A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity

Action Potential Characterization of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Using Automated Patch-Clamp Technology

(2014) Olaf Scheel et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A Simple, Cost-Effective but Highly Efficient System for Deriving Ventricular Cardiomyocytes from Human Pluripotent Stem Cells

(2014) Zhihui Weng et al.   STEM CELLS AND DEVELOPMENT

Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents

(2014) John K. Gibson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Ranolazine: Clinical Applications and Therapeutic Basis

(2013) Nael Hawwa et al.   American Journal of Cardiovascular Drugs

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias

(2013) Jiaxian Wang et al.   BIOMATERIALS

Three-dimensional filamentous human diseased cardiac tissue model

(2013) Zhen Ma et al.   BIOMATERIALS

Safety of Flecainide

(2012) Juan Tamargo et al.   DRUG SAFETY

Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

(2011) Aaron Chen et al.   ADVANCED MATERIALS

Drug Safety Sciences and the Bottleneck in Drug Development

(2011) P B Watkins   CLINICAL PHARMACOLOGY & THERAPEUTICS

Multiscale Biomimetic Topography for the Alignment of Neonatal and Embryonic Stem Cell-Derived Heart Cells

(2011) Jesus Isaac Luna et al.   TISSUE ENGINEERING PART C-METHODS

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

(2010) Shengde Peng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes

(2009) Malin KB Jonsson et al.   Expert Opinion on Drug Discovery

Cisapride and ventricular arrhythmia

(2008) Sean Hennessy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

QT prolongation is an unreliable predictor of ventricular arrhythmia

(2008) Luc M. Hondeghem   HEART RHYTHM

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

(2008) Gary A. Gintant   PHARMACOLOGY & THERAPEUTICS