
Geriatrics & Gerontology
Kevin J. Sullivan, Xinhui Ran, Fan Wu, Chung-Chou H. Chang, Ravi Sharma, Erin Jacobsen, Sarah Berman, Beth E. Snitz, Akira Sekikawa, Evelyn O. Talbott, Mary Ganguli
Summary: This study examined the association between ambient PM2.5 levels and the risk of incident MCI and dementia in an older population, finding that higher estimated PM2.5 levels were associated with increased risk of both conditions, particularly with longer-term exposure.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Health Care Sciences & Services
Lindsay White, Bailey Ingraham, Eric Larson, Paul Fishman, Sungchul Park, Norma B. Coe
Summary: Timely diagnosis of cognitive impairment is a key goal of the National Plan to Address Alzheimer's Disease, but studies on factors contributing to timely diagnosis are limited. This retrospective observational study found that only 26% of respondents with incident dementia and 11.4% with incident MCI received a timely diagnosis. Non-Hispanic Black and individuals with lower educational attainment were less likely to receive timely diagnosis of dementia or MCI compared to Non-Hispanic White respondents or those with a college degree.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
James A. G. Crispo, Melody Lam, Britney Le, Lucie Richard, Salimah Z. Shariff, Dominique R. Ansell, Melanie Squarzolo, Connie Marras, Allison W. Willis, Dallas Seitz
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2020)
Article
Clinical Neurology
Ali G. Hamedani, Danielle S. Abraham, Maureen G. Maguire, Allison W. Willis
MOVEMENT DISORDERS
(2020)
Article
Pharmacology & Pharmacy
Thanh Phuong Pham Nguyen, Yong Chen, Dylan Thibault, Charles E. Leonard, Sean Hennessy, Allison Willis
Article
Public, Environmental & Occupational Health
Darcy E. Ellis, Rebecca A. Hubbard, Allison W. Willis, Athena F. Zuppa, Theoklis E. Zaoutis, Sean Hennessy
Summary: The study found that the use of fluoroquinolone antibiotics was associated with an increased risk of neurological dysfunction compared to the use of a comparator antibiotic in the adult population.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Editorial Material
Clinical Neurology
Allison Willis, Lesli E. Skolarus, Roland Faigle, Uma Menon, Hannah Redwine, Amanda M. Brown, Elizabeth Felton, Adys Mendizabal, Avindra Nath, Frances Jensen, Justin C. McArthur
ANNALS OF NEUROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Darcy E. Ellis, Rebecca A. Hubbard, Allison W. Willis, Athena F. Zuppa, Theoklis E. Zaoutis, Sean Hennessy
Summary: In predicting neurological dysfunction among fluoroquinolone users, the LASSO model outperformed the random forest model in terms of accuracy and calibration, especially when the cohort size is modest, the number of model predictors is modest, and the predictors are primarily binary.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Clinical Neurology
Barbara M. Decker, Dylan Thibault, Kathryn A. Davis, Allison W. Willis
Summary: The study found that women with neurologic comorbidities are at higher risk of severe maternal morbidity at the time of delivery and postpartum readmission, especially for those with previous stroke or MG. More real-world evidence is needed to develop research infrastructure and create efficacious interventions to optimize maternal-fetal outcomes in women with neurologic comorbidities.
Article
Clinical Neurology
Cameron Miller-Patterson, Jesse Y. Hsu, Lana M. Chahine, James F. Morley, Allison W. Willis
Summary: This study aimed to determine whether dysautonomia can stratify individuals with other prodromal markers of Parkinson's disease (PD) for risk of phenoconversion and functional decline. The results showed that symptoms of gastrointestinal and female sexual dysfunction predict phenoconversion in individuals with other risk markers for PD, while signs and symptoms of cardiovascular dysfunction may be associated with functional decline.
CLINICAL AUTONOMIC RESEARCH
(2022)
Article
Clinical Neurology
Emily K. K. Acton, Leah J. J. Blank, Allison W. W. Willis, Ali G. G. Hamedani
Summary: This study evaluated the interfacility transfers following seizure-related emergency department visits. The results showed that the rate of transfer has been increasing in recent years. Factors associated with transfer included nonmetropolitan location, lack of continuous electroencephalography (cEEG) capabilities, and comorbid acute cerebrovascular disease. Therefore, the thoughtful use of novel technologies and tools may help reduce unnecessary emergency department transfers.
Article
Clinical Neurology
Ali G. Hamedani, Dylan Thibault, Allison W. Willis
Summary: A study using data from the National Inpatient Sample in the United States found that certain neurologic diseases exhibit seasonal variation in hospitalization rates. Six diseases showed statistically significant seasonality according to multiple testing methods, while four diseases showed seasonality according to some testing methods. This study highlights the importance of considering seasonality in understanding neurologic diseases.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
A. W. Willis, E. Roberts, J. C. Beck, B. Fiske, W. Ross, R. Savica, S. K. Van den Eeden, C. M. Tanner, C. Marras
Summary: Parkinson's disease is the second most common age-related neurodegenerative condition in North America, with a higher prevalence than previously reported. Age and gender affect the incidence rate, with males having a higher risk. Incidence estimates vary across different data sources, possibly due to factors such as case ascertainment, diagnosis methods, genetic risk factors, exposure to environmental toxins, and geographic location.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Danielle S. Abraham, Thanh Phuong Pham Nguyen, Leah J. Blank, Dylan Thibault, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Daniel Weintraub, Allison W. Willis
Summary: This study examined the differential prescribing patterns between new and established treatments for common neurological conditions. Using data from a national sample of US commercially insured adults from 2005-2019, the study compared new users of recently approved medications for three conditions: diabetic peripheral neuropathy, Parkinson disease psychosis, and epilepsy. The results showed that newer medications were more frequently prescribed to individuals with prior treatment, suggesting potential bias in comparative effectiveness and safety studies. The study emphasizes the importance of reporting propensity score non-overlap in comparative studies involving newer medications and suggests methodological approaches to address channeling bias.
Article
Public, Environmental & Occupational Health
Pilar Hernandez-Con, Justine Shults, Allison W. W. Willis, Yu-Xiao Yang
Summary: This study examined the association between long-term use of dopamine agonists (DAs) and the risk of lung cancer in patients with restless legs syndrome (RLS). The results showed that long-term DA use at typical doses for RLS management did not increase the risk of lung cancer.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Clinical Neurology
Thanh Phuong Pham Nguyen, Shelly L. Gray, Craig W. Newcomb, Qing Liu, Ali G. Hamedani, Daniel Weintraub, Sean Hennessy, Allison W. Willis
Summary: This study found that there were no significant differences in medication prescriptions between Parkinson disease (PD) patients hospitalized for serious injury and those hospitalized for other reasons, indicating a missed opportunity to deprescribe high-risk medications during care transitions.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Caroline Pearson, Alex Hartzman, Dianne Munevar, Megan Feeney, Rachel Dolhun, Veronica Todaro, Sheera Rosenfeld, Allison Willis, James C. Beck
Summary: It is important to understand how people with Parkinson's disease (PD) in the US utilize the healthcare system. A study analyzed the healthcare utilization patterns of PD patients enrolled in Medicare in 2019 and found significant disparities in care. Many patients did not see a neurologist or receive recommended therapy services, indicating the need for further research on barriers to accessing PD-related health care.
NPJ PARKINSONS DISEASE
(2023)
