Bioactivities of EF24, a Novel Curcumin Analog: A Review

Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway inhibition

(2018) Liping Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors

(2018) Rong Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcuminoids as EBV Lytic Activators for Adjuvant Treatment in EBV-Positive Carcinomas

(2018) Octavia Ramayanti et al.   Cancers

Design, synthesis, and evaluation of asymmetric EF24 analogues as potential anti-cancer agents for lung cancer

(2017) Jianzhang Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in Human Leukemia Cells

(2017) Nikola Skoupa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin analog EF24 induces apoptosis and downregulates the mitogen activated protein kinase/extracellular signal-regulated signaling pathway in oral squamous cell carcinoma

(2017) Chongxiang Lin et al.   Molecular Medicine Reports

Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer

(2017) Xuemeng Xie et al.   Drug Design Development and Therapy

Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells

(2016) Guodong He et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells

(2016) Peng Zou et al.   Oncotarget

EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma CellsIn Vitrovia Inhibiting the Phosphorylation of Src

(2016) Ran Zhao et al.   Biomed Research International

A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies

(2016) Savita Bisht et al.   JOURNAL OF NANOBIOTECHNOLOGY

Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

(2016) Weiqian Chen et al.   Redox Biology

EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma

(2016) Da-long Yin et al.   Scientific Reports

Diphenyldifluoroketone EF24 Suppresses Pro-inflammatory Interleukin-1 receptor 1 and Toll-like Receptor 4 in lipopolysaccharide-stimulated dendritic cells

(2015) Prachi Vilekar et al.   Journal of Inflammation-London

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2

(2015) Pu Zhang et al.   TOXICOLOGY LETTERS

The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model

(2015) Vivek R Yadav et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Antibacterial Activity of Synthetic Curcumin Derivatives: 3,5-Bis(benzylidene)-4-Piperidone (EF24) and EF24-Dimer Linked via Diethylenetriaminepentacetic Acid (EF2DTPA)

(2014) Prachi Vilekar et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Hemorrhage-Induced Interleukin-1 Receptor Pathway in Lung Is Suppressed by 3,5-Bis(2-Fluorobenzylidene)-4-Piperidone in a Rat Model of Hypovolemic Shock

(2014) Vivek R. Yadav et al.   ARTIFICIAL ORGANS

Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993)

(2014) Joel M. Reid et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1

(2014) Shala L. Thomas et al.   CELL CYCLE

EF24 and RAD001 potentiates the anticancer effect of platinum-based agents in human malignant pleural mesothelioma (MSTO-211H) cells and protects nonmalignant mesothelial (MET-5A) cells

(2014) HI Onen et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Induction of apoptosis by diphenyldifluoroketone in osteogenic sarcoma cells is associated with activation of caspases

(2014) SEOK-JIN YANG et al.   ONCOLOGY REPORTS

Ursolic Acid Increases Glucose Uptake through the PI3K Signaling Pathway in Adipocytes

(2014) Yonghan He et al.   PLoS One

A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

(2014) Soheil Zorofchian Moghadamtousi et al.   Biomed Research International

Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells

(2013) Dandan Zhang et al.   CANCER SCIENCE

EF24 prevents rotenone-induced estrogenic status alteration in breast cancer

(2013) Debarshi Roy et al.   CELL BIOLOGY INTERNATIONAL

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma

(2013) Yingjian Liang et al.   HEPATOLOGY

Novel Synthetic Monoketone Transmute Radiation-Triggered NFκB-Dependent TNFα Cross-Signaling Feedback Maintained NFκB and Favors Neuroblastoma Regression

(2013) Sheeja Aravindan et al.   PLoS One

The Curcumin Analog EF24 Targets NF-κB and miRNA-21, and Has Potent Anticancer Activity In Vitro and In Vivo

(2013) Chuan He Yang et al.   PLoS One

Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway

(2013) Yonghan He et al.   PLoS One

Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling

(2013) Sheeja Aravindan et al.   Radiation Oncology

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

EF24 suppresses maturation and inflammatory response in dendritic cells

(2012) P. Vilekar et al.   INTERNATIONAL IMMUNOLOGY

In Vivo and In Vitro Suppression of Hepatocellular Carcinoma by EF24, a Curcumin Analog

(2012) Haitao Liu et al.   PLoS One

Anticancer Activity of an Imageable Curcuminoid 1-[2-Aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH)

(2011) Pallavi Lagisetty et al.   Chemical Biology & Drug Design

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

(2011) Anlys Olivera et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diphenyl Difluoroketone: A Potent Chemotherapy Candidate for Human Hepatocellular Carcinoma

(2011) Yingjian Liang et al.   PLoS One

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

(2010) Bharat B. Aggarwal   Annual Review of Nutrition

Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: Implications for subcellular traffic and neurodegenerative disorders

(2010) Rituraj Pal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention

(2010) Rituraj Pal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy

(2010) Shala L. Thomas et al.   BIOCHEMICAL PHARMACOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Liposome-encapsulated EF24-HPβCD inclusion complex: a preformulation study and biodistribution in a rat model

(2010) H. Agashe et al.   JOURNAL OF NANOPARTICLE RESEARCH

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

(2010) Igor Landais et al.   Molecular Cancer

Multiple Anticancer Activities of EF24, a Novel Curcumin Analog, on Human Ovarian Carcinoma Cells

(2010) Xin Tan et al.   Reproductive Sciences

Curcumin, inflammation, ageing and age-related diseases

(2010) E Sikora et al.   Immunity & Ageing

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Diphenyl Difluoroketone: A Curcumin Derivative with Potent In vivo Anticancer Activity

(2008) D. Subramaniam et al.   CANCER RESEARCH

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa

(2008) Mamoru Shoji et al.   JOURNAL OF DRUG TARGETING

Inhibition of I B Kinase-Nuclear Factor- B Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin

(2008) A. L. Kasinski et al.   MOLECULAR PHARMACOLOGY

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY