Journal
BIOCONJUGATE CHEMISTRY
Volume 26, Issue 9, Pages 1873-1878Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.5b00350
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Funding
- CHIESI Foundation (Parma, Italy)
- MIUR [2008J4YNJY]
- UniBo (Marco Polo)
- ERC [247365]
- EU MSCA-IEF [627788]
- MESR
- AXA Research funds
- European Research Council (ERC) [247365] Funding Source: European Research Council (ERC)
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The rapid and exact identification and quantification of specific biomarkers is a key technology for always achieving more efficient diagnostic methodologies. We present the first application of a nanostructured device constituted of patterned self-assembled monolayers of disk-shaped zeolite L coated with the cyclic integrin ligand c[RGDfK] via isocyanate linker, to the rapid detection of cancer cells. With its high specificity toward He La and Glioma cells and fast adhesion ability, this biocompatible monolayer is a promising platform for implementation in diagnostics and personalized therapy formulation devices.
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