A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

(2015) Anke Post et al.   NEUROPSYCHOPHARMACOLOGY

MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats

(2014) Giordano de Guglielmo et al.   ADDICTION BIOLOGY

Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3-c]pyran) Scaffold

(2014) Miguel A. Toledo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic Treatment with Novel Brain-Penetrating Selective NOP Receptor Agonist MT-7716 Reduces Alcohol Drinking and Seeking in the Rat

(2014) Roberto Ciccocioppo et al.   NEUROPSYCHOPHARMACOLOGY

Addiction as a stress surfeit disorder

(2013) George F. Koob et al.   NEUROPHARMACOLOGY

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

(2013) Linda M. Rorick-Kehn et al.   NEUROPHARMACOLOGY

Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs

(2013) Elaine Cristina Gavioli et al.   PHARMACOLOGY & THERAPEUTICS

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

(2013) Jeffrey M. Witkin et al.   PHARMACOLOGY & THERAPEUTICS

Brain and Whole-Body Imaging of Nociceptin/Orphanin FQ Peptide Receptor in Humans Using the PET Ligand 11C-NOP-1A

(2012) T. G. Lohith et al.   JOURNAL OF NUCLEAR MEDICINE

The Nociceptin/Orphanin FQ Receptor (NOP) as a Target for Drug Abuse Medications

(2011) Nurulain T. Zaveri   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis and Evaluation of Radioligands for Imaging Brain Nociceptin/Orphanin FQ Peptide (NOP) Receptors with Positron Emission Tomography

(2011) Victor W. Pike et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors

(2011) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dysregulation of Nociceptin/Orphanin FQ Activity in the Amygdala Is Linked to Excessive Alcohol Drinking in the Rat

(2008) Daina Economidou et al.   BIOLOGICAL PSYCHIATRY

Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum

(2008) Maria C. Olianas et al.   JOURNAL OF NEUROCHEMISTRY