Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 358, Issue 6, Pages 977-983Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500844
Keywords
cross-coupling reactions; homocoupling; Miyaura borylation; palladium; solvent-free reactions
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Funding
- RFBR [13-03-1224013 ofi m]
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Solvent-free protocols for Miyaura borylation and the one-pot, two-step homocoupling of aryl halides are reported for the first time. Bis(di-benzylideneacetone) palladium(0) [Pd(dba)(2)] is an optimal source of palladium for Miyaura borylation, while for one-pot two-step homocoupling palladium(II) acetate [Pd(OAc)(2)] gives highest yields. Aryl bromides are coupled most efficiently using the DPEphos ligand. Chlorides are coupled using XPhos. The developed protocols are robust, versatile and easily reproducible on a large scale.
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