Review
Neurosciences
Jordan DeKraker, Stefan Kohler, Ali R. Khan
Summary: This article discusses the application of surface-based methods in modeling hippocampal folding, allowing interindividual alignment in a 2D space, which helps in detailed morphological characterization and solving the problem of subfield segmentation.
TRENDS IN NEUROSCIENCES
(2021)
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Panagiota-Eleni Tsalouchidou, Christina-Julia Mueller, Marcus Belke, Felix Zahnert, Katja Menzler, Eugen Trinka, Susanne Knake, Aljoscha Thomschewski
Summary: This study investigated the relationship between hippocampal subfield volume and verbal and visual memory function in patients with temporal lobe epilepsy, mild amnestic cognitive impairment, and healthy participants. The results suggest that verbal memory performance is associated with specific hippocampal subfields, particularly the left subicular complex and left CA2/CA3.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Christine Coughlin, Eliya Ben-Asher, Hannah E. Roome, Nicole L. Varga, Michelle M. Moreau, Lauren L. Schneider, Alison R. Preston
Summary: Normative variation in social environments can influence hippocampal volume, and interpersonal family dynamics are identified as an impactful environmental feature.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Jordan DeKraker, Roy A. M. Haast, Mohamed D. Yousif, Bradley Karat, Jonathan C. Lau, Stefan Kohler, Ali R. Khan
Summary: The article introduces an automated and robust BIDS-App tool called HippUnfold, which can be used to define and index individual-specific hippocampal folding in MRI for more detailed neuroimaging analysis.
Article
Genetics & Heredity
Nana Liu, Longjiang Zhang, Tian Tian, Jingliang Cheng, Bing Zhang, Shijun Qiu, Zuojun Geng, Guangbin Cui, Quan Zhang, Weihua Liao, Yongqiang Yu, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Wen Qin, Feng Liu, Meng Liang, Qiang Xu, Jilian Fu, Jiayuan Xu, Wenzhen Zhu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Su Lui, Zhihan Yan, Feng Chen, Jiance Li, Jing Zhang, Dawei Wang, Wen Shen, Yanwei Miao, Junfang Xian, Jia-Hong Gao, Xiaochu Zhang, Mulin Jun Li, Kai Xu, Xi-Nian Zuo, Meiyun Wang, Zhaoxiang Ye, Chunshui Yu, CHIMGEN Consortium
Summary: Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant-trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.
Article
Neurosciences
Julian Macoveanu, Iselin Meluken, Lars Vedel Kessing, Hartwig Roman Siebner, Maj Vinberg, Kamilla Woznica Miskowiak
Summary: The study found that in remitted affected twins with affective disorders, a smaller volume of left dorsomedial prefrontal cortex was observed, while unaffected discordant twins showed larger hippocampal volumes, possibly associated with resilience in healthy relatives.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Summary: This study aimed to assess volumetric differences in hippocampal subfields between patients with major depressive disorder (MDD), treatment-resistant depression (TRD) and healthy controls (HC) using high-resolution MRI data. The results showed that MDD and TRD patients had reduced volume in the right-hemisphere CA2/3 subfield compared to HC. Negative correlations between subfield volumes and life-stressor checklist scores were also found. This study provides valuable insights into the pathophysiology of depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Yuanzhi Xu, Ahmed Mohyeldin, Maximiliano Alberto Nunez, Ayoze Doniz-Gonzalez, Vera Vigo, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: The authors investigated the microvascular anatomy of the hippocampus and its implications for medial temporal tumor surgery, revealing the anatomical variability of the arterial supply and venous drainage of the hippocampus. The study found rich anastomoses between hippocampal arteries and highlighted the importance of understanding the vascular variability and network of the hippocampus for surgery in this region, including anterior temporal lobectomy with amygdalohippocampectomy and transsylvian selective amygdalohippocampectomy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Katja Menzler, Hajo M. Hamer, Peter Mross, Felix Rosenow, Ralf Deichmann, Marlies Wagner, Rene-Maxime Gracien, Arnd Doerfler, Ingmar Bluemcke, Roland Coras, Marcus Belke, Susanne Knake
Summary: This study validates the correlation between automated hippocampal subfield segmentation and histopathology, with potential prognostic implications.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Behavioral Sciences
Takahiro Tsuchiya, Takeshi Matsuo, So Fujimoto, Yasuhiro Nakata, Michiharu Morino
Summary: This study aimed to investigate the relationship between hippocampal sclerosis (HS) and hippocampal gray-white matter boundary blurring (HGWBB) and its impact on clinical outcomes. A total of 54 patients with temporal lobe epilepsy who underwent hippocampal resection were included. The HGWBB index was significantly lower on the affected side compared to the unaffected side, and this trend was more pronounced in the poor prognosis group. A prognostic scoring system combining multiple criteria showed high sensitivity (87.5%) and specificity (71.7%) in predicting seizure outcomes.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Robin de Flores, Sandhitsu R. Das, Long Xie, Laura E. M. Wisse, Xueying Lyu, Preya Shah, Paul A. Yushkevich, David A. Wolk
Summary: This study reveals the relationship between the medial temporal lobe and the anterior-temporal and posterior-medial networks, and explores the vulnerability of these networks to proteinopathies in Alzheimer's disease. The results show that the atrophy of distinct subregions in the medial temporal lobe propagates differently within the anterior-temporal and posterior-medial networks. Additionally, these networks are differentially associated with relative tau and amyloid burden.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Masashi Mizutani, Daichi Sone, Terunori Sano, Yukio Kimura, Norihide Maikusa, Yoko Shigemoto, Yuichi Goto, Masaki Takao, Masaki Iwasaki, Hiroshi Matsuda, Noriko Sato, Yuko Saito
Summary: This study aimed to validate hippocampal subfield volumetry based on T2-weighted MRI and explore its clinical impact in TLE patients with HS. Results showed a significant correlation between presurgical MRI-based CA4/DG volume and CA4 cross-sectional area calculated with tissue specimens, suggesting potential for predicting postsurgical memory changes in these patients.
Article
Behavioral Sciences
Bohee Lee, June Sic Kim, Chun Kee Chung
Summary: Working memory is crucial for goal-directed behavior, and the frontoparietal network and medial temporal lobe play important roles in working memory. Through intracranial electroencephalography recording, it was found that low-frequency power in the frontal lobe and medial temporal lobe increased and sustained throughout the working memory task, while parietal alpha power peaked during memory operation. Furthermore, there was a positive correlation in the alpha band between the medial temporal lobe and the parietal lobe during memory operation.
