Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 358, Issue 11, Pages 1741-1745Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600154
Keywords
acid catalysis; heterocycles; homogeneous catalysis; indoles; synthetic methods
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Funding
- MINECO-Spain [CTQ2013-41336-P]
- MEC
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The pyrrolo[3,2,1-ij]quinoline heterocyclic core is found in the structure of a variety of compounds with interesting applications and then, new efficient and flexible strategies to construct this skeleton are required. Here, a new diastereoselective tetrafluoroboric acid (HBF4)-catalyzed three-component coupling reaction of 1H-indole-7-carbaldehyde derivatives, anilines and electron-rich alkenes to give pyrrolo[3,2,1-ij]quinolines is described. The reaction involves an unusual [4+2]-heterocyclization between an in situ formed imine and an alkene. The new catalytic method, where water is the only by-product, is efficient, robust and flexible, and allows for multigram-scale synthesis.
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