Article
Otorhinolaryngology
Baruch Weizman, Nili Golan, Ohad Ronen
Summary: The study aimed to assess the survival outcomes of head and neck cancer patients by socioeconomic status. It found that patients from higher socioeconomic areas had better survival rates, with age over 65 and low socioeconomic status being correlated with inferior overall survival.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Kate Ingarfield, Alex D. McMahon, Katrina Hurley, Stu Toms, Miranda Pring, Steve J. Thomas, Andrea Waylen, Michael Pawlita, Tim Waterboer, Andy R. Ness, David I. Conway
Summary: This study analyzed the UK Head and Neck 5000 prospective clinical cohort, finding that inequalities in survival among head and neck cancer patients could be explained by age, sex, health, and behavioral factors related to deprivation category, highest education level, and financial concerns. However, the inequality associated with annual household income or the proportion of income of benefits remained unexplained by the potential explanatory factors.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Ahmed Bedir, Semaw Ferede Abera, Ljupcho Efremov, Lamiaa Hassan, Dirk Vordermark, Daniel Medenwald
Summary: This study confirms survival disparities between affluent and deprived HNC patients in Germany. Although data limitations exist, the results suggest that eliminating differences in stage at diagnosis within six months after HNC diagnosis could reduce survival inequalities.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ivana Simic, Ksenija Bozinovic, Nina Milutin Gasperov, Mario Kordic, Ena Pesut, Luka Manojlovic, Magdalena Grce, Emil Dediol, Ivan Sabol
Summary: Head and neck cancers (HNC) are a diverse group of tumours linked to tobacco, alcohol, and human papillomavirus (HPV). Most HNC cases are squamous cell carcinomas (HNSCC). A study on primary HNSCC patients revealed a predominance of male gender, HPV-negative tumors mainly located in the oral region, and a high proportion of stage IV cancer. Survival analysis showed that the presence of perineural and angioinvasion had a significant impact on patient survival. Additionally, upregulation of miR-21 was consistently associated with poor prognosis and could serve as a prognostic biomarker in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Nicholas R. Lenze, Douglas Farquhar, Siddharth Sheth, Jose P. Zevallos, Jeffrey Blumberg, Catherine Lumley, Samip Patel, Trevor Hackman, Mark C. Weissler, Wendell G. Yarbrough, Adam M. Zanation, Andrew F. Olshan
Summary: A study of HPV-negative head and neck squamous cell carcinoma patients found that racial disparities in diagnosis and survival are primarily influenced by socioeconomic status, with low SES serving as a target for interventions aimed at mitigating these disparities.
Article
Oncology
Nicholas R. Lenze, Douglas R. Farquhar, Siddharth Sheth, Jose P. Zevallos, Catherine Lumley, Jeffrey Blumberg, Samip Patel, Trevor Hackman, Mark C. Weissler, Wendell G. Yarbrough, Andrew F. Olshan, Adam M. Zanation
Summary: In this study, it was found that socioeconomic status (SES) may have a prognostic ability similar to overall stage for HPV-negative head and neck squamous cell carcinoma (HNSCC) patients. Low SES was associated with significantly increased risk of mortality and this association persisted even after adjusting for other factors.
Article
Orthopedics
J. F. Maempel, N. D. Clement, S. P. Mackenzie, C. McCann, T. O. White
Summary: This study aimed to describe the epidemiology of Achilles tendon rupture (ATR) and its relationship with socioeconomic deprivation status (SEDS). The study found that ATR occurs more frequently in less socioeconomically deprived populations.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Medicine, General & Internal
Matteo Scampa, Rastine Merat, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Head and neck porocarcinoma is a rare tumor with male predominance. The incidence of distant metastasis is low, and surgery is the main treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Andreas Knopf, Simon Teutsch, Henning Bier
Summary: This study found that insurance status did not significantly impact the time of diagnosis, quality of treatment, and survival in HNSCC patients. There were no differences in age, gender, tumor localization, and therapy between patients with general insurance and private insurance, but overall survival was better in patients with private insurance.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Otorhinolaryngology
Lauren A. Lawrence, Mitchell L. Heuermann, Pardis Javadi, Arun Sharma
Summary: This study examined the relationship among rurality, socioeconomic status, and patient/tumor characteristics in head and neck cancer patients. It found that rural residence was associated with lower SES, and T and N stages were related to rurality. Additionally, higher educational status was linked to oropharyngeal cancer.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Paul Zolkind, Jake J. Lee, Ryan S. Jackson, Patrik Pipkorn, Sean T. Massa
Summary: This study aimed to provide modern estimates of survival for untreated head and neck cancer patients and identify factors associated with not receiving definitive treatment. The results showed that untreated HNC patients had a median survival of 12 months, with significant variability by site and stage. Factors such as advanced age, black race, unmarried status, and lack of private insurance were associated with not receiving treatment.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Critical Care Medicine
Daniel Mullany, David Pilcher, Annette J. Dobson
Summary: The study found a correlation between the average socioeconomic status of a patient's area and ICU admission diagnosis, comorbidities, severity of illness, and inhospital mortality. However, after adjusting for severity of illness and admission diagnosis, socioeconomic status was not found to be associated with inhospital mortality. Risk adjustment measures in intensive care can improve understanding of the relationship between socioeconomic status and outcomes.
CRITICAL CARE MEDICINE
(2021)
Article
Oncology
Dongjie He, Siying Zhu, Qianqian Zhao, Hao Chang, Gaiyan Li, Qiuju Shao, Chao Zhang, Peiwen Wu
Summary: This retrospective study analyzed the incidence, prevalence, and overall survival of patients with head and neck adenoid cystic carcinoma (HNACC) and developed a prognostic model. The results showed a decrease in HNACC incidence over the past 40 years with slightly improved survival rates. The prognostic model demonstrated moderate accuracy in predicting 5-year and 10-year overall survival rates.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
David Conway, Jan Hovanec, Wolfgang Ahrens, Alastair Ross, Ivana Holcatova, Pagona Lagiou, Diego Serraino, Cristina Canova, Lorenzo Richiardi, Claire Healy, Kristina Kjaerheim, Gary J. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Paul Brennan, Daniele Luce, Gwenn Menvielle, Isabelle Stucker, Simone Benhamou, Heribert Ramroth, Paolo Boffetta, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander Daudt, Rosalina Koifman, Victor Wunsch-Filho, Amy Lee Yuan-Chin, Mia Hashibe, Thomas Behrens, Alex D. McMahon
Summary: Low occupational socioeconomic prestige, position, and manual work are associated with head and neck cancer risk, which is only partially explained by smoking, alcohol, and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor relative to socioeconomic position and manual/non-manual work in relation to head and neck cancer risk.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Article
Neurosciences
Iain J. Marshall, Charles Wolfe, Eva Emmett, Hatem Wafa, Yanzhong Wang, Abdel Douiri, Ajay Bhalla, Matthew D. L. O'Connell
Summary: The South London Stroke Register (SLSR) is a population-based cohort study that investigates the causes, incidence, and outcomes of stroke. It aims to estimate stroke incidence and assess acute and long-term needs in a diverse urban population. The SLSR has had significant findings regarding the inequalities in stroke risk and outcomes and the improvements in stroke care over the years.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Otorhinolaryngology
Nidal Muhanna, Catriona M. Douglas, Michael J. Daly, Harley H. L. Chan, Robert Weersink, Jimmy Qiu, Jason Townson, John R. de Almeida, David Goldstein, Ralph Gilbert, Eugene Yu, Walter Kucharczyk, David A. Jaffray, Jonathan C. Irish
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Oncology
Nidal Muhanna, Harley H. L. Chan, Jason L. Townson, Cheng S. Jin, Lili Ding, Michael S. Valic, Catriona M. Douglas, Christina M. MacLaughlin, Juan Chen, Gang Zheng, Jonathan C. Irish
ENDOCRINE-RELATED CANCER
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Douglas, R. Crosbie, D. Young, J. Montgomery, G. O'Neill, C. McArthur
CLINICAL RADIOLOGY
(2020)
Article
Health Care Sciences & Services
Catriona R. Mayland, Kate Ingarfield, Simon N. Rogers, Paola Dey, Steven Thomas, Andrea Waylen, Sam D. Leary, Miranda Pring, Katrina Hurley, Tim Waterboer, Michael Pawlita, Andy R. Ness
PALLIATIVE MEDICINE
(2020)
Article
Otorhinolaryngology
Alison E. Lim, Catriona M. Douglas, Jenny Montgomery
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2020)
Article
Oncology
Julia Simon, Lea Schroeder, Kate Ingarfield, Stefan Diehl, Jill Werner, Nicole Brenner, Zhiwei Liu, Michael Pawlita, Miranda Pring, Julia Butt, Andy Ness, Tim Waterboer
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Ryan J. Langdon, Rhona A. Beynon, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Richard M. Martin, Andy R. Ness, Michael Pawlita, Tim Waterboer, Caroline Relton, Steven J. Thomas, Rebecca C. Richmond
CLINICAL EPIGENETICS
(2020)
Article
Oncology
Katrina Hueniken, Catriona M. Douglas, Ashok R. Jethwa, Maryam Mirshams, Lawson Eng, Andrew Hope, Douglas B. Chepeha, David P. Goldstein, Jolie Ringash, Aaron Hansen, Rosemary Martino, Madeline Li, Geoffrey Liu, Wei Xu, John R. de Almeida
Article
Engineering, Biomedical
Runjie B. Shi, Souzan Mirza, Diego Martinez, Catriona Douglas, John Cho, Jonathon C. Irish, David A. Jaffray, Robert A. Weersink
PHYSICS IN MEDICINE AND BIOLOGY
(2020)
Article
Otorhinolaryngology
Catriona M. Douglas, Ashock R. Jethwa, Wael Hasan, Amy Liu, Ralph Gilbert, David Goldstein, John De Almedia, Jeff Lipton, Jonathan C. Irish
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Otorhinolaryngology
Kate Ingarfield, Alex D. McMahon, Katrina Hurley, Stu Toms, Miranda Pring, Steve J. Thomas, Andrea Waylen, Michael Pawlita, Tim Waterboer, Andy R. Ness, David I. Conway
Summary: This study analyzed the UK Head and Neck 5000 prospective clinical cohort, finding that inequalities in survival among head and neck cancer patients could be explained by age, sex, health, and behavioral factors related to deprivation category, highest education level, and financial concerns. However, the inequality associated with annual household income or the proportion of income of benefits remained unexplained by the potential explanatory factors.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Rhona A. Beynon, Suzanne M. Ingle, Ryan Langdon, Margaret May, Andy Ness, Richard M. Martin, Matthew Suderman, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Tim Waterboer, Michael Pawlita, Caroline Relton, George Davey Smith, Rebecca C. Richmond
Summary: In a clinical cohort of individuals with head and neck cancer, epigenetic markers of aging were found to enhance survival prediction, beyond established prognostic factors, suggesting potential utility in clinical and non-clinical contexts for treatment planning and patient stratification.
CLINICAL EPIGENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mark Gormley, Grant Creaney, Andrew Schache, Kate Ingarfield, David I. Conway
Summary: The incidence of head and neck cancer has been increasing globally, mainly driven by oropharyngeal cancer. Major risk factors include tobacco smoking, alcohol consumption, betel chewing, and human papillomavirus.
BRITISH DENTAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Gwenllian Moody, Elinor Coulman, David Gillespie, Mark Goddard, Corinna Grindle, Richard P. Hastings, Carl Hughes, Kate Ingarfield, Zac Taylor, Louise Denne
Summary: This study aims to assess the feasibility of delivering the READ-IT reading program to adults with intellectual disabilities by family carers/support workers. The results will have significant scientific impact in the field of intellectual disability and contribute to improving outcomes for adults with ID and their caregivers.
PILOT AND FEASIBILITY STUDIES
(2022)