Article
Biochemistry & Molecular Biology
Shuichi Shibuya, Kenji Watanabe, Yusuke Ozawa, Takahiko Shimizu
Summary: While XOR-mediated O-2(center dot-) production contributes to aging-like pathologies in mice, its involvement in age-related tissue damage induced by SOD1 loss remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Konstantinos Tsesmelis, Gandhari Maity-Kumar, Dana Croner, Jasmin Sprissler, Miltiadis Tsesmelis, Tabea Hein, Bernd Baumann, Thomas Wirth
Summary: Aging of the central nervous system (CNS) leads to motoric and cognitive decline and increases the probability for neurodegenerative disease development. Astrocytes fulfill central homeostatic functions in the CNS including regulation of immune responses and metabolic support of neurons and oligodendrocytes. Our study identifies maintenance of ROS homeostasis in astrocytes as a critical prerequisite for physiological CNS aging.
Article
Geriatrics & Gerontology
Daniela Toebelmann, Manuela Dittmar
Summary: The study demonstrated a circadian pattern of expression for SOD1 mRNA and SOD1 protein levels in healthy young and older women, with a delay observed between the peak levels of SOD1 mRNA and protein possibly due to translation time. Differences in the timing of 24-h maxima and relationships between characters in young and older women may be attributed to age-related alterations in circadian system. The absence of relationships between SOD1 levels and oxidative RNA/DNA damage suggests a complex interaction between the antioxidant system and circadian system.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Kayo Machihara, Shoma Oki, Yuka Maejima, Sou Kageyama, Ayumu Onda, Yurino Koseki, Yasuyuki Imai, Takushi Namba
Summary: Spirulina polysaccharide complex (SPC) restores mitochondrial function and collagen production by scavenging superoxide via upregulation of superoxide dismutase 2 (SOD2) in aging fibroblasts. SPC also stimulates endoplasmic reticulum (ER) protein folding by upregulating ER chaperones expression. Therefore, SPC is proposed as an antiaging material that rejuvenates aging fibroblasts by increasing their antioxidant potential via upregulation of SOD2.
Article
Cell Biology
Deng-Tai Wen, Lan Zheng, Kai Lu, Wen-Qi Hou
Summary: The study indicates that long-term high-salt intake may accelerate cardiac aging and age-related diseases, while long-term exercise can delay cardiac aging. Through fruit fly experiments, it was found that long-term exercise and RNAi could significantly prevent the aging defects caused by high-salt pressure and salt overexpression in the heart, including increased heart period, arrhythmia, oxidative stress, and decreased mitochondrial quantity.
Article
Biochemistry & Molecular Biology
Audrey Dangoumau, Sylviane Marouillat, Roxane Coelho, Francois Wurmser, Celine Brulard, Shanez Haouari, Frederic Laumonnier, Philippe Corcia, Christian R. Andres, Helene Blasco, Patrick Vourc'h
Summary: Protein aggregates in motor neurons affected by ALS are associated with oxidative stress, which alters the expression of genes involved in ubiquitin and SUMO pathways. The combined effects of oxidative stress and ALS-related genetic mutations on gene expression highlight potential mechanisms underlying ALS pathophysiology and suggest targets for protecting motor neurons from neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gareth S. A. Wright
Summary: The internalization of a bacteria by an archaeal cell accelerated eukaryotic evolution by utilizing a specific copper chaperone to activate CuZnSOD for combating oxidative stress. The adoption of a single protein interface with structural characteristics necessary for homodimerization and heterodimerization played a crucial role in evolution.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Geriatrics & Gerontology
Serafino Teseo, Benjamin Houot, Kaiye Yang, Veronique Monnier, Guangrong Liu, Herve Tricoire
Summary: The global increase in the proportion of older people and prevalence of age-related diseases has intensified research in aging biology. Using Drosophila melanogaster model, the study confirmed the potential of herbal extracts from traditional Chinese medicine in slowing down aging, improving healthspan, and providing protection against age-related diseases.
Article
Biotechnology & Applied Microbiology
Duygu Aydemir, Anjum Naeem Malik, Ibrahim Kulac, Ayse Nazli Basak, Ismail Lazoglu, Nuriye Nuray Ulusu
Summary: This study found increased lung stiffness, decreased antioxidant status, elevated levels of oxidative stress, impaired mineral and trace element homeostasis, and mutated SOD1(G93A) protein accumulation in the mutated rats even at the earlier stages of ALS. These findings could potentially contribute to increased lung stiffness and tissue damage in ALS.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Wei-Syun Hu, Wei-Yu Liao, Chin-Hsien Chang, Tung-Sheng Chen
Summary: This study investigates the mechanism of biomolecules released from mesenchymal stem cells in the treatment of cardiac aging. The results suggest that paracrine release of IGF-1 from mesenchymal stem cells increases the expression of antioxidant marker SOD2, reduces oxidative stress, and suppresses p53, leading to a reduction in cardiac senescence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Peike Sheng, Lu Li, Tianqi Li, Yuzhi Wang, Nicholas M. Hiers, Jennifer S. Mejia, Jossie S. Sanchez, Lei Zhou, Mingyi Xie
Summary: MicroRNAs (miRNA) bind to AGO proteins to degrade target mRNAs. However, extended base-pairing can trigger miRNA degradation and AGO protein degradation mediated by ZSWIM8 ubiquitin ligase. This study identifies TDMD triggers in AGO1 mRNA and demonstrates the physiological importance of miRNA degradation in Drosophila.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Nirthieca Suthakaran, Sanjana Chandran, Michael Iacobelli, David Binninger
Summary: Research findings suggest that flies lacking MSR activity exhibit longer recovery times and reduced survival ability under sudden hypoxia; however, they recover quicker when hypoxia is induced slowly. Decreased apoptotic pathway activation, gene reprogramming, and metabolic downregulation may contribute to the faster recovery time and higher survival rate in MSR deficient flies under slow induction of spreading depression.
Article
Oncology
Alvan Amos, Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He, Yong Xu, Lirong Wu
Summary: This study aimed to increase the sensitivity of nasopharyngeal carcinoma cells to ionizing radiation by enhancing oxidative stress and ferroptosis through disrupting the mitochondrial anti-oxidant enzyme system. The results showed that SOD2 inhibition induced oxidative stress and ferroptosis, leading to increased sensitivity of nasopharyngeal carcinoma cells to ionizing radiation, and this effect was dependent on the activity of DHODH.
Article
Chemistry, Medicinal
Su Ni, Ning Yi, Hang Yuan, Dong Li, Xu Chen, Chao Zhuang
Summary: This study found that angelica sinensis polysaccharide (ASP) improves mitochondrial metabolism in osteoarthritis (OA) chondrocytes by activating PPAR gamma/SOD2/ROS pathways, thereby alleviating the progression of OA.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biology
Tatsuya Sato, Jason Solomon Shapiro, Hsiang-Chun Chang, Richard A. Miller, Hossein Ardehali
Summary: Iron is essential but its accumulation can be harmful. The study found that iron accumulation mainly occurs in the brain cortex of aged mice, which is associated with increased expression of hepcidin and decreased iron exporter.