Iridium-Catalyzed Asymmetric Hydrogenation of Tosylamido-Substituted Pyrazines for Constructing Chiral Tetrahydropyrazines with an Amidine Skelton

Asymmetric Hydrogenation of 3-Amido-2-arylpyridinium Salts by Triply Chloride-Bridged Dinuclear Iridium Complexes Bearing Enantiopure Diphosphine Ligands: Synthesis of Neurokinin-1 Receptor Antagonist Derivatives

(2016) Atsuhiro Iimuro et al.   ADVANCED SYNTHESIS & CATALYSIS

Chloride-Bridged Dinuclear Rhodium(III) Complexes Bearing Chiral Diphosphine Ligands: Catalyst Precursors for Asymmetric Hydrogenation of Simple Olefins

(2016) Yusuke Kita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts

(2016) Marc Renom-Carrasco et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides

(2016) Wen-Xue Huang et al.   ORGANIC LETTERS

Asymmetric Hydrogenation of Heteroarenes with Multiple Heteroatoms

(2016) Yong-Gui Zhou et al.   SYNTHESIS-STUTTGART

Strong Brønsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh–thiourea chiral phosphine complex via anion binding

(2016) Jialin Wen et al.   Chemical Science

Catalytic Asymmetric Hydrogenation of Pyrimidines

(2015) Ryoichi Kuwano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric hydrogenation of quinazolinium salts catalysed by halide-bridged dinuclear iridium complexes bearing chiral diphosphine ligands

(2015) Yusuke Kita et al.   CHEMICAL COMMUNICATIONS

Substrate Activation in the Catalytic Asymmetric Hydrogenation ofN-Heteroarenes

(2015) Bugga Balakrishna et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Enantiopure Piperazines via Asymmetric Lithiation–Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent

(2015) James D. Firth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst

(2014) Mingxin Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric synthesis of 2-arylpiperazines

(2014) Satoshi Yokoshima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhancing Effects of Salt Formation on Catalytic Activity and Enantioselectivity for Asymmetric Hydrogenation of Isoquinolinium Salts by Dinuclear Halide-Bridged Iridium Complexes Bearing Chiral Diphosphine Ligands

(2014) Yusuke Kita et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecule VI: Sulfonimide or Sulfonamide?

(2014) Sten O. Nilsson Lill et al.   CRYSTAL GROWTH & DESIGN

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

(2014) Kate S. Ashton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iridium-Catalyzed Asymmetric Hydrogenation of Pyrrolo[1,2-a]pyrazinium Salts

(2014) Wen-Xue Huang et al.   ORGANIC LETTERS

A general method for the facile synthesis of optically active 2-substituted piperazines via functionalized 2,5-diketopiperazines

(2014) Kate S. Ashton et al.   TETRAHEDRON LETTERS

Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts

(2013) Zhi-Shi Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of Isoquinolinium Salts Catalyzed by Chiral Iridium Complexes: Direct Synthesis for Optically Active 1,2,3,4-Tetrahydroisoquinolines

(2013) Atsuhiro Iimuro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-catalyzed Asymmetric Hydrogenation of Pyridinium Salts for Constructing Multiple Stereogenic Centers on Piperidines

(2013) Yusuke Kita et al.   CHEMISTRY LETTERS

Enantioselective Iridium-Catalyzed Hydrogenation of 3,4-Disubstituted Isoquinolines

(2012) Lei Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts

(2012) Zhi-Shi Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-based optimization of aminopyridines as PKCθ inhibitors

(2012) Juan-Miguel Jimenez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Linear and cyclic dipeptides with antimalarial activity

(2012) Lemuel Pérez-Picaso et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Additive Effects of Amines on Asymmetric Hydrogenation of Quinoxalines Catalyzed by Chiral Iridium Complexes

(2012) Takuto Nagano et al.   CHEMISTRY-A EUROPEAN JOURNAL

A General, Enantioselective Synthesis of Protected Morpholines and Piperazines

(2012) Matthew C. O’Reilly et al.   ORGANIC LETTERS

Ligand-Controlled Highly Regioselective and Asymmetric Hydrogenation of Quinoxalines Catalyzed by Ruthenium N-Heterocyclic Carbene Complexes

(2011) Slawomir Urban et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of Heteroarenes and Arenes

(2011) Duo-Sheng Wang et al.   CHEMICAL REVIEWS

Co-Crystals of Sulfamethazine with Some Carboxylic Acids and Amides: Co-Former Assisted Tautomerism in an Active Pharmaceutical Ingredient and Hydrogen Bond Competition Study

(2011) Soumyajit Ghosh et al.   CRYSTAL GROWTH & DESIGN

Catalytic Kinetic Resolution of Cyclic Secondary Amines

(2011) Michael Binanzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Convergent Asymmetric Disproportionation Reactions: Metal/Brønsted Acid Relay Catalysis for Enantioselective Reduction of Quinoxalines

(2011) Qing-An Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric hydrogenation of quinolines activated by Brønsted acids

(2010) Duo-Sheng Wang et al.   TETRAHEDRON LETTERS

Unprecedented Halide Dependence on Catalytic Asymmetric Hydrogenation of 2-Aryl- and 2-Alkyl-Substituted Quinolinium Salts by Using Ir Complexes with Difluorphos and Halide Ligands

(2009) Hiroshi Tadaoka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery Process and Pharmacological Characterization of 2-(S)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(R)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK1Receptor Antagonist

(2009) Romano Di Fabio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expedite Protocol for Construction of Chiral Regioselectively N-Protected Monosubstituted Piperazine, 1,4-Diazepane, and 1,4-Diazocane Building Blocks

(2009) François Crestey et al.   JOURNAL OF ORGANIC CHEMISTRY

Complete Regioselective Addition of Grignard Reagents to PyrazineN-Oxides, Toward an Efficient Enantioselective Synthesis of Substituted Piperazines

(2009) Hans Andersson et al.   ORGANIC LETTERS

Asymmetric Hydrogenation of Quinolines Catalyzed by Iridium Complexes of Monodentate BINOL-Derived Phosphoramidites

(2008) Nataša Mršić et al.   ADVANCED SYNTHESIS & CATALYSIS

First Example of s-BuLi/(-)-Sparteine-Mediated Chiral Deprotonation of a Piperazine and Proof of the Sense of Induction

(2008) Benjamin McDermott et al.   SYNLETT