Simulation of dry powder inhalers: Combining micro-scale, meso-scale and macro-scale modeling

A numerical study exploring the effect of particle properties on the fluidization of adhesive particles

(2016) Robert Wilson et al.   AICHE JOURNAL

Effect of Device Design and Formulation on the In Vitro Comparability for Multi-Unit Dose Dry Powder Inhalers

(2015) Jagdeep Shur et al.   AAPS Journal

Development and Validation of an HPLC Method for Quantitative Determination of Seven Impurities in Orlistat Capsules and Characterization of Two Novel Impurities

(2015) Wenning Yang et al.   Current Pharmaceutical Analysis

Recent advances in the fundamental understanding of adhesive mixtures for inhalation

(2015) Floris Grasmeijer et al.   CURRENT PHARMACEUTICAL DESIGN

Formulating powder–device combinations for salmeterol xinafoate dry powder inhalers

(2015) Mireille Hassoun et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterisation of dry powder inhaler formulations using atomic force microscopy

(2015) Cordula Weiss et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

DEM analysis of the effect of particle–wall impact on the dispersion performance in carrier-based dry powder inhalers

(2015) Jiecheng Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Formulation Design of Dry Powders for Inhalation

(2015) Jeffry G. Weers et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Towards the optimisation and adaptation of dry powder inhalers

(2014) Y. Cui et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fully-Coupled Balanced-Force VOF Framework for Arbitrary Meshes with Least-Squares Curvature Evaluation from Volume Fractions

(2014) Fabian Denner et al.   NUMERICAL HEAT TRANSFER PART B-FUNDAMENTALS

New Mechanisms to Explain the Effects of Added Lactose Fines on the Dispersion Performance of Adhesive Mixtures for Inhalation

(2014) Floris Grasmeijer et al.   PLoS One

Large Eddy Simulations of turbulent particle-laden channel flow

(2013) George Mallouppas et al.   INTERNATIONAL JOURNAL OF MULTIPHASE FLOW

Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffraction

(2013) Sara Jaffari et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Drug Content Effects on the Dispersion Performance of Adhesive Mixtures for Inhalation

(2013) Floris Grasmeijer et al.   PLoS One

Influence of primary crystallisation conditions on the mechanical and interfacial properties of micronised budesonide for dry powder inhalation

(2012) Harshal A. Kubavat et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modeling dispersion of dry powders for inhalation. The concepts of total fines, cohesive energy and interaction parameters

(2012) Kyrre Thalberg et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Studies on the Effect of the Size of Polycaprolactone Microspheres for the Dispersion of Salbutamol Sulfate from Dry Powder Inhaler Formulations

(2012) Rinku A. Tuli et al.   PHARMACEUTICAL RESEARCH

A critical view on lactose-based drug formulation and device studies for dry powder inhalation: Which are relevant and what interactions to expect?

(2011) A.H. de Boer et al.   ADVANCED DRUG DELIVERY REVIEWS

Kinetics of emitted mass—A study with three dry powder inhaler devices

(2011) Srinivas Ravindra Babu Behara et al.   CHEMICAL ENGINEERING SCIENCE

Does carrier size matter? A fundamental study of drug aerosolisation from carrier based dry powder inhalation systems

(2011) Jesslynn Ooi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The influence of drug loading on formulation structure and aerosol performance in carrier based dry powder inhalers

(2011) Paul M. Young et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanistic analysis and computer simulation of the aerodynamic dispersion of loose aggregates

(2010) Graham Calvert et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

The relationship between drug concentration, mixing time, blending order and ternary dry powder inhalation performance

(2010) Matthew D. Jones et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment of rolling resistance models in discrete element simulations

(2010) Jun Ai et al.   POWDER TECHNOLOGY

Predicting discharge dynamics of wet cohesive particles from a rectangular hopper using the discrete element method (DEM)

(2009) Anshu Anand et al.   CHEMICAL ENGINEERING SCIENCE

Dry powder inhalers (DPIs)—A review of device reliability and innovation

(2008) Nazrul Islam et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS