Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine

Improving recruitment of older people to clinical trials: use of the cohort multiple randomised controlled trial design

(2015) A. Clegg et al.   AGE AND AGEING

Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): The TRIPOD Statement

(2015) Gary S. Collins et al.   ANNALS OF INTERNAL MEDICINE

RandomizEd controlled trial for pre-operAtive dose-escaLation BOOST in locally advanced rectal cancer (RECTAL BOOST study): study protocol for a randomized controlled trial

(2015) JP Maarten Burbach et al.   Trials

Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study

(2014) Masaaki Yamamoto et al.   LANCET ONCOLOGY

An umbrella protocol for standardized data collection (SDC) in rectal cancer: A prospective uniform naming and procedure convention to support personalized medicine

(2014) Elisa Meldolesi et al.   RADIOTHERAPY AND ONCOLOGY

Creating a data exchange strategy for radiotherapy research: Towards federated databases and anonymised public datasets

(2014) Tomas Skripcak et al.   RADIOTHERAPY AND ONCOLOGY

Rapid learning in practice: A lung cancer survival decision support system in routine patient care data

(2014) Andre Dekker et al.   RADIOTHERAPY AND ONCOLOGY

A TCP model for external beam treatment of intermediate-risk prostate cancer

(2013) Seán Walsh et al.   MEDICAL PHYSICS

The clinical utility of prognostic scoring systems in patients with brain metastases treated with radiosurgery

(2013) Jaap D. Zindler et al.   RADIOTHERAPY AND ONCOLOGY

‘Rapid Learning health care in oncology’ – An approach towards decision support systems enabling customised radiotherapy’

(2013) Philippe Lambin et al.   RADIOTHERAPY AND ONCOLOGY

Problems With the Collection and Interpretation of Asian-American Health Data: Omission, Aggregation, and Extrapolation

(2012) Ariel T. Holland et al.   ANNALS OF EPIDEMIOLOGY

Independent and functional validation of a multi-tumour-type proliferation signature

(2012) M H W Starmans et al.   BRITISH JOURNAL OF CANCER

Interim Data from the Medical Research Council QUARTZ Trial: Does Whole Brain Radiotherapy Affect the Survival and Quality of Life of Patients with Brain Metastases from Non-small Cell Lung Cancer?

(2012) R.E. Langley et al.   CLINICAL ONCOLOGY

Radiomics: Extracting more information from medical images using advanced feature analysis

(2012) Philippe Lambin et al.   EUROPEAN JOURNAL OF CANCER

Obstacles to participation in randomised cancer clinical trials: A systematic review of the literature

(2012) Melissa M Grand et al.   Journal of Medical Imaging and Radiation Oncology

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Predicting outcomes in radiation oncology—multifactorial decision support systems

(2012) Philippe Lambin et al.   Nature Reviews Clinical Oncology

No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

(2012) An M. Voets et al.   RADIOTHERAPY AND ONCOLOGY

The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

(2012) Maud H.W. Starmans et al.   RADIOTHERAPY AND ONCOLOGY

Nomograms for Predicting Local Recurrence, Distant Metastases, and Overall Survival for Patients With Locally Advanced Rectal Cancer on the Basis of European Randomized Clinical Trials

(2011) Vincenzo Valentini et al.   JOURNAL OF CLINICAL ONCOLOGY

Results of a Multicentric In Silico Clinical Trial (ROCOCO): Comparing Radiotherapy with Photons and Protons for Non-small Cell Lung Cancer

(2011) Erik Roelofs et al.   Journal of Thoracic Oncology

Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: A prospective validation

(2011) Hugo J.W.L. Aerts et al.   LUNG CANCER

Longer-term influence of breast cancer genetic counseling on cognitions and distress: Smaller benefits for affected versus unaffected women

(2011) Arwen H. Pieterse et al.   PATIENT EDUCATION AND COUNSELING

A Simple but Highly Effective Approach to Evaluate the Prognostic Performance of Gene Expression Signatures

(2011) Maud H. W. Starmans et al.   PLoS One

Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients

(2011) Ada G.T.M. Egelmeer et al.   RADIOTHERAPY AND ONCOLOGY

Dose–effect relation in stereotactic radiotherapy for brain metastases. A systematic review

(2011) Ruud Wiggenraad et al.   RADIOTHERAPY AND ONCOLOGY

PET imaging of hypoxia using [18F]HX4: a phase I trial

(2010) Judith van Loon et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Improving Normal Tissue Complication Probability Models: The Need to Adopt a “Data-Pooling” Culture

(2010) Joseph O. Deasy et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury

(2010) Jeff M. Michalski et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Development and Validation of a Prognostic Model Using Blood Biomarker Information for Prediction of Survival of Non–Small-Cell Lung Cancer Patients Treated With Combined Chemotherapy and Radiation or Radiotherapy Alone (NCT00181519, NCT00573040, and NCT00572325)

(2010) Cary Dehing-Oberije et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Rapid-Learning System for Cancer Care

(2010) Amy P. Abernethy et al.   JOURNAL OF CLINICAL ONCOLOGY

The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: Exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer

(2010) Philippe Lambin et al.   RADIOTHERAPY AND ONCOLOGY

Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients

(2010) Cary Dehing-Oberije et al.   RADIOTHERAPY AND ONCOLOGY

Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage I non-small cell lung cancer. A propensity score matched analysis

(2010) Marcelo F. Jimenez et al.   RADIOTHERAPY AND ONCOLOGY

Adaptive increase in sample size when interim results are promising: A practical guide with examples

(2010) Cyrus R. Mehta et al.   STATISTICS IN MEDICINE

Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up?

(2010) Hilda Bastian et al.   PLOS MEDICINE

Assessing the Performance of Prediction Models

(2009) Ewout W. Steyerberg et al.   EPIDEMIOLOGY

The importance of patient characteristics for the prediction of radiation-induced lung toxicity

(2009) Cary Dehing-Oberije et al.   RADIOTHERAPY AND ONCOLOGY

Increased 18F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): A prospective pilot study

(2009) Dirk De Ruysscher et al.   RADIOTHERAPY AND ONCOLOGY

The use of a comprehensive tumour xenograft dataset to validate gene signatures relevant for radiation response

(2009) Maud H.W. Starmans et al.   RADIOTHERAPY AND ONCOLOGY

Development and External Validation of Prognostic Model for 2-Year Survival of Non–Small-Cell Lung Cancer Patients Treated With Chemoradiotherapy

(2008) Cary Dehing-Oberije et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer

(2008) Dirk De Ruysscher et al.   RADIOTHERAPY AND ONCOLOGY