Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals

Potential of single cationic amino acid molecule “Arginine” for stimulating oral absorption of insulin

(2017) Noriyasu Kamei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Region-Dependent Role of Cell-Penetrating Peptides in Insulin Absorption Across the Rat Small Intestinal Membrane

(2015) El-Sayed Khafagy et al.   AAPS Journal

The role of tryptophans on the cellular uptake and membrane interaction of arginine-rich cell penetrating peptides

(2015) Marie-Lise Jobin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lessons learned from the clinical development of oral peptides

(2015) Morten Asser Karsdal et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium

(2015) Noriyasu Kamei et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol

(2015) David J. Brayden et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

The Uptake of Arginine-Rich Cell-Penetrating Peptides: Putting the Puzzle Together

(2014) Roland Brock   BIOCONJUGATE CHEMISTRY

The enhanced membrane interaction and perturbation of a cell penetrating peptide in the presence of anionic lipids: Toward an understanding of its selectivity for cancer cells

(2013) Marie-Lise Jobin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Mechanistic Study of the Uptake/Permeation of Cell-Penetrating Peptides Across a Caco-2 Monolayer and Their Stimulatory Effect on Epithelial Insulin Transport

(2013) Noriyasu Kamei et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon

(2013) Yosuke Shimada et al.   PLoS One

Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells

(2012) Susanne M. Krug et al.   BIOMATERIALS

Tryptophan within basic peptide sequences triggers glycosaminoglycan-dependent endocytosis

(2012) Chérine Bechara et al.   FASEB JOURNAL

Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography

(2010) Noriyasu Kamei et al.   JOURNAL OF CONTROLLED RELEASE

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic

(2009) Sam Maher et al.   ADVANCED DRUG DELIVERY REVIEWS

Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins

(2009) El-Sayed Khafagy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides

(2009) Noriyasu Kamei et al.   JOURNAL OF CONTROLLED RELEASE

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells

(2008) Takahiro Kimoto et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Usefulness of cell-penetrating peptides to improve intestinal insulin absorption

(2008) Noriyasu Kamei et al.   JOURNAL OF CONTROLLED RELEASE

Effect of cell-penetrating peptides on the nasal absorption of insulin

(2008) El-Sayed Khafagy et al.   JOURNAL OF CONTROLLED RELEASE

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY